DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and egl-19

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001023079.1 Gene:egl-19 / 177513 WormBaseID:WBGene00001187 Length:1877 Species:Caenorhabditis elegans


Alignment Length:1989 Identity:469/1989 - (23%)
Similarity:791/1989 - (39%) Gaps:637/1989 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 ASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCI-LMIMPTTPT---------VESTEV 183
            :.:::..|...||||::.|.|:....|...|:..|..||| |.|....|.         :|:.|.
 Worm    64 SERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEY 128

  Fly   184 IFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVT-----MGIDLGNLAALRTFR 243
            :|..::|.|..:|::|.||:..|..|||:|||.|||:::.:..|:     |.|...::.|||.||
 Worm   129 VFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFR 193

  Fly   244 VLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLD 308
            |||.|:.|:.||.|:.::.|::.::..|..:.:|.:|.:.::|::||:::.|.|...||     |
 Worm   194 VLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI-----D 253

  Fly   309 GSWGNLTDENWDYHNRNSSNWYSEDEGISFPLC------GNISGAGQCDDDYVCLQGFGPNPNYG 367
            .:.|.|.       .::.:...::.||.:|. |      .|:....:|..:..     .|.||.|
 Worm   254 PATGQLA-------QKDPTPCGTDTEGSAFK-CQPSDSLTNMGVRWECSSNTT-----WPGPNNG 305

  Fly   368 YTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMS 431
            .|:||:||.|.|:.|:.::.:.|.|:...|..|.| .|..::|:.::.||||:::||:|.:::..
 Worm   306 ITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGE 370

  Fly   432 YDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTY 496
            :.                               :||..|:|:..                     
 Worm   371 FS-------------------------------KEREKARARGL--------------------- 383

  Fly   497 SCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPG 561
                ::.|           :||..:.                                       
 Worm   384 ----FQKF-----------REKQQLE--------------------------------------- 394

  Fly   562 SPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAI 626
                                                   :|.:.:|.:...:..:.|::|:    
 Worm   395 ---------------------------------------EDLKGYLDWITQAEDIEPVNED---- 416

  Fly   627 IVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGG 691
                                                                ...::.|..|..|
 Worm   417 ----------------------------------------------------EQEDEPVAQTVVG 429

  Fly   692 TTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHS 756
                               |..||.|:.:..|   :.|  ::....||.:..||....:|..|..
 Worm   430 -------------------EEADEEGEERVED---VRP--SKWAARMKRLEKLNRRCRRACRRLV 470

  Fly   757 RASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVE 821
            ::.                   ||                      .||                
 Worm   471 KSQ-------------------TF----------------------YWL---------------- 478

  Fly   822 LFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFD 886
              :.|.:::||:.:..:|:..::.::......|.||...|::|..:|:.::....|....:|.||
 Worm   479 --VILLVLLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFD 541

  Fly   887 FIIVALSLLE-----LGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFV 946
            ..:|..|:||     ..|....|:|||||.||||:||:.|.|.:|..|:|.:..::.::.:|..:
 Worm   542 CFVVISSILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIISLLLL 606

  Fly   947 LCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-W-------IE 1003
            |.:.|.|||::|||:||..::.:    |....||.||..|:.:.:.||::|.|| |       ||
 Worm   607 LFLFIVIFALLGMQVFGGKFNFN----PQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIE 667

  Fly  1004 SMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIG 1068
            |......:|.:.|| :::...:.||.::||:|||:.:.|.         ||.|:           
 Worm   668 SFGGVGTLGVIVCI-YYIVLFICGNYILLNVFLAIAVDNL---------ADADS----------- 711

  Fly  1069 RFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHD 1133
                                |||                             ||           
 Worm   712 --------------------LTN-----------------------------AE----------- 716

  Fly  1134 EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNR 1198
                        ||:.|.|:                                             
 Worm   717 ------------KEEEQQEI--------------------------------------------- 724

  Fly  1199 PFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDI-------L 1256
                          |||::.....||.|.:..:||    .||           ||::       :
 Worm   725 --------------EGEDEEFEEGEDEGEEHGMDE----PEG-----------DEEMTSARPRRM 760

  Fly  1257 DEYPADCCPDSYYKKFP------ILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSS 1315
            .|.||    .|..|..|      ||:..:         :.|:....::.:.||..||:..||:||
 Worm   761 SEVPA----ASTVKPIPKASSLFILSHTN---------SFRVFCNMVVNHSYFTNAVLFCILVSS 812

  Fly  1316 LALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC-----WLDFVIV 1375
            ..||.|| .|........||.|.|..||.:|.:|:.:|.:..|. |:...::|     .||.::|
 Worm   813 AMLAAED-PLQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGL-VFHKGSFCRNAFNLLDILVV 875

  Fly  1376 MVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIF 1440
            .|||.:||   :....:...|.:|.||.||||||::|.:|::.||..::.|:.:|.|::||..:.
 Worm   876 AVSLTSFV---LRTDAMSVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFML 937

  Fly  1441 WLIFAIMGVQLFAGKYFKCEDMN--------GTKLSHEI-IPNRNACESENYTWVNSAMNFDHVG 1496
            ..:|||:|||||.|.:|.|.|::        |..:.:|. .|.:..  |:...|.|:..|||:||
 Worm   938 QFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDGDPTKPV--SKKRVWSNNDFNFDNVG 1000

  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561
            :|.:.||.|:||:||.|::..||||.|.||.||..:...:.|:|:.|||..:||.:|:|:|.:| 
 Worm  1001 DAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVI- 1064

  Fly  1562 NFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKK----PLKAIPR----PRWRPQAIVFEIVTD 1618
                         ..|..|.:::|.|.......:|    .|||.|.    ||.|.|..|:..||.
 Worm  1065 -------------VTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTS 1116

  Fly  1619 KKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYFIEPW 1682
            :.|:.:|.|.|.:|..::....|.:|..:...||..|.||..:|:.|.:|||.||. .:|..:.|
 Worm  1117 RAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRW 1181

  Fly  1683 NLFDVVVVILSILGLVLSDIIEKYFVSP--TLLRVVRVAKVGRVLRLVK---GAKGIRTLLFALA 1742
            |:||::||:.|.:.:....:      :|  |.|..:...::.||:||||   ..:||||||:...
 Worm  1182 NVFDLLVVVGSFIDITYGKL------NPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFM 1240

  Fly  1743 MSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWD 1805
            .|..||..:.||:.|:.||:|:.||.||  :.:.:.:.|:...||.:|..::::||:.:|...|.
 Worm  1241 KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQ 1305

  Fly  1806 GVLDAIINEE--ACDPPDND--KG--YPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYS 1864
            .::.:..:.|  .|||..:|  ||  ....||: .....:.:|:.::...:|||:::|||::|:.
 Worm  1306 DIMLSCSDREDVRCDPMSDDYHKGGLNESRCGN-NFAYPYFISFFMLCSFLVINLFVAVIMDNFD 1369

  Fly  1865 QATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KII 1924
            ..|.| ...|.....:.:..:|.::||:....|::..:...|..:.|||...|  |::.   :::
 Worm  1370 YLTRD-WSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLV 1433

  Fly  1925 SMDIPICRGDLMYCVD-ILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE 1988
            ||::|: ..|...|.: .|.||     .|....|...|.|.|.     .|........:|::..:
 Worm  1434 SMNMPL-NSDGTVCFNATLFAL-----VRTNLKIYTEGNIDEA-----NEQLRSAIKRIWKRTHK 1487

  Fly  1989 ---------------------YCARLIQHAWRKHKARGE 2006
                                 |...|||..:|:.|.|.|
 Worm  1488 DLLDEVVPPAGKEDDVTVGKFYATFLIQDYFRRFKKRKE 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 87/292 (30%)
Na_trans_cytopl 515..648 CDD:288761 6/132 (5%)
Ion_trans 835..1028 CDD:278921 62/205 (30%)
Na_trans_assoc 1054..1296 CDD:284034 32/254 (13%)
Ion_trans 1318..1571 CDD:278921 96/266 (36%)
Na_channel_gate 1561..1613 CDD:240441 13/59 (22%)
Ion_trans 1636..1871 CDD:278921 77/248 (31%)
GPHH 1880..1930 CDD:293510 12/54 (22%)
egl-19NP_001023079.1 Ion_trans 105..379 CDD:278921 86/322 (27%)
Ion_trans 493..714 CDD:278921 74/265 (28%)
Ion_trans 815..1074 CDD:278921 98/279 (35%)
Ion_trans 1134..1376 CDD:278921 77/249 (31%)
GPHH 1384..1447 CDD:293510 14/63 (22%)
Ca_chan_IQ 1449..1521 CDD:285917 15/81 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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