DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1f

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_446153.2 Gene:Cacna1f / 114493 RGDID:621535 Length:1980 Species:Rattus norvegicus


Alignment Length:2116 Identity:501/2116 - (23%)
Similarity:856/2116 - (40%) Gaps:610/2116 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 EDEGPQPDPTLEQGVPIPVRLQGSFPPELAS---------TPLEDIDPYYSNVLTFVVVSKGKDI 124
            :|..|:|.|....| |.|.......||.:.:         ||.....  ::...|.||.|..:  
  Rat     8 KDTTPEPSPANGTG-PGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQ--HNKHKTVVVASAQR-- 67

  Fly   125 FRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVE 179
                :.:|::.|...|||||..|.|:....|.:.|:.||..||:.:  .:|        ....:|
  Rat    68 ----SPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLE 128

  Fly   180 STEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG---------- 234
            ..|.:|..|:|.|:.:|::|.|.:|.|..|:|:.||.|||:::.:...::.::.|          
  Rat   129 QVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHT 193

  Fly   235 -------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 292
                   ::.|||.|||||.|:.|:.||.|..::.::::::..|..:.:|.:|.:.::|::||::
  Rat   194 GGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258

  Fly   293 YMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CDDDYVC 356
            ::|.:.:.|                    :...|.....||..   | |.: ||:|: |..:...
  Rat   259 FLGRMHKTC--------------------YFLGSDMEAEEDPS---P-CAS-SGSGRSCTLNQTE 298

  Fly   357 LQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSF 418
            .:|..|.||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||
  Rat   299 CRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSF 361

  Fly   419 YLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEE 483
            :::||:|.:::..:.:.::||:..  .:.:.:||.::        :||...........   |||
  Rat   362 FVLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------MEEDLRGYLDWITQ---AEE 413

  Fly   484 AALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATK 548
            ..||..                                                           
  Rat   414 LDLHDP----------------------------------------------------------- 419

  Fly   549 VRKVSTTSLSLPGSPFNIRRGSRSSHKYTI------RNGRGRFGIPGSDRKPLVLSTYQDAQQHL 607
                     |:.|:..::....|:.|:..:      |.||.|:                      
  Rat   420 ---------SVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRW---------------------- 453

  Fly   608 PYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKE 672
                                         ..||:.::|    |.:||..|               
  Rat   454 -----------------------------FSHSTRSTH----STSSHASL--------------- 470

  Fly   673 SKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVD 737
                                                   ...:.|.|.  |.|..|..:..|:..
  Rat   471 ---------------------------------------PASDTGSIT--DTPGDEDEEEGTMAS 494

  Fly   738 MKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCW 802
            .  .:.||.|::....||.|.::||:                 :.:....:....       |.|
  Rat   495 C--TLCLNKIMKTKVCRHFRRANRGL-----------------RARCRRAVKSNA-------CYW 533

  Fly   803 VWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATM 867
            .       |.|:||             :||:.:|.:||.....:.:..:..|......|.:|..:
  Rat   534 A-------VLLLVF-------------LNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLL 578

  Fly   868 KLMAMSPKYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLN 927
            ||..:.|..|....:|.||..:|.     .:|:|:|.....|:||||..||||:||:.:.|.:|:
  Rat   579 KLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLS 643

  Fly   928 LLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMI 992
            .|::.:..:|.::.:|..:|.:.|.||:::||||||..::     |......|..|..|..:.:.
  Rat   644 NLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDQTHTKRSTFDTFPQALLT 703

  Fly   993 VFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLS 1049
            ||::|.|| |...|:|.:       :.|.:.|: :|:...:.||.::||:|||:.:.|..|..  
  Rat   704 VFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCV-YFIILFICGNYILLNVFLAIAVDNLASGD-- 765

  Fly  1050 APTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKG 1114
                       |.|....||.||                                     |||  
  Rat   766 -----------AGAAKDKGREKS-------------------------------------SEG-- 780

  Fly  1115 VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYL- 1178
                                                                   |.|:::|.| 
  Rat   781 -------------------------------------------------------NPPQENKVLV 790

  Fly  1179 NNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD 1243
            ....::||....|              :|:|..||.||:.:        :||.:|.|.       
  Rat   791 PGGENEDTEGTKS--------------EGAAPGMEEEEEEE--------EEEEEENGA------- 826

  Fly  1244 GDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFW--QGWGNLRLKTFQLIENKYFETA 1306
                  .|.|.:.:..|.:       |..||..|   |.|:  .....||.....||.:..|.:.
  Rat   827 ------GHVELLQEVVPKE-------KVVPIPEG---SAFFCLSQTNPLRKACHTLIHHHVFTSL 875

  Fly  1307 VITMILMSSLALALEDVHLPQR--PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVY---FTNA 1366
            ::..|::||::||.||   |.|  .....||.|.|..||.||.:|:|:|....|..::   |..:
  Rat   876 ILVFIILSSVSLAAED---PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRS 937

  Fly  1367 WC-WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1430
            |. .||.::|.||||:|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|
  Rat   938 WFNLLDLLVVSVSLISFG---IHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 999

  Fly  1431 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCED-----MNGTKLSHEIIPNRNACES--ENYTWVNS 1488
            .|:::|..:...:||.:|||||.||::.|.|     :...|.|..|.|:.:....  ....||||
  Rat  1000 GNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNS 1064

  Fly  1489 AMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLN 1553
            ..|||:|.:|.:.||.|:||:||..::..|||:...|:.||...::.:.::|:.:||..:||.:|
  Rat  1065 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMN 1129

  Fly  1554 LFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QAIVFE 1614
            :|:|.:|..|..|.::...:.|:...:.|...|          .|||.|..|:.|    |..|:.
  Rat  1130 IFVGFVIITFRAQGEQEYQNCELDKNQRQCVEY----------ALKAQPLRRYIPKNPHQYRVWA 1184

  Fly  1615 IVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYF 1678
            .|....|:.::.|.|.||...:.:..|:.:..:|..:|.||.:|..:|:.|.:|||.|.: .|||
  Rat  1185 TVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYF 1249

  Fly  1679 IEPWNLFDVVVVILSILGLVLSDI----------IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1733
            .:.||.||.::|:.|::.:.::::          .:...:|.|..|:.||.   |:::|:...:|
  Rat  1250 ADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVM---RLVKLLSKGEG 1311

  Fly  1734 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQSMILLF 1796
            |||||:....|..||..:.||:.::.||:|:.||..|..|..:.|  ||...||:||.|:::|||
  Rat  1312 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLF 1376

  Fly  1797 QMSTSAGWDGVLDAIINEEACDPPDNDKGYPG---NCGSATVGITFLLSYLVISFLIVINMYIAV 1858
            :.:|...|..::.|.:....|| |::|.| ||   .||| ...|.:.:|:.::...::||:::||
  Rat  1377 RCATGEAWQEIMLASLPGNRCD-PESDFG-PGEEFTCGS-NFAIVYFISFFMLCAFLIINLFVAV 1438

  Fly  1859 ILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY 1921
            |::|:...|.| ...|.....|.:..||.::||.....|::..:...|..::|||...|  |::.
  Rat  1439 IMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRV 1502

  Fly  1922 ---KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGE----------------IGE 1965
               ::::|::|:.....:.....|.||.:.....|  ||..:...|                :.|
  Rat  1503 ACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQANQELRMVIKKIWKRIKQKLLDE 1567

  Fly  1966 IAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGG--GSFEP--------------- 2013
            :...||.|     ..|:.:   .|...|||..:||.:.|.|.|  |:..|               
  Rat  1568 VIPPPDEE-----EVTVGK---FYATFLIQDYFRKFRRRKEKGLLGADAPTSTSSVLQAGLRSLQ 1624

  Fly  2014 ------------DTDHGDGGDPDAGDPAPDEATDGD 2037
                        ||:..:..:..||..|.:|..:.:
  Rat  1625 DLGPEIRQALTYDTEEEEEEEEAAGQEAEEEEAENN 1660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 78/301 (26%)
Na_trans_cytopl 515..648 CDD:288761 11/138 (8%)
Ion_trans 835..1028 CDD:278921 58/205 (28%)
Na_trans_assoc 1054..1296 CDD:284034 37/244 (15%)
Ion_trans 1318..1571 CDD:278921 96/265 (36%)
Na_channel_gate 1561..1613 CDD:240441 12/55 (22%)
Ion_trans 1636..1871 CDD:278921 80/250 (32%)
GPHH 1880..1930 CDD:293510 13/54 (24%)
Cacna1fNP_446153.2 Ion_trans 91..383 CDD:395416 83/318 (26%)
Ion_trans 532..763 CDD:395416 73/256 (29%)
Ion_trans 869..1106 CDD:395416 88/242 (36%)
Ion_trans 1188..1451 CDD:395416 85/269 (32%)
GPHH 1460..1513 CDD:407139 12/52 (23%)
Ca_chan_IQ 1524..1595 CDD:400901 17/78 (22%)
CAC1F_C 1618..1977 CDD:407123 6/43 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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