DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1d

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_006518538.1 Gene:Cacna1d / 12289 MGIID:88293 Length:2207 Species:Mus musculus


Alignment Length:2324 Identity:533/2324 - (22%)
Similarity:896/2324 - (38%) Gaps:752/2324 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 KKQKEIRYDDED---------------EDEGPQPDP------TLEQGVPIPVRLQG--------S 92
            ||.:..|...||               ..|||...|      .|.....|....|.        |
Mouse     8 KKMQHQRQHQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTS 72

  Fly    93 FPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSAS---KAMWMLDPFNPIRRVAIYILVHPL 154
            .||.:.|........|          :|.|.....|.|   :|::.|...|||||..|.|:....
Mouse    73 APPPVGSLSQRKRQQY----------AKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127

  Fly   155 FSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            |.:||:..|..||:.:.:          .|...:|..|..|..|:|.|:.:|::|.|.:|.|..|
Mouse   128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAY 192

  Fly   210 LRDAWNWLDFVV-------IALAYVTMGIDLGN----------LAALRTFRVLRALKTVAIVPGL 257
            :|:.||.||||:       :.|..:|...:.||          :.|||.|||||.|:.|:.||.|
Mouse   193 VRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSL 257

  Fly   258 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYH 322
            :.::.::|:::..|..:.:|.:|.:.::|::||::::|.:.:.|   |..|              
Mouse   258 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTC---FFAD-------------- 305

  Fly   323 NRNSSNWYSEDEGISFPLCGNISGAGQCD-DDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMT 386
                |:..:|::.......||   ..||. :...|..|: ..||.|.|:||:|.:|.|:.|:.:|
Mouse   306 ----SDIVAEEDPAPCAFSGN---GRQCTANGTECRSGW-VGPNGGITNFDNFAFAMLTVFQCIT 362

  Fly   387 QDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAI 450
            .:.|.|:...|..|.| .|..::|:.:|.||||:::||:|.:::..:.:.::||:..  .:.:.:
Mouse   363 MEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKAR--GDFQKL 425

  Fly   451 REAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNN 515
            ||.::        |||...........   ||:  :.||..:.            |||:|     
Mouse   426 REKQQ--------LEEDLKGYLDWITQ---AED--IDPENEEE------------GGEEG----- 460

  Fly   516 KEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNI---------RRGSR 571
            |...|:.:.|.||                       |:|.::|..|.....         |||:.
Mouse   461 KRNTSMPTSETES-----------------------VNTENVSGEGETQGCCGTLWCWWKRRGAA 502

  Fly   572 SSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636
            .:                                                           |..|
Mouse   503 KT-----------------------------------------------------------GPSG 508

  Fly   637 SRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
            .|.......:|::|                      .:.|..|..|:                  
Mouse   509 CRRWGQAISKSKLS----------------------RRWRRWNRFNR------------------ 533

  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVY 766
                                                                |..||:.:.|:.|
Mouse   534 ----------------------------------------------------RRCRAAVKSVTFY 546

  Fly   767 YFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVN 831
                                                 ||     |.::||             :|
Mouse   547 -------------------------------------WL-----VIVLVF-------------LN 556

  Fly   832 TMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA----- 891
            |:.::.:|::....:.::....|....|.|..|..:|:.::..:.||...:|.||..:|.     
Mouse   557 TLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITE 621

  Fly   892 LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAV 956
            ..|:||.|....|:||.|..||||:||:.:.|.:|:.|::.:..:|.::.:|..:|.:.|.||::
Mouse   622 TILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSL 686

  Fly   957 MGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYV-------GD 1013
            :||||||..::     |.:....|..|.:|..:.:.||::|.|| |...|:|.:..       |.
Mouse   687 LGMQLFGGKFN-----FDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGM 746

  Fly  1014 VSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNI 1078
            :.|| :|:...:.||.::||:|||:.:.|.         ||      ||:.|             
Mouse   747 IVCI-YFIILFICGNYILLNVFLAIAVDNL---------AD------AESLN------------- 782

  Fly  1079 ADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKK 1143
                                   |.|                                     |:
Mouse   783 -----------------------TAQ-------------------------------------KE 787

  Fly  1144 GIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGS 1208
            ..:|:.:.::|..:.:|     :.|||||:.::..|:   |:..:|:.|    ....:|:.....
Mouse   788 EAEEKERKKIARKESLE-----NKKNNKPEVNQIANS---DNKVTIDDY----QEDAEDKDPYPP 840

  Fly  1209 AETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFP 1273
            .:...|||:          :||.::|.|...||....|     .|..:.|           |..|
Mouse   841 CDVPVGEEE----------EEEEEDEPEVPAGPRPRRI-----SELNMKE-----------KIAP 879

  Fly  1274 ILAGDDDSPFW--QGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILY 1336
            |..|   |.|:  .....:|:...:||.:..|...::..|::||.|||.|| .:........||.
Mouse   880 IPEG---SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED-PIRSHSFRNTILG 940

  Fly  1337 YMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC-----WLDFVIVMVSLINFVASLVGAGGIQAFK 1396
            |.|..||.||.:|:|:|....|..:: ..|:|     .||.::|.|||::|.   :.:..|...|
Mouse   941 YFDYAFTAIFTVEILLKMTTFGAFLH-KGAFCRNYFNLLDMLVVGVSLVSFG---IQSSAISVVK 1001

  Fly  1397 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCED 1461
            .:|.||.||||||::|.:|::.||..:..||.:|.|:::|..:...:||.:|||||.||:::|.|
Mouse  1002 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1066

  Fly  1462 MNGTKLSHEIIPNRNACES---------------ENYTWVNSAMNFDHVGNAYLCLFQVATFKGW 1511
                    |...|...|..               ....|.||..|||:|.:|.:.||.|:||:||
Mouse  1067 --------EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGW 1123

  Fly  1512 IQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEM 1576
            ..::..||||...:..|:....:.:.::|:.:||..:||.:|:|:|.:|..|.||.:|...:.|:
Mouse  1124 PALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCEL 1188

  Fly  1577 FMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QAIVFEIVTDKKFDIIIMLFIGLNMFTMT 1637
            ...:.|...|          .|||.|..|:.|    |...:.:|....|:.::.:.|.||...:.
Mouse  1189 DKNQRQCVEY----------ALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLA 1243

  Fly  1638 LDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR---Y------------------------ 1675
            :..|:.|..:|..:|.||.:|..:|:.|.:||:.|.:   |                        
Mouse  1244 MQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSE 1308

  Fly  1676 --HYFIEPWNLFDVVVVILSILGLVLSDI------------------IEKYFVSPTLLRVVRVAK 1720
              |||.:.||.||.::|:.|::.:.::::                  .|...:|.|..|:.||. 
Mouse  1309 ADHYFTDAWNTFDALIVVGSVVDIAITEVNPSESETIPLPTATPGNSEESNRISITFFRLFRVM- 1372

  Fly  1721 VGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVY 1783
              |:::|:...:||||||:....|..||..:.||:.::.||:|:.||..|  :.:::.:.||...
Mouse  1373 --RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN 1435

  Fly  1784 NFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVIS 1847
            ||:||.|:::|||:.:|...|..::.|.:..:.||| .|.:.|....|||....:.|:..|::.:
Mouse  1436 NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYMLCA 1500

  Fly  1848 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPP 1912
            ||| ||:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::||
Mouse  1501 FLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1563

  Fly  1913 LQIHK--PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAAR 1969
            |...|  |::.   ::::|::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.| 
Mouse  1564 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLF-ALVRTALKIKTEGN-LEQANE--ELRA- 1623

  Fly  1970 PDTEGYEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGG--GSF- 2011
                    |...:|::.                    :.|...|||..:||.|.|.|.|  |.: 
Mouse  1624 --------VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYP 1680

  Fly  2012 ---------------------------------EPDT-----------------DHGDGGDPDAG 2026
                                             ||:.                 :|.:..:.|..
Mouse  1681 AKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNHVNHVNSDRR 1745

  Fly  2027 D----------------PAPDEATDGD----APAGGDGSVNGTAEGAADADESNVNSPGEDAAAA 2071
            |                |:...|:|.:    .|||..|..|          ..|.||.|:.|..:
Mouse  1746 DSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAGNSGCHN----------HHNHNSIGKQAPTS 1800

  Fly  2072 AAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSR 2120
            ..|....|.......|.|.:          :.:...|::|||....|.|
Mouse  1801 TNANLNNANMSKAAHGKPPS----------IGNLEHVSENGHYSCKHDR 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/299 (28%)
Na_trans_cytopl 515..648 CDD:288761 15/141 (11%)
Ion_trans 835..1028 CDD:278921 57/205 (28%)
Na_trans_assoc 1054..1296 CDD:284034 39/243 (16%)
Ion_trans 1318..1571 CDD:278921 92/272 (34%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 81/284 (29%)
GPHH 1880..1930 CDD:293510 14/54 (26%)
Cacna1dXP_006518538.1 Ion_trans 125..417 CDD:366146 89/316 (28%)
Ion_trans 545..780 CDD:366146 76/310 (25%)
Ion_trans 905..1182 CDD:366146 96/289 (33%)
Ion_trans 1224..1523 CDD:366146 85/303 (28%)
GPHH 1532..1585 CDD:374878 13/52 (25%)
Ca_chan_IQ 1596..1667 CDD:370105 16/83 (19%)
CAC1F_C 1690..2206 CDD:374867 28/170 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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