DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and cacna1c

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_021330579.1	Gene:	cacna1c / 170581	ZFINID:	ZDB-GENE-020129-1	Length:	2202	Species:	Danio rerio

Alignment Length:	2305	Identity:	538/2305 - (23%)
Similarity:	897/2305 - (38%)	Gaps:	678/2305 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EHEKQKELERKRAEGEVPQYGRKKKQKEIRYD--------------------DEDEDEG------ 72
            :||:.:|      |.||...|:...::|:.|.                    :|||..|
Zfish    12 KHERLEE------EVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVL 70

  Fly    73 ---PQPDPTLEQGVPI----------PVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDI 124
               |:..||  .|.|:          ..:|.|:     ...|:............:....|....
Zfish    71 GLAPEHIPT--PGAPLSWQAAIDAARQAKLMGT-----TGAPISTASSTQRKRQHYTKPKKQAST 128

  Fly   125 FRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVE 179
            ......:|:..|...|||||..|.|:....|.:.|:.||..||:.:.:          .|...:|
Zfish   129 ASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLE 193

  Fly   180 STEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTM----------GIDLG 234
            ..|.:|..|:|.|:.:||:|.|.:..|..|||:.||.|||:::.:...:.          |..:|
Zfish   194 RVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMG 258

  Fly   235 NLA------ALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 293
            ..|      |||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||:::
Zfish   259 GKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 323

  Fly   294 MGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPL-CGNISGAGQ-CDDDYV- 355
            ||.:.:.|.  |..||..|::.:|.                    |. |...|..|: |....:
Zfish   324 MGKMHRTCF--FYKDGHKGHIAEEK--------------------PAPCAPSSAHGRHCSPPNIT 366

  Fly   356 -CLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLG 416
             |:.|: ..||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|
Zfish   367 QCMMGW-EGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFG 428

  Fly   417 SFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAA 481
            ||:::||:|.:::..:.:.::||:..  .:.:.:||.::        |||...........   |
Zfish   429 SFFVLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQ---A 480

  Fly   482 EEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQA 546
            |:  :.||                ..::|.||:...
Zfish   481 ED--IDPE----------------NDDEGLDDDKPR----------------------------- 498

  Fly   547 TKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYAD 611
                     :||:|.|
Zfish   499 ---------NLSMPAS------------------------------------------------- 505

  Fly   612 DSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLR 676
                      ||.::
Zfish   506 ----------ENESV-------------------------------------------------- 510

  Fly   677 NRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV 741
              ||.|...|... |.||                 ||..|.:|
Zfish   511 --NTDNAPAGDME-GETC-----------------CTRMANRI---------------------- 533

  Fly   742 MVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWD--C---C 801
                     :..:.||.|.|                                    |:  |   |
Zfish   534 ---------SKSKFSRYSRR------------------------------------WNRLCRRKC 553

  Fly   802 WVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEAT 866
            ...:|...:..|::|          .:.:||:.:|.:||...:.:..|....|....|.|..|..
Zfish   554 RAAVKSNVFYWLVIF----------LVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEML 608

  Fly   867 MKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL 926
            :|:.::..:.||...:|.||..:|...:||..|...:     |:||||..||||:||:.:.|.:|
Zfish   609 LKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSL 673

  Fly   927 NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFM 991
            :.|::.:..::.::.:|..:|.:.|.||:::||||||..::..:.|       |..|.:|..|.:
Zfish   674 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETR-------RSTFDNFPQSLL 731

  Fly   992 IVFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSS 1047
            .||::|.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:.|.. :.|
Zfish   732 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAES 795

  Fly  1048 LSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEG 1112
            |::...:.:..|..:   ::.|..|..||               |.|::|..|
Zfish   796 LTSAQKEEEEEKERK---KLARTASPEKR---------------QNSEKPPLE------------ 830

  Fly  1113 KGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKY 1177
                                ||       ||  :|:.:|:....||           ..|..:|
Zfish   831 --------------------DE-------KK--EEKIELKSITSDG-----------ETPTATK- 854

  Fly  1178 LNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPL 1242
                     .:|:.|....|                 |||......|....|:.:||.|...||.
Zfish   855 ---------INIDEYTGEDN-----------------EEKNPYPVNDFPAGEDDEEEPEMPVGPR 893

  Fly  1243 DGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAV 1307
            ...:      .||  :......|....|.|.|.:..:         ..|:...:::.:..|...:
Zfish   894 PRPL------SDI--QLKEKAVPMPQAKAFFIFSPSN---------KFRVLCHKIVNHNIFTNLI 941

  Fly  1308 ITMILMSSLALALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YF 1363
            :..||:||::||.||      |:..|     ||.|.|.:||.||.:|:::|..|.|..:    :.
Zfish   942 LFFILLSSISLAAED------PVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFC 1000

  Fly  1364 TNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1428
            .|.:..||.|:|.||||   :|.:.:..|...|.:|.||.||||||::|.:|::.||..:..||.
Zfish  1001 RNYFNILDLVVVSVSLI---SSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIR 1062

  Fly  1429 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN--------GTKLSHEIIPNRNACESENYTW 1485
            :|.|:::|..:...:||.:|||||.||:|.|.|.:        |..:.:: ..|....|....:|
Zfish  1063 TIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYK-DGNVGKPEKAQRSW 1126

  Fly  1486 VNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFF 1550
            .||..|||.|....:.||.|:||:||..::..||||...|..||....:.:.::|:.:||..:||
Zfish  1127 ENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFF 1191

  Fly  1551 TLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QAI 1611
            .:|:|:|.:|..|.||.::...:.|:...:.|...|          .|||.|..|:.|    |..
Zfish  1192 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY----------ALKARPLRRYIPKNPYQYK 1246

  Fly  1612 VFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH 1676
            |:.:|....|:.::...|.||...:.:..:..|.::|..::.||.:|..:|:.|.:||:.|.:..
Zfish  1247 VWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPR 1311

  Fly  1677 -YFIEPWNLFDVVVVILSILGLVLSDI----------------------IEKYFVSPTLLRVVRV 1718
             ||.:|||:||.::||.||:.::||:|                      .:...:|.|..|:.||
Zfish  1312 GYFSDPWNVFDFLIVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRV 1376

  Fly  1719 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGIND 1781
            .   |:::|:...:||||||:....|..||..:.||:.::.||:|:.||..|  :.:::.|.||.
Zfish  1377 M---RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINR 1438

  Fly  1782 VYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVI 1846
            ..||:||.|:::|||:.:|...|..::.|......|:..........:|||......|:..|::.
Zfish  1439 NNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLC 1503

  Fly  1847 SFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEP 1911
            :||| ||:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|
Zfish  1504 AFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP 1566

  Fly  1912 PLQIHK--PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAA 1968
            ||...|  |::.   :::||::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|
Zfish  1567 PLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLF-ALVRTALRIKTEGN-LEQANE--ELRA 1627

  Fly  1969 RPDTEGYEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGG--GSF 2011
                     :...:|::.                    :.|...|||..:||.|.|.|.|  ...
Zfish  1628 ---------IVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKI 1683

  Fly  2012 EPDTDHG-DGGDPDAGDPAPD--EATDGD---------------APAGGDGSVNGTAEGAADADE 2058
            .|.|... ..|.....|..|:  .|..||               ..|..|........|....:.
Zfish  1684 PPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNH 1748

  Fly  2059 SNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPG-AGSAGRQTAVLVESDGFVT------------- 2109
            .|.....:...:...:.........:.:|||| |.|...|..|    |...|
Zfish  1749 VNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLV----DSTFTPSSYSSSGSNANI 1809

  Fly  2110 KNGHKVVIHSRSPSITSRTADVXARPRPPL 2139
            .|.:...|..|.|..|..|.|  .:..|||
Zfish  1810 NNANNTAIGHRYPKPTVSTVD--GQTGPPL 1837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	84/303 (28%)
		Na_trans_cytopl	515..648	CDD:288761	6/132 (5%)
		Ion_trans	835..1028	CDD:278921	60/205 (29%)
		Na_trans_assoc	1054..1296	CDD:284034	39/241 (16%)
		Ion_trans	1318..1571	CDD:278921	96/269 (36%)
		Na_channel_gate	1561..1613	CDD:240441	13/55 (24%)
		Ion_trans	1636..1871	CDD:278921	79/259 (31%)
		GPHH	1880..1930	CDD:293510	15/54 (28%)
cacna1c	XP_021330579.1	Ion_trans	156..452	CDD:306908	89/320 (28%)
		Ion_trans	559..798	CDD:306908	74/256 (29%)
		Ion_trans	934..1211	CDD:306908	101/286 (35%)
		Ion_trans	1253..1527	CDD:306908	83/278 (30%)
		GPHH	1528..1598	CDD:318993	18/69 (26%)
		Ca_chan_IQ	1600..1671	CDD:312334	15/83 (18%)
		CAC1F_C	1694..2129	CDD:318975	30/150 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940