DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1i

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_006521012.1 Gene:Cacna1i / 239556 MGIID:2178051 Length:2226 Species:Mus musculus


Alignment Length:2411 Identity:533/2411 - (22%)
Similarity:908/2411 - (37%) Gaps:775/2411 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 EDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAM 133
            |..||:..|....|:..|  |.|:.|    ..|..|:.|    |..|.:        |.:.|...
Mouse    22 EQPGPRSPPPSPPGLEEP--LDGTNP----DVPHPDLAP----VAFFCL--------RQTTSPRN 68

  Fly   134 WMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCIL--MIMP------TTPTVESTEVIFTGIYT 190
            |           .|.::.:|.|....:..||:||:.  |..|      .:...:..:|....|:.
Mouse    69 W-----------CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDRCKILQVFDDFIFI 122

  Fly   191 F---ESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG--NLAALRTFRVLRALKT 250
            |   |..:|::|.| |.....||.|.||.|||.::....|...:||.  ||:|:||.||||.||.
Mouse   123 FFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKA 186

  Fly   251 VAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCI--KKFPLDGSWGN 313
            :..||.::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.  :.|.:.|... 
Mouse   187 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVA- 250

  Fly   314 LTDENWDYHNRNSSNWYSEDEGISFPLCGNISG----------------AGQC----DDDY---- 354
                        ...:|..:|....|...::||                ..:|    ||.|    
Mouse   251 ------------LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDMYDFGA 303

  Fly   355 -------------------VCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRA 400
                               ||..| ..||:.|..:||:.|:|::..|:::|.:.|.::...|:.|
Mouse   304 GRQDLNASGLCVNWNRYYNVCRTG-NANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA 367

  Fly   401 AGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK---------------------AEEEEA 444
            ...::.::||::|.:|||:::||.|.::|..:.|.:::                     ||..:.
Mouse   368 HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC 432

  Fly   445 AEE------EAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYEL 503
            .||      ..:|:|:..|......|:.|  .||......|.|:..   |. ||.|:: |     
Mouse   433 YEEIFQYVCHILRKAKRRALGLYQALQNR--RQATGPGTPAPAKPG---PH-AKEPSH-C----- 485

  Fly   504 FVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGS-PFNIR 567
                          |:..|             ..|..||.|  |.|:.:|....|.|.| |    
Mouse   486 --------------KLCPR-------------HSPLDTTPH--TLVQPISAILASDPSSCP---- 517

  Fly   568 RGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYY 632
               |..|:              :.|:|..|.:....|:                           
Mouse   518 ---RCQHE--------------AGRRPSGLGSTDSGQE--------------------------- 538

  Fly   633 GNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDT 697
                                                                 |:.:||:.    
Mouse   539 -----------------------------------------------------GSGSGGSA---- 546

  Fly   698 NHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRG 762
                             ||                                 :|.|...::|:.|
Mouse   547 -----------------EA---------------------------------EANGDGPQSSEDG 561

  Fly   763 VSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLC 827
            || .....|::.|||      |..:            |..||.:.:..:..||...:....|.:.
Mouse   562 VS-SGLGKEEEQEDG------AARL------------CGDVWRETRAKLRGIVDSKYFNRGIMMA 607

  Fly   828 IVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVAL 892
            |:|||:.|.::||:..:|:..:|:..|..||:.||:|..:||.|.....|.:..:||||.|||.:
Mouse   608 ILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVII 672

  Fly   893 SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVM 957
            |:.|:..:...||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:::
Mouse   673 SIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSIL 737

  Fly   958 GMQLFGKNYH---DHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVGDVSCIP 1018
            ||.:||..:.   |..|..||    |.||...:.:.:.||::|..|    .|: .:|.|..|..|
Mouse   738 GMHIFGCKFSLRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE----DWNVVLYNGMASTTP 794

  Fly  1019 ----FFLATVVIGNLVVLNLFLALLLSNF---GSSSLSAPTADNDTNKIAE-------------- 1062
                :|:|.:..||.|:.||.:|:|:..|   |.::.|....|..::.:.|              
Mouse   795 WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEELDKLPEGLDSSRDL 859

  Fly  1063 ------------------------------------------------------AFNRI------ 1067
                                                                  :..|:      
Mouse   860 KLCPIPMTPNGHLDPSLPLGGHLGPAGAMGAAPRLSLQPDPVLVALESRKSSVMSLGRMSYDQRS 924

  Fly  1068 ------------GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCIS 1120
                        ||..:|..|.  ..:..:::|       .||.|..:.:|     |:....|:.
Mouse   925 LSSSRSSYYGPWGRSGTWASRR--SSWNSLKHK-------PPSAEHESLLS-----GERGGSCVR 975

  Fly  1121 AEHGDNE--------LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKY 1177
            |..|..|        |...|......|                       .|...::...:::..
Mouse   976 ACEGAREDAPPRAAPLHAPHTHHAHHG-----------------------PHLAHRHRHHRRTLS 1017

  Fly  1178 LNNATDDDTAS-INSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGP 1241
            |:.....|.|. :...|:|....::........|...|.....|......:|:..| .||.||  
Mouse  1018 LDTRDSVDLAELVPVVGAHSRAAWRAAGQAPGHEDCNGRMPNIAKDVFTKMDDRRD-RGEDEE-- 1079

  Fly  1242 LDGDIIIHAHDEDILDEYPADCC------------PDSYYKKFPILAGDDDSPFWQGWGNLRLKT 1294
             :.|..:......::|.|..|.|            |::   ||.||..                 
Mouse  1080 -EIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPEN---KFRILCQ----------------- 1123

  Fly  1295 FQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF 1359
             .:|.:|.|:..|:..|.::.:.:|||...:......:..|...:.|||.||..||.:|.::||.
Mouse  1124 -TIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGL 1187

  Fly  1360 ----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMR 1417
                :.|..::|..||..:|.||:|:.|.|:..|||   :...:.:|.||.|||||.:||..|::
Mouse  1188 YFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLK 1252

  Fly  1418 VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESEN 1482
            :||..|:.::..|.|::|:|..|::||.|:|||||.||::.|..::...     |.||:.|.:.|
Mouse  1253 LVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN-----ITNRSDCVAAN 1312

  Fly  1483 YTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFG 1547
            |.||:...|||::|.|.:.||.:|:..||:.||.:.:|:..||:||:...|.:|.|||:.|::..
Mouse  1313 YRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIV 1377

  Fly  1548 SFFTLNLFIGVIIDNFNE--QKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWR--- 1607
            |||.||:|:||:::||::  |.::|        .|.:::....:::: .||..||...|.:.   
Mouse  1378 SFFVLNMFVGVVVENFHKCRQHQEA--------EEARRREEKRLRRL-EKKRRKAQRLPYYATYC 1433

  Fly  1608 -PQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI- 1670
             .:.::..:.|....||.|...|.||:.||:|:.|:...:....|.|.|.:|..:|..|.:||: 
Mouse  1434 PTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLV 1498

  Fly  1671 -FALRYHYFIEPWNLFDVVVVILSILGLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAK 1732
             |.|| .:|.:.||..|:.:|:||::|:.|.:| |.... ::||::|::||.::.|||:|:|.|.
Mouse  1499 AFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMAT 1562

  Fly  1733 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV-----KEKSGINDVYNFKTFGQSM 1792
            |:|.||..:..:||.:.|:.||..|:.||:|..|:..|..:     ....|::....|:.||.:.
Mouse  1563 GMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAF 1627

  Fly  1793 ILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSAT--VGITFLLSYLVISFLIVINMY 1855
            :.|||:||...|:|::...:.:  |...:.      :|.|:.  |...:.:|:::.:..::||:.
Mouse  1628 LTLFQVSTGDNWNGIMKDTLRD--CTHDER------SCLSSLQFVSPLYFVSFVLTAQFVLINVV 1684

  Fly  1856 IAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDP----------------------------- 1891
            :||::::...:.::.||. .:.|.::..|:.....|                             
Mouse  1685 VAVLMKHLDDSNKEAQED-AEMDAEIELEMAHGLGPGPGPCPCPCPCPCPCPCPGPRMPTSSPGA 1748

  Fly  1892 --------------------------------EGTQYIRYDQLSEFLDVLE-------------- 1910
                                            :....|..|.|...|.:::              
Mouse  1749 PGRGSGGAGVGGDTESHLCRHCYSPAQETLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPA 1813

  Fly  1911 ------------------------------------PPLQIHKPNKYKI-------------ISM 1926
                                                |.:|:.:...:.:             :|:
Mouse  1814 GCDKCHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPPQVQLAETEAFSLNSDRSSSVLLGDDLSL 1878

  Fly  1927 DIPIC-------------------RGDLMYCVDILDALTKDFFARKGNPIEETGE--IGEIAARP 1970
            :.|..                   .|||..|          ||...|.|:....|  :.|:.|.|
Mouse  1879 EDPTACPQGPKESKGELEPPEPMQAGDLDEC----------FFPFAGEPVSAGPESLLCEMGAIP 1933

  Fly  1971 DTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDP------DAGDPA 2029
                :.||.|                 |.||::.......|.|     ||..|      :...||
Mouse  1934 ----FNPVQS-----------------WLKHESNQAPPSPFSP-----DGSSPLLQMPAEFFHPA 1972

  Fly  2030 PDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSA 2094
            ...:..|..|....|::   .:.|.....:::.||    :........|..:.|:...||.:.:.
Mouse  1973 VSASQKGQEPGMSSGTL---PKIALQGSWASLRSP----SVNCTLLRQATVSDTSLDASPSSSAG 2030

  Fly  2095 GRQTAV 2100
            ..||.:
Mouse  2031 SLQTTL 2036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/328 (26%)
Na_trans_cytopl 515..648 CDD:288761 19/133 (14%)
Ion_trans 835..1028 CDD:278921 69/200 (35%)
Na_trans_assoc 1054..1296 CDD:284034 45/348 (13%)
Ion_trans 1318..1571 CDD:278921 99/261 (38%)
Na_channel_gate 1561..1613 CDD:240441 10/57 (18%)
Ion_trans 1636..1871 CDD:278921 71/245 (29%)
GPHH 1880..1930 CDD:293510 9/173 (5%)
Cacna1iXP_006521012.1 Ion_trans 76..407 CDD:366146 88/345 (26%)
Ion_trans 597..824 CDD:366146 81/234 (35%)
Ion_trans 1128..1400 CDD:366146 103/276 (37%)
Ion_trans 1445..1700 CDD:366146 78/263 (30%)
PHA03307 1867..>2226 CDD:223039 39/213 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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