Protein Alignment para and Cacna1c

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_036021662.1
• Gene: Cacna1c / 12288
• MGIID: 103013
• Length: 2245
• Species: Mus musculus
• Alignment Length: 2120
• Identity: 505/2120 - (23%)
• Similarity: 862/2120 - (40%)
• Gaps: 635/2120 - (29%)

  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIF 185
            :|:..|...|||||..|.|:....|.:.|:.||..||:.:.:          .|...:|..|.:|
Mouse   132 RALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLF 196

  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGID----------LG------ 234
            ..|:|.|:.:||:|.|.:..|..|||:.||.|||:::.:...:..::          ||
Mouse   197 LIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 261

  Fly   235 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 299
            ::.|||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||:::||.:.:
Mouse   262 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 326

  Fly   300 KCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPL------CGNISGAG-QCDDDYVCL 357
            .|                            |:::..|..|.      |...:|.| ||.:..||.
Mouse   327 TC----------------------------YNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCK 363

  Fly   358 QGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFY 419
            .|: ..|.:|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||:
Mouse   364 PGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFF 425

  Fly   420 LVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEA 484
            ::||:|.:::..:.:.::||:..  .:.:.:||.::        |||...........   ||:
Mouse   426 VLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQ---AED- 476

  Fly   485 ALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKV 549
             :.||                     |:|...::...|:             :.||...|...|
Mouse   477 -IDPE---------------------NEDEGMDEDKPRN-------------RGAPAGLHDQKK- 505

  Fly   550 RKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSN 614
                                             |:|
Mouse   506 ---------------------------------GKF----------------------------- 508

  Fly   615 AVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRN 679
                                      ::.||    |..:|           ||..|.|::  :.|
Mouse   509 --------------------------AWFSH----STETH-----------VSMPTSETE--SVN 530

  Fly   680 TRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744
            |.|.: |....|..|   ..:|.||
Mouse   531 TENVA-GGDIEGENC---GARLAHR---------------------------------------- 551

  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDC-------CW 802
              |.:....|:.|..:|                                 ||...|       .:
Mouse   552 --ISKSKFSRYWRRWNR---------------------------------FCRRKCRAAVKSNVF 581

  Fly   803 VWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATM 867
            .||     |..:||             :||:.:|.:|::....:..|..:.|....|.|..|..:
Mouse   582 YWL-----VIFLVF-------------LNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLL 628

  Fly   868 KLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTLN 927
            |:.::..:.||...:|.||..||...:||..|...:     |:||||..||||:||:.:.|.:|:
Mouse   629 KMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 693

  Fly   928 LLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMI 992
            .|::.:..::.::.:|..:|.:.|.||:::||||||..::     |.:....|..|.:|..|.:.
Mouse   694 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDEMQTRRSTFDNFPQSLLT 753

  Fly   993 VFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSL 1048
            ||::|.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:.|.. :.||
Mouse   754 VFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESL 817

  Fly  1049 SAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGK 1113
            ::...:.:..|..:...|..|..|..|:              .::.::|:.|
Mouse   818 TSAQKEEEEEKERKKLARPARTASPEKK--------------QEVMEKPAVE------------- 855

  Fly  1114 GVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYL 1178
                    |..:.::||  ..|.|||                              ..|..:| :
Mouse   856 --------ESKEEKIEL--KSITADG------------------------------ESPPTTK-I 879

  Fly  1179 NNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD 1243
            |  .||                        .:..|.|:|...|..|.. .||.:||.|...||..
Mouse   880 N--MDD------------------------LQPSENEDKSPHSNPDTA-GEEDEEEPEMPVGPRP 917

  Fly  1244 GDII-IHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAV 1307
            ..:. :|..::.:         |......|.|.:.::         ..||:..:::.:..|...:
Mouse   918 RPLSELHLKEKAV---------PMPEASAFFIFSPNN---------RFRLQCHRIVNDTIFTNLI 964

  Fly  1308 ITMILMSSLALALED--VHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALG---FKVYFT--- 1364
            :..||:||::||.||  .|...|   ..||:|.|.:||.||.:|:.:|.|...   |...||
Mouse   965 LFFILLSSISLAAEDPVQHTSFR---NHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEI 1026

  Fly  1365 ------------------NAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMS 1411
                              |.:..||.::|.||||:|.   :.:..|...|.:|.||.||||||::
Mouse  1027 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFG---IQSSAINVVKILRVLRVLRPLRAIN 1088

  Fly  1412 RMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN------------- 1463
            |.:|::.||..:..||.:|.|:::|..:...:||.:|||||.||.:.|.|.:
Mouse  1089 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYIT 1153

  Fly  1464 --GTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDK 1526
              ..::.|.||..|        :|.||..:||:|..|.:.||.|:||:||.:::..:|||...||
Mouse  1154 YKDGEVDHPIIQPR--------SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDK 1210

  Fly  1527 QPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKK 1591
            .||....:.:.::|:.:||..:||.:|:|:|.:|..|.||.::...:.|:...:.|...|
Mouse  1211 GPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY----- 1270

  Fly  1592 MGSKKPLKAIPRPRWRP----QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLD 1652
                 .|||.|..|:.|    |..|:.:|....|:.::.:.|.||...:.:..|..|..:...::
Mouse  1271 -----ALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMN 1330

  Fly  1653 YLNAIFVVIFSSECLLKIFALR-YHYFIEPWNLFDVVVVILSILGLVLSDIIEKYF--------- 1707
            .||.:|..:|:.|.:||:.|.: ..||.:|||:||.::||.||:.::||: ...||
Mouse  1331 ILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSE-TNHYFCDAWNTFDA 1394

  Fly  1708 ----------------------VSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1741
                                  .||::         :...|:.:|.|:::|:...:||||||:..
Mouse  1395 LIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTF 1459

  Fly  1742 AMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGW 1804
            ..|..||..:.||:.::.||:|:.||..|  :.:.:.:.||...||:||.|:::|||:.:|...|
Mouse  1460 IKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1524

  Fly  1805 DGVLDAIINEEACDP---PDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQA 1866
            ..::.|.:..:.|.|   |.|.......|||:.....|:..|::.:||| ||:::|||::|:...
Mouse  1525 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLI-INLFVAVIMDNFDYL 1588

  Fly  1867 TEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISM 1926
            |.| ...|.....|.:..||.::|||....|::..:...|..::|||...|  |::.   :::||
Mouse  1589 TRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSM 1652

  Fly  1927 DIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEGYEPVSSTLWRQR-- 1986
            ::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|         :...:|::.
Mouse  1653 NMPLNSDGTVMFNATLF-ALVRTALRIKTEGN-LEQANE--ELRA---------IIKKIWKRTSM 1704

  Fly  1987 ------------------EEYCARLIQHAWRKHKARGEGGGSFEPDTDHG---DGGDPDAGDPAP 2030
                              :.|...|||..:||.|.|.|.|...:|...:.   ..|.....|..|
Mouse  1705 KLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGP 1769

  Fly  2031 D--EATDGDAPAGGDGSVNGTAEGAAD-ADESNVNSPGED 2067
            :  .|..||.          |||...| |.:..|::..||
Mouse  1770 EIRRAISGDL----------TAEEELDKAMKEAVSAASED 1799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	85/319 (27%)
		Na_trans_cytopl	555..740	CDD:463401	19/184 (10%)
		Ion_trans	817..1028	CDD:459842	62/223 (28%)
		Na_trans_assoc	1054..1296	CDD:461936	37/242 (15%)
		Ion_trans	1300..1571	CDD:459842	102/311 (33%)
		Na_channel_gate	1561..1613	CDD:240441	13/55 (24%)
		Ion_trans	1621..1871	CDD:459842	85/295 (29%)
		GPHH	1882..1929	CDD:465306	14/51 (27%)
Cacna1c	XP_036021662.1	Ion_trans	153..446	CDD:459842	86/323 (27%)
		Ion_trans	578..819	CDD:459842	77/264 (29%)
		Ion_trans	957..1254	CDD:459842	102/310 (33%)
		Ion_trans	1296..1593	CDD:459842	85/299 (28%)
		GPHH	1602..1655	CDD:465306	14/52 (27%)
		Ca_chan_IQ	1665..1739	CDD:462591	16/86 (19%)
		CAC1F_C	1759..2194	CDD:465298	14/51 (27%)