DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Scn9a

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001277603.1	Gene:	Scn9a / 20274	MGIID:	107636	Length:	1984	Species:	Mus musculus

Alignment Length:	2136	Identity:	936/2136 - (43%)
Similarity:	1302/2136 - (60%)	Gaps:	272/2136 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            |..||::||..|||||:.|..|                |.|.::|      :||:|||:|...||
Mouse    12 FVHFTKQSLALIEQRISEEKAK----------------GHKDEKK------DDEEEGPKPSSDLE 54

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..||.:.|.||||:||||::..||:|::|||.||||:|:.|::||.||:|:||:
Mouse    55 AGKQLPF-IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRI 118

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            :|.||||.|||:.|:.|||.|||.|.|...|. .::.|..|||||||||.:|::||||.:..||:
Mouse   119 SIKILVHSLFSMLIMCTILTNCIFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCVGEFTF 183

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.|||||||||..||:|..::|||::|||||||||||||::::|||||||||:|:|||.|.||
Mouse   184 LRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 248

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKK-----FPLDGSWGNLTDE----NWDYHNRNSSNWY 330
            :|||:|.||||||:|||::||.|..||.:|     ..|:........|    .:.|:...|.:..
Mouse   249 MILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQNETLESIMSTAESEEELKRYFYYLEGSKDAL 313

  Fly   331 SEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQ 395
                     |||..:.:|||.:.|.|:.. |.||:|||||||:||||||:.|||||||:||:|||
Mouse   314 ---------LCGFSTDSGQCPEGYECVTA-GRNPDYGYTSFDTFGWAFLALFRLMTQDYWENLYQ 368

  Fly   396 LVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE---------AIR 451
            ..|||||..:|:||:|:||||||||:|||||:|||:|:| |.:|..|||.::|         ..:
Mouse   369 QTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEE-QNQANIEEAKQKELEFQQMLDRLKK 432

  Fly   452 EAEEAAAAKAAKLEERANAQAQ-AAADAAAAEEAALHPEMAKS--PTYSCISYELFVGGEKGNDD 513
            |.|||.|..||..|..:..::: .....:::|.:.|..:.||.  ........:|..|.|||:|:
Mouse   433 EQEEAEAIAAAAAEYTSLGRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKLSSGEEKGDDE 497

  Fly   514 NNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVST---TSLSLPGSPFNIRRGSRSSHK 575
            ...:..|..|:..:|..:.|        ..|...:.:::||   :.||:.||.|:.||.||:| .
Mouse   498 KLSKSGSEESIRKKSFHLGV--------EGHHRAREKRLSTPNQSPLSIRGSLFSARRSSRTS-L 553

  Fly   576 YTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHS 640
            ::.: ||||                 |......:|||.:::               :|:..||..
Mouse   554 FSFK-GRGR-----------------DLGSETEFADDEHSI---------------FGDNESRRG 585

  Fly   641 SYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRD 705
            |.        :..|                     |.|..|:.::...:.....|..|.|:
Mouse   586 SL--------FVPH---------------------RPRERRSSNISQASRSPPVLPVNGKM---- 617

  Fly   706 YEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA-----GRHSRASDRGVSV 765
             ...::|.   |.:...|.|        :.:.:.:..:|.::|...|     |..::...:.:|.
Mouse   618 -HSAVDCN---GVVSLVDGP--------SALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSS 670

  Fly   766 YYFPTEDDDEDGPTFKDKAL---EVILKGID------------------VFCVWDCCWVWLKFQE 809
            .||.:||...| |..:.:|:   .::...::                  .|.:|:|...|:||::
Mouse   671 SYFLSEDMLND-PHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKK 734

  Fly   810 WVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSP 874
            ::..||.||||:|.||:|||:||:||||:||.|..|.:.||..||..||..||.|..:||:||.|
Mouse   735 FIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDP 799

  Fly   875 KYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGA 939
            ..|||.||||||.:||.|||:||.|..|:||||||||||||||||||||||||:||.|:|.::||
Mouse   800 YEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 864

  Fly   940 LGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIE 1003
            |||||.||.||:|||||:|||||||:|.:...:..:. .||||:..||.|||:||||||||||||
Mouse   865 LGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINENCKLPRWHMNDFFHSFLIVFRVLCGEWIE 929

  Fly  1004 SMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRI 1067
            :|||||.| |...|:..::..:|||||||||||||||||:|.|.:|:|...|.|.|.:..|..||
Mouse   930 TMWDCMEVAGQTMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAVARI 994

  Fly  1068 GRFKSWVKRNIADCF------KLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDN 1126
            .|..::||:.:.:..      |...:|.|.:.:| |:.:|.|.||         .|.::....|:
Mouse   995 KRGINYVKQTLREFILKSFSKKPKGSKDTKRTAD-PNNKRENYIS---------NRTLAEISKDH 1049

  Fly  1127 ELELGHDEI--LADGLIKKGIKEQTQLEVAIGDGMEFTI-----HGDMKNNKPKKSKYLNNATDD 1184
            ......|:|  .:..|.|..:.|...........:..|:     ..|::|   ..::.|::.:|.
Mouse  1050 NFLKEKDKISGFSSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLEN---MNTEELSSDSDS 1111

  Fly  1185 DTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIH 1249
            |.:        |.|                 ..|.:|.|...:|..|..|.|.|..|::.|
Mouse  1112 DYS--------KER-----------------RNRSSSSECSTVDNPLPGEEEAEAEPINAD---- 1147

  Fly  1250 AHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMS 1314
                     .|..|..|...::||....:.||...:.|..:|...::::|:.:||:.::.|||:|
Mouse  1148 ---------EPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYRIVEHSWFESFIVLMILLS 1203

  Fly  1315 SLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSL 1379
            |.|||.||:::.::..::.||.|.|:|||.||.||||:||:|.|:|.|||||||||||:||.|||
Mouse  1204 SGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSL 1268

  Fly  1380 INFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIF 1444
            :..||:.:|...:...|::|||||||||||:||.:|||||||||:.|||||.|||||||||||||
Mouse  1269 VTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIF 1333

  Fly  1445 AIMGVQLFAGKYFKC-EDMNGTKLSHEIIPNRNAC-----ESENYTWVNSAMNFDHVGNAYLCLF 1503
            :||||.|||||:::| ...:|::.|...:.||:.|     .|.|..|.|..:|||:||..||.|.
Mouse  1334 SIMGVNLFAGKFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLL 1398

  Fly  1504 QVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKK 1568
            ||||||||:.||..|:||..|:.|||.|.|:|||:|||.||||||||||||||||||||||:|||
Mouse  1399 QVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1463

  Fly  1569 KAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNM 1633
            |.||. ::||||:||||||||||:|||||.|.||||..:.|..:|::||::.|||.||:.|.|||
Mouse  1464 KLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNM 1527

  Fly  1634 FTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLV 1698
            .||.:::...:|..:.||.::|.:|:::|:.||:||:.:||::||...||:||.|||||||:|:.
Mouse  1528 VTMMVEKEGQTDYMSFVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMF 1592

  Fly  1699 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1763
            |:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:|
Mouse  1593 LAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1657

  Fly  1764 IFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDND--KGY 1826
            |||||.|.:||:::||||::||:|||.|||.|||::|||||||:|..|:|..   |||.|  |.:
Mouse  1658 IFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSA---PPDCDPKKVH 1719

  Fly  1827 P-----GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIW 1886
            |     |:||:.:|||.:.:||::||||:|:||||||||||:|.|||:..|.|::||::|:||:|
Mouse  1720 PGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVW 1784

  Fly  1887 QQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFA 1951
            ::|||:.||:|.:.:||:|...|:|||.|.||||.::|:||:|:..||.::|:|||.|.||....
Mouse  1785 EKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1849

  Fly  1952 RKGNPIEETGEIGE--IAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPD 2014
            ..|.......::.|  ::|.|....|||:::||.|::|:..|.:||.|:|:::.|..........
Mouse  1850 ESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATIIQRAYRRYRLRQNVKNISSIY 1914

  Fly  2015 TDHGDGGD--PDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDA 2068
            ...||..|  |:..|...|...:..:|.            ..||..|.::.|..|:
Mouse  1915 IKDGDRDDDLPNKEDIVFDNVNENSSPE------------KTDATASTISPPSYDS 1958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	156/280 (56%)
		Na_trans_cytopl	515..648	CDD:288761	29/135 (21%)
		Ion_trans	835..1028	CDD:278921	122/194 (63%)
		Na_trans_assoc	1054..1296	CDD:284034	52/254 (20%)
		Ion_trans	1318..1571	CDD:278921	160/258 (62%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	145/241 (60%)
		GPHH	1880..1930	CDD:293510	25/49 (51%)
Scn9a	NP_001277603.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..55		14/50 (28%)
		I. /evidence=ECO:0000305	112..410		173/308 (56%)
		Ion_trans	147..410	CDD:278921	152/273 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..540		19/89 (21%)
		Na_trans_cytopl	487..606	CDD:288761	39/189 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..609		8/78 (10%)
		II. /evidence=ECO:0000305	725..988		163/262 (62%)
		Ion_trans	760..955	CDD:278921	122/194 (63%)
		Na_trans_assoc	981..1185	CDD:284034	52/254 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1039		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1089..1145		16/83 (19%)
		III. /evidence=ECO:0000305	1178..1486		185/308 (60%)
		Ion_trans	1224..1464	CDD:278921	153/239 (64%)
		Na_channel_gate	1456..1508	CDD:240441	35/52 (67%)
		IV. /evidence=ECO:0000305	1495..1793		174/300 (58%)
		Ion_trans	1530..1768	CDD:278921	145/240 (60%)
		GPHH	1780..1835	CDD:293510	27/54 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1933..1984		7/38 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	346	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1639	1.000	Inparanoid score	I81
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm43765
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870