DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1g

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_011246988.1 Gene:Cacna1g / 12291 MGIID:1201678 Length:2392 Species:Mus musculus


Alignment Length:2335 Identity:563/2335 - (24%)
Similarity:957/2335 - (40%) Gaps:551/2335 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 DEDED-----EGPQPDPTLE----------QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTF 115
            ||:||     |..||....:          ||.....:..||...|....|...:.|     :.|
Mouse     2 DEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSADSEAEGLPYPALAP-----VVF 61

  Fly   116 VVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTP-- 176
            ..:|:       .:....|.|      |.|.     :|.|....:..||:||:.  |..|...  
Mouse    62 FYLSQ-------DSRPRSWCL------RTVC-----NPWFERVSMLVILLNCVTLGMFRPCEDIA 108

  Fly   177 -------TVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG 234
                   .:::.:......:..|..||::|.| |.....||.|.||.|||.::....:...:||.
Mouse   109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQ 172

  Fly   235 NL--AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 297
            |:  :|:||.||||.|:.:..||.::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|
Mouse   173 NVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237

  Fly   298 TQKCI--KKFPLDGSWGNLTDENWDYHNRNSSNWYSEDE-----------GI----SFP-LCGNI 344
            ..:|.  :.|.|..|    .|....|...|      |||           |:    |.| |.|..
Mouse   238 RNRCFLPENFSLPLS----VDLEPYYQTEN------EDESPFICSQPRENGMRSCRSVPTLRGEG 292

  Fly   345 SGAGQCDDDYV-------------------CLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFW 390
            .|...|..||.                   |..| ..||..|..:||:.|:|:::.|:::|.:.|
Mouse   293 GGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAG-EHNPFKGAINFDNIGYAWIAIFQVITLEGW 356

  Fly   391 EDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEE 455
            .|:...|:.|...::.::||::|.:|||:::||.|.::|..:.|.:::       |.:.:|    
Mouse   357 VDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-------ESQLMR---- 410

  Fly   456 AAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMS 520
                     |:|....:.|:..|:.:|..:.:.|:.|        |.:::          ..|.:
Mouse   411 ---------EQRVRFLSNASTLASFSEPGSCYEELLK--------YLVYI----------LRKAA 448

  Fly   521 IRSVEVE----------SESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHK 575
            .|..:|.          |..|:...::|.|:.:...:. |::|...|        :.......|.
Mouse   449 RRLAQVSRAVGVRAGLLSSPVARGGQEPQPSGSCSRSH-RRLSVHHL--------VHHHHHHHHH 504

  Fly   576 YTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYY-------- 632
            |.:.||..|  :|.:  .|.:.....:..:.|.....|..........||..|..:|        
Mouse   505 YHLGNGTLR--VPRA--SPEIQDRDANGSRWLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEP 565

  Fly   633 -------GNLGSRHSSYTSHQSRISYTSH----GDLLGGMAVM------GVSTMTKES------- 673
                   ....|..|..|....::..|.|    .::|...|::      |..|:|..:       
Mouse   566 VRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPEMLKDKALVEVAPSPGPPTLTSFNIPPGPFS 630

  Fly   674 ---KLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTD-EAGKIKHHDNPFIEPVQTQT 734
               ||....:..:||||      |        |...:|...|:. ::|.......|:....... 
Mouse   631 SMHKLLETQSTGESVGA------C--------HSSCKISSPCSKADSGACGPDSCPYCARTGAG- 680

  Fly   735 VVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTED----DDEDGPTFKDKALEVILKGIDVF 795
                          |..:..|........:||.| |:|    |..|....:..:|....:...|.
Mouse   681 --------------EPESADHEMPDSDSEAVYEF-TQDAQHSDLRDPHRRRRPSLGPDAEPSSVL 730

  Fly   796 CVWD-CCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTA 859
            ..|. .|..:.|       ||...:....|.:.|:|||:.|.:::|:..:|:...|:..|..||:
Mouse   731 AFWRLICDTFRK-------IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTS 788

  Fly   860 TFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLEL-GLEGVQGLSVLRSFRLLRVFKLAKSW 923
            .||:|..:||:...|..|.:..:||||.:||.:|:.|: |.:| .||||||:|||:||.||.:..
Mouse   789 LFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQG-GGLSVLRTFRLMRVLKLVRFL 852

  Fly   924 PTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGD-LP-RWNFTDF 986
            |.|...:.::.:||..:.....:|.:.||||:::||.|||..:...:    ||| || |.||...
Mouse   853 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER----DGDTLPDRKNFDSL 913

  Fly   987 MHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSA 1050
            :.:.:.||::|..| |.:.:::.|.........:|:|.:..||.|:.||.:|:|:..|.:..:. 
Mouse   914 LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIG- 977

  Fly  1051 PTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNK----LTNQISD----QPS----GERTN 1103
              ...||:         |:.         .|.:|..|.    .|...|:    .||    |:|..
Mouse   978 --KREDTS---------GQL---------SCIQLPVNSQGGDATKSESEPDFFSPSVDGDGDRKK 1022

  Fly  1104 QISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEV--AIGDGME------ 1160
            :::.:          ...||.:....|....|:........:.:.:...|  |:|.|..      
Mouse  1023 RLALV----------ALGEHSELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSG 1077

  Fly  1161 ----FTIHGDMKN-----NKPKKSKYLNNATDDDTASINSYG---SHKNR-PFKDESHKGSAETM 1212
                .|.|.:||:     :.|.......::.....:|.||.|   |.|.| |..:.....|.|..
Mouse  1078 SAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQ 1142

  Fly  1213 EGEEKRDASKED----LGLD-------------------------------------EELDEEGE 1236
            |.:::.::|:||    .|.|                                     |..|..|:
Mouse  1143 ESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGK 1207

  Fly  1237 CEEG-----------PLDGDIIIHAHDEDILDE-----------YPADCCPDSYYKKFPILAGDD 1279
            ...|           |||||   ...||..|.:           .|| ||.:.            
Mouse  1208 SASGRLARTLRADDPPLDGD---DGDDEGNLSKGERLRAWVRARLPA-CCRER------------ 1256

  Fly  1280 DSPFWQGW-----GNLRLKTFQLIENKYFETAVITMILMSSLALALE----DVHLPQRPILQDIL 1335
            ||  |..:     ...||...::|.:|.|:..|:.:|.::.:.:|:|    |.|..:|..|....
Mouse  1257 DS--WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1319

  Fly  1336 YYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGG---IQ 1393
            |    |||.:|..||.:|.:|||:    :.|..::|..||.::|::|:|:.:.|:|...|   :.
Mouse  1320 Y----IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1380

  Fly  1394 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1458
            ..:.:|.||.|||||.:||.||:::||..|:.::..|.|::::|..|::||.|:|||||.||:|.
Mouse  1381 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1445

  Fly  1459 C--EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDS 1521
            |  ||...       |.|::.|...:|.||....|||::|.|.:.||.:|:..||:.||.|.:|:
Mouse  1446 CQGEDTRN-------ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1503

  Fly  1522 REVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNF-----NEQKKKAGGSLEMFMTED 1581
            ..||:|||...|.:|.|||:.|::..:||.||:|:||:::||     ::::::|....|..:...
Mouse  1504 VGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRL 1568

  Fly  1582 QKKYYNAMKKM---------GSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDIIIMLFI 1629
            :||..:..|:|         .|.....|....:.:|        :.:|..:.|....|:.|...|
Mouse  1569 EKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1633

  Fly  1630 GLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILS 1693
            |||:.||.::.|......:..|...|.||.|||..|.:.|:.|..: .:|.:.||..|:.:|:||
Mouse  1634 GLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLS 1698

  Fly  1694 ILGLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1756
            |:|:.|.:|  .....::||::|::||.::.|||:|:|.|.|:|.||..:..:||.:.|:.||..
Mouse  1699 IMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1763

  Fly  1757 LVMFIFAIFGMSFF-------MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE 1814
            |:.||||..|:..|       .|..|  |:.....|:.||.:.:.||::||...|:|::...:.:
Mouse  1764 LLFFIFAALGVELFGDLECDETHPCE--GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD 1826

  Fly  1815 EACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1879
              ||       ....|.:..:...:.:|:::.:..:::|:.|||::::..::.::.:|   :.:.
Mouse  1827 --CD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE---EAEL 1879

  Fly  1880 DMYYEIW------QQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYC 1938
            :...|:.      |...|.|:.::                   .|....:.|.|.|         
Mouse  1880 EAELELEMKTLSPQPHSPLGSPFL-------------------WPGVEGVNSPDSP--------- 1916

  Fly  1939 VDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKA 2003
                         :.|.| ..|..||..::....|  .|..    ||..:..:.|||        
Mouse  1917 -------------KPGAP-HTTAHIGAASSGFSLE--HPTD----RQLFDTISLLIQ-------- 1953

  Fly  2004 RGEGGGSFE-----PDTDHGDGGDPDAGDPAPDEA-TDGDAPAGGDGSVNGTAEGAADADES--- 2059
                 ||.|     .|...|.||.|.|...||... :|...|.....:::.|:|..::...|   
Mouse  1954 -----GSLEGELKLMDELAGPGGQPSAFPSAPSPGDSDPQIPLAEMEALSLTSEIVSEPSCSLAL 2013

  Fly  2060 NVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAG-------SAGRQTAVLVESDGFVTKNG 2112
            ..:|..:|......:|..:.....|..|....|       .:|......:.:|.::.:||
Mouse  2014 TDDSLPDDTHTLLLSALESNMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNG 2073

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 86/320 (27%)
Na_trans_cytopl 515..648 CDD:288761 26/157 (17%)
Ion_trans 835..1028 CDD:278921 67/196 (34%)
Na_trans_assoc 1054..1296 CDD:284034 62/342 (18%)
Ion_trans 1318..1571 CDD:278921 100/270 (37%)
Na_channel_gate 1561..1613 CDD:240441 11/73 (15%)
Ion_trans 1636..1871 CDD:278921 70/244 (29%)
GPHH 1880..1930 CDD:293510 7/55 (13%)
Cacna1gXP_011246988.1 Ion_trans 80..406 CDD:366146 90/344 (26%)
Ion_trans 746..972 CDD:366146 79/230 (34%)
Ion_trans 1280..1552 CDD:366146 104/282 (37%)
Ion_trans 1622..1863 CDD:366146 77/251 (31%)
PHA03307 2110..>2389 CDD:223039
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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