Protein Alignment para and LOC3290639

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_061519822.1
• Gene: LOC3290639 / 3290639
• VectorBaseID: AGAMI1_006897
• Length: 1874
• Species: Anopheles gambiae
• Alignment Length: 2019
• Identity: 466/2019 - (23%)
• Similarity: 816/2019 - (40%)
• Gaps: 601/2019 - (29%)

  Fly   140 NPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----------TTPTVESTEVIFTGIYTFESA 194
            |.||:...:|:..|.|...::.||:.||:::.:.          ....:|.||..|..|:|.|:|
Mosquito    54 NFIRKATKFIIEWPPFEYAVLLTIIANCVVLALEEHLPKGDKTVLAQKLELTESYFLCIFTIEAA 118

  Fly   195 VKVMARGFILCPFTYLRDAWNWLDFVVIALAYVT---MGIDLGNLAALRTFRVLRALKTVAIVPG 256
            :|::|.|.:|...:|||:.||.:||.|:....||   :.:|: :|..||:.||||.||.|:.||.
Mosquito   119 LKIVALGLVLHADSYLRNIWNMMDFFVVFTGLVTLLPLPLDV-DLRTLRSIRVLRPLKLVSGVPS 182

  Fly   257 LKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW-----GNLTD 316
            |:.::.::|:::..|..:.:|.:|::.:||::||:.|.|||.:.|   :.|:.::     |:|
Mosquito   183 LQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGVLHKSC---YSLENAFEIIEEGDL-- 242

  Fly   317 ENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCD-DDYVCLQGFGPNPNYGYTSFDSFGWAFLS 380
                     .:..|.:|:.::..|   .:|...|: ::..|::.: ..||||.|:||:.|:|.|:
Mosquito   243 ---------PTPCYDDDDTMNAEL---PAGVHLCNHNESACIEQW-EGPNYGITNFDNIGFAMLT 294

  Fly   381 AFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEA 444
            .|:.:|.:.|.........|.| .::.::|:.:|.:|||:::||:|.:::..:...::|.|..:
Mosquito   295 VFQCITMEGWTSTMYWTNDAIGSTFNWIYFVPLIIIGSFFMLNLVLGVLSGEFAREREKVENRQ- 358

  Fly   445 AEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEK 509
                     |.....:..:||:..|...:                      :.|.:.|:.:..::
Mosquito   359 ---------EFLKLRRQQQLEKELNGFVE----------------------WICKAEEIILAEDR 392

  Fly   510 GNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSH 574
            ..::   |:|.|.....::                 |.|.:|:.
Mosquito   393 TTEE---ERMYIMEARKKA-----------------AAKRKKLK--------------------- 416

  Fly   575 KYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRH 639
                                                                       |||...
Mosquito   417 -----------------------------------------------------------NLGKSK 422

  Fly   640 SSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHR 704
            ||.|.
Mosquito   423 SSETD------------------------------------------------------------ 427

  Fly   705 DYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFP 769
            |.|...|..|| |.:|....|                         |.....||..|
Mosquito   428 DEEATTESGDE-GILKKEKKP-------------------------AKSGFWRAEKR-------- 458

  Fly   770 TEDDDEDGPTFKDKALEVILKGIDVFCV-------WDCCWVWLKFQEWVSLIVFDPFVELFITLC 827
                      |:             :|:       |   :.|                  |:.:.
Mosquito   459 ----------FR-------------YCIRHTVKTQW---FYW------------------FVIVL 479

  Fly   828 IVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVAL 892
            :.:||:.:|::|:.....:...|....:.|...|..|..:|:.|:.|:.||:..:|.||.|::|.
Mosquito   480 VFLNTICVAVEHYGQPNWLALFLYYAEFVFLGLFMCEMLIKIYALGPRIYFESAFNRFDCIVIAG 544

  Fly   893 SLLEL----GLEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIF 952
            |:.|:    ..||..|:||||:.||||:||:.|.|.:| ||:||::. :|.::.:|.|:|.:.|.
Mosquito   545 SIFEVVWSAYKEGSFGISVLRALRLLRIFKVTKYWSSLRNLVISLLS-SMRSIISLLFLLFLFIL 608

  Fly   953 IFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVG---- 1012
            |||::||||||..:     ..|:| .|..||..|..:.:.||::|.|| |.|    .||:|
Mosquito   609 IFALLGMQLFGGQF-----ILPEG-TPPTNFNTFTIALLTVFQILTGEDWNE----VMYLGINSQ 663

  Fly  1013 -----DVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKS 1072
                 .:....:|:...:.||..:||:|||:.:.|..::
Mosquito   664 GGHESGMIYSLYFIILTLFGNYTLLNVFLAIAVDNLANA-------------------------- 702

  Fly  1073 WVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILA 1137
                          .:||                             :||....|.:
Mosquito   703 --------------QELT-----------------------------AAEEQQQERD-------- 716

  Fly  1138 DGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKD 1202
                    ||:.|:|:                  .|:.:.|..|.|
Mosquito   717 --------KEKQQMEL------------------EKEMEALQKAKD------------------- 736

  Fly  1203 ESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDS 1267
                |:..|.:.|.:::..||. ..:|:.:||.| ||.|                |.|....|.|
Mosquito   737 ----GTPTTEDAEAEKEKEKES-KKEEKKEEEPE-EEAP----------------EGPKPMLPYS 779

  Fly  1268 YYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQ 1332
            ....|     ...:|       :|.....::..:||:..::.:|.:||:|||.||      |:.:
Mosquito   780 CMFIF-----SSTNP-------MRRAAHWVVNLRYFDFFIMIVISLSSIALAAED------PVQE 826

  Fly  1333 D-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLVG 1388
            |     :|..:|..||.:|.:|||:|.:.||..:    |....|..:|.|:|..::::....:.|
Mosquito   827 DSPRNKVLNNLDYAFTCVFTIEMLLKVIDLGIILHPGSYLREIWNIMDAVVVGCAVVSIGFDISG 891

  Fly  1389 --AGG-IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1450
              ||. :...|::|.||.||||:.:.|:..::.|.:.:|.::.::.|:|:|.::|..|||::.||
Mosquito   892 SDAGADLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVGSLKNVINILIVYILFQFIFAVIAVQ 956

  Fly  1451 LFAGKYFKCEDMNGTKLSHEIIPNRNACE--------------SENYTWVNSAMNFDHVGNAYLC 1501
            ||.||:|.|.|.:    .|..|.    |:              |....|.....|:|:|..|.|.
Mosquito   957 LFNGKFFYCTDDS----KHNSID----CQGSYFIYSEVDGLPRSAKREWKTQYFNYDNVATAMLT 1013

  Fly  1502 LFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQ 1566
            ||.|.|.:||.|::.:::.:...|:.||:...|.|.:::|.:.:...||.:|:|:.:||..|.||
Mosquito  1014 LFAVQTGEGWPQVLQNSMAATYEDEGPIQNFRIEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ 1078

  Fly  1567 KKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIG 1630
                 |..|:...|..|...:.:......:|| :.||......:..|:.|:....|:..||..|.
Mosquito  1079 -----GEAELQDGEIDKNQKSCIDFTIGARPLERYIPTKHSGFKYTVWRIIVSAPFEYFIMTLIV 1138

  Fly  1631 LNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI--FALRYHYFIEPWNLFDVVVVILS 1693
            .|...:.:..:|.:......:.|||.||..:||.|.:|||  |..| ::|.:.||:||::.||.|
Mosquito  1139 FNTLLLMMKCHDQNKKLENFMKYLNMIFTGMFSVETVLKIIGFGAR-NFFKDAWNVFDLITVIGS 1202

  Fly  1694 ILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1758
            |:..::..:.|..| :...||:.|.|   |:::|::....||.||:....|..||..:|||:.::
Mosquito  1203 IVDALILLLWENSF-NVGFLRLFRAA---RLIKLLRQGDTIRILLWTFVQSFKALPYVCLLIAML 1263

  Fly  1759 MFIFAIFGMSFFMHVK--EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPD 1821
            .||:||.||..|.:::  ..:.|:...||::|...::|||:.:|...|..::.|.:....|||..
Mosquito  1264 FFIYAIIGMQVFGNIELDPDTAISRHNNFRSFLDGLMLLFRCATGESWPNIMLACLKGRPCDPRA 1328

  Fly  1822 NDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIW 1886
            |...  ..||| |:...:.:|::.....:::|:::|||::|:...|.| ...|.....|.:..||
Mosquito  1329 NKPN--ETCGS-TLAYGYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD-SSILGAHHLDEFVRIW 1389

  Fly  1887 QQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDLMYCVDILDALT 1946
            .::||..:..:.|.::.:.|..:.|||....  ||:.   |:|.|::|:.....:.....|.||.
Mosquito  1390 AEYDPSASGKLHYTEMYDMLKNMAPPLGFGNKCPNRLAYKKLIRMNMPVDEEGRVGFTTTLFALI 1454

  Fly  1947 KDFFARKGNPIEETG-----------EIGEIAARPDTEGYEPVSSTLWRQR----EEYCARLIQH 1996
            ::..:.|..|.||..           :|..|.|:...:...|.::.|...:    :.|...|:..
Mosquito  1455 RENLSIKMRPAEEMDQADMELRQTIRQIWPIQAKKMVDLLVPPNNVLNTGKMTVGKIYAGILMLE 1519

  Fly  1997 AWRKHK-ARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESN 2060
            .||.:| ||.:    |||:..          :..|.|..:   |...||.::      .|....:
Mosquito  1520 TWRNNKGARYD----FEPELQ----------EHKPHEIQE---PYIDDGHLH------PDQRNGH 1561

  Fly  2061 VNSP 2064
            |.||
Mosquito  1562 VRSP 1565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	87/303 (29%)
		Na_trans_cytopl	555..740	CDD:463401	14/184 (8%)
		Ion_trans	817..1028	CDD:459842	72/225 (32%)
		Na_trans_assoc	1054..1296	CDD:461936	32/241 (13%)
		Ion_trans	1300..1571	CDD:459842	90/296 (30%)
		Na_channel_gate	1561..1613	CDD:240441	11/52 (21%)
		Ion_trans	1621..1871	CDD:459842	79/253 (31%)
		GPHH	1882..1929	CDD:465306	14/51 (27%)
LOC3290639	XP_061519822.1	None