DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and cca-1

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001367691.1 Gene:cca-1 / 181045 WormBaseID:WBGene00000367 Length:1885 Species:Caenorhabditis elegans


Alignment Length:2112 Identity:525/2112 - (24%)
Similarity:895/2112 - (42%) Gaps:531/2112 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RESLVQIEQRIAAEHEKQKELERKRA-EG-----EVPQYGRKKKQKEI---RYDDEDEDEGPQPD 76
            |.|.:.:.:|.:....:.:::|...: ||     ::.::||.....|.   |::....:.|.:..
 Worm    29 RTSAITVNRRQSQSTRRHEDVEALGSIEGSKETLQLSEHGRLASSSEASPSRWEGRQIEWGNEEQ 93

  Fly    77 PTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNP 141
            ...|..:|.|    |...|.|..        :|.                            ..|
 Worm    94 IEEESELPYP----GFAEPALRC--------FYQ----------------------------ARP 118

  Fly   142 IRRVAIYILVHPLFSLFIITTILVNCILMIM-------PTTPT--VESTEVIFTGI---YTFESA 194
            .|:.|:.:::.|.|....:..|::||:.:.|       |...|  .:..::|...|   :.||..
 Worm   119 PRKWALQMVMSPWFDRITMAVIMINCVTLGMYRPCEDGPDCDTYRCQILDIIDNCIFVYFAFEMV 183

  Fly   195 VKVMARGFILCPFTYLRDAWNWLDFVVI--ALAYVTMGIDLG---NLAALRTFRVLRALKTVAIV 254
            :|:||.|| ..|..|:.|.||.|||.::  .:|...:...||   ||.|:||.||||.|:.|..:
 Worm   184 IKIMALGF-YGPAAYMSDTWNRLDFFIVMAGIAEFVLHEYLGGNINLTAIRTVRVLRPLRAVNRI 247

  Fly   255 PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENW 319
            |.::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|:...|      ....||.
 Worm   248 PSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLP------KTISENQ 306

  Fly   320 D--YHNRNSSNWY-SEDEGISFPLCGNISGAG---------------QCD---DDY------VCL 357
            .  ::|...:.:| .||..:.: :|......|               :|:   |:|      .|:
 Worm   307 SALFNNVKLTRFYIPEDTSLEY-ICSQPDANGLHTCSNLPPYTVDGVKCNLTLDEYDKVTNDSCI 370

  Fly   358 ---------QGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVII 413
                     |....||..|..|||:.|:|:::.|.:::.:.|.|:...|..|...|:.::|:::|
 Worm   371 NWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDIMYYVQDAHSFWNWIYFVLLI 435

  Fly   414 FLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADA 478
            .:|:|:::||.|.::|..:.|.::             ||.|.       .|:||           
 Worm   436 VIGAFFMINLCLVVIATQFAETKR-------------RETER-------MLQER----------- 469

  Fly   479 AAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTA 543
                     ..:....:.||...|  :||.     ::||         |.::|            
 Worm   470 ---------KMLLNRDSISCTGSE--IGGA-----SSKE---------EGDTV------------ 497

  Fly   544 HQATKVRKVSTTSLSLPGSPFNIRRGSRSS-HKYT--IRNGRGRFGIPGSDRKPLVLSTYQDAQQ 605
             .|..||.:..|          .||..|:: .|||  :.....|.......|:...|.......:
 Worm   498 -YAAFVRFIGHT----------FRRTKRAAKKKYTAYMEERAERKSSERQQRRKSKLDDMATLSR 551

  Fly   606 HLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMT 670
            ....|:|....|.::.|||                     ..:|.  .:||   |:.:..|. :.
 Worm   552 IEEKAEDEEDETTITRENG---------------------DDQIE--QNGD---GVRIKRVK-IE 589

  Fly   671 KESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTV 735
            :|.|::..|      |.:||      .::|....|.|     :||.|:                 
 Worm   590 EEPKIKIGN------GNSNG------PHYKHSSSDEE-----SDEDGE----------------- 620

  Fly   736 VDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDC 800
                                               ||...||...|.|:....|        |  
 Worm   621 -----------------------------------EDQVYDGEEAKKKSTPSKL--------W-- 640

  Fly   801 CWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEA 865
             |...|.|::|   :.|.|.. .|.:.|:|||:.|.:::|...:.:..:|:..|.||||.||:|.
 Worm   641 -WFREKIQKFV---ICDHFTR-GILVAILVNTLSMGVEYHQQPEILTVILEYSNLFFTALFALEM 700

  Fly   866 TMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLI 930
            .:|::|.....|..:|:|:||..|||||:|||..||..||||||:|||||:.||.:..|.|...:
 Worm   701 LLKIIASGLFGYLADGFNLFDGGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQL 765

  Fly   931 SIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF---------------------- 973
            .:|.|||..:.....:|.:.||||:::||.|||..:...:::|                      
 Worm   766 VVMLRTMDNVTVFFGLLVLFIFIFSILGMNLFGCKFCKVEEKFLGGLAKKCERKNFDTLLWALIT 830

  Fly   974 ---------------PDGDL--------------PRWNFTDFMHSFMIVFRVLCGE-WIESMWDC 1008
                           ||..|              .|.||.:|:.:.:.||::|..| |...:::.
 Worm   831 VTLGMVLFGCKFCNHPDTGLQCTSAQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNG 895

  Fly  1009 MYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAP-TADNDTNK--IAEAFNRIGRF 1070
            |...:.....:|:|.:..||.|:.||.:|:|:..|..|..... ..:.|..|  :.|...|    
 Worm   896 MAQTNPWAALYFVALMTFGNYVLFNLLVAILVEGFQESKEEEKRQLEEDARKQAVEEEDER---- 956

  Fly  1071 KSWVKRNIADCFKLIRNKLT-----NQIS------DQPSGERTNQISWIWSEGKGVCRCISAEHG 1124
                ||.:    :||..|.|     |.::      .:||.          .|.....|.:||.:.
 Worm   957 ----KREL----ELIIAKTTSPAFNNGVAPAECTCQRPSS----------PEESPSPRLLSANYH 1003

  Fly  1125 DNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASI 1189
            .:. |..|...| |.:|.|.:.                    ::|:.|.....::...||  :.:
 Worm  1004 PSP-ERKHSANL-DAIIDKRLV--------------------LRNSAPFDRSPVSEGRDD--SRL 1044

  Fly  1190 NSYGS------------------------HKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEE 1230
            |.:.|                        |.|........:...||...|:..:||:|   |.:.
 Worm  1045 NRHASLVLPVANGVPYRRQRVHSWSGLCHHFNPNCPVHGRRALIETYAREKFLEASQE---LKQA 1106

  Fly  1231 LDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGN-LRLKT 1294
            |.||.:..|...:..:                   ....||..:....:.|.|..|..| ||:|.
 Worm  1107 LAEEEKRNEAKQNTFV-------------------RKLLKKTCLHNRTEFSLFLMGPKNPLRIKC 1152

  Fly  1295 FQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLA--- 1356
            .|..:.|:|:..|:..|.::.:.||:|...:|.....:..|:....||||||..||::|.:|   
 Worm  1153 LQTTQKKWFDYTVLFFIGINCITLAMERPSIPPDSFERQFLHISGYIFTVIFTGEMMMKVIANGC 1217

  Fly  1357 -LGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAG------GIQAFKTMRTLRALRPLRAMSRMQ 1414
             :|...||.:.|..||.::|::||||....|:..|      |:  .:.:|.||||||||.::|..
 Worm  1218 FIGQAAYFKDGWNILDGILVVISLINIAFELLATGDSPKIFGV--IRVLRLLRALRPLRVINRAP 1280

  Fly  1415 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACE 1479
            |:::||..|:.::..|.|::|:|..|::||.|:|||||.|..:.|   .|.::.: :....:..|
 Worm  1281 GVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHC---IGPEVGN-VTTKADCIE 1341

  Fly  1480 SENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFI 1544
            .....|||...|||::|.|.:.||.:::..||:.||...||:..||.|||...|.:..:||:.|:
 Worm  1342 DYRNKWVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFL 1406

  Fly  1545 IFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK-----------KYYNAM----KKMGS 1594
            :...||.||:|:||:::||::.|:    :||..|.|.:|           |:..:|    |||..
 Worm  1407 LLVGFFVLNMFVGVVVENFHKCKE----ALEKEMREKEKEKRLKRKLKRQKFEESMAGKRKKMER 1467

  Fly  1595 KKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFV 1659
            ..|..   ......:..:..|||.|.||:.|...||:|:.:|.::.|........||..||..|.
 Worm  1468 NYPYY---HDYGHTRLFLHGIVTSKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFT 1529

  Fly  1660 VIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLSDI-IEKYFVSPTLLRVVRVAKVG 1722
            .:|:.|..:|:.||.: .:|||.||..|:.:|||||.|::..:. ..:..::||::||:||.::.
 Worm  1530 AVFTLEAAMKLIALGFKRFFIEKWNRLDMFIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIA 1594

  Fly  1723 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEK---SGINDV 1782
            |||:|:|.|||||:||..:..:||.:.|:..|.||:.||||..|:..|  :...|.   .|:.:.
 Worm  1595 RVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSEDHPCDGLGEH 1659

  Fly  1783 YNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVIS 1847
            .:||.||.:.:.||:::|...|:|::...:.:: ||..|:.:  ...|....:...|.:.:::||
 Worm  1660 AHFKNFGMAFLTLFRIATGDNWNGIMKDALRDD-CDSSDHCE--TNCCVDPILAPCFFVIFVLIS 1721

  Fly  1848 FLIVINMYIAVILENYSQAT------------EDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYD 1900
            ..:::|:.:||::::..::.            |:::..:|..|.|   ||.::.:|...::::..
 Worm  1722 QFVLVNVVVAVLMKHLEESNKRDAEGPAEPTGENIENEITKSDDD---EIVEEHEPLAIEHVKEG 1783

  Fly  1901 QLSEFLDVLE-PPLQIHKPNKY---KIISMDI 1928
            :|.|..:..| |..||  |:.:   |.:||.:
 Worm  1784 ELDEEEETEEGPTTQI--PDGHGGIKRLSMQV 1813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 85/323 (26%)
Na_trans_cytopl 515..648 CDD:288761 23/135 (17%)
Ion_trans 835..1028 CDD:278921 73/244 (30%)
Na_trans_assoc 1054..1296 CDD:284034 51/279 (18%)
Ion_trans 1318..1571 CDD:278921 95/262 (36%)
Na_channel_gate 1561..1613 CDD:240441 14/66 (21%)
Ion_trans 1636..1871 CDD:278921 76/253 (30%)
GPHH 1880..1930 CDD:293510 14/53 (26%)
cca-1NP_001367691.1 Ion_trans 129..461 CDD:395416 88/352 (25%)
Ion_trans 659..938 CDD:395416 87/278 (31%)
Ion_trans 1159..1430 CDD:395416 98/276 (36%)
Ion_trans 1488..1721 CDD:395416 77/235 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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