DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Scn10a

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_058943.2	Gene:	Scn10a / 29571	RGDID:	3629	Length:	1956	Species:	Rattus norvegicus

Alignment Length:	2156	Identity:	912/2156 - (42%)
Similarity:	1216/2156 - (56%)	Gaps:	321/2156 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||.|||.:||::|||....:|...:.|.:                   ||:.|.|:|...|:
  Rat    13 FRRFTPESLAEIEKQIAAHRAAKKARTKHRGQ-------------------EDKGEKPRPQLDLK 58

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            ....:| :..|..|.||...||||:||:||...||:|::|.:.|.||||:.|:|:..|||.|||.
  Rat    59 ACNQLP-KFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKSRTISRFSATWALWLFSPFNLIRRT 122

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYL 210
            ||.:.||..||:||..||||||:.|.....|  |..|.:||.|||||:.:|::||||.|..||||
  Rat   123 AIKVSVHSWFSIFITITILVNCVCMTRTDLP--EKVEYVFTVIYTFEALIKILARGFCLNEFTYL 185

  Fly   211 RDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275
            ||.||||||.||.||||...|||..::.|||||||||||||:::||||.||||:|.||:.|.||.
  Rat   186 RDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVT 250

  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFP- 339
            |||:|.||||||:|||::.|.|..|||:.........||:.|..:|        .....|.:.|
  Rat   251 ILTVFCLSVFALVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEY--------IFIKPGTTDPL 307

  Fly   340 LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPW 404
            ||||.|.||.|...||||: ...||::.|||||||.|||||.|||||||.||.|||..|||:|..
  Rat   308 LCGNGSDAGHCPGGYVCLK-TPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKM 371

  Fly   405 HMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERAN 469
            :|:||:::||||||||||||||:|.|:|:|..:....|..|:|:..:||.|.       |::...
  Rat   372 YMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFQEALEV-------LQKEQE 429

  Fly   470 AQAQAAADAAAAEEAALHPEMAKSP------TYSCISYELFVGGEKGNDDN--------NKEKMS 520
            ..|....|..:.:..:..|..:|:.      ..|.:|       |...|||        |:.:||
  Rat   430 VLAALGIDTTSLQSHSGSPLASKNANERRPRVKSRVS-------EGSTDDNRSPQSDPYNQRRMS 487

  Fly   521 IRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPG--SPFNIRRGSRSSHKYTIRNGRG 583
            ...:.......|           |.:....:..:..:|.|.  :...:..|.:.|.:.:|..|||
  Rat   488 FLGLSSGRRRAS-----------HGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRG 541

  Fly   584 RFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSR 648
            ........|.||                      |.|.            |.|.||
  Rat   542 AGQTGPLPRSPL----------------------PQSP------------NPGRRH--------- 563

  Fly   649 ISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECT 713
                      |....:||.            |...:.||..|  ..|||.          |.:..
  Rat   564 ----------GEEGQLGVP------------TGELTAGAPEG--PALDTT----------GQKSF 594

  Fly   714 DEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGP 778
            ..||.:.       ||.:.|..  |..|.::..:||:.                       |:.
  Rat   595 LSAGYLN-------EPFRAQRA--MSVVSIMTSVIEEL-----------------------EES- 626

  Fly   779 TFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMN 843
              |.|....::.....:.:|:||..|.||:..:..:|.|||.||.|||||||||:||||:|:.|.
  Rat   627 --KLKCPPCLISFAQKYLIWECCPKWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYPMT 689

  Fly   844 KEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVL 908
            ...:.:|::||..||..|.:|...|::|..|.||||:.|||||.:||.:|||||.......||||
  Rat   690 DAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGSLSVL 754

  Fly   909 RSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF 973
            |:|||||||||||||||||.||.|:|.::||||||||:|.||:||||::|.||..::|...||..
  Rat   755 RTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRKDGV 819

  Fly   974 P--DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVGDVS-CIPFFLATVVIGNLVVLNLF 1035
            .  :|:..||:..||.|||::|||:|||||||:||.||.|...| |:..||..:|:|||||||||
  Rat   820 SVWNGEKLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQKSICLILFLTVMVLGNLVVLNLF 884

  Fly  1036 LALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIAD-----CFKLIRNKLTNQISD 1095
            :||||::|.:.:|:||..|.:.|.:..|..||........|.||.     | :....|:..|:..
  Rat   885 IALLLNSFSADNLTAPEDDGEVNNLQLALARIQVLGHRASRAIASYISSHC-RFRWPKVETQLGM 948

  Fly  1096 QP---SGERTNQISWIWSEGKGVCRCISAEHGD------NELELGHDEILADG------LIKKGI 1145
            :|   |.|..|.|:         ...:||..|:      :..:..|.:.:.|.      .|.:|.
  Rat   949 KPPLTSSEAKNHIA---------TDAVSAAVGNLTKPALSSPKENHGDFITDPNVWVSVPIAEGE 1004

  Fly  1146 KEQTQLEVAIGDGMEFTIHGDMKNNKPK--------KSKYLNNATDDDTASINSYGSHKNRPFKD 1202
            .:..:||    :.||.......:...||        ..|..|:......||:.|  |....|:..
  Rat  1005 SDLDELE----EDMEQASQSSWQEEDPKGQQEQLPQVQKCENHQAARSPASMMS--SEDLAPYLG 1063

  Fly  1203 ESHKGSAETMEGEEKRDASKEDL-GLDEELDEEGECEEGPLDGDIIIHAHDE--DILDEYPADCC 1264
            ||.|          ::|:.:... |:|:....||...:.| |.:.|:....|  |.||| |.||.
  Rat  1064 ESWK----------RKDSPQVPAEGVDDTSSSEGSTVDCP-DPEEILRKIPELADDLDE-PDDCF 1116

  Fly  1265 PDSYYKKFPIL-AGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR 1328
            .:...::.|.. .....||:..|| .:|...::::|:.:||:.:|.|||:||.|||.||.:|.::
  Rat  1117 TEGCTRRCPCCNVNTSKSPWATGW-QVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEK 1180

  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQ 1393
            |.::.:|.|.||:||.||..|||:||:|.|||.|||||||||||:||.:||.:.:|.::....:.
  Rat  1181 PRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVA 1245

  Fly  1394 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1458
            :.|.:|||||||||||:||.:||||||:|||.|||||.|||||||||||||:||||.|||||:.|
  Rat  1246 SIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSK 1310

  Fly  1459 CEDMNGTKLSH---EIIPNRNACESENYT----WVNSAMNFDHVGNAYLCLFQVATFKGWIQIMN 1516
            |.|......|:   .::.|::.|.::|.|    |||..:|||:|...||.|.||||||||:.||.
  Rat  1311 CVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMY 1375

  Fly  1517 DAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1581
            .|:||.|::.||..|.|:|||||||.|||||.|||||||:||||||||:||||.||. ::||||:
  Rat  1376 AAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ-DIFMTEE 1439

  Fly  1582 QKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDT 1646
            ||||||||||:|||||.|.||||..:.|..||:|||.:.||||||:.|.|||.||.::..:..:.
  Rat  1440 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDEQGEE 1504

  Fly  1647 YNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDI---IEKYFV 1708
            ...||..:|..||.:|:.||::|:||||.:||...||:||.:||||||..|:.|.|   :|.||
  Rat  1505 KTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIGSLLFSAILKSLENYF- 1568

  Fly  1709 SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV 1773
            ||||.||:|:|::||:|||::.|||||||||||.|||||||||.|||||||||::||||:.|.:|
  Rat  1569 SPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANV 1633

  Fly  1774 KEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN--EEACDPP-DNDKGYPGNCGSATV 1835
            .:::||:|::||||||.||:.|||::|||||||:|..|:|  ...|||. .|..|..|||||..|
  Rat  1634 VDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAV 1698

  Fly  1836 GITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYD 1900
            ||.|..:|::||||||:||||||||||::.|||:..|.|::||:||:||.|::||||.||:|.:.
  Rat  1699 GIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFS 1763

  Fly  1901 QLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGE 1965
            .||:|.|.|..||:|.|||:..:|.||:|:..||.::|:|||.|.||       |.:.|:||:..
  Rat  1764 ALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTK-------NVLGESGELDS 1821

  Fly  1966 I---------AARPDTEGYEPVSSTL-WRQREEYCARLIQHAWRK-------------HKARGEG 2007
            :         |.......|||:::|| |:| |:..|.:||.|:|.             |..|.|.
  Rat  1822 LKTNMEEKFMATNLSKASYEPIATTLRWKQ-EDLSATVIQKAYRSYMLHRSLTLSNTLHVPRAEE 1885

  Fly  2008 GGSFEPDTDHGDG--------GDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVN-- 2062
            .|...|    |:|        |.||..:.|  .||  ..|...|....|.      :|.:|:|
  Rat  1886 DGVSLP----GEGYVTFMANSGLPDKSETA--SAT--SFPPSYDSVTRGL------SDRANINPS 1936

  Fly  2063 --SPGEDAAAA 2071
              ...||..||
  Rat  1937 SSMQNEDEVAA 1947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	155/271 (57%)
		Na_trans_cytopl	515..648	CDD:288761	22/134 (16%)
		Ion_trans	835..1028	CDD:278921	106/195 (54%)
		Na_trans_assoc	1054..1296	CDD:284034	61/273 (22%)
		Ion_trans	1318..1571	CDD:278921	156/259 (60%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	138/240 (58%)
		GPHH	1880..1930	CDD:293510	26/49 (53%)
Scn10a	NP_058943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..54		6/41 (15%)
		I. /evidence=ECO:0000305	116..404		171/298 (57%)
		Ion_trans	129..406	CDD:395416	163/287 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..484		9/49 (18%)
		Na_trans_cytopl	<482..614	CDD:403218	39/228 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..581		17/108 (16%)
		II. /evidence=ECO:0000305	646..910		146/263 (56%)
		Ion_trans	663..893	CDD:395416	134/229 (59%)
		Na_trans_assoc	903..1148	CDD:399489	61/273 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1008..1094		22/102 (22%)
		III. /evidence=ECO:0000305	1141..1450		182/309 (59%)
		Ion_trans	1152..1428	CDD:395416	163/275 (59%)
		Na_channel_gate	1420..1472	CDD:240441	36/52 (69%)
		IV. /evidence=ECO:0000305	1459..1758		172/299 (58%)
		Ion_trans	1476..1733	CDD:395416	149/257 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1906..1956		14/52 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1036
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1645	1.000	Inparanoid score	I74
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm45846
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740