Protein Alignment para and Tpcn1

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: NP_665852.1
• Gene: Tpcn1 / 252972
• MGIID: 2182472
• Length: 817
• Species: Mus musculus
• Alignment Length: 843
• Identity: 167/843 - (19%)
• Similarity: 305/843 - (36%)
• Gaps: 260/843 - (30%)

  Fly  1252 DEDI-----LDEYPADCCPDS------------------YYKKFPILAGDDDSP-------FW-- 1284
            |:|:     |||..:...|.|                  :..:.|.|....|||       .|
Mouse     6 DDDVPLILTLDEAESAPLPPSNSLGQEQLPSKNGGSHSIHNSQVPSLVSGADSPPSSPTGHNWEM 70

  Fly  1285 ----------QGWGNLR----------LKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRP 1329
                      :|..|.:          |..:..:.|.:|   .:..:|.:.|.|.|.....|..|
Mouse    71 NYQEAAIYLQEGQNNDKFFTHPKDARALAAYLFVHNHFF---YMMELLTALLLLLLSLCESPAVP 132

  Fly  1330 ILQDILYY-----MDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGA 1389
            :|:...|.     :..:..|:|.|.|.::|  |||..:..:....:...:::|..|..:..||
Mouse   133 VLKLHTYVHATLELFALMVVVFELCMKLRW--LGFHTFVRHKRTMVKTSVLVVQFIEAIVVLV-- 193

  Fly  1390 GGIQAFKTMRTLRALRPLRAMS--RMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1452
               :....:|..||||.:..:.  ...|:|..:..:.|::|...::||:.|.|.:||||:|..||
Mouse   194 ---RQTSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF 255

  Fly  1453 AGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMND 1517
            :..                       .|:.|        |..:.|:.:.||.:.|...:..:|
Mouse   256 STN-----------------------PSDPY--------FSTLENSIVNLFVLLTTANFPDVM-- 287

  Fly  1518 AIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNE----------------- 1565
                     .|....|.:..::|:.::....:|.:||.:.|:.|.||:
Mouse   288 ---------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFKSLLLHKRTAI 343

  Fly  1566 ---------QKKKAGGSLEMFMTEDQKKYYN----------AMKKMG-SKKPLKAIP-------- 1602
                     |::.||.|...|  |...::|.          ..|.:. |..||.::.
Mouse   344 QHAYGLLASQRRPAGISYRQF--EGLMRFYKPRMSARERFLTFKALNQSNTPLLSLKDFYDIYEV 406

  Fly  1603 ----------RPRW-----RPQAIVFE----IVTDKKFDIIIMLFIGLNMFTMTLDRYDAS---- 1644
                      |..|     |...::|:    :|..|.|...:.|.:.:|...:.::.:...
Mouse   407 AALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVNGVWILVETFMLKGGNF 471

  Fly  1645 DTYNAVLDYLNAIFVVIFSSECLLKIFAL-RYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFV 1708
            .:.:....||  :|:.|:..|..:|:..| ...|....|||||..|...:.|||:...:..:.|.
Mouse   472 TSKHVPWSYL--VFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFY 534

  Fly  1709 SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--- 1770
            ...:||.:      ::|||.|..|..|.:|..:...||.:.::.|.|....:.|||.||.||
Mouse   535 FIVVLRPL------QLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTFYYSFAIVGMEFFNGR 593

  Fly  1771 ------------------MH-VKEKSGINDVY----NFKTFGQSMILLFQMSTSAGWDGVLDAII 1812
                              .| |..|:.:.:.|    ||.....|.:.||:::....|..:::.:.
Mouse   594 LTPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVT 658

  Fly  1813 NEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILE------NYSQATED-- 1869
            ::.                |....:.|:..|:|.  ::|:.:.:|.|||      |||:.::|
Mouse   659 SQT----------------SHWSRLYFMTFYIVT--MVVMTIIVAFILEAFVFRMNYSRKSQDSE 705

  Fly  1870 ------VQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISM 1926
                  :::.::.::.....|:::  :..||.    ..::..||.|.      :..||:..||
Mouse   706 VDSGIVIEKEMSKEELMAVLELYR--EERGTS----SDVTRLLDTLS------QMEKYQQNSM 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842
		Na_trans_cytopl	555..740	CDD:463401
		Ion_trans	817..1028	CDD:459842
		Na_trans_assoc	1054..1296	CDD:461936	16/95 (17%)
		Ion_trans	1300..1571	CDD:459842	61/303 (20%)
		Na_channel_gate	1561..1613	CDD:240441	17/111 (15%)
		Ion_trans	1621..1871	CDD:459842	64/294 (22%)
		GPHH	1882..1929	CDD:465306	10/45 (22%)
Tpcn1	NP_665852.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..65		7/44 (16%)
		Ion_trans	137..331	CDD:459842	51/242 (21%)
		Ion_trans	441..692	CDD:459842	61/276 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	785..817