Protein Alignment para and Cacna1i

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_006521012.1
• Gene: Cacna1i / 239556
• MGIID: 2178051
• Length: 2226
• Species: Mus musculus
• Alignment Length: 2411
• Identity: 533/2411 - (22%)
• Similarity: 908/2411 - (37%)
• Gaps: 775/2411 - (32%)

  Fly    69 EDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAM 133
            |..||:..|....|:..|  |.|:.|    ..|..|:.|    |..|.:        |.:.|...
Mouse    22 EQPGPRSPPPSPPGLEEP--LDGTNP----DVPHPDLAP----VAFFCL--------RQTTSPRN 68

  Fly   134 WMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCIL--MIMP------TTPTVESTEVIFTGIYT 190
            |           .|.::.:|.|....:..||:||:.  |..|      .:...:..:|....|:.
Mouse    69 W-----------CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDRCKILQVFDDFIFI 122

  Fly   191 F---ESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG--NLAALRTFRVLRALKT 250
            |   |..:|::|.| |.....||.|.||.|||.::....|...:||.  ||:|:||.||||.||.
Mouse   123 FFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKA 186

  Fly   251 VAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCI--KKFPLDGSWGN 313
            :..||.::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.  :.|.:.|...
Mouse   187 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVA- 250

  Fly   314 LTDENWDYHNRNSSNWYSEDEGISFPLCGNISG----------------AGQC----DDDY---- 354
                        ...:|..:|....|...::||                ..:|    ||.|
Mouse   251 ------------LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDMYDFGA 303

  Fly   355 -------------------VCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRA 400
                               ||..| ..||:.|..:||:.|:|::..|:::|.:.|.::...|:.|
Mouse   304 GRQDLNASGLCVNWNRYYNVCRTG-NANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA 367

  Fly   401 AGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK---------------------AEEEEA 444
            ...::.::||::|.:|||:::||.|.::|..:.|.:::                     ||..:.
Mouse   368 HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC 432

  Fly   445 AEE------EAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYEL 503
            .||      ..:|:|:..|......|:.|  .||......|.|:..   |. ||.|:: |
Mouse   433 YEEIFQYVCHILRKAKRRALGLYQALQNR--RQATGPGTPAPAKPG---PH-AKEPSH-C----- 485

  Fly   504 FVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGS-PFNIR 567
                          |:..|             ..|..||.|  |.|:.:|....|.|.| |
Mouse   486 --------------KLCPR-------------HSPLDTTPH--TLVQPISAILASDPSSCP---- 517

  Fly   568 RGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYY 632
               |..|:              :.|:|..|.:....|:
Mouse   518 ---RCQHE--------------AGRRPSGLGSTDSGQE--------------------------- 538

  Fly   633 GNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDT 697
                                                                 |:.:||:.
Mouse   539 -----------------------------------------------------GSGSGGSA---- 546

  Fly   698 NHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRG 762
                             ||                                 :|.|...::|:.|
Mouse   547 -----------------EA---------------------------------EANGDGPQSSEDG 561

  Fly   763 VSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLC 827
            || .....|::.|||      |..:            |..||.:.:..:..||...:....|.:.
Mouse   562 VS-SGLGKEEEQEDG------AARL------------CGDVWRETRAKLRGIVDSKYFNRGIMMA 607

  Fly   828 IVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVAL 892
            |:|||:.|.::||:..:|:..:|:..|..||:.||:|..:||.|.....|.:..:||||.|||.:
Mouse   608 ILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVII 672

  Fly   893 SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVM 957
            |:.|:..:...||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:::
Mouse   673 SIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSIL 737

  Fly   958 GMQLFGKNYH---DHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVGDVSCIP 1018
            ||.:||..:.   |..|..||    |.||...:.:.:.||::|..|    .|: .:|.|..|..|
Mouse   738 GMHIFGCKFSLRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE----DWNVVLYNGMASTTP 794

  Fly  1019 ----FFLATVVIGNLVVLNLFLALLLSNF---GSSSLSAPTADNDTNKIAE-------------- 1062
                :|:|.:..||.|:.||.:|:|:..|   |.::.|....|..::.:.|
Mouse   795 WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEELDKLPEGLDSSRDL 859

  Fly  1063 ------------------------------------------------------AFNRI------ 1067
                                                                  :..|:
Mouse   860 KLCPIPMTPNGHLDPSLPLGGHLGPAGAMGAAPRLSLQPDPVLVALESRKSSVMSLGRMSYDQRS 924

  Fly  1068 ------------GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCIS 1120
                        ||..:|..|.  ..:..:::|       .||.|..:.:|     |:....|:.
Mouse   925 LSSSRSSYYGPWGRSGTWASRR--SSWNSLKHK-------PPSAEHESLLS-----GERGGSCVR 975

  Fly  1121 AEHGDNE--------LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKY 1177
            |..|..|        |...|......|                       .|...::...:::..
Mouse   976 ACEGAREDAPPRAAPLHAPHTHHAHHG-----------------------PHLAHRHRHHRRTLS 1017

  Fly  1178 LNNATDDDTAS-INSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGP 1241
            |:.....|.|. :...|:|....::........|...|.....|......:|:..| .||.||
Mouse  1018 LDTRDSVDLAELVPVVGAHSRAAWRAAGQAPGHEDCNGRMPNIAKDVFTKMDDRRD-RGEDEE-- 1079

  Fly  1242 LDGDIIIHAHDEDILDEYPADCC------------PDSYYKKFPILAGDDDSPFWQGWGNLRLKT 1294
             :.|..:......::|.|..|.|            |::   ||.||..
Mouse  1080 -EIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPEN---KFRILCQ----------------- 1123

  Fly  1295 FQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF 1359
             .:|.:|.|:..|:..|.::.:.:|||...:......:..|...:.|||.||..||.:|.::||.
Mouse  1124 -TIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGL 1187

  Fly  1360 ----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMR 1417
                :.|..::|..||..:|.||:|:.|.|:..|||   :...:.:|.||.|||||.:||..|::
Mouse  1188 YFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLK 1252

  Fly  1418 VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESEN 1482
            :||..|:.::..|.|::|:|..|::||.|:|||||.||::.|..::...     |.||:.|.:.|
Mouse  1253 LVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN-----ITNRSDCVAAN 1312

  Fly  1483 YTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFG 1547
            |.||:...|||::|.|.:.||.:|:..||:.||.:.:|:..||:||:...|.:|.|||:.|::..
Mouse  1313 YRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIV 1377

  Fly  1548 SFFTLNLFIGVIIDNFNE--QKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWR--- 1607
            |||.||:|:||:::||::  |.::|        .|.:::....:::: .||..||...|.:.
Mouse  1378 SFFVLNMFVGVVVENFHKCRQHQEA--------EEARRREEKRLRRL-EKKRRKAQRLPYYATYC 1433

  Fly  1608 -PQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI- 1670
             .:.::..:.|....||.|...|.||:.||:|:.|:...:....|.|.|.:|..:|..|.:||:
Mouse  1434 PTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLV 1498

  Fly  1671 -FALRYHYFIEPWNLFDVVVVILSILGLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAK 1732
             |.|| .:|.:.||..|:.:|:||::|:.|.:| |.... ::||::|::||.::.|||:|:|.|.
Mouse  1499 AFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMAT 1562

  Fly  1733 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV-----KEKSGINDVYNFKTFGQSM 1792
            |:|.||..:..:||.:.|:.||..|:.||:|..|:..|..:     ....|::....|:.||.:.
Mouse  1563 GMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAF 1627

  Fly  1793 ILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSAT--VGITFLLSYLVISFLIVINMY 1855
            :.|||:||...|:|::...:.:  |...:.      :|.|:.  |...:.:|:::.:..::||:.
Mouse  1628 LTLFQVSTGDNWNGIMKDTLRD--CTHDER------SCLSSLQFVSPLYFVSFVLTAQFVLINVV 1684

  Fly  1856 IAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDP----------------------------- 1891
            :||::::...:.::.||. .:.|.::..|:.....|
Mouse  1685 VAVLMKHLDDSNKEAQED-AEMDAEIELEMAHGLGPGPGPCPCPCPCPCPCPCPGPRMPTSSPGA 1748

  Fly  1892 --------------------------------EGTQYIRYDQLSEFLDVLE-------------- 1910
                                            :....|..|.|...|.:::
Mouse  1749 PGRGSGGAGVGGDTESHLCRHCYSPAQETLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPA 1813

  Fly  1911 ------------------------------------PPLQIHKPNKYKI-------------ISM 1926
                                                |.:|:.:...:.:             :|:
Mouse  1814 GCDKCHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPPQVQLAETEAFSLNSDRSSSVLLGDDLSL 1878

  Fly  1927 DIPIC-------------------RGDLMYCVDILDALTKDFFARKGNPIEETGE--IGEIAARP 1970
            :.|..                   .|||..|          ||...|.|:....|  :.|:.|.|
Mouse  1879 EDPTACPQGPKESKGELEPPEPMQAGDLDEC----------FFPFAGEPVSAGPESLLCEMGAIP 1933

  Fly  1971 DTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDP------DAGDPA 2029
                :.||.|                 |.||::.......|.|     ||..|      :...||
Mouse  1934 ----FNPVQS-----------------WLKHESNQAPPSPFSP-----DGSSPLLQMPAEFFHPA 1972

  Fly  2030 PDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSA 2094
            ...:..|..|....|::   .:.|.....:::.||    :........|..:.|:...||.:.:.
Mouse  1973 VSASQKGQEPGMSSGTL---PKIALQGSWASLRSP----SVNCTLLRQATVSDTSLDASPSSSAG 2030

  Fly  2095 GRQTAV 2100
            ..||.:
Mouse  2031 SLQTTL 2036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	88/341 (26%)
		Na_trans_cytopl	555..740	CDD:463401	15/185 (8%)
		Ion_trans	817..1028	CDD:459842	74/218 (34%)
		Na_trans_assoc	1054..1296	CDD:461936	45/348 (13%)
		Ion_trans	1300..1571	CDD:459842	103/279 (37%)
		Na_channel_gate	1561..1613	CDD:240441	10/57 (18%)
		Ion_trans	1621..1871	CDD:459842	78/260 (30%)
		GPHH	1882..1929	CDD:465306	9/170 (5%)
Cacna1i	XP_006521012.1	Ion_trans	76..407	CDD:459842	88/345 (26%)
		Ion_trans	597..824	CDD:459842	81/234 (35%)
		Ion_trans	1128..1400	CDD:459842	103/276 (37%)
		Ion_trans	1445..1700	CDD:459842	78/263 (30%)
		PHA03307	1867..>2226	CDD:223039	39/213 (18%)