DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Ca-alpha1T

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster

Alignment Length:	2904	Identity:	601/2904 - (20%)
Similarity:	1007/2904 - (34%)	Gaps:	1069/2904 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST-------------EVIFTGIYTFESA 194
            |...:.::.:|.|....|..||:|||.:.| ..|.|:..             ::|| ..:..|..
  Fly   291 RNWCLMLITNPWFERVSILVILLNCITLGM-YQPCVDDACVTNRCKILQIFDDIIF-AFFALEMT 353

  Fly   195 VKVMARGFILC-PFTYLRDAWNWLDFVVI---ALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 255
            :|::|.|  :| ..|||.|:||.|||.::   .|.|| |.::..||.|:||.||||.|:.:..:|
  Fly   354 IKMVAMG--ICGKNTYLADSWNRLDFFIVLAGLLEYV-MHVENLNLTAIRTIRVLRPLRAINRIP 415

  Fly   256 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCI------KKFPLDGSWGNL 314
            .::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|.|:|.      ..:||      .
  Fly   416 SMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPL------T 474

  Fly   315 TDENWDYHNR-NSSNWYSE-------------DEGISFPLCGNIS----GAGQCDDD-------- 353
            ..|.:....| ||.:.|.|             |.|:.  ||||..    |:..|:::
  Fly   475 VPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMH--LCGNFPPYRIGSLVCNEEAKLFDFNE 537

  Fly   354 ------------YVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHM 406
                        |...:..|.||..|..|||:.|.|:::.|.:::.:.|.|:...|..|...|..
  Fly   538 PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDW 602

  Fly   407 LFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ 471
            ::|:::|.:|||:::||.|.::|..:.|.:|:  |.|...:|..|....:..|.:....|.|...
  Fly   603 IYFVLLIVIGSFFMINLCLVVIATQFSETKKR--EMERMRQERARYTSTSTLASSTNNSEPATCY 665

  Fly   472 AQAA-----------------------------------ADAAAAEEAALHPEMAKSPTY----- 496
            |:..                                   ||......:.:.....|.|.|
  Fly   666 AEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKP 730

  Fly   497 SCISYELFV-----------------------------------GGEKGNDDNNKEKMSIRSVE- 525
            |.|..::..                                   ||...|::||....|..:|.
  Fly   731 SSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVAL 795

  Fly   526 ---VESESVSVI--------------QRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSS 573
               :...:.||.              |:|.......|..:.:..|:.:.....:|..:.|.| |.
  Fly   796 VNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSS-SL 859

  Fly   574 HKYTIRNGRGRFGIPGSDRKPLVLSTYQ---DAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNL 635
            .|.|..:.....| ..:::|.::|...|   |::|.:                      :..|||
  Fly   860 KKSTAHHQLKPEG-SAAEQKTILLKFPQQMIDSEQLI----------------------LQLGNL 901

  Fly   636 GSRH-------SSYTSHQSRISYTSHGDLL---------------------------GGMAVMGV 666
            |..|       |..||...|.|...:..:|                           .|.|....
  Fly   902 GKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAA 966

  Fly   667 STMTKESKLRNRNTRN--QSVGATNGGTT---CLDTNHKL----DHRDYEIGL------------ 710
            :.....|...|.|.:|  .|.||..||||   .:.:..|:    |...:::.|
  Fly   967 AAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYA 1031

  Fly   711 ECTD-------------------------------------------EAGKIKHHDNPFIEPV-Q 731
            :|::                                           .|..::.|..|...|. |
  Fly  1032 DCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQ 1096

  Fly   732 TQTV--VDMKDVM-------------------VLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDE 775
            .||.  .:...||                   |:...|:..|..|.|......|.::....:...
  Fly  1097 NQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTS 1161

  Fly   776 DGPTFKDKA-----------------LEVILKGIDVFCVWD------------------------ 799
            ....::.:.                 :|      |..|.:|
  Fly  1162 HSRNYRSRQGQGNSRMREPRAPTGNYME------DYACCYDLYQNALSPLDERPRQRSPTTRCLI 1220

  Fly   800 ---------CCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNY 855
                     |.|:    :.::..:|...:.:..|.|.|::||:.|.:::|:...|:..::::.|.
  Fly  1221 SVYRCMSRVCSWI----RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNV 1281

  Fly   856 FFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLEL----------GLEGVQGLSVLRS 910
            .|:..||:|..:|::|..|..|...|:|:||.|||.||.:|:          |  |..||||||:
  Fly  1282 VFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGG--GGSGLSVLRT 1344

  Fly   911 FRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKD---- 971
            |||||:.||.:..|.|...:.:|.|||..:.....:|.:.||||:::||.|||..:....|
  Fly  1345 FRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGL 1409

  Fly   972 -----------RFPDGDLPRWNFTDFMHSFMIVFRVLCGE-W-------IE--SMWDCMYVGDVS 1015
                       |.|..:..|.:|.:.:.:.:.||::|..| |       :|  |.|..:|
  Fly  1410 ERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAALY----- 1469

  Fly  1016 CIPFFLATVVIGNLVVLNLFLALLLSNFGSS------------------------------SLSA 1050
                |:|.:..||.|:.||.:|:|:..|.|.                              ..|.
  Fly  1470 ----FVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESR 1530

  Fly  1051 PTADNDT--NKIAEAFNRIGRFKSWVK----RNIADCFKLIRNKLTN-------------QISDQ 1096
            ..||:.|  :...|..||      |..    |.:.|..:||....:|             ||::.
  Fly  1531 SEADSSTTNDSYYEVRNR------WRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINEL 1589

  Fly  1097 PS----------------GER-------------------------------------------- 1101
            |:                |:|
  Fly  1590 PASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKK 1654

  Fly  1102 TNQISWIWSEGKGVCRCISA----------------------------EHGDNE----------- 1127
            |..|....||...:.:...|                            :.||.|
  Fly  1655 TYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLR 1719

  Fly  1128 ---LELGHDEILADGLIK--------------KGIKEQTQLEVAIGDGMEFT------IH----- 1164
               :..|....|.:|:..              ..|...:||.|.:|.|:..|      :|
  Fly  1720 PPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIID 1784

  Fly  1165 ----------------------------------------------------------------- 1164

  Fly  1785 DISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSS 1849

  Fly  1165 -------------GDMK------NNKPKKSKYLNNATDD-------------------------- 1184
                         |..|      ::|.:::..|..||||
  Fly  1850 SSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNN 1914

  Fly  1185 --------------------------------------DTASINS--YGSHK------------- 1196
                                                  :|.||.|  .||.:
  Fly  1915 GGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQN 1979

  Fly  1197 -NRP------------------FKDESH----------KGSAET--------------------- 1211
             |:|                  |...||          |..:.|
  Fly  1980 LNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDN 2044

  Fly  1212 -----MEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDE------------- 1258
                 ||..:||..|.....|.:.| ||.|.::       :...|.:.:|.:
  Fly  2045 MLQQYMEARDKRKNSISHYNLKKRL-EEKELQQ-------LQQLHQQQLLQQRQDSFSSTTQQQQ 2101

  Fly  1259 -----------------YPADCCP--DSYYKKFPILAGD-------------------DDSPFWQ 1285
                             .|....|  ...|.|..:|...                   :|:.|.|
  Fly  2102 QQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQ 2166

  Fly  1286 --GWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFL 1348
              .|         .:..|:|:..|:..|.::.:.||:|..::|.....:..|...:.:|||:|.:
  Fly  2167 ICTW---------FVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTV 2222

  Fly  1349 EMLIKWLALGF----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAF---KTMRTLRALRP 1406
            ||.||.:|.|.    ..|||:.|..:|..:|.:|:|:.:.||:.....:.|   :..|.||:|||
  Fly  2223 EMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRP 2287

  Fly  1407 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEI 1471
            ||.::|..|:::||..|:.::..|.|::|:|..|::||.|:|||||.|.::.||..|       |
  Fly  2288 LRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGEN-------I 2345

  Fly  1472 IPNRNACESENY---TWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETN 1533
            ...|||.|....   .|.|...|||.:|.|.:.||.:::..||:.||...:|:..||:|||...|
  Fly  2346 KGVRNADECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYN 2410

  Fly  1534 IYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKK-MGSKKP 1597
            .:..|||:.||:...||.||:|:||:::||:..:::         .|.::|...|.|: :..:|.
  Fly  2411 EWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREE---------QEKEEKIRRAAKRALQMEKK 2466

  Fly  1598 LKAIPRP----RWRP-QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAI 1657
            .:.:..|    .:.| :..|..:||.|.||:.|...||||:.||.::.|.........|...|..
  Fly  2467 RRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYF 2531

  Fly  1658 FVVIFSSECLLKIFALRYH-YFIEPWNLFDVVVVILSILGLVLSDIIEKYF----VSPTLLRVVR 1717
            |..:|..|..:|:.||.:. |..:.||..||.:|:|||:|:||.::.....    ::||::||:|
  Fly  2532 FTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMR 2596

  Fly  1718 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-----EKS 1777
            |.::.|||:|:|.|.|||.||..:..:||.:.|:.||.||:.||||..|:..|..::     ...
  Fly  2597 VLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQ 2661

  Fly  1778 GINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLS 1842
            |:.:..:|..||.:.:.||:::|...|:|::...:.:...|..|..:..   |.|:.:...|.:.
  Fly  2662 GLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNC---CVSSVIAPIFFVI 2723

  Fly  1843 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFL- 1906
            :::::..:::|:.:||::::..::.:.:     :|:.||..|:.::...| .::.:..:|.:.|
  Fly  2724 FVLMAQFVLVNVVVAVLMKHLEESHKQM-----EDELDMEVELERELVRE-QEFAQEQKLCQQLA 2782

  Fly  1907 ----DVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG--NP--------- 1956
                ....||..:.|..       .:|   .:.:|....||   |.|.|..|  ||
  Fly  2783 EAQSKAAAPPRPLAKVK-------SLP---KNFIYSTPSLD---KKFPAVSGVNNPSLTSSAATN 2834

  Fly  1957 IEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR------GEGGGSFEPDT 2015
            :.:....|...|.|   |..|..|....:|:     .:|:..:..::.      .|.||:..|..
  Fly  2835 LNQVATAGSGGAAP---GAVPAGSGAGPRRQ-----TVQYFQQPPQSMLGGLSLAEMGGTLTPQA 2891

  Fly  2016 -------DHGDGGDPDAG---------DP-------APDEATDGDA----------------PAG 2041
                   ..|.||...:|         :|       :.:.:.|..|                |.|
  Fly  2892 LGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWG 2956

  Fly  2042 GDG--SVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVL--- 2101
            ||.  ...||...:.::|...|...|                    :|..|.|..|..:..|
  Fly  2957 GDALDCRRGTIFESLESDGGGVGGGG--------------------SGGGGGGLGGGVSYDLRSV 3001

  Fly  2102 -------VESDGFVTKNGHKVVIHSRSPSITSRTADVXARPRPP 2138
                   .|.||.|:.:    |:.:..||:|:        |.||
  Fly  3002 RSADVGHSEMDGDVSLS----VVSALVPSVTT--------PLPP 3033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	91/331 (27%)
		Na_trans_cytopl	515..648	CDD:288761	29/160 (18%)
		Ion_trans	835..1028	CDD:278921	69/227 (30%)
		Na_trans_assoc	1054..1296	CDD:284034	77/658 (12%)
		Ion_trans	1318..1571	CDD:278921	95/262 (36%)
		Na_channel_gate	1561..1613	CDD:240441	9/57 (16%)
		Ion_trans	1636..1871	CDD:278921	69/244 (28%)
		GPHH	1880..1930	CDD:293510	9/54 (17%)
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	86/317 (27%)
		Ion_trans	1261..1495	CDD:278921	77/244 (32%)
		Ion_trans	2192..2448	CDD:278921	95/271 (35%)
		Ion_trans	2510..2728	CDD:278921	66/220 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439104
Domainoid	1	1.000	73	1.000	Domainoid score	I3264
eggNOG	1	0.900	-	-		E1_KOG2301
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.890