DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and nca-2

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_498054.2 Gene:nca-2 / 175674 WormBaseID:WBGene00003558 Length:1785 Species:Caenorhabditis elegans


Alignment Length:2057 Identity:392/2057 - (19%)
Similarity:720/2057 - (35%) Gaps:698/2057 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 LFSLFIITTILVNCIL----MIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFIL 204
            |...|:...:.|.|:|    :.:.|..|::          :.:||.|.|:..|:||.:...|...
 Worm    69 LHERFLRDMVRVACLLSMISLCLHTPETIKMWPPLNYIILANDVIVTLIFIGEAAVTINQNGLFD 133

  Fly   205 CPFTYLRDAWNWLDFVVI--------------------ALAYVTMGIDLGNLAALRTFRVLRALK 249
            ...:||||.|...:|.::                    ||.:|.... ||.|.:.|.|..||.::
 Worm   134 NQNSYLRDRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVYYPW-LGALRSARPFIFLRFIR 197

  Fly   250 TVAIVPGLKTIVGAVIE-SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGN 313
            ::......|..:..:|: |.:.:::|.|..||.:..:|:||:|:: |.|...|:.         |
 Worm   198 SIVRFKLPKNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLF-GRLNYHCVV---------N 252

  Fly   314 LTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAG--QCDDDYVCL--------QGFGPNPNYGY 368
            .||.|         |....|..|...:|.. .|||  :|..:.||:        :||       |
 Worm   253 GTDPN---------NVTIADLAIPDTMCSQ-KGAGGYECPGNMVCMRLQLKPQEEGF-------Y 300

  Fly   369 TSFDSFGWAFLSAFRLMTQDFW-EDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSY 432
            ..|..|..:..:.:...:|:.| ..||..:..........:|:.:||..::.:.|:.:|::..::
 Worm   301 GQFSDFASSLFTVYLAASQEGWVYVLYDCLDSLPSFLAFFYFVTLIFFLAWLVKNVFIAVITETF 365

  Fly   433 DELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYS 497
            .|::.:..|        :.:..||                                         
 Worm   366 AEIRVQFSE--------MWQTREA----------------------------------------- 381

  Fly   498 CISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQAT-KVRKVSTTSLSLPG 561
                                                       ||.|..| |:.|          
 Worm   382 -------------------------------------------TTDHVYTQKLEK---------- 393

  Fly   562 SPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAI 626
                                                                       :|:|..
 Worm   394 -----------------------------------------------------------DEDGWK 399

  Fly   627 IVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGG 691
            :|.|         ..|                                  ||...|.|:      
 Worm   400 LVEV---------DKY----------------------------------NRAHSNNSL------ 415

  Fly   692 TTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHS 756
                                              |:..:.|.|                      
 Worm   416 ----------------------------------FLHTIVTST---------------------- 424

  Fly   757 RASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVE 821
                                       |.:.:::                               
 Worm   425 ---------------------------AFQTVMQ------------------------------- 431

  Fly   822 LFITLCIVVNTMFMA--MDHHDMNKEMERVLKSGNYF----FTATFAIEATMKLMAMSPKYYFQE 880
                |.|:.|.:|.|  :.:||   |.:::.|...|:    ||..|..|..:|:.|...|.|...
 Worm   432 ----LLILANAIFHATFVFYHD---ESDQIRKIWYYYVEVGFTILFNTEVIIKIYAFGWKAYIAR 489

  Fly   881 GWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLT 944
            |.:.||.|:...|.|. .:..:...::...|::.|:.:|.|:.|.| :.:..|.|... .||.|.
 Worm   490 GQHKFDCILCVGSSLN-AIWVLYETNIFTYFQVFRIARLIKASPMLEDFVYKIFGPGK-KLGGLV 552

  Fly   945 FVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWN-FTDFMHSFMIVFRVLCGE-WIESMWD 1007
            ....|::.:.:.:.:|||..             :|:.| ||:|..:||.:|:::..| |.:.:.:
 Worm   553 IFTGILLIVTSAISLQLFCY-------------VPKLNKFTNFAVAFMSMFQIITQEGWTDVVIE 604

  Fly  1008 CMYVGDVSCIPF----FLATVVIGNLVVLNLFLALLLSNFGS-------SSLSAPTADNDTNKIA 1061
            .:...:...:||    |:|..::..|.||:||:|::|.|...       ..|.|  .:.||.|..
 Worm   605 ILRACNEQAVPFVAIYFVAYHLLVTLFVLSLFVAVILDNLEMDEELKKVKQLKA--REQDTIKTT 667

  Fly  1062 -----EAFNRIGRFKSWV-KRNIADCFKL--IRNKLTNQISDQPSGERTNQISWIWSEGKGVCRC 1118
                 ..|||.....:.| .:.::..|.|  ||:..|.|.:|:                      
 Worm   668 LPMRLRIFNRFPTAPTMVTMKKVSSEFPLPKIRDSFTRQFADE---------------------- 710

  Fly  1119 ISAEHGDNEL-ELGHDEILADGLIKKGIKEQTQLEVAI---GDGMEFTIHGDM--KNNK-----P 1172
             ..|..|:.: |:|..  :...|..:|..::|::...|   |.....||...|  ::|:     .
 Worm   711 -FVETSDDTIQEIGFK--VRSMLSGRGPSKETRITTTIRHVGQLSNKTILTSMLTESNRNRALFS 772

  Fly  1173 KKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEE-----LD 1232
            :.:::|.:.|..:|:|  .:|..........|......:::|:...:..||:..|..|     ::
 Worm   773 ESNQHLASLTRSNTSS--KHGKSGALSTNSRSRTRGLASLKGKHMVEGFKENGDLRPEDTARKVE 835

  Fly  1233 EEGECEEGPLD-----GDIIIHAHDEDILDEYPADCCP------DSYYKKFPILAGDDDSPFWQG 1286
            :.||.:...|.     .:|..:..:|::.:.:|....|      :|..::...|.......:.|.
 Worm   836 KHGEIDFKALQMKRAHAEITRNRIEEEMRENHPMFDRPLFLVGRESSLRRMCQLIAHSRHSYDQN 900

  Fly  1287 WGNLRLKTFQLIENKYFE----TAVI-----TMILMSSLALALEDVHLPQRPILQDIL---YYM- 1338
            .|..|..:     |||.:    .|::     ||:|:::|:........|.....::::   :|: 
 Worm   901 DGQHRKHS-----NKYKQFHDFLAIMTYMDWTMVLVTTLSCCSMLWESPWPTTGENLIFNNFYLQ 960

  Fly  1339 --DRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSL-----------INFVASL 1386
              :.||.::...|:::|.:|.|.    |...|:....|...|.:.||           ||..|.|
 Worm   961 IAEYIFVLVMSFELIVKCIANGLFFTPKALVTDVGDILTIFIYITSLMFLIWMPNHIEINSWAQL 1025

  Fly  1387 VGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQL 1451
                       :...||:||||..:.:..:|.||..|.:....|..|.::.::...|||..||||
 Worm  1026 -----------LMVCRAMRPLRVYALIPHIRRVVVELCRGFREILLVTILLVVLMFIFASFGVQL 1079

  Fly  1452 FAGKYFKCEDMNGTKLSHEIIPNRNAC-----------------ESENY---------TWVNSA- 1489
            ..||...|.|        .:|.:|..|                 :::|.         .|.|.. 
 Worm  1080 VGGKLASCND--------PMITSRENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVPRVWTNPRN 1136

  Fly  1490 MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNL 1554
            .||||:|||.|.||:..::||| .::.|.:..|.         ..:..|:...::..|....|.|
 Worm  1137 FNFDHIGNAMLALFETLSYKGW-NVVRDVLYLRH---------GAWAVLFIHIYVFIGCMIGLTL 1191

  Fly  1555 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQA-----IVFE 1614
            |:||::.|:.|.:..|      .:|.||:::::...::...:||...|:|   |::     .:::
 Worm  1192 FVGVVVANYTENRGTA------LLTVDQRRWHDLKARLKMAQPLHVPPKP---PESAKLRCYLYD 1247

  Fly  1615 IVTDKKFDIIIMLFIGLNMFTMTLDRYDASD-----TYNAVLDYLNAIFVVIFSSECLLKIFALR 1674
            :.|.:.|..:..:.:.:|.||:.:. ::.|:     |:...|..::||..::|:.|||||:.|..
 Worm  1248 LTTSRWFKQLFAVLVVVNSFTLVIP-WNVSEEQDRKTFLLCLTVISAICNILFTLECLLKMIAFT 1311

  Fly  1675 YHYFIEPW----NLFDVVVVILSILGLVLSDIIE--KYFVS---------------PTLLRVVRV 1718
            ...|   |    |..|.::.||.|..:|...:.:  .||..               ..:||...:
 Worm  1312 LSGF---WQSRRNRIDFIITILGINWIVFHFLFQLPAYFAGGITEWKRLTYTYGYLVVILRFFTI 1373

  Fly  1719 AKVGRVLRLVKGAKG-IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDV 1782
            |          |.|. ::.|:..:.||:.....|...:||::..:|..|:..|..||....:...
 Worm  1374 A----------GRKSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGVVLFGMVKYGQAVGKH 1428

  Fly  1783 YNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG------NCGSATVGITFLL 1841
            .||:...:::::||:..|...|:.::     .:....|.....:||      :||:....|.:..
 Worm  1429 VNFRNGREALVVLFRSVTGEDWNDIM-----HDCMRAPPFCNWHPGLSYWQTDCGNYVGAIVYFC 1488

  Fly  1842 SYLVISFLIVINMYIAVILENYS---QATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLS 1903
            |:.:|...||:|:.:|:|:||:|   .:.||..  |:..|...:..:|...|.|..:.|...::.
 Worm  1489 SFYLIITYIVLNLLVAIIMENFSLFYSSEEDAL--LSYADIRNFQLVWNMVDIEQKRSIPVRRVK 1551

  Fly  1904 EFLDVLEPPLQIHKPN-----KYKIISMDIPICRGDLMYCVDILDALT-KDFFARKGNPIEETGE 1962
            ..|.:|:..|:::..:     |:....|: .:..||.:...|:|:.|: :....||...:||   
 Worm  1552 FLLRLLKGRLEVNDESDGLLFKHMCHEME-RLHNGDDVSFHDVLNMLSYRSVDIRKSLQLEE--- 1612

  Fly  1963 IGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR 2004
                              .|.|:..||   :|:....||..|
 Worm  1613 ------------------LLQREELEY---IIEEEVAKHTIR 1633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 72/316 (23%)
Na_trans_cytopl 515..648 CDD:288761 11/133 (8%)
Ion_trans 835..1028 CDD:278921 49/205 (24%)
Na_trans_assoc 1054..1296 CDD:284034 50/276 (18%)
Ion_trans 1318..1571 CDD:278921 71/300 (24%)
Na_channel_gate 1561..1613 CDD:240441 11/56 (20%)
Ion_trans 1636..1871 CDD:278921 62/270 (23%)
GPHH 1880..1930 CDD:293510 9/54 (17%)
nca-2NP_498054.2 Ion_trans 95..371 CDD:278921 68/303 (22%)
Ion_trans 444..649 CDD:278921 56/222 (25%)
Ion_trans 959..1202 CDD:278921 68/271 (25%)
Ion_trans 1288..1518 CDD:278921 58/247 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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