DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Scn3a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001342095.1 Gene:Scn3a / 20269 MGIID:98249 Length:1996 Species:Mus musculus


Alignment Length:2149 Identity:967/2149 - (44%)
Similarity:1314/2149 - (61%) Gaps:279/2149 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||:|.|.|..|                 :.||:::|  |||::   |:|:..||
Mouse    14 FRLFTRESLAAIEKRAAEEKAK-----------------KPKKEQDI--DDENK---PKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.:..||||::|||.||||||:.|:::|.|.||:|::
Mouse    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRFSATSALYILTPLNPVRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.:...|. .::.|..|||||||||.:|::||||.|..||:
Mouse   121 AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
Mouse   186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLD------------------GSWGNLTDE--NW 319
            :|||:|.||||||:|||::||.|..||::..|.|                  |::.|:|..  ||
Mouse   251 MILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNW 315

  Fly   320 DYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            ..:..:.|::|..| |...| ||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
Mouse   316 KDYIADDSHFYVLD-GQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 378

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            |||||:||:||||.|||||..:|:||:::||||||||||||||:|||:|:| |.:|..|||.::|
Mouse   379 LMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKE 442

  Fly   449 A---------IREAEEAAAAKAAKLEER-------------ANAQAQAAADAAAAE--------- 482
            |         .::.|||.|..||....|             ::::|...:..:|.|         
Mouse   443 AEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRR 507

  Fly   483 -----EAALHPE---MAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPA 539
                 |....||   ..||.:...:....|:....||..:..:|:                    
Mouse   508 QREHLEGNHRPEGDRFPKSESEDSVKRRSFLFSLDGNPLSGDKKL-------------------- 552

  Fly   540 PTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQ 604
             .:.||:.         ||:.||.|:.||.|::|    |.:.|||....||:.            
Mouse   553 -CSPHQSL---------LSIRGSLFSPRRNSKTS----IFSFRGRAKDVGSEN------------ 591

  Fly   605 QHLPYADDSNAVTPMSE-ENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVST 668
               .:|||.::....|| ...::.||...|...:.:.|..|..||        ::.|:...|...
Mouse   592 ---DFADDEHSTFEDSESRRDSLFVPHRPGERRNSNVSQASMSSR--------MVPGLPANGKMH 645

  Fly   669 MTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQ 733
            .|.:.         ..|.:..||.:.|                 |...|::..      |...|:
Mouse   646 STVDC---------NGVVSLVGGPSAL-----------------TSPTGQLPP------EGTTTE 678

  Fly   734 TVV---DMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGI 792
            |.|   .:....:..:::|.::||     .|.:|:....|   |:.:|.    :.|......:..
Mouse   679 TEVRKRRLSSYQISMEMLEDSSGR-----QRAMSIASILTNTMEELEES----RQKCPPCWYRFA 734

  Fly   793 DVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFF 857
            :||.:||||..|||.:..|:|||.||||:|.||:|||:||:||||:|:.|.::...||..||..|
Mouse   735 NVFLIWDCCDSWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVF 799

  Fly   858 TATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKS 922
            |..|..|..:|::||.|.|||||||||||.|||:|||:||||..|:|||||||||||||||||||
Mouse   800 TGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKS 864

  Fly   923 WPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDF 986
            |||||:||.|:|.::|||||||.||.||:|||||:|||||||:|.:...:. .|..||||:..||
Mouse   865 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINEDCKLPRWHMNDF 929

  Fly   987 MHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSA 1050
            .|||:||||||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|
Mouse   930 FHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAA 994

  Fly  1051 PTADNDTNKIAEAFNRIGRFKSWVKRNIADCFK--LIRNKLTNQISDQPSGERTNQISWIWSEGK 1113
            ...||:.|.:..|..|:.:...:||..|.:||:  ..|.....:|                .||.
Mouse   995 TDDDNEMNNLQIAVGRMQKGIDYVKNKIRECFRKAFFRKPKVIEI----------------HEGN 1043

  Fly  1114 GVCRCISAEHGDNEL--ELGHDEILADGL-IKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKS 1175
            .:..|:|...|..|:  ||.:   |.||. ...|:...:.:|..:.|..::             .
Mouse  1044 KIDSCMSNNTGVVEISKELNY---LKDGNGTTSGVGTGSSVEKYVIDENDY-------------M 1092

  Fly  1176 KYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG 1240
            .::||.:...|..| :.|.........|.....:|..|.:||.:|:....|...::....|.|:.
Mouse  1093 SFINNPSLTVTVPI-AVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQA 1156

  Fly  1241 PLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFET 1305
            .::       .:||:   .|..|..:...||||......:....:.|.|||...:.::|:.:|||
Mouse  1157 EIE-------PEEDL---KPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFET 1211

  Fly  1306 AVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWL 1370
            .::.|||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.||:.|||||||||
Mouse  1212 FIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWL 1276

  Fly  1371 DFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLL 1435
            ||:||.|||::.||:.:|...:.|.|::|||||||||||:||.:||||||||||.|||||.||||
Mouse  1277 DFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1341

  Fly  1436 VCLIFWLIFAIMGVQLFAGKYFKCEDM-NGTKLSHEIIPNRNACES--ENYTWVNSAMNFDHVGN 1497
            |||||||||:||||.|||||::.|.:| .|:......:.|.:.|::  :...|.|..:|||:||.
Mouse  1342 VCLIFWLIFSIMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGA 1406

  Fly  1498 AYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDN 1562
            .||.|.||||||||:.||..|:|||:|..||:.|.|:|||||||.||||||||||||||||||||
Mouse  1407 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1471

  Fly  1563 FNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIML 1627
            ||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:
Mouse  1472 FNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMI 1535

  Fly  1628 FIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVIL 1692
            .|.|||.||.::..|.|.....||..:|.:|:|:|:.|.|||:.:|||:||...||:||.|||||
Mouse  1536 LICLNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVIL 1600

  Fly  1693 SILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFL 1757
            ||:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||
Mouse  1601 SIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFL 1665

  Fly  1758 VMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPP 1820
            ||||:||||||.|.:||:::||:|::||:|||.|||.|||::|||||||:|..|:|...  ||| 
Mouse  1666 VMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDP- 1729

  Fly  1821 DNDKGYP-----GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYD 1880
              |..:|     |:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|::||::
Mouse  1730 --DAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1792

  Fly  1881 MYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDAL 1945
            |:||:|::|||:.||:|.:.:||:|...|:|||.|.||||.::|:||:|:..||.::|:|||.|.
Mouse  1793 MFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAF 1857

  Fly  1946 TKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH 2001
            ||       ..:.|:||:..:         |:.|....|||:::||.|::||..|.:||..:|.:
Mouse  1858 TK-------RVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCY 1915

  Fly  2002 --KARGEG-GGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNS 2063
              |.|.:. ..:::.:|..|....|..||...|:......|...|||.:.|:..:.|    :|..
Mouse  1916 LLKQRLKNISNTYDKETIKGRIVLPIKGDMVIDKLNGNSTPEKTDGSSSTTSPPSYD----SVTK 1976

  Fly  2064 PGED 2067
            |.::
Mouse  1977 PDKE 1980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 168/292 (58%)
Na_trans_cytopl 515..648 CDD:288761 28/133 (21%)
Ion_trans 835..1028 CDD:278921 124/194 (64%)
Na_trans_assoc 1054..1296 CDD:284034 52/246 (21%)
Ion_trans 1318..1571 CDD:278921 160/255 (63%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 147/241 (61%)
GPHH 1880..1930 CDD:293510 25/49 (51%)
Scn3aNP_001342095.1 Ion_trans 127..434 CDD:306908 177/309 (57%)
Na_trans_cytopl 510..697 CDD:314757 51/275 (19%)
Ion_trans 759..972 CDD:306908 137/212 (65%)
Na_trans_assoc 998..1201 CDD:310839 52/245 (21%)
Ion_trans 1206..1478 CDD:306908 167/271 (62%)
Na_channel_gate 1470..1522 CDD:240441 36/52 (69%)
Ion_trans 1526..1782 CDD:306908 157/258 (61%)
GPHH 1786..1849 CDD:318993 31/62 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 346 1.000 Domainoid score I1042
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1639 1.000 Inparanoid score I81
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm43765
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.880

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