Protein Alignment para and Scn5a

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_038936827.1
• Gene: Scn5a / 25665
• RGDID: 3637
• Length: 2020
• Species: Rattus norvegicus
• Alignment Length: 2174
• Identity: 944/2174 - (43%)
• Similarity: 1274/2174 - (58%)
• Gaps: 308/2174 - (14%)

  Fly    14 SLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPT 78
            |.||.||||||..||:|:|   |||     .|......|..|:..|         |:|.|:|...
  Rat    11 SSFRRFTRESLAAIEKRMA---EKQ-----ARGGSATSQESREGLQ---------EEEAPRPQLD 58

  Fly    79 LEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIR 143
            |:....:| .|.|:.|.||...||||:||:||...||:|::|||.||||||:.|:::|.||:|:|
  Rat    59 LQASKKLP-DLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVR 122

  Fly   144 RVAIYILVHPLFSLFIITTILVNCILMIM----PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 204
            |.|:.||||.|||:.|:.|||.||:.|..    |.|..||.|   ||.||||||.||::||||.|
  Rat   123 RAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYT---FTAIYTFESLVKILARGFCL 184

  Fly   205 CPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 269
            ..||:|||.||||||.||.:||.|..:||||::|||||||||||||::::.||||||||:|:|||
  Rat   185 HAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVK 249

  Fly   270 NLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKF-PLDGSWGNLTDEN--W---DYHNRNSSN 328
            .|.||::||:|.||||||:|||::||.|..||::.| .|:|:.|::..:.  |   |.:..:.:|
  Rat   250 KLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPAN 314

  Fly   329 WYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDL 393
            :..::......||||.|.||.|.:.|.||:. |.||::||||||||.||||:.|||||||.||.|
  Rat   315 YLLKNGTTDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAFLALFRLMTQDCWERL 378

  Fly   394 YQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAA 458
            ||..||:||..:|:||:::||||||||||||||:|||:|:| |.:|...|..|:|  :..:||.
  Rat   379 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE-QNQATIAETEEKE--KRFQEAM- 439

  Fly   459 AKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRS 523
                                          ||.|                     ...|.::||.
  Rat   440 ------------------------------EMLK---------------------KEHEALTIRG 453

  Fly   524 VEVESESVSVIQRQP-APTTAHQATKVRKVSTTSLSLPGSPFNIRR-----GSRSSHKYTIRNGR 582
            |:..|.  |.::..| ||.|.|:....|:...:|.:..|....:.:     |.|:.::.::.:|.
  Rat   454 VDTVSH--SSLEMSPLAPVTNHERKSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGL 516

  Fly   583 GRFGI-PGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEEN-GAIIVPVYYGNLGSRHSSYTSH 645
            .|..: |.|.|..:.....:|......:|||.|:....||.: .:::||     ...||.|....
  Rat   517 SRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVP-----WPLRHPSAQGQ 576

  Fly   646 ----QSRISYTSHG------DLLGGMAVMGV----STMTKESKLR----NRNTRNQSVGATNGGT 692
                .|...|..:|      |..|.::::|.    :|......||    :|.....:.....||.
  Rat   577 PGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSYLLRPMVLDRPPDTTTPSEEPGGP 641

  Fly   693 TCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSR 757
            ..|...           ..|.|          .|.||...|..  :..|.||...:|:....|.:
  Rat   642 QMLTPQ-----------APCAD----------GFEEPGARQRA--LSAVSVLTSALEELEESHRK 683

  Fly   758 ASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVEL 822
            ..                  |.:...|..        :.:|:||.:|:..::.|..:|.|||.:|
  Rat   684 CP------------------PCWNRFAQH--------YLIWECCPLWMSIKQKVKFVVMDPFADL 722

  Fly   823 FITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDF 887
            .||:|||:||:|||::|::|..|.|.:|:.||..||..|..|.|.|::|:.|.||||:||||||.
  Rat   723 TITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 787

  Fly   888 IIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIF 952
            |||.|||:||||..:..|||||||||||||||||||||||.||.|:|.::|||||||.||.||:|
  Rat   788 IIVILSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVF 852

  Fly   953 IFAVMGMQLFGKNYHDHKDRFPD-GDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVS 1015
            ||||:|||||||||.:.:.|..| |.||||:..||.|:|:|:||:|||||||:|||||.| |...
  Rat   853 IFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSL 917

  Fly  1016 CIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIAD 1080
            |:..||..:|||||||||||||||||:|.:.:|:||..|.:.|.:..|..||.|...:|||...|
  Rat   918 CLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTWD 982

  Fly  1081 ------------------------CFKLIRNKLTNQISDQPSGERTNQISWIWSEGKG------- 1114
                                    |....|:....::...|...:..:.......|:|
  Rat   983 FCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRPGQGTPGDSEP 1047

  Fly  1115 VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLN 1179
            ||..|:....|.| :...||..:.|..::..|:| :.:|..|        |.....:|:....::
  Rat  1048 VCVPIAVAESDTE-DQEEDEENSLGTEEESSKQQ-ESQVVSG--------GHEPYQEPRAWSQVS 1102

  Fly  1180 NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDL----GLDEELDEEGECEEG 1240
            ..|..:..:..|....:.....:....|..||.| :...:.|..|:    .|.|::.:.|
  Rat  1103 ETTSSEAGASTSQADWQQEQKTEPQAPGCGETPE-DSYSEGSTADMTNTADLLEQIPDLG----- 1161

  Fly  1241 PLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFET 1305
                        ||:.|  |.||..:...::.|....|......:.|..||...::::|:.:|||
  Rat  1162 ------------EDVKD--PEDCFTEGCVRRCPCCMVDTTQSPGKVWWRLRKTCYRIVEHSWFET 1212

  Fly  1306 AVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWL 1370
            .:|.|||:||.|||.||::|.:|..::.:|.|.|::||.:|.||||:||:|.|||.|||||||||
  Rat  1213 FIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWL 1277

  Fly  1371 DFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLL 1435
            ||:||.|||::.||:.:|...:...|::|||||||||||:||.:||||||||||.|||||.||||
  Rat  1278 DFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1342

  Fly  1436 VCLIFWLIFAIMGVQLFAGKYFKCEDMNGTK----LSHEIIPNRNACESENYT----WVNSAMNF 1492
            |||||||||:||||.|||||:.:|  :|.|:    |::.|:.|::.|||.|.|    |....:||
  Rat  1343 VCLIFWLIFSIMGVNLFAGKFGRC--INQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNF 1405

  Fly  1493 DHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIG 1557
            |:||..||.|.||||||||:.||..|:|||..::||..|.|:|||:|||.|||||||||||||||
  Rat  1406 DNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIG 1470

  Fly  1558 VIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFD 1622
            |||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|..:|:|||.:.||
  Rat  1471 VIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFD 1534

  Fly  1623 IIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDV 1687
            :.||..|.|||.||.::..|.|.....:|..:|.:||.||:.||::|:.|||::||...||:||.
  Rat  1535 VTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDF 1599

  Fly  1688 VVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNIC 1752
            |||||||:|.||||||:|||.||||.||:|:|::||:|||::||||||||||||.|||||||||.
  Rat  1600 VVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1664

  Fly  1753 LLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN--EE 1815
            |||||||||::||||:.|.:||.::||:|::||:||..||:.|||::|||||||:|..|:|  ..
  Rat  1665 LLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1729

  Fly  1816 ACDPP-DNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1879
            .|||. .|..|..|||||..|||.|..:|::||||||:|||||:||||:|.|||:..|.|::||:
  Rat  1730 YCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1794

  Fly  1880 DMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDA 1944
            ||:||||::||||.||:|.|..||:|.|.|..||:|.|||:..:|:||:|:..||.::|:|||.|
  Rat  1795 DMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFA 1859

  Fly  1945 LTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRK 2000
            .||       ..:.|:||:..:         ||.|....|||:::||.|:.||..|.:||.|:|:
  Rat  1860 FTK-------RVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRR 1917

  Fly  2001 HKA-----------RGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSV----NGT- 2049
            |..           |.:.|||...|.|            ||:.          :|.:    ||.
  Rat  1918 HLLQRSVKHASFLFRQQAGGSGLSDED------------APER----------EGLIAYMMNGNF 1960

  Fly  2050 AEGAADADESNVNS----PGEDAAAAAAA 2074
            :..:|....|:::|    |..|:...|.:
  Rat  1961 SRRSAPLSSSSISSTSFPPSYDSVTRATS 1989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	167/293 (57%)
		Na_trans_cytopl	555..740	CDD:463401	40/209 (19%)
		Ion_trans	817..1028	CDD:459842	134/212 (63%)
		Na_trans_assoc	1054..1296	CDD:461936	51/276 (18%)
		Ion_trans	1300..1571	CDD:459842	172/278 (62%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1621..1871	CDD:459842	153/252 (61%)
		GPHH	1882..1929	CDD:465306	26/46 (57%)
Scn5a	XP_038936827.1	Ion_trans	131..424	CDD:459842	168/297 (57%)
		Na_trans_cytopl	510..668	CDD:463401	36/185 (19%)
		Ion_trans	717..930	CDD:459842	134/212 (63%)
		Na_trans_assoc	956..1203	CDD:461936	51/276 (18%)
		Ion_trans	1207..1482	CDD:459842	170/276 (62%)
		Na_channel_gate	1474..1526	CDD:240441	35/52 (67%)
		Ion_trans	1531..1785	CDD:459842	153/253 (60%)