DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_006530650.1 Gene:Cacna1a / 12286 MGIID:109482 Length:2464 Species:Mus musculus


Alignment Length:2350 Identity:532/2350 - (22%)
Similarity:906/2350 - (38%) Gaps:702/2350 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 HEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTL------------EQGVPIPV 87
            |:.....:.:|.|.|:.::|   .:...||.......||.....:            :.|.|...
Mouse    75 HKMHSTPQARRKEWEMARFG---DEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQ 136

  Fly    88 RLQGSFPPELAST-PLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILV 151
            |:......:.|.| .|.:..|...|.||.     .:.:|.||..         |.:|:.|..|..
Mouse   137 RMYKQSMAQRARTMALYNPIPVRQNCLTV-----NRSLFLFSED---------NVVRKYAKKITE 187

  Fly   152 HPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCP 206
            .|.|...|:.||:.|||::.:          |.:..::.||..|.||:.||:.:|::|.||....
Mouse   188 WPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHK 252

  Fly   207 FTYLRDAWNWLDFVVIALAYV-TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKN 270
            .:|||:.||.:||||:....: |:|.:. :|..||..||||.||.|:.:|.|:.::.::::::..
Mouse   253 GSYLRNGWNVMDFVVVLTGILATVGTEF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIP 316

  Fly   271 LRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEG 335
            |..:.:|..|::.:||::||:.|||.....|.             :|..|           :.:|
Mouse   317 LLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-------------EEGTD-----------DIQG 357

  Fly   336 ISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRA 400
            .|...||....|..|.:...| |.:...||.|.|.||:..:|.|:.|:.:|.:.|.||......|
Mouse   358 ESPAPCGTEEPARTCPNGTKC-QPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA 421

  Fly   401 AG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKL 464
            :| .|:.|:||.:|.:|||:::||:|.:::..:      |:|.|..|.            :.|.|
Mouse   422 SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF------AKERERVEN------------RRAFL 468

  Fly   465 EERANAQAQAAADA-----AAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSV 524
            :.|...|.:...:.     :.|||..|                                      
Mouse   469 KLRRQQQIERELNGYMEWISKAEEVIL-------------------------------------- 495

  Fly   525 EVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPG 589
             .|.|: .|.||.|....|.:...::| |.|.|..|                             
Mouse   496 -AEDET-DVEQRHPFDVGALRRATLKK-SKTDLLNP----------------------------- 528

  Fly   590 SDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSH 654
                       ::|:..|  ||.::..:|.:..:                               
Mouse   529 -----------EEAEDQL--ADIASVGSPFARAS------------------------------- 549

  Fly   655 GDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKI 719
                           .|.:||.|              :|..   ||.:.|              :
Mouse   550 ---------------IKSAKLEN--------------STFF---HKKERR--------------M 568

  Fly   720 KHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKA 784
            :.:   ....|:||                               .:|                 
Mouse   569 RFY---IRRMVKTQ-------------------------------AFY----------------- 582

  Fly   785 LEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERV 849
                                     |..|.:            :.:||:.:|:.|::..:.:...
Mouse   583 -------------------------WTVLSL------------VALNTLCVAIVHYNQPEWLSDF 610

  Fly   850 LKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLR 909
            |....:.|...|..|..:|:..:..:.||...:|.||..::..|:.|:....::     |:||||
Mouse   611 LYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLR 675

  Fly   910 SFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF 973
            :.||||:||:.|.|.:| ||::|:: .:|.::.:|.|:|.:.|.:||::||||||..::     |
Mouse   676 ALRLLRIFKVTKYWASLRNLVVSLL-NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-----F 734

  Fly   974 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-----YVGDVSCIPFFLATVVIGNLVVL 1032
            .:| .|..||..|..:.|.||::|.|| |.|.|:|.:     ..|.:....:|:...:.||..:|
Mouse   735 DEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLL 798

  Fly  1033 NLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQP 1097
            |:|||:.:.|..    :|.....|..:..||.|:  :......:.:|:...|....::..:.:|.
Mouse   799 NVFLAIAVDNLA----NAQELTKDEQEEEEAANQ--KLALQKAKEVAEVSPLSAANMSIAVKEQQ 857

  Fly  1098 SGERTNQISWIWSEGKGVCR----CISAE------------------------HGDNELELGHDE 1134
            ..::..:.  :|.:.....|    ..|.|                        |.|..|.:...|
Mouse   858 KNQKPTKS--VWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQE 920

  Fly  1135 ILADGLIKKGI----------------------------------------KEQTQLEVA----- 1154
            ...:...|...                                        .|..|.|.|     
Mouse   921 NRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREH 985

  Fly  1155 -----------IGDGMEFTIH-----------------GDMKNNKPKKSKYLNNAT--------- 1182
                       .||......|                 ||..:::|::.....:||         
Mouse   986 APWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGE 1050

  Fly  1183 DDDTASINSYGSHKNR-----PFKDE---------SHKGSAETMEGEE-------KRDASKEDLG 1226
            .||       |..|.|     |..|:         .::||...:.|..       ::|..::||.
Mouse  1051 GDD-------GERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLP 1108

  Fly  1227 LDEELDE-------EGE-----------------------CEEGPL------------------- 1242
            |.|:||.       .||                       ...||.                   
Mouse  1109 LAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGN 1173

  Fly  1243 ----------DGDIII-------------HAHDEDILDEYPADC--------------CPDSYYK 1270
                      :..:|:             ....|.:..|.|..|              .||...|
Mouse  1174 PSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPK 1238

  Fly  1271 K----------FPILAGDD--------DSPFWQGWGN-LRLKTFQLIENKYFETAVITMILMSSL 1316
            |          .|   |:|        .|.|.....| ||.....::..:|||..::.:|.|||:
Mouse  1239 KEEEKKEEEEADP---GEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1300

  Fly  1317 ALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMV 1377
            |||.||...|..| ..::|.|.|.:||.:|..||:||.:.||..:    ||.:.|..|||::|..
Mouse  1301 ALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSG 1364

  Fly  1378 SLINFVASLVGAGG-----IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVC 1437
            :|:.|..:....|.     |...|::|.||.||||:.:.|:..::.|.:.:|.::.::||:|:|.
Mouse  1365 ALVAFAFTSSTRGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVY 1429

  Fly  1438 LIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDH 1494
            ::|..|||::.||||.||:|.|        .|..|..|.:|    :|..::.:..|.....::|:
Mouse  1430 MLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYE----KNEVKARDREWKKYEFHYDN 1490

  Fly  1495 VGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPI----RETNIYMYLYFVFFIIFGSFFTLNLF 1555
            |..|.|.||.|:|.:||.|::..::|:...::.|.    .|.:|:   |.|:|::| .||.:|:|
Mouse  1491 VLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIF---YVVYFVVF-PFFFVNIF 1551

  Fly  1556 IGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDK 1619
            :.:||..|.||..|   .:|.:..|..::  ..:....|.||| :.:|:.:...|..:::.|...
Mouse  1552 VALIIITFQEQGDK---MMEEYSLEKNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSP 1611

  Fly  1620 KFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYFIEPWN 1683
            .|:..||..|.||...:.:..|.||..|...|...|.:|..:||.||:||:.|.. .:||.:.||
Mouse  1612 PFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWN 1676

  Fly  1684 LFDVVVVILSILGLVLSDI-IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1747
            :||.|.|:.||..:::::. ....|::.:.||:.|.|   |:::|::....||.||:....|..|
Mouse  1677 IFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKA 1738

  Fly  1748 LFNICLLLFLVMFIFAIFGMSFFMHV----------KEKSGINDVYNFKTFGQSMILLFQMSTSA 1802
            |..:|||:.::.||:||.||..|.::          :::..|.:..||:||.|:::|||:.:|..
Mouse  1739 LPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGE 1803

  Fly  1803 GWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQAT 1867
            .|..::.:.::.:.||  .|......:||: .....:.:|::.:...:::|:::|||::|:...|
Mouse  1804 AWHNIMLSCLSGKPCD--KNSGILTADCGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLT 1865

  Fly  1868 EDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMD 1927
            .| ...|.....|.|..:|.::||.....|.|..:...|.|:.|||.:.|  |::.   :::.||
Mouse  1866 RD-SSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMD 1929

  Fly  1928 IPICRGDLMYCVDILDALTK---DFFARKGNPIEE--TGEIGE--IAARPDTEG------YEPVS 1979
            :|:...:.::....|.||.:   |....||...::  ..|:.:  :|..|:...      ..|..
Mouse  1930 LPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1994

  Fly  1980 STLWRQREEYCARLIQHAWRKHKA------RGEGGGS------FEPDTDHGDGGDPDAGDPAPDE 2032
            ||.....:.|.|.:|...:|:.||      |.|...:      .||.:...:||......|    
Mouse  1995 STDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALP---- 2055

  Fly  2033 ATDGDAPAGG 2042
            :|..| |.||
Mouse  2056 STQLD-PGGG 2064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 85/282 (30%)
Na_trans_cytopl 515..648 CDD:288761 17/132 (13%)
Ion_trans 835..1028 CDD:278921 62/204 (30%)
Na_trans_assoc 1054..1296 CDD:284034 66/477 (14%)
Ion_trans 1318..1571 CDD:278921 91/273 (33%)
Na_channel_gate 1561..1613 CDD:240441 12/52 (23%)
Ion_trans 1636..1871 CDD:278921 72/246 (29%)
GPHH 1880..1930 CDD:293510 16/54 (30%)
Cacna1aXP_006530650.1 Ion_trans 188..462 CDD:366146 93/305 (30%)
Ion_trans 579..817 CDD:366146 77/333 (23%)
PHA03247 <895..1277 CDD:223021 55/391 (14%)
Ion_trans 1285..1520 CDD:366146 82/239 (34%)
Ion_trans 1610..1869 CDD:366146 78/265 (29%)
GPHH 1878..1931 CDD:374878 15/52 (29%)
Ca_chan_IQ 1942..2015 CDD:370105 15/72 (21%)
PHA03307 2046..>2460 CDD:223039 7/23 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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