DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1c

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_036021662.1 Gene:Cacna1c / 12288 MGIID:103013 Length:2245 Species:Mus musculus


Alignment Length:2120 Identity:505/2120 - (23%)
Similarity:862/2120 - (40%) Gaps:635/2120 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIF 185
            :|:..|...|||||..|.|:....|.:.|:.||..||:.:.:          .|...:|..|.:|
Mouse   132 RALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLF 196

  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGID----------LG------ 234
            ..|:|.|:.:||:|.|.:..|..|||:.||.|||:::.:...:..::          ||      
Mouse   197 LIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 261

  Fly   235 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 299
            ::.|||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||:::||.:.:
Mouse   262 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 326

  Fly   300 KCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPL------CGNISGAG-QCDDDYVCL 357
            .|                            |:::..|..|.      |...:|.| ||.:..||.
Mouse   327 TC----------------------------YNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCK 363

  Fly   358 QGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFY 419
            .|: ..|.:|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||:
Mouse   364 PGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFF 425

  Fly   420 LVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEA 484
            ::||:|.:::..:.:.::||:..  .:.:.:||.::        |||...........   ||: 
Mouse   426 VLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQ---AED- 476

  Fly   485 ALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKV 549
             :.||                     |:|...::...|:             :.||...|...| 
Mouse   477 -IDPE---------------------NEDEGMDEDKPRN-------------RGAPAGLHDQKK- 505

  Fly   550 RKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSN 614
                                             |:|                             
Mouse   506 ---------------------------------GKF----------------------------- 508

  Fly   615 AVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRN 679
                                      ::.||    |..:|           ||..|.|::  :.|
Mouse   509 --------------------------AWFSH----STETH-----------VSMPTSETE--SVN 530

  Fly   680 TRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744
            |.|.: |....|..|   ..:|.||                                        
Mouse   531 TENVA-GGDIEGENC---GARLAHR---------------------------------------- 551

  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDC-------CW 802
              |.:....|:.|..:|                                 ||...|       .:
Mouse   552 --ISKSKFSRYWRRWNR---------------------------------FCRRKCRAAVKSNVF 581

  Fly   803 VWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATM 867
            .||     |..:||             :||:.:|.:|::....:..|..:.|....|.|..|..:
Mouse   582 YWL-----VIFLVF-------------LNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLL 628

  Fly   868 KLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTLN 927
            |:.::..:.||...:|.||..||...:||..|...:     |:||||..||||:||:.:.|.:|:
Mouse   629 KMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 693

  Fly   928 LLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMI 992
            .|::.:..::.::.:|..:|.:.|.||:::||||||..::     |.:....|..|.:|..|.:.
Mouse   694 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDEMQTRRSTFDNFPQSLLT 753

  Fly   993 VFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSL 1048
            ||::|.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:.|.. :.||
Mouse   754 VFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESL 817

  Fly  1049 SAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGK 1113
            ::...:.:..|..:...|..|..|..|:              .::.::|:.|             
Mouse   818 TSAQKEEEEEKERKKLARPARTASPEKK--------------QEVMEKPAVE------------- 855

  Fly  1114 GVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYL 1178
                    |..:.::||  ..|.|||                              ..|..:| :
Mouse   856 --------ESKEEKIEL--KSITADG------------------------------ESPPTTK-I 879

  Fly  1179 NNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD 1243
            |  .||                        .:..|.|:|...|..|.. .||.:||.|...||..
Mouse   880 N--MDD------------------------LQPSENEDKSPHSNPDTA-GEEDEEEPEMPVGPRP 917

  Fly  1244 GDII-IHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAV 1307
            ..:. :|..::.:         |......|.|.:.::         ..||:..:::.:..|...:
Mouse   918 RPLSELHLKEKAV---------PMPEASAFFIFSPNN---------RFRLQCHRIVNDTIFTNLI 964

  Fly  1308 ITMILMSSLALALED--VHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALG---FKVYFT--- 1364
            :..||:||::||.||  .|...|   ..||:|.|.:||.||.:|:.:|.|...   |...||   
Mouse   965 LFFILLSSISLAAEDPVQHTSFR---NHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEI 1026

  Fly  1365 ------------------NAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMS 1411
                              |.:..||.::|.||||:|.   :.:..|...|.:|.||.||||||::
Mouse  1027 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFG---IQSSAINVVKILRVLRVLRPLRAIN 1088

  Fly  1412 RMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN------------- 1463
            |.:|::.||..:..||.:|.|:::|..:...:||.:|||||.||.:.|.|.:             
Mouse  1089 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYIT 1153

  Fly  1464 --GTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDK 1526
              ..::.|.||..|        :|.||..:||:|..|.:.||.|:||:||.:::..:|||...||
Mouse  1154 YKDGEVDHPIIQPR--------SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDK 1210

  Fly  1527 QPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKK 1591
            .||....:.:.::|:.:||..:||.:|:|:|.:|..|.||.::...:.|:...:.|...|     
Mouse  1211 GPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY----- 1270

  Fly  1592 MGSKKPLKAIPRPRWRP----QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLD 1652
                 .|||.|..|:.|    |..|:.:|....|:.::.:.|.||...:.:..|..|..:...::
Mouse  1271 -----ALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMN 1330

  Fly  1653 YLNAIFVVIFSSECLLKIFALR-YHYFIEPWNLFDVVVVILSILGLVLSDIIEKYF--------- 1707
            .||.:|..:|:.|.:||:.|.: ..||.:|||:||.::||.||:.::||: ...||         
Mouse  1331 ILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSE-TNHYFCDAWNTFDA 1394

  Fly  1708 ----------------------VSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1741
                                  .||::         :...|:.:|.|:::|:...:||||||:..
Mouse  1395 LIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTF 1459

  Fly  1742 AMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGW 1804
            ..|..||..:.||:.::.||:|:.||..|  :.:.:.:.||...||:||.|:::|||:.:|...|
Mouse  1460 IKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW 1524

  Fly  1805 DGVLDAIINEEACDP---PDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQA 1866
            ..::.|.:..:.|.|   |.|.......|||:.....|:..|::.:||| ||:::|||::|:...
Mouse  1525 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLI-INLFVAVIMDNFDYL 1588

  Fly  1867 TEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISM 1926
            |.| ...|.....|.:..||.::|||....|::..:...|..::|||...|  |::.   :::||
Mouse  1589 TRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSM 1652

  Fly  1927 DIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEGYEPVSSTLWRQR-- 1986
            ::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|         :...:|::.  
Mouse  1653 NMPLNSDGTVMFNATLF-ALVRTALRIKTEGN-LEQANE--ELRA---------IIKKIWKRTSM 1704

  Fly  1987 ------------------EEYCARLIQHAWRKHKARGEGGGSFEPDTDHG---DGGDPDAGDPAP 2030
                              :.|...|||..:||.|.|.|.|...:|...:.   ..|.....|..|
Mouse  1705 KLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGP 1769

  Fly  2031 D--EATDGDAPAGGDGSVNGTAEGAAD-ADESNVNSPGED 2067
            :  .|..||.          |||...| |.:..|::..||
Mouse  1770 EIRRAISGDL----------TAEEELDKAMKEAVSAASED 1799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 81/306 (26%)
Na_trans_cytopl 515..648 CDD:288761 9/132 (7%)
Ion_trans 835..1028 CDD:278921 60/205 (29%)
Na_trans_assoc 1054..1296 CDD:284034 37/242 (15%)
Ion_trans 1318..1571 CDD:278921 97/293 (33%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 81/280 (29%)
GPHH 1880..1930 CDD:293510 15/54 (28%)
Cacna1cXP_036021662.1 Ion_trans 153..446 CDD:395416 86/323 (27%)
Ion_trans 578..819 CDD:395416 77/264 (29%)
Ion_trans 957..1254 CDD:395416 102/310 (33%)
Ion_trans 1296..1593 CDD:395416 85/299 (28%)
GPHH 1602..1655 CDD:407139 14/52 (27%)
Ca_chan_IQ 1666..1737 CDD:400901 15/83 (18%)
CAC1F_C 1759..2194 CDD:407123 14/51 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.