DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Cacna1e

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_011246211.1	Gene:	Cacna1e / 12290	MGIID:	106217	Length:	2466	Species:	Mus musculus

Alignment Length:	2263	Identity:	527/2263 - (23%)
Similarity:	887/2263 - (39%)	Gaps:	713/2263 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SLFRPFTRESLVQ-----IEQR--IAAE--HEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDE 69
            |.|.|.:.|.:.:     ||||  |.|.  |:.|...:.:|.|.|:.::|...........|.|.
Mouse   102 SPFLPVSPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVVGRPGSGDGDS 166

  Fly    70 DEGPQPDPTLEQGVPIP-----VRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSA 129
            |:...     .||.|:|     ...:.|......:..|.:..|...|.              |:.
Mouse   167 DQSRN-----RQGTPVPASGPAAAYKQSKAQRARTMALYNPIPVRQNC--------------FTV 212

  Fly   130 SKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVI 184
            ::::::....|.:|:.|..::..|.|...|:.||:.|||::.:          |.:..:|.||..
Mouse   213 NRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPY 277

  Fly   185 FTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYV-TMGIDLG---NLAALRTFRVL 245
            |.||:.||:.:|::|.|||....:|||:.||.:||:|:....: |.|....   :|..||..|||
Mouse   278 FIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVL 342

  Fly   246 RALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS 310
            |.||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::||:.|.|.|.:.|.
Mouse   343 RPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACF-------- 399

  Fly   311 WGNLTDENWDYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSF 374
                         .|:|...   ||...| .|| :.|   |...|.|....|||.  |.|.||:.
Mouse   400 -------------MNNSGIL---EGFDPPHPCG-VQG---CPAGYECKDWIGPND--GITQFDNI 442

  Fly   375 GWAFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK 438
            .:|.|:.|:.:|.:.|.. ||.........|:.|:||.:|.:|||:::||:|.:::..:.:.:::
Mouse   443 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 507

  Fly   439 AEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYEL 503
            .|...|..:  :|..::        :|...|.. :|..|  .|||..|..|...|.|
Mouse   508 VENRRAFMK--LRRQQQ--------IERELNGY-RAWID--KAEEVMLAEENKNSGT-------- 551

  Fly   504 FVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRR 568
                                     .::.|::|         || :::..|.:::         |
Mouse   552 -------------------------SALEVLRR---------AT-IKRSRTEAMT---------R 572

  Fly   569 GSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYG 633
            .|...|                                  ..|.|:..||:
Mouse   573 DSSDEH----------------------------------CVDISSVGTPL-------------- 589

  Fly   634 NLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTN 698
               :|.|..::.....||..|                ||..||.
Mouse   590 ---ARASIKSTKVDGASYFRH----------------KERLLRI--------------------- 614

  Fly   699 HKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGV 763
                               .|:|       .|::|
Mouse   615 -------------------SIRH-------MVKSQ------------------------------ 623

  Fly   764 SVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCI 828
             |:|                                          |:.|.|            :
Mouse   624 -VFY------------------------------------------WIVLSV------------V 633

  Fly   829 VVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALS 893
            .:||..:|:.||:..:.:..:|....:.|...|.:|.::|:..|.|:.||...:|.|||.:...|
Mouse   634 ALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGS 698

  Fly   894 LLE----LGLEGVQ-GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIF 952
            :.|    :...|.. |:||||:.||||:||:.|.|.:| ||::|:|. :|.::.:|.|:|.:.|.
Mouse   699 IFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIV 762

  Fly   953 IFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE------------- 1003
            :||::||||||..::     |.|| .|..||..|..:.|.||::|.|| |.|
Mouse   763 VFALLGMQLFGGRFN-----FNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVS 821

  Fly  1004 -SMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRI 1067
             .||..:|         |:...:.||..:||:|||:.:.|..    :|.....|..:..||||:
Mouse   822 SGMWSAIY---------FIVLTLFGNYTLLNVFLAIAVDNLA----NAQELTKDEQEEEEAFNQ- 872

  Fly  1068 GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQIS-W-----------------IWSEGKG 1114
                   |..:....::......|..|.:....|.:.:| |                 :|.:...
Mouse   873 -------KHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTS 930

  Fly  1115 VCR---CISAEHGDNELEL-------------------GHDEI---------LADGLIKKGIKEQ 1148
            ..|   .:|::...|:.|.                   .|..:         ||.||   |:::.
Mouse   931 QLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSPLNPLNAHPSLYRRPRPIEGLALGL---GLEKC 992

  Fly  1149 TQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGS----------HKN-RPFKD 1202
            .:..::.|..::..|.|            |.:|.|:..:.: |.|.          |.| .|.:.
Mouse   993 EEERISRGGSLKGDIGG------------LTSALDNQRSPL-SLGKREPPWLPRSCHGNCDPIQQ 1044

  Fly  1203 ESHKGSAETM-----------------------EGEEKRDASK-----EDLGLDEELDEEGECEE 1239
            |:  |..||:                       ||::...||:     ::..|||.:..|||.|.
Mouse  1045 EA--GGGETVVTFEDRARHRQSQRRSRHRRVRTEGKDSASASRSRSASQERSLDEGVSVEGEKEH 1107

  Fly  1240 GPLD----------------------------GDIIIHAHDE-----------------DILDEY 1259
            .|..                            |..::.|.||                 ..|.|.
Mouse  1108 EPHSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAETPLVQPQPELEVGKDAALTEQ 1172

  Fly  1260 PADCCPDSYYKKFPILAGD---------------------------------------------- 1278
            .|:...:.      .|.||
Mouse  1173 EAEGSSEQ------ALLGDVQLDVGRGISQSEPDLSCMTANMDKATTESTSVTVAIPDVDPLVDS 1231

  Fly  1279 -----------DDSP-------------------------------------FWQGWGNLRLKTF 1295
                       :.||                                     .:.....:|....
Mouse  1232 TVVNISNKTDGEASPLKEAETKEEEEEVEKKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACH 1296

  Fly  1296 QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWL 1355
            .::..:|||..::.:|..||:|||.||      |:|.:     :|.|.|.:||.:|..||:||.:
Mouse  1297 YIVNLRYFEMCILLVIAASSIALAAED------PVLTNSERNKVLRYFDYVFTGVFTFEMVIKMI 1355

  Fly  1356 ALGFKV----YFTNAWCWLDFVIVMVSLINF-VASLVGAG---GIQAFKTMRTLRALRPLRAMSR 1412
            ..|..:    ||.:.|..||||:|:.:|:.| :|:.:|..   .|:..|::|.||.||||:.:.|
Mouse  1356 DQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKR 1420

  Fly  1413 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN--------GTKLSH 1469
            :..::.|.:.:|.::.::||:|:|..:|..|||::.||||.||:|.|.|.:        |..:.|
Mouse  1421 LPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDH 1485

  Fly  1470 EIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNI 1534
            |    :|..|.:...|.....::|::..|.|.||.|:|.:||.|::..::|..|.|:.|.|...:
Mouse  1486 E----KNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRM 1546

  Fly  1535 YMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKK 1596
            .|.:::|.:.:...||.:|:|:.:||..|.||..|        |.|:   :|.....:....|.|
Mouse  1547 EMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK--------MMEECSLEKNERACIDFAISAK 1603

  Fly  1597 PL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVV 1660
            || :.:|:.|...|..|:..|....|:..||..|.||...:.:..|.|..||...|.|||..|.:
Mouse  1604 PLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTM 1668

  Fly  1661 IFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLSD--IIEKYFVSPTLLRVVRVAKVG 1722
            :||.||:||:.|..: :||.:.||:||.:.||.||..::|:|  ::.....:.:.|::.|.|
Mouse  1669 VFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAA--- 1730

  Fly  1723 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK--EKSGINDVYNF 1785
            |:::|::....||.||:....|..||..:|||:.::.||:||.||..|.::|  |:|.||...||
Mouse  1731 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNF 1795

  Fly  1786 KTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG------NCGSATVGITFLLSYL 1844
            ::|..|::|||:.:|...|..::.:.:.|:.|:|   |...|.      .||: .:...:.:|::
Mouse  1796 RSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP---DTTAPSGQNESERCGT-DLAYVYFVSFI 1856

  Fly  1845 VISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVL 1909
            .....:::|:::|||::|:...|.| ...|.....|.:..:|.::|......|.|.::.|.|.::
Mouse  1857 FFCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLM 1920

  Fly  1910 EPPLQIHK--PNK--YK-IISMDIPICRGDLMYCVDILDALTK---DFFARKG 1954
            .|||.:.|  |:|  || ::.|::|:.....::....|.||.:   |....||
Mouse  1921 SPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKG 1973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	86/286 (30%)
		Na_trans_cytopl	515..648	CDD:288761	14/132 (11%)
		Ion_trans	835..1028	CDD:278921	69/213 (32%)
		Na_trans_assoc	1054..1296	CDD:284034	62/468 (13%)
		Ion_trans	1318..1571	CDD:278921	91/273 (33%)
		Na_channel_gate	1561..1613	CDD:240441	14/55 (25%)
		Ion_trans	1636..1871	CDD:278921	79/245 (32%)
		GPHH	1880..1930	CDD:293510	16/54 (30%)
Cacna1e	XP_011246211.1	Ion_trans	235..509	CDD:366146	91/303 (30%)
		Ion_trans	622..861	CDD:366146	86/343 (25%)
		Ion_trans	1302..1536	CDD:366146	82/243 (34%)
		Ion_trans	1626..1883	CDD:366146	85/264 (32%)
		GPHH	1892..1945	CDD:374878	15/52 (29%)
		Ca_chan_IQ	1956..2029	CDD:370105	6/18 (33%)
		SR-25	2168..>2243	CDD:371095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810