DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Scn5a

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_006512056.1	Gene:	Scn5a / 20271	MGIID:	98251	Length:	2085	Species:	Mus musculus

Alignment Length:	2115	Identity:	933/2115 - (44%)
Similarity:	1259/2115 - (59%)	Gaps:	268/2115 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPT 78
            |.||.||||||..||:|:|.:..:.....::..|| :|                 |:|.|:|...
Mouse    76 SSFRRFTRESLAAIEKRMAEKQARGSATSQESREG-LP-----------------EEEAPRPQLD 122

  Fly    79 LEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIR 143
            |:....:| .|.|:.|.||...||||:||:||...||:|::|||.||||||:.|:::|.||:|:|
Mouse   123 LQASKKLP-DLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVR 186

  Fly   144 RVAIYILVHPLFSLFIITTILVNCILMIM----PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 204
            |.|:.||||.|||:.|:.|||.||:.|..    |.|..||.|   ||.||||||.||::||||.|
Mouse   187 RAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYT---FTAIYTFESLVKILARGFCL 248

  Fly   205 CPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 269
            ..||:|||.||||||.||.:||.|..:||||::|||||||||||||::::.||||||||:|:|||
Mouse   249 HAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVK 313

  Fly   270 NLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKF-PLDGSWGNLTDEN--W---DYHNRNSSN 328
            .|.||::||:|.||||||:|||::||.|..||::.| .|:|:.|::..:.  |   |.:..:.:|
Mouse   314 KLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPAN 378

  Fly   329 WYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDL 393
            :..::......||||.|.||.|.:.|.||:. |.||::||||||||.||||:.|||||||.||.|
Mouse   379 YLLKNGTTDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAFLALFRLMTQDCWERL 442

  Fly   394 YQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAA 458
            ||..||:||..:|:||:::||||||||||||||:|||:|:| |.:|...|..|:|  :..:||.
Mouse   443 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE-QNQATIAETEEKE--KRFQEAM- 503

  Fly   459 AKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRS 523
                                          ||.|                     ...|.::||.
Mouse   504 ------------------------------EMLK---------------------KEHEALTIRG 517

  Fly   524 VEVESESVSVIQRQP-APTTAHQATKVRKVSTTSLSLPGSPFNIRR-----GSRSSHKYTIRNGR 582
            |:..|.  |.::..| ||.|.|:....|:...:|.:..|....:.:     |.|:.::.::.:|.
Mouse   518 VDTVSR--SSLEMSPLAPVTNHERRSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGL 580

  Fly   583 GRFGI-PGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEEN-GAIIVPVYYGNLGSRHSSYTSH 645
            .|..: |.|.|..:.....:|......:|||.|:....||.: .:::||     ...|..| |..
Mouse   581 SRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVP-----WPLRRPS-TQG 639

  Fly   646 QSRISYTSHGDLLGG-----------MAVMGV----STMTKESKLR----NRNTRNQSVGATNGG 691
            |.....::.|.:|.|           ::::|.    :|......||    :|.....:.....||
Mouse   640 QPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGG 704

  Fly   692 TTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHS 756
            ...|...           ..|.|          .|.||...|..  :..|.||...:|:....|.
Mouse   705 PQMLTPQ-----------APCAD----------GFEEPGARQRA--LSAVSVLTSALEELEESHR 746

  Fly   757 RASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVE 821
            :..                  |.:...|..        :.:|:||.:|:..::.|..:|.|||.:
Mouse   747 KCP------------------PCWNRFAQH--------YLIWECCPLWMSIKQKVKFVVMDPFAD 785

  Fly   822 LFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFD 886
            |.||:|||:||:|||::|::|..|.|.:|:.||..||..|..|.|.|::|:.|.||||:||||||
Mouse   786 LTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 850

  Fly   887 FIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 951
            .|||.|||:||||..:..|||||||||||||||||||||||.||.|:|.::|||||||.||.||:
Mouse   851 SIIVILSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIV 915

  Fly   952 FIFAVMGMQLFGKNYHDHKDRFPD-GDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDV 1014
            |||||:|||||||||.:.:.|..| |.||||:..||.|:|:|:||:|||||||:|||||.| |..
Mouse   916 FIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQS 980

  Fly  1015 SCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIA 1079
            .|:..||..:|||||||||||||||||:|.:.:|:||..|.:.|.:..|..||.|...:|||...
Mouse   981 LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTW 1045

  Fly  1080 D-CFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGD------------NELELG 1131
            | |..|:|.:     ..:|:...|:         ..:..||:|....            .|....
Mouse  1046 DFCCGLLRRR-----PKKPAALATH---------SQLPSCIAAPRSPPPPEVEKAPPARKETRFE 1096

  Fly  1132 HDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHK 1196
            .|:....|  ..|..|...:.:|:.:........|.:|:...:.:..:...:....|    |.|:
Mouse  1097 EDKRPGQG--TPGDTEPVCVPIAVAESDTDDQEEDEENSLGTEEEESSKQQESQVVS----GGHE 1155

  Fly  1197 NRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGE-CEEGPLD-------------GDII 1247
             .|.:..:....:||...|.:...|:.|...:.|.:.... |.|.|.|             .|::
Mouse  1156 -PPQEPRAWSQVSETTSSEAEASTSQADWQQEREAEPRAPGCGETPEDSYSEGSTADMTNTADLL 1219

  Fly  1248 IHAHD--EDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITM 1310
            ....|  ||:.|  |.||..:...::.|....|......:.|..||...::::|:.:|||.:|.|
Mouse  1220 EQIPDLGEDVKD--PEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTCYRIVEHSWFETFIIFM 1282

  Fly  1311 ILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIV 1375
            ||:||.|||.||::|.:|..::.:|.|.|::||.:|.||||:||:|.|||.|||||||||||:||
Mouse  1283 ILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIV 1347

  Fly  1376 MVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIF 1440
            .|||::.||:.:|...:...|::|||||||||||:||.:||||||||||.|||||.|||||||||
Mouse  1348 DVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIF 1412

  Fly  1441 WLIFAIMGVQLFAGKYFKCEDMNGTK----LSHEIIPNRNACESENYT----WVNSAMNFDHVGN 1497
            ||||:||||.|||||:.:|  :|.|:    |::.|:.|::.|||.|.|    |....:|||:||.
Mouse  1413 WLIFSIMGVNLFAGKFGRC--INQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGA 1475

  Fly  1498 AYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDN 1562
            .||.|.||||||||:.||..|:|||..::||..|.|:|||:|||.||||||||||||||||||||
Mouse  1476 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDN 1540

  Fly  1563 FNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIML 1627
            ||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|..:|:|||.:.||:.||.
Mouse  1541 FNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMF 1604

  Fly  1628 FIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVIL 1692
            .|.|||.||.::..|.|.....:|..:|.:||.||:.||::|:.|||::||...||:||.|||||
Mouse  1605 LICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVIL 1669

  Fly  1693 SILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFL 1757
            ||:|.||||||:|||.||||.||:|:|::||:|||::||||||||||||.|||||||||.|||||
Mouse  1670 SIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1734

  Fly  1758 VMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN--EEACDPP 1820
            ||||::||||:.|.:||.::||:|::||:||..||:.|||::|||||||:|..|:|  ...|||.
Mouse  1735 VMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPN 1799

  Fly  1821 -DNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYE 1884
             .|..|..|||||..|||.|..:|::||||||:|||||:||||:|.|||:..|.|::||:||:||
Mouse  1800 LPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1864

  Fly  1885 IWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDF 1949
            ||::||||.||:|.|..||:|.|.|..||:|.|||:..:|:||:|:..||.::|:|||.|.||
Mouse  1865 IWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTK-- 1927

  Fly  1950 FARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH-KAR 2004
                 ..:.|:||:..:         ||.|....|||:::||.|:.||..|.:||.|:|:| ..|
Mouse  1928 -----RVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQR 1987

  Fly  2005 GEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAP 2039
            .....||......|..|           .:|.|||
Mouse  1988 SVKHASFLFRQQAGSSG-----------LSDEDAP 2011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	159/280 (57%)
		Na_trans_cytopl	515..648	CDD:288761	34/140 (24%)
		Ion_trans	835..1028	CDD:278921	122/194 (63%)
		Na_trans_assoc	1054..1296	CDD:284034	53/270 (20%)
		Ion_trans	1318..1571	CDD:278921	162/260 (62%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	144/237 (61%)
		GPHH	1880..1930	CDD:293510	28/49 (57%)
Scn5a	XP_006512056.1	Ion_trans	195..488	CDD:366146	168/297 (57%)
		Na_trans_cytopl	550..732	CDD:371806	38/210 (18%)
		Ion_trans	781..994	CDD:366146	134/212 (63%)
		Na_trans_assoc	1020..1268	CDD:368948	53/270 (20%)
		Ion_trans	1272..1547	CDD:366146	170/276 (62%)
		Na_channel_gate	1539..1591	CDD:240441	35/52 (67%)
		Ion_trans	1596..1850	CDD:366146	153/253 (60%)
		GPHH	1862..1909	CDD:374878	26/46 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	346	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1639	1.000	Inparanoid score	I81
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm43765
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740