DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and CATSPER1

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_444282.3	Gene:	CATSPER1 / 117144	HGNCID:	17116	Length:	780	Species:	Homo sapiens

Alignment Length:	379	Identity:	87/379 - (22%)
Similarity:	156/379 - (41%)	Gaps:	102/379 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1297 LIENKYFETAVITMILMSSLALALE---DVHLPQRPILQDILYYM--DRIFTVIFFLEMLIKWLA 1356
            |.::..|||.:..::.::::.|..:   :|.      ::...|:|  |.||..|:.:|.|:|.:|
Human   443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVE------IRGEWYFMALDSIFFCIYVVEALLKIIA 501

  Fly  1357 LGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGI---------QAFKTMRTLRALRPLRAMSR 1412
            ||.. ||.:.|..|||.|:.:::::|:.....:..|         :.||::|.|||:|.||.:|.
Human   502 LGLS-YFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSF 565

  Fly  1413 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNA 1477
            :..::.|...|.|::|||..:|:  |:|..:|....|   ....|:..|           |.|
Human   566 LTSVQEVTGTLGQSLPSIAAILI--LMFTCLFLFSAV---LRALFRKSD-----------PKR-- 612

  Fly  1478 CESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVF 1542
                          |.::......||.:.|...|..|.   :|||       .:...|:....|.
Human   613 --------------FQNIFTTIFTLFTLLTLDDWSLIY---MDSR-------AQGAWYIIPILVI 653

  Fly  1543 FIIFGSFFTLNLFIGVIIDNF--------NEQKKKAGGSLEMFMTEDQKKYYNA----------- 1588
            :||...|..|||.|.|::|:|        .:.|::....::..:.||......|
Human   654 YIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGT 718

  Fly  1589 -MKKMGSKK--------------PLKAI-----PRPRWRPQAIVFEIVTDKKFD 1622
             :|::..||              .|:.:     .:.::|.||.|.:.:.|..|:
Human   719 MLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFE 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034
		Ion_trans	1318..1571	CDD:278921	70/274 (26%)
		Na_channel_gate	1561..1613	CDD:240441	13/90 (14%)
		Ion_trans	1636..1871	CDD:278921
		GPHH	1880..1930	CDD:293510
CATSPER1	NP_444282.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..306
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..412
		Ion_trans	483..677	CDD:278921	65/236 (28%)
		7TMR-DISM_7TM	486..629	CDD:284997	46/175 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810