DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and cac

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster


Alignment Length:2169 Identity:499/2169 - (23%)
Similarity:863/2169 - (39%) Gaps:655/2169 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 AMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----------TTPTVESTEVIFT 186
            ::::|...||||:...:|:..|.|...::.||:.||:::.:.          ....:|.||..|.
  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81

  Fly   187 GIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG---NLAALRTFRVLRAL 248
            .|:..|:::|::|.|.:|...:|||:.||.:||.|:...::|....:|   :|..||..||||.|
  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146

  Fly   249 KTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGN 313
            |.|:.:|.|:.::.::|:::..|..:.:|.:|::.:||::||:.|.|.|.:.|   :.|:.. ..
  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC---YSLEDP-NK 207

  Fly   314 LTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAF 378
            |..|.......|:.|...:..| || :|.|.:.        :||:.: ..||.|.||||:.|:|.
  Fly   208 LVKEGESETPCNTDNILEKATG-SF-VCNNTTS--------MCLEKW-EGPNSGITSFDNIGFAM 261

  Fly   379 LSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEE 442
            |:.|:.:|.:.|..:......|.| .::.::|:.:|.:|||:::||:|.:::..:.:.::|.|..
  Fly   262 LTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENR 326

  Fly   443 EAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGG 507
            :          |.....:..:||...|...:                      :.|.:.|:.:..
  Fly   327 Q----------EFLKLRRQQQLERELNGYVE----------------------WICKAEEVILAE 359

  Fly   508 EKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRS 572
            |:..::   |||                                                     
  Fly   360 ERTTEE---EKM----------------------------------------------------- 368

  Fly   573 SHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGS 637
                                             |:..|...||                      
  Fly   369 ---------------------------------HIMEARRRNA---------------------- 378

  Fly   638 RHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLD 702
                                            .|..||::.           |.:...||..:..
  Fly   379 --------------------------------AKRKKLKSL-----------GKSKSTDTEEEEA 400

  Fly   703 HRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYY 767
            ..||       .:.|.:|                                   :|:..:|     
  Fly   401 EEDY-------GDDGYLK-----------------------------------TRSKPQG----- 418

  Fly   768 FPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVW---LKFQEWVSLIVFDPFVELFITLCIV 829
                                           .|...|   .:|:.|:...|...:...|:.:.:.
  Fly   419 -------------------------------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVF 452

  Fly   830 VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSL 894
            :||:.:|::|:.....:...|....:.|...|..|..:|:.|:.|:.||:..:|.||.::::.|:
  Fly   453 LNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSI 517

  Fly   895 LELGLEGVQ----GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIF 954
            .|:....|:    ||||||:.||||:||:.|.|.:| ||:||:: .:|.::.:|.|:|.:.|.||
  Fly   518 FEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLL-NSMRSIISLLFLLFLFILIF 581

  Fly   955 AVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVS--- 1015
            |::||||||..::     .| |..|..||..|..:.:.||::|.|| |.|    .||.|.:|   
  Fly   582 ALLGMQLFGGQFN-----LP-GGTPETNFNTFPIALLTVFQILTGEDWNE----VMYQGIISQGG 636

  Fly  1016 ------CIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWV 1074
                  ...:|:..|:.||..:||:|||:.:.|..::                            
  Fly   637 AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANA---------------------------- 673

  Fly  1075 KRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADG 1139
                        .:||....:|...::..|:                    .|||...:.:.|||
  Fly   674 ------------QELTAAEEEQVEEDKEKQL--------------------QELEKEMEALQADG 706

  Fly  1140 LIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDES 1204
                       :.|..|||..          .|.|||                            
  Fly   707 -----------VHVENGDGAV----------APSKSK---------------------------- 722

  Fly  1205 HKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYY 1269
                     |::|          :||..||.|..|||.                      |...|
  Fly   723 ---------GKKK----------EEEKKEEEEVTEGPK----------------------PMLPY 746

  Fly  1270 KKFPILAGDDDSPFWQG--WGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQ 1332
            ....||:  ..:|..:|  |         ::...||:..::.:|.|||:|||.||      |:.:
  Fly   747 SSMFILS--PTNPIRRGAHW---------VVNLPYFDFFIMVVISMSSIALAAED------PVRE 794

  Fly  1333 D-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLVG 1388
            :     ||.|.|..||.:|.:|||:|.:.||..:    |....|..:|.|:|:.:.::|...:.|
  Fly   795 NSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSG 859

  Fly  1389 AG---GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1450
            :.   .:...|::|.||.||||:.:.|:..::.|.:.:|.::.::.|:|:|.::|..||:::|||
  Fly   860 SSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQ 924

  Fly  1451 LFAGKYFKCED--------MNGTKLSH---EIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQ 1504
            ||.||:|.|.|        ..|:...:   |::|     :.|...|...|.::|:|..|.|.||.
  Fly   925 LFNGKFFYCTDESKHTSAECQGSYFKYEEDELLP-----KQELRVWKPRAFHYDNVAAAMLTLFA 984

  Fly  1505 VATFKGWIQIMNDAIDSREVDKQPIRETNIYMYL-YFVFFIIFGSFFTLNLFIGVIIDNFNEQKK 1568
            |.|.:||.|::..::.:...|:.||:...|.|.: |.|:||:| .||.:|:|:.:||..|.||  
  Fly   985 VQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF-PFFFVNIFVALIIITFQEQ-- 1046

  Fly  1569 KAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLN 1632
               |..|:...|..|...:.:......:|| :.:|:.|...:..|:.||....|:..||:.|..|
  Fly  1047 ---GEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFN 1108

  Fly  1633 MFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI--FALRYHYFIEPWNLFDVVVVILSIL 1695
            ...:.:..::..|.|...|.|:|..|..:||.|.:|||  |.:: ::|.:|||:||::.|:.||:
  Fly  1109 TLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVK-NFFKDPWNIFDLITVLGSIV 1172

  Fly  1696 GLVLSDIIEKYFVSPTL----LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1756
                 |.:...|.|.::    ||:.|.|   |:::|::....||.||:....|..||..:|||:.
  Fly  1173 -----DALWMEFGSNSINVGFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1229

  Fly  1757 LVMFIFAIFGMSFFMHVK---EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACD 1818
            ::.||:||.||..|.::|   .::.|....||::|.|.::|||:.:|...|..::.|.:..:|||
  Fly  1230 MLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACD 1294

  Fly  1819 PPDNDKGYPGN-CGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMY 1882
              |:.:..||. ||| |:...:.:|::.....:::|:::|||::|:...|.| ...|.....|.:
  Fly  1295 --DDAEKAPGEYCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD-SSILGAHHLDEF 1355

  Fly  1883 YEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDLMYCVDIL 1942
            ..||.::||..|..|.|.::.:.|..::|||....  ||:.   |:|.|::|:.....:.....|
  Fly  1356 VRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTL 1420

  Fly  1943 DALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE------------------- 1988
            .||.::..:.|....||..:       .|.|..|.::: :|..:.:                   
  Fly  1421 FALIRENLSIKMRAPEEMDQ-------ADMELRETITN-IWPLQAKKMLNLLVPPSDQLNKGKLS 1477

  Fly  1989 ----YCARLIQHAWR--------------------KHKAR----GEGGGSFEPDTDHGDG----- 2020
                |...||..:||                    :|.::    |...|...|...:.:|     
  Fly  1478 VGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSP 1542

  Fly  2021 -----GDPDAGDPAP----DEATDGDAPAGGDGSVNGTAE-------------------GAADAD 2057
                 |.|.|..|:|    .:....|  .|...:|:...|                   |:..|.
  Fly  1543 SLRHNGSPLARSPSPRRRGHQYIHHD--IGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSAS 1605

  Fly  2058 ESNVNSP-----GEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESD--GFVTKNGHKV 2115
            .|...||     |...:.:..........|||:........:..:...:.|.|  |:....|...
  Fly  1606 TSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTH 1670

  Fly  2116 VIHSRSPSITSRTADVXAR--PRP 2137
            |.|| .|::.||.|.: .|  |.|
  Fly  1671 VQHS-YPTLASRRAGIGRRLPPTP 1693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 81/284 (29%)
Na_trans_cytopl 515..648 CDD:288761 7/132 (5%)
Ion_trans 835..1028 CDD:278921 69/207 (33%)
Na_trans_assoc 1054..1296 CDD:284034 35/243 (14%)
Ion_trans 1318..1571 CDD:278921 88/276 (32%)
Na_channel_gate 1561..1613 CDD:240441 11/52 (21%)
Ion_trans 1636..1871 CDD:278921 78/244 (32%)
GPHH 1880..1930 CDD:293510 17/54 (31%)
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 86/301 (29%)
Ion_trans 441..677 CDD:334124 80/286 (28%)
Ion_trans 769..1050 CDD:334124 96/297 (32%)
Ion_trans 1094..1345 CDD:334124 83/263 (32%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 13/81 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439103
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 1 0.900 - - E1_KOG2301
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
65.820

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