DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and SCN11A

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_016861136.1 Gene:SCN11A / 11280 HGNCID:10583 Length:1916 Species:Homo sapiens


Alignment Length:2120 Identity:817/2120 - (38%)
Similarity:1160/2120 - (54%) Gaps:407/2120 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEG 72
            |..:||: |||||.:||..||:|||.:.||:|.   |...|||||                    
Human   134 IFPDERN-FRPFTSDSLAAIEKRIAIQKEKKKS---KDQTGEVPQ-------------------- 174

  Fly    73 PQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLD 137
            |:|...|:....:| :|.|..|.||...||||:||:|.|..||:|:::.:.|:||||..|:::..
Human   175 PRPQLDLKASRKLP-KLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFG 238

  Fly   138 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES-------TEVIFTGIYTFESAV 195
            |||.||.:||.:.||.|||:|||.|:::||:  .|.|.|...|       .|.:|||||.||:.:
Human   239 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCV--FMATGPAKNSNSNNTDIAECVFTGIYIFEALI 301

  Fly   196 KVMARGFILCPFTYLRDAWNWLDFVVIALAYVTM--GIDLGNLAALRTFRVLRALKTVAIVPGLK 258
            |::||||||..|::|||.|||||.:||.:|.|:.  ||.: .|..||||||.||||.:::|..||
Human   302 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLK 365

  Fly   259 TIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHN 323
            .||||::.|||.|.:|||||.|.||:|||:|.|::||.|..|||.:               |..|
Human   366 VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISR---------------DCKN 415

  Fly   324 RNSSNWY-----SEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            .::...|     .::....|.:||...|...|...|.| :....||:|.||:||:|||:||:.||
Human   416 ISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYEC-KHTKINPDYNYTNFDNFGWSFLAMFR 479

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            |||||.||.|||..||..|.:.:.||||:||||||||:||.||:|.|:|:|..|....|..|:|:
Human   480 LMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEK 544

  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDD 513
            ..:||::.       |:|                                               
Human   545 MFQEAQQL-------LKE----------------------------------------------- 555

  Fly   514 NNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTI 578
               ||.::.::.::..|::.::      |::...|.||:.               |::....:.:
Human   556 ---EKEALVAMGIDRSSLTSLE------TSYFTPKKRKLF---------------GNKKRKSFFL 596

  Fly   579 RNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYT 643
            |.. |:...||||       :.:|.|                                       
Human   597 RES-GKDQPPGSD-------SDEDCQ--------------------------------------- 614

  Fly   644 SHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEI 708
                                       |:.:|..:..|             |..|..|||.|   
Human   615 ---------------------------KKPQLLEQTKR-------------LSQNLSLDHFD--- 636

  Fly   709 GLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDD 773
                       :|.|     |:|.|..:....::.:. :.||                    |..
Human   637 -----------EHGD-----PLQRQRALSAVSILTIT-MKEQ--------------------EKS 664

  Fly   774 DED----GPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMF 834
            .|.    |.....|           :.||:||..||..::.:..::.|||.||.||:||::||:|
Human   665 QEPCLPCGENLASK-----------YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 718

  Fly   835 MAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGL 899
            :||:||.|....|::|..||..||:.|..|..:|::|:.|.:||:.||||||.|:..||..::..
Human   719 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMN 783

  Fly   900 EGVQGLS--VLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 962
            ..:|..|  .|||||:||||||||||||||.||.|:|.::||||:||.||.|:||||:|:|||||
Human   784 CVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 848

  Fly   963 GKNYHDHKDR---FPDGD----LPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVGDVS---CI 1017
            |::::..|..   .|.|.    |..|:..||.|||::|||:|||||||:||:||...:.|   |:
Human   849 GRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCV 913

  Fly  1018 PFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAP-TADNDTNKIAEAFNRIGRFKSWVKRNIAD- 1080
            ..|:...|||.|||||||:||||::|.:...:.. ..:....|:..|.:|..|...:|:..:.. 
Human   914 IVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHF 978

  Fly  1081 CFKLIRNKLTNQISDQPSG---ERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIK 1142
            |.|..|.:...|..:...|   :..:.|..:....:|         .:.:.|||   ||......
Human   979 CHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRG---------SETQEELG---ILTSVPKT 1031

  Fly  1143 KGIK-----------EQTQLEVAIGDGME-----------FTIHGDMKNNKPKKSKYLNNATDDD 1185
            .|::           |:..:|.:..|..:           :.:|  .:|.||...:.       .
Human  1032 LGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELH--QENKKPTSQRV-------Q 1087

  Fly  1186 TASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHA 1250
            :..|:.:.       :||.|.    |::...|:......|         .||.        .|..
Human  1088 SVEIDMFS-------EDEPHL----TIQDPRKKSDVTSIL---------SECS--------TIDL 1124

  Fly  1251 HD------EDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVIT 1309
            .|      |.:..:.|..|.|..:...||..:.|...|.|..|.|||...:|::::.:||:.:|.
Human  1125 QDGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIF 1189

  Fly  1310 MILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVI 1374
            :||:||.||..|||||..:|.:|::|...|.|||.||.|||::||:|.||..|||:|||.|||:|
Human  1190 VILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFII 1254

  Fly  1375 VMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1439
            |:||:...:       .:...|:.|||||||||||:|:.:||:||||||:.|||:|.||||||||
Human  1255 VIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLI 1312

  Fly  1440 FWLIFAIMGVQLFAGKYFKCEDMNGTK--LSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCL 1502
            |||:|.|:||..|:||:.||  :|||.  :::.||.|::.|||.|::|:|..:|||:||||||.|
Human  1313 FWLVFCILGVYFFSGKFGKC--INGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLAL 1375

  Fly  1503 FQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQK 1567
            .||||||||:.|:..|:||.|.::||..|:|...|:|||.||||||||||||||||||||||:|:
Human  1376 LQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1440

  Fly  1568 KKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLN 1632
            ||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:|||.:.|||||:..|.||
Human  1441 KKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILN 1504

  Fly  1633 MFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGL 1697
            |.:|..:.|:......::||:||.:|||||:.|||:||||||.:||...|||||.|||:|||:..
Human  1505 MISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVST 1569

  Fly  1698 VLSDIIEKYFV--SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1760
            ::|.:..:..:  .|||.|:||:|::||:||||:.|:|||||||||.||||:||||.|||||:||
Human  1570 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1634

  Fly  1761 IFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAII-NEEACDPPDNDK 1824
            |:||.||::|..|..:|||:|::|||||..||:.|||:|||||||.:|..:: ::|:|:....  
Human  1635 IYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSE-- 1697

  Fly  1825 GYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQF 1889
                ||....:..::.:||::||||||:||||||||||::.|||:.::.|.:||:|::||:|::|
Human  1698 ----NCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKF 1758

  Fly  1890 DPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG 1954
            |||.||:|:|..||:|.|.|..||::.|||||:.:.||:|:...|.::|:|||.|.|........
Human  1759 DPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSD 1823

  Fly  1955 --NPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDH 2017
              :.::...|...:.|.|..:.|||:.:|..|:.||..|.:||.|:||:..:...|       |.
Human  1824 GLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMKVTKG-------DQ 1881

  Fly  2018 GDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADAD 2057
            ||..|.:.|..:|.:..     ..||.|..|.|:|....|
Human  1882 GDQNDLENGPHSPLQTL-----CNGDLSSFGVAKGKVHCD 1916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 134/284 (47%)
Na_trans_cytopl 515..648 CDD:288761 16/132 (12%)
Ion_trans 835..1028 CDD:278921 101/204 (50%)
Na_trans_assoc 1054..1296 CDD:284034 49/273 (18%)
Ion_trans 1318..1571 CDD:278921 149/254 (59%)
Na_channel_gate 1561..1613 CDD:240441 34/51 (67%)
Ion_trans 1636..1871 CDD:278921 126/237 (53%)
GPHH 1880..1930 CDD:293510 26/49 (53%)
SCN11AXP_016861136.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 342 1.000 Domainoid score I1069
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm41716
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.690

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