DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Scn10a

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001192250.1	Gene:	Scn10a / 20264	MGIID:	108029	Length:	1958	Species:	Mus musculus

Alignment Length:	2177	Identity:	909/2177 - (41%)
Similarity:	1223/2177 - (56%)	Gaps:	363/2177 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||.|||.:||::|||....:|              ||.|::.:     :|:.|.|:|...|:
Mouse    13 FRRFTPESLAEIEKQIAAHRAAKK--------------GRPKQRGQ-----KDKSEKPRPQLDLK 58

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            ....:| |..|..|.||...||||:||:||...||:|:.|.:.|.||||:.|:|:..|||.|||.
Mouse    59 ACNQLP-RFYGELPAELVGEPLEDLDPFYSTHRTFIVLDKSRTISRFSATWALWLFSPFNLIRRT 122

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYL 210
            ||.:.||..||:||..||||||:.|.....|  |..|..||.:||||:.:|::||||.|..||||
Mouse   123 AIKVSVHSWFSIFITVTILVNCVCMTRTDLP--EKLEYAFTVVYTFEALIKILARGFCLNEFTYL 185

  Fly   211 RDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275
            ||.||||||.||.||||...|||..::.|||||||||||||:::||||.||||:|.||:.|.||.
Mouse   186 RDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVT 250

  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISF-- 338
            |||:|.||||||:|||::.|.|..||||         |.||.:      .:.|..||..|..|
Mouse   251 ILTVFCLSVFALVGLQLFKGNLKNKCIK---------NGTDPH------KADNLSSEMAGDIFIK 300

  Fly   339 -----P-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLV 397
                 | ||||.|.||.|.:|||| :....||::.|||||||.|||||.|||||||.||.|||..
Mouse   301 PGTTDPLLCGNGSDAGHCPNDYVC-RKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQT 364

  Fly   398 LRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAA 462
            |||:|..:|:||:::||||||||||||||:|.|:|:|..:....|..|:|:..:||.|.
Mouse   365 LRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFKEALEV------ 423

  Fly   463 KLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVE 527
             |::.....|....|                 |.|..|:.   |......:.|:.:..::|
Mouse   424 -LQKEQEVLAALGID-----------------TTSLYSHN---GSPLAPKNANERRPRVKS---- 463

  Fly   528 SESVSVIQRQPAPTTAHQATKVRKVST-TSLSLPGSPFNIRRGS---------RSSHKYTIRNGR 582
                                ::.:.|| .:.||...|:|.||.|         |:||....
Mouse   464 --------------------RMSEGSTDDNRSLQSDPYNQRRMSFLGLSSGRRRASHSSVF---- 504

  Fly   583 GRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQS 647
             .|..|..|                           :|..:|.:...|::|:..||.||.
Mouse   505 -HFRAPSQD---------------------------VSFPDGILDDGVFHGDQESRRSSI----- 536

  Fly   648 RISYTSHGDLLG-GMAVMGVSTMTK------------ESKLRNRNTRNQSVGATNGGTTCLDTNH 699
                     ||| |....|....:.            |...|...|...:.||..|
Mouse   537 ---------LLGRGAGQAGPLPRSPLPQSPNPGPRRGEEGQRGVPTGELATGAPEG--------- 583

  Fly   700 KLDHRDYEIGLECTDEAGKIKHHDNPFI-EPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGV 763
                       ...|.||:.......:: ||.:.|..  |..|.::..:||:.
Mouse   584 -----------PALDAAGQKNFLSADYLNEPFRAQRA--MSVVSIMTSVIEEL------------ 623

  Fly   764 SVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCI 828
                       |:.   |.|....::.....:.:|:||..|.||:..:..:|.|||.||.|||||
Mouse   624 -----------EES---KLKCPPCLISLAQKYLIWECCPKWKKFKMVLFELVTDPFAELTITLCI 674

  Fly   829 VVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALS 893
            ||||:||||:|:.|....:.:|::||..||..|.:|...|::|..|.||||:.|||||.:||.:|
Mouse   675 VVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVS 739

  Fly   894 LLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMG 958
            ||||.......|||||:|||||||||||||||||:||.|:|.::||||||||:|.||:||||::|
Mouse   740 LLELSTSKKGSLSVLRTFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVG 804

  Fly   959 MQLFGKNYHDHKDRFP--DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVG-DVSCIPFF 1020
            .||..:||...:|...  :|:..||:..||.|||::|||:|||||||:||.||.|. |..|:..|
Mouse   805 KQLLSENYGCRRDGISVWNGERLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQDYICLTLF 869

  Fly  1021 LATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNI-----AD 1080
            |..:|:|||||||||:||||::|.:.:|:||..|.:.|.:..|..||..|.....|.|     :.
Mouse   870 LTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRASRAITSYIRSH 934

  Fly  1081 CFKLIRNKLTNQISDQP---SGERTNQISWIWSEGKGVCRCISAEHGD-NELELG-----HDEIL 1136
            | :|...|:..|:..:|   |.:..|.|:         ...::|..|: .:..||     |.:.:
Mouse   935 C-RLRWPKVETQLGMKPPLTSCKAENHIA---------TDAVNAAVGNLAKPALGGPKENHGDFI 989

  Fly  1137 ADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFK 1201
            .|        ....:.|.|.:|     ..|:...:          .|.:.||.:|:        :
Mouse   990 TD--------PNVWVSVPIAEG-----ESDLDELE----------EDVEHASQSSW--------Q 1023

  Fly  1202 DESHKGSAETMEGEEKRD-----------ASKEDL-------------------GLDEELDEEGE 1236
            :||.||..|.::..:|.:           .|.|||                   |:|:....||.
Mouse  1024 EESPKGQQELLQQVQKCEDHQAARSPPSGMSSEDLAPYLGERWQREESPRVPAEGVDDTSSSEGS 1088

  Fly  1237 CEEGPLDGDIIIHAHDE--DILDEYPADCCPDSYYKKFPIL-AGDDDSPFWQGWGNLRLKTFQLI 1298
            ..:.| |.:.|:....|  :.||| |.||.|:...::.|.. ......|:..|| .:|...::::
Mouse  1089 TVDCP-DPEEILRKIPELAEELDE-PDDCFPEGCTRRCPCCKVNTSKFPWATGW-QVRKTCYRIV 1150

  Fly  1299 ENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYF 1363
            |:.:||:.:|.|||:||.|||.||.:|.::|.::.:|.|.||:||.||..|||:||:|.|||.||
Mouse  1151 EHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYF 1215

  Fly  1364 TNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1428
            |||||||||:||.:||.:.:|.::....:.:.|.:|||||||||||:||.:||||||:|||.|||
Mouse  1216 TNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIP 1280

  Fly  1429 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLS---HEIIPNRNACESENYT----WV 1486
            ||.|||||||||||||:||||.|||||:.:|.|......|   ...:.|::.|.::|.|    ||
Mouse  1281 SIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGHFFWV 1345

  Fly  1487 NSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFT 1551
            |..:|||:|...||.|.||||||||:.||..|:|||:::.||..|.::|||||||.|||||.|||
Mouse  1346 NVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFGGFFT 1410

  Fly  1552 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIV 1616
            ||||:||||||||:||||..|. ::||||:||||||||||:|||||.|.||||..:.|..||:||
Mouse  1411 LNLFVGVIIDNFNQQKKKIRGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIV 1474

  Fly  1617 TDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEP 1681
            |.:.||||||..|.|||.||.::..:.|:....||..:|..||.:|:.||::|:||||.:||...
Mouse  1475 TRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNG 1539

  Fly  1682 WNLFDVVVVILSILGLVLSDI---IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1743
            ||:||.:||||||..|:.|.|   :|.|| |||||||:|:|::||:|||::.|||||||||||.|
Mouse  1540 WNVFDFIVVILSISSLLFSAILSSLESYF-SPTLLRVIRLARIGRILRLIRAAKGIRTLLFALMM 1603

  Fly  1744 SLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVL 1808
            ||||||||.|||||||||::||||:.|.:|.:::||:|::||||||.||:.|||::|||||||:|
Mouse  1604 SLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLL 1668

  Fly  1809 DAIIN--EEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDV 1870
            ..|:|  ...||| ..|..|..|||||..|||.|..:|::||||||:||||||||||::.|||:.
Mouse  1669 SPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFNVATEES 1733

  Fly  1871 QEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDL 1935
            .|.|::||:||:||.|::||||.||:|.:..||:|.|.|..||:|.|||:..:|.||:|:..||.
Mouse  1734 TEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDK 1798

  Fly  1936 MYCVDILDALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCA 1991
            ::|:|||.|.||       |.:.|:||:..:         |.......|||:::||..::|:..|
Mouse  1799 IHCLDILFAFTK-------NVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLRCKQEDISA 1856

  Fly  1992 RLIQHAWRK-------------HKARGEGGGSFEPDTDH------GDGGDPDAGDPAPDEATDGD 2037
            .:||.|:|.             |..|.|..|...|...:      .:||.||..:.|  .||  .
Mouse  1857 TIIQKAYRNYMLQRSLMLSNPLHVPRAEEDGVSLPREGYVTFMANDNGGLPDKSETA--SAT--S 1917

  Fly  2038 APAGGDGSVNGTAEGAADADESNVNSPGEDAA 2069
            .|...|....|.::.|..:..|::.:..|..|
Mouse  1918 FPPSYDSVTRGLSDRANISTSSSMQNEDEVTA 1949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	158/278 (57%)
		Na_trans_cytopl	515..648	CDD:288761	25/142 (18%)
		Ion_trans	835..1028	CDD:278921	106/195 (54%)
		Na_trans_assoc	1054..1296	CDD:284034	60/288 (21%)
		Ion_trans	1318..1571	CDD:278921	154/259 (59%)
		Na_channel_gate	1561..1613	CDD:240441	34/51 (67%)
		Ion_trans	1636..1871	CDD:278921	140/240 (58%)
		GPHH	1880..1930	CDD:293510	26/49 (53%)
Scn10a	NP_001192250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..54		10/45 (22%)
		I. /evidence=ECO:0000305	116..404		174/305 (57%)
		Ion_trans	147..406	CDD:278921	155/276 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..483		8/65 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..583		8/43 (19%)
		II. /evidence=ECO:0000305	646..910		146/263 (56%)
		Ion_trans	681..893	CDD:278921	119/211 (56%)
		Na_trans_assoc	903..1148	CDD:284034	60/288 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1006..1094		20/106 (19%)
		III. /evidence=ECO:0000305	1141..1450		179/309 (58%)
		Ion_trans	1170..1428	CDD:278921	152/257 (59%)
		Na_channel_gate	1420..1472	CDD:240441	35/52 (67%)
		IV. /evidence=ECO:0000305	1459..1758		174/299 (58%)
		Ion_trans	1494..1733	CDD:278921	140/239 (59%)
		GPHH	1743..1800	CDD:293510	29/56 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1901..1958		14/53 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	346	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1639	1.000	Inparanoid score	I81
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm43765
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740