Protein Alignment para and Tpcn2

DIOPT Version :9

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_006508676.1
• Gene: Tpcn2 / 233979
• MGIID: 2385297
• Length: 769
• Species: Mus musculus
• Alignment Length: 758
• Identity: 145/758 - (19%)
• Similarity: 263/758 - (34%)
• Gaps: 279/758 - (36%)

  Fly  1346 FFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAM 1410
            |.:::.:|...:|......|.|....|::::||:::::.||    .:...:.:|..|.|||...:
Mouse   120 FLVDLSVKGYLVGQAQLQQNLWLLAYFMVLVVSVVDWIVSL----SLACEEPLRMRRLLRPFFLL 180

  Fly  1411 SRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA-GKYFKCEDMNGTKLSHEIIPN 1474
            .....|:..:..:..::|.:.:|.|:..|...:|.|:|:.||. |:..:.:|..  :|::
Mouse   181 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTIIGMLLFTIGEKDEAQDQE--RLAY----- 238

  Fly  1475 RNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLY 1539
                             |.::..|...|..:.|......:|           .|....|....|:
Mouse   239 -----------------FRNLPEALTSLLVLLTTSNNPDVM-----------IPAYTQNRAFALF 275

  Fly  1540 FVFFIIFGSFFTLNLFIGVIIDNFNEQKKK--------------------------AGGSLE--- 1575
            |:.|.:.||.|.:||...:|.:.|.....|                          ||.:.|
Mouse   276 FIVFTLIGSLFLMNLLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLASRAGPAGTTPEFPC 340

  Fly  1576 ----------------------------------------------------------------- 1575
                                                                             
Mouse   341 WPAPDWIFHRELYGLPSPQCFHYPVCSFLLAHLCLRVGVNPETFLPVLQKTQLNKTHKQAIMQKV 405

  Fly  1576 -------MFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP---QAIVFEIVTDKKFDII------ 1624
                   |...|.||.:....|.:..::|||    |:::.   |...| |.:...||.:
Mouse   406 QSYEGRPMLADEFQKLFDEVDKGLAKERPLK----PQYQSPFLQTAQF-IFSHHYFDYLGNLVAL 465

  Fly  1625 -----IMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFA------LRYHYF 1678
                 |.:|:.|:...:..:|   .|....:|||   ||::.:..|.|.|:||      |.||.
Mouse   466 GNLLSICVFLVLDSDLLPGER---DDFVLGILDY---IFILYYLLELLFKVFALGLPGYLSYHS- 523

  Fly  1679 IEPWNLFDVVVVILSILGLVLSDII--------------EKYFVSPTLL----RVVRVAKVGRVL 1725
                |:||.::.|:    |::|:|.              |:|  .|..|    |::....|.|.|
Mouse   524 ----NVFDGLLTII----LLVSEICTLAVYRLPHSGWKPEQY--GPLSLWDMTRLMNTLIVFRFL 578

  Fly  1726 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVY------- 1783
            |::...|.:..:...:...:|.|.....:|.:..::||:.|::.|..|....|.:.:.
Mouse   579 RIIPNIKPMAEVANTILGLIPNLRAFGGILVVAYYVFAMIGINLFRGVIVPPGNSSLVPDNNSAV 643

  Fly  1784 ------------NFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVG 1836
                        ||..|..::|.|:.:.....|..:|:|.            |.|.|....
Mouse   644 CGSFEQLGYWPNNFDDFAAALITLWNVMVVNNWQVILEAY------------KRYAGPWSM---- 692

  Fly  1837 ITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQ--YIRY 1899
            :.|:|.:|| |.:|.||:::|::|||:                      ..::||:|.:  .:..
Mouse   693 VYFVLWWLV-SSVIWINLFLALLLENF----------------------LHRWDPQGHKQLLVGT 734

  Fly  1900 DQLS---EFLDVLEPPLQ------IHK-PNKYKIISMDIPICR 1932
            .|:|   .|.|:||.|.:      :|| |:        :.:||
Mouse   735 KQMSVELMFRDILEEPKEEELMEKLHKHPH--------LHLCR 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034
		Ion_trans	1318..1571	CDD:278921	46/251 (18%)
		Na_channel_gate	1561..1613	CDD:240441	15/155 (10%)
		Ion_trans	1636..1871	CDD:278921	64/277 (23%)
		GPHH	1880..1930	CDD:293510	13/61 (21%)
Tpcn2	XP_006508676.1	Ion_trans	68..299	CDD:366146	44/217 (20%)
		Ion_trans	453..718	CDD:366146	68/298 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810