Protein Alignment para and NALCN

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_024305104.1
• Gene: NALCN / 259232
• HGNCID: 19082
• Length: 1786
• Species: Homo sapiens
• Alignment Length: 2190
• Identity: 434/2190 - (19%)
• Similarity: 746/2190 - (34%)
• Gaps: 725/2190 - (33%)

  Fly    88 RLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVH 152
            |.|.|   .:.:.|:.|..|..|       :|...||        :|:..|:           ||
Human    23 RKQSS---RVEAQPVTDFGPDES-------LSDNADI--------LWINKPW-----------VH 58

  Fly   153 PLFSLFIITTILVNCILMIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFILCPF 207
            .|..:..|.:::..|    |.|..|.|          :.:.:...:||.|...|:..||.:....
Human    59 SLLRICAIISVISVC----MNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDS 119

  Fly   208 TYLRDAWNWLDFVVIALAYVTMGIDLGNLA----------ALRTFRVLRALKTVAI-----VPGL 257
            :|::|.|...|..::...:|::.:.:..:|          .||..|.|..::...|     :|..
Human   120 SYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 184

  Fly   258 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYH 322
            : |...:..|.:.:..|.|..:|.|.::.::|:|:: |..|..|:..   |...||:|
Human   185 R-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVN---DTKPGNVT------- 237

  Fly   323 NRNSSNWYSEDEGISFP--LCG-NISGAGQCDDDYVC--LQGFG-PNPNYGYTSFDSFGWAFLSA 381
                  |.|    ::.|  .|. .:....||...:.|  |:..| .....||:.|:..|.:..:.
Human   238 ------WNS----LAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 292

  Fly   382 FRLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAA 445
            :...:|:.|..|....:.:...|...| ||.:||..::.:.|:.:|::..::.|::.:
Human   293 YEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ------- 350

  Fly   446 EEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKG 510
                                                                             
Human   351 ----------------------------------------------------------------- 350

  Fly   511 NDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHK 575
                                                                 |....|||||
Human   351 -----------------------------------------------------FQQMWGSRSS-- 360

  Fly   576 YTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHS 640
                                               ..|.|.|.|
Human   361 -----------------------------------TTSTATTQM--------------------- 369

  Fly   641 SYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRD 705
                        .|.|..||..::.|.....:.:                ...||
Human   370 ------------FHEDAAGGWQLVAVDVNKPQGR----------------APACL---------- 396

  Fly   706 YEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV-MVLNDIIEQAAGRHSRASDRGVSVYYFP 769
                                  :.:...:|..|..: ||..|:|..|            |.||
Human   397 ----------------------QKMMRSSVFHMFILSMVTVDVIVAA------------SNYY-- 425

  Fly   770 TEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMF 834
                  .|..|:.:                                :|.|              :
Human   426 ------KGENFRRQ--------------------------------YDEF--------------Y 438

  Fly   835 MAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGL 899
            :|                 ...||..|.:||.:|:..:....|.....:.|:.::|..:.|.:..
Human   439 LA-----------------EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYP 486

  Fly   900 EGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFG 963
            :...  |....|::|||.:|.|..|.| :.:..|.|... .||:|......::.:.:.:.:|:|
Human   487 DLYH--SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGK-KLGSLVVFTASLLIVMSAISLQMF- 547

  Fly   964 KNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE----------SMWDCMYVGDVSCI 1017
             .:.:..||          ||.|..:||.:|::|..| |::          .||     ..|..|
Human   548 -CFVEELDR----------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMW-----APVVAI 596

  Fly  1018 PFFLATVVIGNLVVLNLFLALLLSN------------FGSSSLSAPT------------------ 1052
             :|:...:...|::|:||:|::|.|            ...|..:|.|
Human   597 -YFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 660

  Fly  1053 ---------ADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLT----------------NQ 1092
                     :|....||.|:|     .|.::.|...|...|:|:..|                |:
Human   661 QMVKISKLPSDFTVPKIRESF-----MKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNK 720

  Fly  1093 ISDQPSG------------ERTNQISWIWSE-----------------GKGVCRCISAEHGDNEL 1128
            ..||...            |:...::.|.|:                 |:..|      |.....
Human   721 YIDQKLRKSVFSIRARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHC------HSSGVR 779

  Fly  1129 ELGHDEILADGLIKKGIKEQTQLEVA--IGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINS 1191
            ......:|:.....:..||::.|.|.  |........||. .:.:..:.|.|...|.|.:.::.
Human   780 ACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGS-NSQRISRGKSLETLTQDHSNTVR- 842

  Fly  1192 YGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDIL 1256
               ::|...:|...|     |..|:|..|..:....:|||.|.....:.||  .|:...|
Human   843 ---YRNAQREDSEIK-----MIQEKKEQAEMKRKVQEEELRENHPYFDKPL--FIVGREH----- 892

  Fly  1257 DEYPADCCPDSYYKKF---------------PILAGDDDSPFWQGWGNLRLKTFQLIENKYFETA 1306
                       .::.|               |:.....::.:.|.:..|.|.|       |.:..
Human   893 -----------RFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVT-------YLDWV 939

  Fly  1307 VITMILMSSLALALEDVHLPQRPILQ-DILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWL 1370
            :|.:.:.|.:::..|.   |.|.::. ..|...:.:|.:...:|:.:|.:|.|  ::||......
Human   940 MIIVTICSCISMMFES---PFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADG--LFFTPTAVIR 999

  Fly  1371 DF------VIVMVSLINFVA----SLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQ 1425
            ||      .|.:|||| |:.    ::....|.|   .:..||.|||||....:..||.||..|..
Human  1000 DFGGVMDIFIYLVSLI-FLCWMPQNVPAESGAQ---LLMVLRCLRPLRIFKLVPQMRKVVRELFS 1060

  Fly  1426 AIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNACESEN 1482
            ....||.|.::.|...|:||..||||||||..||        ||.||       |...|...|:|
Human  1061 GFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNG-------IFRINVSVSKN 1118

  Fly  1483 Y-----------------TWVNSA-MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPI 1529
            .                 .|.|.. .|||:||||.|.||:|.:.|||::: .|.|..|   ..||
Human  1119 LNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV-RDVIIHR---VGPI 1179

  Fly  1530 RETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGS 1594
            .  .||:::    |:..|....|.||:||:|.||||.|..|      .:|.||:::.:...::..
Human  1180 H--GIYIHV----FVFLGCMIGLTLFVGVVIANFNENKGTA------LLTVDQRRWEDLKSRLKI 1232

  Fly  1595 KKPLKAIPRP---RWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNA 1656
            .:||...|||   .:|  |.:::|.....|...|.|.: |....:...::|..|.....|..::.
Human  1233 AQPLHLPPRPDNDGFR--AKMYDITQHPFFKRTIALLV-LAQSVLLSVKWDVEDPVTVPLATMSV 1294

  Fly  1657 IFVVIFSSECLLKIFALRYHYFIEPW----NLFDVVVVILSILGLVLS-DIIEKY-FVSPTLLRV 1715
            :|..||..|..:||.|:....|   |    |.:|::|..|.::.:||. .::..| ::....:.|
Human  1295 VFTFIFVLEVTMKIIAMSPAGF---WQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIV 1356

  Fly  1716 VRVAKV-GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGI 1779
            .|...: |:.:.|       :.||..:.:|:...|.|.:.:||::..:|..|:..|..||....|
Human  1357 FRFFSICGKHVTL-------KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENI 1414

  Fly  1780 NDVYNFKTFGQSMILLFQMSTSAGWDGVL-DAIINEEACDPPDNDKGYPGNCGSATVGITFLLSY 1843
            |...||.:.|:::.:||::.|...|:.:: |.::....| .||....:..:||:....:.:..|:
Human  1415 NRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFC-TPDEFTYWATDCGNYAGALMYFCSF 1478

  Fly  1844 LVISFLIVINMYIAVILENYS--QATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFL 1906
            .||...|::|:.:|:|:||:|  .:||:.|. |:.:|...:..||...|.:....|...::...|
Human  1479 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQL-LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLL 1542

  Fly  1907 DVLEPPLQIHKPN-----KYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEI 1966
            .:|...|::....     |:....|:.....||:.: .|:|..|     :.:...|.::.::.|:
Human  1543 RLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTF-HDVLSML-----SYRSVDIRKSLQLEEL 1601

  Fly  1967 AARPDTEGY---EPVSSTLWRQREEYCARLIQ----------HAWRKHK----ARGEGGGSFE-- 2012
            .||...| |   |.|:....|...:.|.:.|:          |:.|:.:    :|.....|.|
Human  1602 LAREQLE-YTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETT 1665

  Fly  2013 -PDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADA 2056
             |..|.......::..|.........:|...|.  .|:.:.||||
Human  1666 QPSEDTNANSQDNSMQPETSSQQQLLSPTLSDR--GGSRQDAADA 1708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	66/315 (21%)
		Na_trans_cytopl	555..740	CDD:463401	19/184 (10%)
		Ion_trans	817..1028	CDD:459842	45/222 (20%)
		Na_trans_assoc	1054..1296	CDD:461936	53/303 (17%)
		Ion_trans	1300..1571	CDD:459842	97/307 (32%)
		Na_channel_gate	1561..1613	CDD:240441	16/54 (30%)
		Ion_trans	1621..1871	CDD:459842	66/259 (25%)
		GPHH	1882..1929	CDD:465306	9/51 (18%)
NALCN	XP_024305104.1	Ion_trans	55..350	CDD:459842	68/331 (21%)
		Ion_trans	402..622	CDD:459842	64/323 (20%)
		Ion_trans	935..1209	CDD:459842	94/299 (31%)
		Ion_trans	1257..1506	CDD:459842	65/260 (25%)