DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Tpcn2

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_038935131.1	Gene:	Tpcn2 / 309139	RGDID:	1311779	Length:	867	Species:	Rattus norvegicus

Alignment Length:	883	Identity:	155/883 - (17%)
Similarity:	279/883 - (31%)	Gaps:	355/883 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1316 LALALEDVHLPQR-PILQDILY-------------YMDRIFTVIFFLEMLIKWLALGFKVYFTNA 1366
            |.|||..|.:|.. ....|:.|             .::.:..::|..::.:|...:|......|.
  Rat    74 LILALAFVEVPSSFTRTADVRYRSQPWQPPCGLTETIEALCLLVFLADLSVKGYLVGQAQLQQNL 138

  Fly  1367 WCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1431
            |....||:::||:::::.||    .:...:::|..|.|||...:.....|:..:..:..::|.:.
  Rat   139 WLLAYFVVLVVSVVDWIVSL----SLNCEESLRVRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMA 199

  Fly  1432 NVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVG 1496
            :|.|:..|...:|.::|:.||.                 |.....|...|..|:      |.::.
  Rat   200 SVGLLLTIHLCLFTVIGMLLFT-----------------IAEKDEAQNKERLTY------FRNLP 241

  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561
            .|...|..:.|......:|           .|....|....|:|:.|.:.||.|.:||...:|.:
  Rat   242 EALTSLLVLLTTSNNPDVM-----------IPAYTQNRAYALFFIIFTLIGSLFLMNLLTAIIYN 295

  Fly  1562 NFNEQKKKA---------------------------------GGSLEMFMTEDQKKYYNAMKKMG 1593
            .|.....|:                                 |.:.|.|:...||...|.:.|..
  Rat   296 QFRGYLMKSLQTSLFRRRLGARAAYEVLTLQAGPNGTTSELVGVNPENFLRVLQKTQLNKIHKQA 360

  Fly  1594 --------SKKPL-------------KAI-----PRPRWRP---QAIVFEIVTDKKFDIIIMLF- 1628
                    ..:|:             |.|     |:|:::.   |...| |.:.:.||.:..|.
  Rat   361 IIQKVHSYEGRPILADEFQKLFDEVDKGIVKERPPKPQYQSPFLQTAQF-IFSHRYFDYLGNLIA 424

  Fly  1629 -----------IGLNMFTMTLDRYDASDT---YNAVL---------------------------- 1651
                       .||.......:|....|:   ::.||
  Rat   425 LGNLLSICVPGAGLKPAAWGTERLCPGDSQLHFHLVLPAGAAVQGVRAGPTGLPVLPQQRVRWPP 489

  Fly  1652 DYLNAIFVVIF-------------SSECLLKIFALRYHYFIEPWN-------------------- 1683
            |:..|.|...:             ||..|.:.:||......:.|.
  Rat   490 DHHPAGFGDFYSGRVPIAAPRMELSSAGLPRSWALTTISAFKLWGCSERCGPGCGRCGCDCGRYD 554

  Fly  1684 --------LFDVVVVILSIL-----GLVLSDIIEKYFV--------------------------- 1708
                    |..|.:.:||:.     |::::.::..:.:
  Rat   555 WQLGALAVLGSVAMTVLSVAVAVLGGMMVAVVMAAWALGMSRVWLGSVSHLLGAFSAWCPYSDYC 619

  Fly  1709 --------------SPTLL----------------------RVVRVAKVGRVLRLVKGAKG---I 1734
                          ||.|:                      |:|.:..|.|.||::...|.   :
  Rat   620 CLVTPAASSLSPSASPNLVTRLRYLLRKPEQYGPLSLWDMTRLVNILIVIRFLRIIPSIKPTAVV 684

  Fly  1735 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVY---------------- 1783
            .:.:..|..:|.|...|   |.:|.::||:.|::.|..|....|.:.:.
  Rat   685 ASTILGLIQNLRAFGGI---LVVVYYVFAMIGINLFRGVIVPPGNSSLVPDNSSAPCGSFEQLGY 746

  Fly  1784 ---NFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLV 1845
               ||..|..::|.|:.:.....|..:|:|.            |.|.|....    :.|:|.:||
  Rat   747 WPNNFDDFAAALITLWDVMVVNNWQVILEAY------------KHYSGPWSM----VYFVLWWLV 795

  Fly  1846 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPE-------GTQYIRYDQLS 1903
             |.:|.||:::|::|||:                      ..::||:       ||:.|.|:...
  Rat   796 -SSVIWINLFLALLLENF----------------------LHRWDPQGHKQLLVGTKQITYEMSV 837

  Fly  1904 E--FLDVLEPPLQ------IHK-PNKYKIISMDIPICR 1932
            |  |.|:||.|.:      :|| |:        :.:||
  Rat   838 ELMFRDILEEPKEEELMEKLHKHPH--------LHLCR 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034
		Ion_trans	1318..1571	CDD:278921	54/299 (18%)
		Na_channel_gate	1561..1613	CDD:240441	15/113 (13%)
		Ion_trans	1636..1871	CDD:278921	63/396 (16%)
		GPHH	1880..1930	CDD:293510	15/65 (23%)
Tpcn2	XP_038935131.1	Ion_trans	66..297	CDD:395416	53/260 (20%)
Tpcn2	XP_038935131.1	Ion_trans	<661..812	CDD:395416	41/170 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810