DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and NALCN

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_024305104.1 Gene:NALCN / 259232 HGNCID:19082 Length:1786 Species:Homo sapiens


Alignment Length:2194 Identity:432/2194 - (19%)
Similarity:745/2194 - (33%) Gaps:733/2194 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 RLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVH 152
            |.|.|   .:.:.|:.|..|..|       :|...||        :|:..|:           ||
Human    23 RKQSS---RVEAQPVTDFGPDES-------LSDNADI--------LWINKPW-----------VH 58

  Fly   153 PLFSLFIITTILVNCILMIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFILCPF 207
            .|..:..|.:::..|    |.|..|.|          :.:.:...:||.|...|:..||.:....
Human    59 SLLRICAIISVISVC----MNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDS 119

  Fly   208 TYLRDAWNWLDFVVIALAYVTMGIDLGNLA-------------------ALRTFRVLRALKTVAI 253
            :|::|.|...|..::...:|::.:.:..:|                   .:|.||:....:    
Human   120 SYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFE---- 180

  Fly   254 VPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDEN 318
            :|..: |...:..|.:.:..|.|..:|.|.::.::|:|:: |..|..|:..   |...||:|   
Human   181 LPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVN---DTKPGNVT--- 237

  Fly   319 WDYHNRNSSNWYSEDEGISFP--LCG-NISGAGQCDDDYVC--LQGFG-PNPNYGYTSFDSFGWA 377
                      |.|    ::.|  .|. .:....||...:.|  |:..| .....||:.|:..|.:
Human   238 ----------WNS----LAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTS 288

  Fly   378 FLSAFRLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEE 441
            ..:.:...:|:.|..|....:.:...|...| ||.:||..::.:.|:.:|::..::.|::.:   
Human   289 IFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ--- 350

  Fly   442 EEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVG 506
                                                                             
Human   351 ----------------------------------------------------------------- 350

  Fly   507 GEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSR 571
                                                                     |....|||
Human   351 ---------------------------------------------------------FQQMWGSR 358

  Fly   572 SSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636
            ||                                     ..|.|.|.|                 
Human   359 SS-------------------------------------TTSTATTQM----------------- 369

  Fly   637 SRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
                            .|.|..||..::.|.....:.:                ...||      
Human   370 ----------------FHEDAAGGWQLVAVDVNKPQGR----------------APACL------ 396

  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV-MVLNDIIEQAAGRHSRASDRGVSV 765
                                      :.:...:|..|..: ||..|:|..|            |.
Human   397 --------------------------QKMMRSSVFHMFILSMVTVDVIVAA------------SN 423

  Fly   766 YYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVV 830
            ||        .|..|:.:                                :|.|           
Human   424 YY--------KGENFRRQ--------------------------------YDEF----------- 437

  Fly   831 NTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLL 895
               ::|                 ...||..|.:||.:|:..:....|.....:.|:.::|..:.|
Human   438 ---YLA-----------------EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTL 482

  Fly   896 ELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGM 959
            .:..:...  |....|::|||.:|.|..|.| :.:..|.|... .||:|......::.:.:.:.:
Human   483 HVYPDLYH--SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGK-KLGSLVVFTASLLIVMSAISL 544

  Fly   960 QLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE----------SMWDCMYVGD 1013
            |:|  .:.:..||          ||.|..:||.:|::|..| |::          .||     ..
Human   545 QMF--CFVEELDR----------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMW-----AP 592

  Fly  1014 VSCIPFFLATVVIGNLVVLNLFLALLLSN------------FGSSSLSAPT-------------- 1052
            |..| :|:...:...|::|:||:|::|.|            ...|..:|.|              
Human   593 VVAI-YFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKF 656

  Fly  1053 -------------ADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLT-------------- 1090
                         :|....||.|:|     .|.::.|...|...|:|:..|              
Human   657 PNRPQMVKISKLPSDFTVPKIRESF-----MKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAI 716

  Fly  1091 --NQISDQPSG------------ERTNQISWIWSE-----------------GKGVCRCISAEHG 1124
              |:..||...            |:...::.|.|:                 |:..|      |.
Human   717 EDNKYIDQKLRKSVFSIRARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHC------HS 775

  Fly  1125 DNELELGHDEILADGLIKKGIKEQTQLEVA--IGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTA 1187
            ..........:|:.....:..||::.|.|.  |........||. .:.:..:.|.|...|.|.:.
Human   776 SGVRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGS-NSQRISRGKSLETLTQDHSN 839

  Fly  1188 SINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHD 1252
            ::.    ::|...:|...|     |..|:|..|..:....:|||.|.....:.||  .|:...| 
Human   840 TVR----YRNAQREDSEIK-----MIQEKKEQAEMKRKVQEEELRENHPYFDKPL--FIVGREH- 892

  Fly  1253 EDILDEYPADCCPDSYYKKF---------------PILAGDDDSPFWQGWGNLRLKTFQLIENKY 1302
                           .::.|               |:.....::.:.|.:..|.|.|       |
Human   893 ---------------RFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVT-------Y 935

  Fly  1303 FETAVITMILMSSLALALEDVHLPQRPILQ-DILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNA 1366
            .:..:|.:.:.|.:::..|.   |.|.::. ..|...:.:|.:...:|:.:|.:|.|  ::||..
Human   936 LDWVMIIVTICSCISMMFES---PFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADG--LFFTPT 995

  Fly  1367 WCWLDF------VIVMVSLINFVA----SLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVN 1421
            ....||      .|.:|||| |:.    ::....|.|   .:..||.|||||....:..||.||.
Human   996 AVIRDFGGVMDIFIYLVSLI-FLCWMPQNVPAESGAQ---LLMVLRCLRPLRIFKLVPQMRKVVR 1056

  Fly  1422 ALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNAC 1478
            .|......||.|.::.|...|:||..||||||||..||        ||.||       |...|..
Human  1057 ELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNG-------IFRINVS 1114

  Fly  1479 ESENY-----------------TWVNSA-MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVD 1525
            .|:|.                 .|.|.. .|||:||||.|.||:|.:.|||::: .|.|..|   
Human  1115 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV-RDVIIHR--- 1175

  Fly  1526 KQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMK 1590
            ..||.  .||:::    |:..|....|.||:||:|.||||.|..|      .:|.||:::.:...
Human  1176 VGPIH--GIYIHV----FVFLGCMIGLTLFVGVVIANFNENKGTA------LLTVDQRRWEDLKS 1228

  Fly  1591 KMGSKKPLKAIPRP---RWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLD 1652
            ::...:||...|||   .:|  |.:::|.....|...|.|.: |....:...::|..|.....|.
Human  1229 RLKIAQPLHLPPRPDNDGFR--AKMYDITQHPFFKRTIALLV-LAQSVLLSVKWDVEDPVTVPLA 1290

  Fly  1653 YLNAIFVVIFSSECLLKIFALRYHYFIEPW----NLFDVVVVILSILGLVLS-DIIEKY-FVSPT 1711
            .::.:|..||..|..:||.|:....|   |    |.:|::|..|.::.:||. .::..| ::...
Human  1291 TMSVVFTFIFVLEVTMKIIAMSPAGF---WQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA 1352

  Fly  1712 LLRVVRVAKV-GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKE 1775
            .:.|.|...: |:.:.|       :.||..:.:|:...|.|.:.:||::..:|..|:..|..||.
Human  1353 CVIVFRFFSICGKHVTL-------KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKY 1410

  Fly  1776 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVL-DAIINEEACDPPDNDKGYPGNCGSATVGITF 1839
            ...||...||.:.|:::.:||::.|...|:.:: |.::....| .||....:..:||:....:.:
Human  1411 GENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFC-TPDEFTYWATDCGNYAGALMY 1474

  Fly  1840 LLSYLVISFLIVINMYIAVILENYS--QATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQL 1902
            ..|:.||...|::|:.:|:|:||:|  .:||:.|. |:.:|...:..||...|.:....|...::
Human  1475 FCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQL-LSYNDLRHFQIIWNMVDDKREGVIPTFRV 1538

  Fly  1903 SEFLDVLEPPLQIHKPN-----KYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGE 1962
            ...|.:|...|::....     |:....|:.....||:.: .|:|..|     :.:...|.::.:
Human  1539 KFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTF-HDVLSML-----SYRSVDIRKSLQ 1597

  Fly  1963 IGEIAARPDTEGY---EPVSSTLWRQREEYCARLIQ----------HAWRKHK----ARGEGGGS 2010
            :.|:.||...| |   |.|:....|...:.|.:.|:          |:.|:.:    :|.....|
Human  1598 LEELLAREQLE-YTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPS 1661

  Fly  2011 FE---PDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADA 2056
            .|   |..|.......::..|.........:|...|.  .|:.:.||||
Human  1662 IETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDR--GGSRQDAADA 1708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 61/306 (20%)
Na_trans_cytopl 515..648 CDD:288761 10/132 (8%)
Ion_trans 835..1028 CDD:278921 43/204 (21%)
Na_trans_assoc 1054..1296 CDD:284034 53/303 (17%)
Ion_trans 1318..1571 CDD:278921 94/289 (33%)
Na_channel_gate 1561..1613 CDD:240441 16/54 (30%)
Ion_trans 1636..1871 CDD:278921 62/244 (25%)
GPHH 1880..1930 CDD:293510 9/54 (17%)
NALCNXP_024305104.1 Ion_trans 55..350 CDD:306908 66/335 (20%)
Ion_trans 402..622 CDD:306908 64/323 (20%)
Ion_trans 935..1209 CDD:306908 94/299 (31%)
Ion_trans 1257..1506 CDD:306908 65/260 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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