DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1h

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_008765754.2 Gene:Cacna1h / 114862 RGDID:68943 Length:2370 Species:Rattus norvegicus


Alignment Length:2339 Identity:557/2339 - (23%)
Similarity:975/2339 - (41%) Gaps:550/2339 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTFESAVK 196
            |...:.::.:|.|....:..|::||:.  |..|....         :|:.:......:..|..:|
  Rat    90 RSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVECRSERCSILEAFDDFIFAFFAVEMVIK 154

  Fly   197 VMARGFI--LCPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALKTVAIVPGL 257
            ::|.|..  .|   ||.|.||.|||.::....:...:|..|  |:|:||.||||.|:.:..||.:
  Rat   155 MVALGLFGQKC---YLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSM 216

  Fly   258 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYH 322
            :.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.    ||.::         ..
  Rat   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF----LDSAF---------VR 268

  Fly   323 NRNSS---NWYSEDEGISFPL------------CGNIS----------------GAGQCDD---- 352
            |.|.:   .:|..:||...|.            |.:|.                |..|.:|    
  Rat   269 NNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGGAG 333

  Fly   353 --------DY--VCLQG-FGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHM 406
                    .|  ||..| |  ||:.|..:||:.|:|:::.|:::|.:.|.|:...|:.|...::.
  Rat   334 RNACINWNQYYNVCRSGEF--NPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNF 396

  Fly   407 LFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ 471
            ::||::|.:|||:::||.|.::|..:.|.:::       |.:.:|             |:||...
  Rat   397 IYFILLIIVGSFFMINLCLVVIATQFSETKQR-------ENQLMR-------------EQRARYL 441

  Fly   472 AQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQR 536
            :..:..|:.:|..:.:.|:.|           :||       :...|:..||:.:.:...|..::
  Rat   442 SNDSTLASFSEPGSCYEELLK-----------YVG-------HIFRKVKRRSLRLYARWQSRWRK 488

  Fly   537 QPAP-TTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSS--------------HKYTIRNGRGRFG 586
            :..| :|.|.....|:..             |.|.|::              |.|...:|..|..
  Rat   489 KVDPSSTVHGQGPGRRPR-------------RAGRRTASVHHLVYHHHHHHHHHYHFSHGGPRRP 540

  Fly   587 IPGSDRKPLVLSTYQDAQQHLPYADDSNAV------TPMSEENG----AIIVPVYYGNL---GSR 638
            .|.                  |.|.|:..|      :|.|..:|    ..:..:|:.:.   |.:
  Rat   541 SPE------------------PGAGDNRLVRACAPPSPPSPGHGPPDSESVHSIYHADCHVEGPQ 587

  Fly   639 HSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNR-NTRNQSVGATNGGTTCLDTN---- 698
            ..:..:|.  |:..:...|..|:..|...|:.....:.:: .|.::..|....|......:    
  Rat   588 ERARVAHS--IATAASLKLASGLGTMNYPTILPSGTVNSKGGTSSRPKGLRGAGAPGAAVHSPLS 650

  Fly   699 -------HKLDHRDYEIGLECTDEAGKIKHHDN------PFIEPVQTQTVVDMKD----VMVLND 746
                   .|:.|...|.||      |:...|.:      |...|.......::|.    ...|.|
  Rat   651 LGSPRPYEKIQHVVGEQGL------GRASSHLSGLSVPCPLPSPQAGTLTCELKSCPYCASALED 709

  Fly   747 IIEQAAGRHSRASDRGVSVYYF-----------PTEDDDEDG-PTFKDKALEVILK------GID 793
            ...:.:|..|..|| ...||.|           |.:...|.| |...::.....|:      ||.
  Rat   710 PEFEFSGSESGDSD-AHGVYEFTQDVRHGDCRDPVQQPHEVGTPGHSNERRRTPLRKASQPGGIG 773

  Fly   794 VFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFT 858
                    .:|..|...:..||...:....|...|:|||:.|.:::|:..:|:...|:..|..||
  Rat   774 --------HLWASFSGKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPEELTNALEISNIVFT 830

  Fly   859 ATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSW 923
            :.||:|..:||:|..|..|.:..:||||.|:|.:|:.|:..:...||||||:||||||.||.:..
  Rat   831 SMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 895

  Fly   924 PTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYH---DHKDRFPDGDLPRWNFTD 985
            |.|...:.::.|||..:.....:|.:.||||:::||.|||..:.   |..|..||    |.||..
  Rat   896 PALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPD----RKNFDS 956

  Fly   986 FMHSFMIVFRVLCGE-W---------IESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLL 1040
            .:.:.:.||::|..| |         ..|.|..:|         |:|.:..||.|:.||.:|:|:
  Rat   957 LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALY---------FVALMTFGNYVLFNLLVAILV 1012

  Fly  1041 SNF---GSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERT 1102
            ..|   |.::.|....|..:.::...|:::...:       |...|:....:|      |:|.  
  Rat  1013 EGFQAEGDATRSDTDEDKTSTQLEGDFDKLRDLR-------ATEMKMYSLAVT------PNGH-- 1062

  Fly  1103 NQISWIWSEGKG----------VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGD 1157
                   .||:|          ....:........|::.|  .|.|...........||      
  Rat  1063 -------LEGRGSLPPPLITHTAATPMPTPKSSPNLDVAH--ALLDSRRSSSGSVDPQL------ 1112

  Fly  1158 GMEFTIHGDMKNNKPKKSKYL-----NNATDDDTASINSYGSHKNRPFKDESHKGSAETM---EG 1214
                   ||.|:....:|...     |:|.....:|.||.|  :....|..|..|..|::   ||
  Rat  1113 -------GDQKSLASLRSSPCTPWGPNSAGSSRRSSWNSLG--RAPSLKRRSQCGERESLLSGEG 1168

  Fly  1215 EEKRDASKED-------------------LGLDEELDEEGE---CEEGP----------LDGDII 1247
            :...|...||                   |...|.||....   |...|          .:|.::
  Rat  1169 KGSTDDEAEDSRPSTGTHPGASPGPRATPLRRAESLDHRSTLDLCPPRPAALLPTKFHDCNGQMV 1233

  Fly  1248 ---------IHAHDEDIL---DEYPADCCPDSYYKKFPILAGDDDSPFW----QGW--------G 1288
                     |.:|.||..   |:....||    ::...:|  :..:|.|    :.|        .
  Rat  1234 ALPSEFFLRIDSHKEDAAEFDDDIEDSCC----FRLHKVL--EPYAPQWCRSRESWALYLFPPQN 1292

  Fly  1289 NLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIK 1353
            .||:...::|.:|.|:..|:..|.::.:.:|||...:......:..|...:.|||.||.:||::|
  Rat  1293 RLRVSCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVK 1357

  Fly  1354 WLALGF----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMS 1411
            .:|||.    ..|..::|..||.::|:|||::.:.::..|||   :...:.:|.||.|||||.:|
  Rat  1358 VVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAMASAGGAKILGVLRVLRLLRTLRPLRVIS 1422

  Fly  1412 RMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRN 1476
            |..|:::||..|:.::..|.|::|:|..|::||.|:|||||.||::.||   ||...:  |..:.
  Rat  1423 RAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCE---GTDTRN--ITTKA 1482

  Fly  1477 ACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFV 1541
            .|.:.:|.||....|||::|.|.:.||.:::..||:.||.|.:|:..:|:||::..|.:|.|||:
  Rat  1483 ECHAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFI 1547

  Fly  1542 FFIIFGSFFTLNLFIGVIIDNFNE--QKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP 1604
            .|::..|||.||:|:||:::||::  |.::|    |.....::|:.....::..|..|   .|..
  Rat  1548 SFLLIVSFFVLNMFVGVVVENFHKCRQHQEA----EEARRREEKRLRRLERRRRSTFP---NPEA 1605

  Fly  1605 RWRP--------QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVI 1661
            :.||        :..:..:.|....|:.|...|.||:.||:::.|:...:.:..|.|.|.:|.::
  Rat  1606 QRRPYYADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1670

  Fly  1662 FSSECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLSDIIEKYF--VSPTLLRVVRVAKVGR 1723
            |..|..||:.|..: .:|.:.||..|:.:|:|||:|:.|.:|.....  ::||::|::||.::.|
  Rat  1671 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLRIAR 1735

  Fly  1724 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKS---GINDVY 1783
            ||:|:|.|.|:|.||..:..:||.:.|:.||..|:.||:|..|:..|  :...|.:   |::...
  Rat  1736 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHA 1800

  Fly  1784 NFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGIT--FLLSYLVI 1846
            .|..||.:.:.||::||...|:|::...:.|  |...|.      :|.|....::  :.::::::
  Rat  1801 TFTNFGMAFLTLFRVSTGDNWNGIMKDTLRE--CTREDK------HCLSYLPALSPVYFVTFVLV 1857

  Fly  1847 SFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEP 1911
            :..:::|:.:||::::..::.::.:|   |.:.|...|:               ::::......|
  Rat  1858 AQFVLVNVVVAVLMKHLEESNKEARE---DAEMDAEIEL---------------EMAQGSTAQPP 1904

  Fly  1912 P-LQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFF---------ARKGNPIEETGEIGEI 1966
            | .|...|.:.:....|.|.........|..:.:|..|.:         |...:|::|. |: |.
  Rat  1905 PTAQPPSPQESQGTQPDTPNLLVVRKVSVSRMLSLPNDSYMFRPVAPAAAPHSHPLQEV-EM-ET 1967

  Fly  1967 AARPDTEGYEP------------VSSTLWRQREEYCA-------------RLIQHAWRKHKARGE 2006
            ...|.|..:.|            .:|:..|..:..||             |::......|....|
  Rat  1968 YTGPVTSAHSPPLEPRASFQVPSAASSPARVSDPLCALSPRGTPRSLSLSRILCRQEAMHSESLE 2032

  Fly  2007 G-----GGSFEPD---------TDHGDGGDPDAGDPAPDEA-------TDGD-------APAGGD 2043
            |     ||...||         |.....|.|.:...:|..|       |.|.       ...|||
  Rat  2033 GKVDDVGGDSIPDYTEPAENMSTSQASTGAPRSPPCSPRPASVRTRKHTFGQRCISSRPPTLGGD 2097

  Fly  2044 GSVNGTAEGAADADE--SNVNS-----PGEDAAAAAAAAAAAAAAGTTTAG-------------- 2087
                 .||.|..|||  |::.|     |..:..:..|:..|:...||..:|              
  Rat  2098 -----EAEAADPADEEVSHITSSAHPWPATEPHSPEASPTASPVKGTMGSGRDPRRFCSVDAQSF 2157

  Fly  2088 --SPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRS----PSITSRTADVXARP----RPPLQD 2141
              .||...|.|.::|.:::.....::|.   :..|:    |::.||.... :.|    .||.:|
  Rat  2158 LDKPGRPDAQRWSSVELDNGESHLESGE---VRGRASELEPALGSRRKKKMSPPCISIEPPTED 2218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/331 (25%)
Na_trans_cytopl 515..648 CDD:288761 26/160 (16%)
Ion_trans 835..1028 CDD:278921 69/205 (34%)
Na_trans_assoc 1054..1296 CDD:284034 55/315 (17%)
Ion_trans 1318..1571 CDD:278921 97/261 (37%)
Na_channel_gate 1561..1613 CDD:240441 11/61 (18%)
Ion_trans 1636..1871 CDD:278921 67/244 (27%)
GPHH 1880..1930 CDD:293510 7/50 (14%)
Cacna1hXP_008765754.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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