DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment para and CATSPER2

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001269239.1	Gene:	CATSPER2 / 117155	HGNCID:	18810	Length:	534	Species:	Homo sapiens

Alignment Length:	311	Identity:	76/311 - (24%)
Similarity:	154/311 - (49%)	Gaps:	57/311 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1284 WQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHL---------PQRPILQDILYYMD 1339
            |.||         ::|...|:..:|.::.::::.|.:| :.|         |.:..|:...:::
Human   106 WAGW---------VLECPLFKNFIIFLVFLNTIILMVE-IELLESTNTKLWPLKLTLEVAAWFI- 159

  Fly  1340 RIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAF-KTMRTLRA 1403
               .:||.||:|:|||: .|.|::.:||...|||:.|:||:..|..|||..|...: :.:|..|.
Human   160 ---LLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 220

  Fly  1404 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLS 1468
            ||.|:.:::.:.:::::..||:|:.|:..:|::.|||:.|||:.||.:|: :|.:....:   |.
Human   221 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS-EYTRSPRQD---LE 281

  Fly  1469 HEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETN 1533
            :.:.                   |..:.|:.:.:|.:.|...|..::.|.....||.:
Human   282 YHVF-------------------FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSR------- 320

  Fly  1534 IYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1584
            |:..:||:.:::.||....::.:.:::.||...:|:.  :.||...|.|.|
Human   321 IFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKEL--NEEMARREVQLK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034	3/11 (27%)
		Ion_trans	1318..1571	CDD:278921	65/262 (25%)
		Na_channel_gate	1561..1613	CDD:240441	8/24 (33%)
		Ion_trans	1636..1871	CDD:278921
		GPHH	1880..1930	CDD:293510
CATSPER2	NP_001269239.1	Ion_trans	178..356	CDD:278921	49/207 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810