DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and Cacna1s

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001074492.1 Gene:Cacna1s / 12292 MGIID:88294 Length:1852 Species:Mus musculus


Alignment Length:2164 Identity:503/2164 - (23%)
Similarity:844/2164 - (39%) Gaps:672/2164 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VESTEVIF 185
            :|::.|...||:|:..|.|:....|...|:.||..||:.:.    ||....      :|..|..|
Mouse    29 RALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93

  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNL-------------- 236
            ..:::.|:|:|::|.||:.....|||..||.|||:::.|...|:.::..|:              
Mouse    94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGAG 158

  Fly   237 ---AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLT 298
               .|||.|||||.|:.|:.||.|:.::.::.:::..|..:.:|.:|.:.::|::||:::.|.:.
Mouse   159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223

  Fly   299 QKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPN 363
            :.|.    ..|     ||......|...|.            |........|..:....:|..|.
Mouse   224 KTCY----FIG-----TDIVATVENEKPSP------------CARTGSGRPCTINGSECRGGWPG 267

  Fly   364 PNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAI 427
            ||:|.|.||:||::.|:.::.::.:.|.|:...|..|.| .|..::|:.:|.||||:::||:|.:
Mouse   268 PNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGV 332

  Fly   428 VAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAK 492
            ::..:.:.::||:.....::  :||.::        |||                          
Mouse   333 LSGEFTKEREKAKSRGTFQK--LREKQQ--------LEE-------------------------- 361

  Fly   493 SPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSL 557
                                                                             
Mouse   362 ----------------------------------------------------------------- 361

  Fly   558 SLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEE 622
                                                                             
Mouse   362 ----------------------------------------------------------------- 361

  Fly   623 NGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGA 687
                                             ||.|.|:.:                       
Mouse   362 ---------------------------------DLRGYMSWI----------------------- 370

  Fly   688 TNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA 752
            |.|....:|     |.|:.::.|   ||.|.            .|:::.:::.   ||.||:.. 
Mouse   371 TQGEVMDVD-----DLREGKLSL---DEGGS------------DTESLYEIEG---LNKIIQFI- 411

  Fly   753 GRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFD 817
             ||.|..:|                 .|:.|..:::...:         :.||            
Mouse   412 -RHWRQWNR-----------------VFRWKCHDLVKSKV---------FYWL------------ 437

  Fly   818 PFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGW 882
                  :.|.:.:||:.:|.:||:....:..:....|......|.||..||:..:..:.||...:
Mouse   438 ------VILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSIF 496

  Fly   883 NIFDFIIVALSLLEL-----GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGN 942
            |.||..:|...:||:     |.....|:||||..||||:||:.|.|.:|:.|::.:..::.::.:
Mouse   497 NRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIAS 561

  Fly   943 LTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 1006
            |..:|.:.|.|||::||||||..|.     |.|.::.|.||.:|..:.:.||:||.|| |...|:
Mouse   562 LLLLLFLFIIIFALLGMQLFGGRYD-----FEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMY 621

  Fly  1007 DCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNF--GSSSLSAPTADNDTNKIAE 1062
            :.:       |.|.:.|| :|:...|.||.::||:|||:.:.|.  ..|..||..|..:..|   
Mouse   622 NGIMAYGGPTYPGVLVCI-YFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERK--- 682

  Fly  1063 AFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNE 1127
                                   |.|::..:.|:...||......:..:.||             
Mouse   683 -----------------------RRKMSKGLPDKSEEERATVTKKLEQKSKG------------- 711

  Fly  1128 LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSY 1192
                           :||....:|::                             |:..:::|..
Mouse   712 ---------------EGIPTTAKLKI-----------------------------DEFESNVNEV 732

  Fly  1193 GSHKNRPFKDESHKGSAETMEGE---EKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDED 1254
                ..|:......|..|..|.|   ..|.....:|.|.|                         
Mouse   733 ----KDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKE------------------------- 768

  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPF--WQGWGNLRLKTFQLIENKYFETAVITMILMSSLA 1317
                           |..||   .:.|.|  :.....:|:...:::...:|...::..||:||.|
Mouse   769 ---------------KAVPI---PEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAA 815

  Fly  1318 LALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFV 1373
            ||.||      ||..|     ||.|.|.:||.:|.:|:::|....|..:    :..|.:..||.:
Mouse   816 LAAED------PIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874

  Fly  1374 IVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1438
            :|.||||:..   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::||..
Mouse   875 VVAVSLISMG---LESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTT 936

  Fly  1439 IFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENY---------------TWVNS 1488
            :...:||.:|||||.||::.|.|:  :|::.|      .|....|               .|:::
Mouse   937 LLQFMFACIGVQLFKGKFYSCNDL--SKMTEE------ECRGYYYIYKDGDPTQIELRPRQWIHN 993

  Fly  1489 AMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLN 1553
            ..:||:|.:|.:.||.|:||:||.|::..||||.|.|..|:....:.|.::|:.:||..:||.:|
Mouse   994 DFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMN 1058

  Fly  1554 LFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVT 1617
            :|:|.:|..|.||.:....:.|:...:.|...| |:|    .:||:. ||:..::.|  |:.:||
Mouse  1059 IFVGFVIVTFQEQGETEYKNCELDKNQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYVVT 1116

  Fly  1618 DKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH-YFIEP 1681
            ...|:.::...|.||...:.:..|:.|:..|.:.|.||..|.:||:.|.:||:.|.:.. ||.:|
Mouse  1117 SSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIAFKPRGYFGDP 1181

  Fly  1682 WNLFDVVVVILSILGLVLSDI----------------------IEKYFVSPTLLRVVRVAKVGRV 1724
            ||:||.::||.||:.::||:|                      .|...:|....|:.||.   |:
Mouse  1182 WNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVM---RL 1243

  Fly  1725 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKT 1787
            ::|:..|:|:||||:....|..||..:.||:.::.||:|:.||..|..:....|  ||...||:|
Mouse  1244 VKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQT 1308

  Fly  1788 FGQSMILLFQMSTSAGWDGVLDAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIV 1851
            |.|:::|||:.:|...|..:|.|....:.||| .|...|....||:......|:..|::.:||| 
Mouse  1309 FPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEHTCGTNFAYYYFISFYMLCAFLI- 1372

  Fly  1852 INMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIH 1916
            ||:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||...
Mouse  1373 INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1436

  Fly  1917 K--PNKY---KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEG 1974
            |  |::.   :::.|::|:.....:.....|.||.:.....|  || .|:..|  |:.|      
Mouse  1437 KFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGN-FEQANE--ELRA------ 1492

  Fly  1975 YEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGGGSFEP--DTDH 2017
               :...:|::.                    :.|...|||..:||...|.|....:.|  ||..
Mouse  1493 ---IIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQ 1554

  Fly  2018 GDGG----DPDAGDPAPDEATDGDAPA---------------------GG-----DGSVNGT--- 2049
            ...|    :.:|. |....|..||..|                     ||     |..:..|   
Mouse  1555 IQAGLRTIEEEAA-PEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSL 1618

  Fly  2050 ------------AEGAADADESNV------NSPGEDAAAAA---AAAAAAAAAGTTTAGSPGAGS 2093
                        ||...:..||.|      .:||....|.|   .|.|..|...::...:|...|
Mouse  1619 PPVMANQRPLQFAEIEMEELESPVFLEDFPQNPGTHPLARANTNNANANVAYGNSSHRNNPVFSS 1683

  Fly  2094 AGRQTAVLVESDGFVTKNG 2112
            ...:...|.|:|..||:.|
Mouse  1684 ICYEREFLGEADMPVTREG 1702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 78/298 (26%)
Na_trans_cytopl 515..648 CDD:288761 0/132 (0%)
Ion_trans 835..1028 CDD:278921 66/205 (32%)
Na_trans_assoc 1054..1296 CDD:284034 28/246 (11%)
Ion_trans 1318..1571 CDD:278921 94/276 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/52 (25%)
Ion_trans 1636..1871 CDD:278921 86/260 (33%)
GPHH 1880..1930 CDD:293510 14/54 (26%)
Cacna1sNP_001074492.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 87/319 (27%)
Ion_trans 68..345 CDD:278921 77/297 (26%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000269|PubMed:28351836 357..374 8/236 (3%)
II. /evidence=ECO:0000305 418..664 81/295 (27%)
Ion_trans 449..672 CDD:278921 75/228 (33%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..712 9/90 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 5/29 (17%)
III. /evidence=ECO:0000305 768..1068 104/359 (29%)
Ion_trans 816..1075 CDD:278921 94/275 (34%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 33/88 (38%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 91/284 (32%)
Ion_trans 1135..1392 CDD:278921 86/261 (33%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 22/67 (33%)
Phenylalkylamine binding. /evidence=ECO:0000250 1349..1392 15/44 (34%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 15/43 (35%)
GPHH 1400..1463 CDD:293510 15/62 (24%)
Ca_chan_IQ 1465..1536 CDD:285917 16/82 (20%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 7/19 (37%)
CAC1F_C <1679..1840 CDD:293490 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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