DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and Cacna1s

DIOPT Version :10

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001074492.1 Gene:Cacna1s / 12292 MGIID:88294 Length:1852 Species:Mus musculus


Alignment Length:2164 Identity:503/2164 - (23%)
Similarity:844/2164 - (39%) Gaps:672/2164 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VESTEVIF 185
            :|::.|...||:|:..|.|:....|...|:.||..||:.:.    ||....      :|..|..|
Mouse    29 RALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93

  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNL-------------- 236
            ..:::.|:|:|::|.||:.....|||..||.|||:::.|...|:.::..|:              
Mouse    94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGAG 158

  Fly   237 ---AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLT 298
               .|||.|||||.|:.|:.||.|:.::.::.:::..|..:.:|.:|.:.::|::||:::.|.:.
Mouse   159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223

  Fly   299 QKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPN 363
            :.|.    ..|     ||......|...|.            |........|..:....:|..|.
Mouse   224 KTCY----FIG-----TDIVATVENEKPSP------------CARTGSGRPCTINGSECRGGWPG 267

  Fly   364 PNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAI 427
            ||:|.|.||:||::.|:.::.::.:.|.|:...|..|.| .|..::|:.:|.||||:::||:|.:
Mouse   268 PNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGV 332

  Fly   428 VAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAK 492
            ::..:.:.::||:.....::  :||.::        |||                          
Mouse   333 LSGEFTKEREKAKSRGTFQK--LREKQQ--------LEE-------------------------- 361

  Fly   493 SPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSL 557
                                                                             
Mouse   362 ----------------------------------------------------------------- 361

  Fly   558 SLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEE 622
                                                                             
Mouse   362 ----------------------------------------------------------------- 361

  Fly   623 NGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGA 687
                                             ||.|.|:.:                       
Mouse   362 ---------------------------------DLRGYMSWI----------------------- 370

  Fly   688 TNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA 752
            |.|....:|     |.|:.::.|   ||.|.            .|:::.:::.   ||.||:.. 
Mouse   371 TQGEVMDVD-----DLREGKLSL---DEGGS------------DTESLYEIEG---LNKIIQFI- 411

  Fly   753 GRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFD 817
             ||.|..:|                 .|:.|..:::...:         :.||            
Mouse   412 -RHWRQWNR-----------------VFRWKCHDLVKSKV---------FYWL------------ 437

  Fly   818 PFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGW 882
                  :.|.:.:||:.:|.:||:....:..:....|......|.||..||:..:..:.||...:
Mouse   438 ------VILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSIF 496

  Fly   883 NIFDFIIVALSLLEL-----GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGN 942
            |.||..:|...:||:     |.....|:||||..||||:||:.|.|.:|:.|::.:..::.::.:
Mouse   497 NRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIAS 561

  Fly   943 LTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 1006
            |..:|.:.|.|||::||||||..|.     |.|.::.|.||.:|..:.:.||:||.|| |...|:
Mouse   562 LLLLLFLFIIIFALLGMQLFGGRYD-----FEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMY 621

  Fly  1007 DCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNF--GSSSLSAPTADNDTNKIAE 1062
            :.:       |.|.:.|| :|:...|.||.::||:|||:.:.|.  ..|..||..|..:..|   
Mouse   622 NGIMAYGGPTYPGVLVCI-YFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERK--- 682

  Fly  1063 AFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNE 1127
                                   |.|::..:.|:...||......:..:.||             
Mouse   683 -----------------------RRKMSKGLPDKSEEERATVTKKLEQKSKG------------- 711

  Fly  1128 LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSY 1192
                           :||....:|::                             |:..:::|..
Mouse   712 ---------------EGIPTTAKLKI-----------------------------DEFESNVNEV 732

  Fly  1193 GSHKNRPFKDESHKGSAETMEGE---EKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDED 1254
                ..|:......|..|..|.|   ..|.....:|.|.|                         
Mouse   733 ----KDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKE------------------------- 768

  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPF--WQGWGNLRLKTFQLIENKYFETAVITMILMSSLA 1317
                           |..||   .:.|.|  :.....:|:...:::...:|...::..||:||.|
Mouse   769 ---------------KAVPI---PEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAA 815

  Fly  1318 LALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFV 1373
            ||.||      ||..|     ||.|.|.:||.:|.:|:::|....|..:    :..|.:..||.:
Mouse   816 LAAED------PIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLL 874

  Fly  1374 IVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1438
            :|.||||:..   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::||..
Mouse   875 VVAVSLISMG---LESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTT 936

  Fly  1439 IFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENY---------------TWVNS 1488
            :...:||.:|||||.||::.|.|:  :|::.|      .|....|               .|:::
Mouse   937 LLQFMFACIGVQLFKGKFYSCNDL--SKMTEE------ECRGYYYIYKDGDPTQIELRPRQWIHN 993

  Fly  1489 AMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLN 1553
            ..:||:|.:|.:.||.|:||:||.|::..||||.|.|..|:....:.|.::|:.:||..:||.:|
Mouse   994 DFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMN 1058

  Fly  1554 LFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVT 1617
            :|:|.:|..|.||.:....:.|:...:.|...| |:|    .:||:. ||:..::.|  |:.:||
Mouse  1059 IFVGFVIVTFQEQGETEYKNCELDKNQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYVVT 1116

  Fly  1618 DKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH-YFIEP 1681
            ...|:.::...|.||...:.:..|:.|:..|.:.|.||..|.:||:.|.:||:.|.:.. ||.:|
Mouse  1117 SSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIAFKPRGYFGDP 1181

  Fly  1682 WNLFDVVVVILSILGLVLSDI----------------------IEKYFVSPTLLRVVRVAKVGRV 1724
            ||:||.::||.||:.::||:|                      .|...:|....|:.||.   |:
Mouse  1182 WNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVM---RL 1243

  Fly  1725 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKT 1787
            ::|:..|:|:||||:....|..||..:.||:.::.||:|:.||..|..:....|  ||...||:|
Mouse  1244 VKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQT 1308

  Fly  1788 FGQSMILLFQMSTSAGWDGVLDAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIV 1851
            |.|:::|||:.:|...|..:|.|....:.||| .|...|....||:......|:..|::.:||| 
Mouse  1309 FPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEHTCGTNFAYYYFISFYMLCAFLI- 1372

  Fly  1852 INMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIH 1916
            ||:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||...
Mouse  1373 INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1436

  Fly  1917 K--PNKY---KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEG 1974
            |  |::.   :::.|::|:.....:.....|.||.:.....|  || .|:..|  |:.|      
Mouse  1437 KFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGN-FEQANE--ELRA------ 1492

  Fly  1975 YEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGGGSFEP--DTDH 2017
               :...:|::.                    :.|...|||..:||...|.|....:.|  ||..
Mouse  1493 ---IIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQ 1554

  Fly  2018 GDGG----DPDAGDPAPDEATDGDAPA---------------------GG-----DGSVNGT--- 2049
            ...|    :.:|. |....|..||..|                     ||     |..:..|   
Mouse  1555 IQAGLRTIEEEAA-PEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSL 1618

  Fly  2050 ------------AEGAADADESNV------NSPGEDAAAAA---AAAAAAAAAGTTTAGSPGAGS 2093
                        ||...:..||.|      .:||....|.|   .|.|..|...::...:|...|
Mouse  1619 PPVMANQRPLQFAEIEMEELESPVFLEDFPQNPGTHPLARANTNNANANVAYGNSSHRNNPVFSS 1683

  Fly  2094 AGRQTAVLVESDGFVTKNG 2112
            ...:...|.|:|..||:.|
Mouse  1684 ICYEREFLGEADMPVTREG 1702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 152..436 CDD:459842 82/311 (26%)
Na_trans_cytopl 555..740 CDD:463401 14/184 (8%)
Ion_trans 817..1028 CDD:459842 69/223 (31%)
Na_trans_assoc 1054..1296 CDD:461936 28/246 (11%)
Ion_trans 1300..1571 CDD:459842 100/294 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/52 (25%)
Ion_trans 1621..1871 CDD:459842 90/275 (33%)
GPHH 1882..1929 CDD:465306 13/51 (25%)
Cacna1sNP_001074492.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 87/319 (27%)
Ion_trans 50..345 CDD:459842 83/315 (26%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000269|PubMed:28351836 357..374 8/236 (3%)
II. /evidence=ECO:0000305 418..664 81/295 (27%)
Ion_trans 431..672 CDD:459842 80/273 (29%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..712 9/90 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 5/29 (17%)
III. /evidence=ECO:0000305 768..1068 104/359 (29%)
Ion_trans 798..1075 CDD:459842 100/293 (34%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 33/88 (38%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 91/284 (32%)
Ion_trans 1117..1392 CDD:459842 90/279 (32%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 22/67 (33%)
Phenylalkylamine binding. /evidence=ECO:0000250 1349..1392 15/44 (34%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 15/43 (35%)
GPHH 1401..1454 CDD:465306 13/52 (25%)
Ca_chan_IQ 1464..1536 CDD:462591 16/83 (19%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 7/19 (37%)
CAC1F_C 1557..1840 CDD:465298 31/147 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1702..1721 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1727..1762
Blue background indicates that the domain is not in the aligned region.

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