back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Scn2a

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001092768.1	Gene:	Scn2a / 110876	MGIID:	98248	Length:	2006	Species:	Mus musculus

Alignment Length:	2165	Identity:	971/2165 - (44%)
Similarity:	1314/2165 - (60%)	Gaps:	291/2165 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||||||.|..|:.:.|||                     |||::.||:|:..||
Mouse    14 FRFFTRESLAAIEQRIAEEKAKRPKQERK---------------------DEDDENGPKPNSDLE 57

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.|.||||:.|:::|.||||||::
Mouse    58 AGKSLPF-IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAISRFSATSALYILTPFNPIRKL 121

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.||::.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
Mouse   122 AIKILVHSLFNVLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 186

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||..||||..::|||::|||||||||||||::::|||||||||:|:|||.|.||
Mouse   187 LRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 251

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS---------WGNLTDENWDYHNR--NSSN 328
            :|||:|.||||||:|||::||.|..||: ::|.|.|         :.|..|.|....||  |..|
Mouse   252 MILTVFCLSVFALIGLQLFMGNLRNKCL-QWPPDNSTFEINITSFFNNSLDWNGTAFNRTMNMFN 315

  Fly   329 W--YSEDEGISF--------PLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            |  |.||:...:        .||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
Mouse   316 WDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 379

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            ||||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.::|
Mouse   380 LMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKE 443

  Fly   449 A---------IREAEEA-AAAKAAKLEER----------ANAQAQAAADAAAAEEAALHPEMAKS 493
            |         .::.||| |||.||..|.|          .:..:..|:..::..|..|.....|.
Mouse   444 AEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKK 508

  Fly   494 PTYSCISYELFVGGEKGNDDNNKEKMSIRSV-------EVESESVSVIQRQPAPTTAHQATKVRK 551
            .       :....||:..:|..::..|..|:       .:|...::..:|..:|   ||:.
Mouse   509 K-------QKEQAGEEEKEDAVRKSASEDSIRKKGFRFSLEGSRLTYEKRFSSP---HQSL---- 559

  Fly   552 VSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAV 616
                 ||:.||.|:.||.||:|    :.:.:||....||:.               .:|||.::.
Mouse   560 -----LSIRGSLFSPRRNSRAS----LFSFKGRVKDIGSEN---------------DFADDEHST 600

  Fly   617 TPMSEEN----GAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRN 677
               .|:|    .::.||..:   |.|..|..|..||.|             .|:.|:....|:.:
Mouse   601 ---FEDNDSRRDSLFVPHRH---GERRPSNVSQASRAS-------------RGIPTLPMNGKMHS 646

  Fly   678 RNTRNQSVGATNG--------------GTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIE 728
            ....|..|....|              |||......|.....|.:.::..:             :
Mouse   647 AVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRKRRSSSYHVSMDLLE-------------D 698

  Fly   729 PVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGID 793
            |...|..:.|  ..:|.:.:|:                   .|:..:..|....|...:.|
Mouse   699 PTSRQRAMSM--ASILTNTMEE-------------------LEESRQKCPPCWYKFANMCL---- 738

  Fly   794 VFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFT 858
               :||||..|||.:..|:|:|.||||:|.||:|||:||:||||:|:.|.::...||..||..||
Mouse   739 ---IWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFT 800

  Fly   859 ATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSW 923
            ..|..|..:|::||.|.|||||||||||..||:|||:||||..|:||||||||||||||||||||
Mouse   801 GIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 865

  Fly   924 PTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFP-DGDLPRWNFTDFM 987
            ||||:||.|:|.::|||||||.||.||:|||||:|||||||:|.:...:.. |.:||||:..||.
Mouse   866 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFF 930

  Fly   988 HSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAP 1051
            |||:||||||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|.
Mouse   931 HSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT 995

  Fly  1052 TADNDTNKIAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTNQISWIWSEGK 1113
            ..||:.|.:..|..|:.:...:|||.|.:..:   :.:.|..::|  :|..:..|:..
Mouse   996 DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI--KPLEDLNNKKD------- 1051

  Fly  1114 GVCRCISAEHGDNELELGHD-EILADGLIKKGIKEQTQLEVAIGDGME-FTIHGDMKNNKPKKSK 1176
               .|||   ....:|:|.| ..|.||   .|...      .||..:| :.:      ::.....
Mouse  1052 ---SCIS---NHTTIEIGKDLNYLKDG---NGTTS------GIGSSVEKYVV------DESDYMS 1095

  Fly  1177 YLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDA--SKEDLGLDEELDEEGECEE 1239
            ::||.:...|..| :.|.........|.....::..|.:||.:|  |.|...:|.....|||..|
Mouse  1096 FINNPSLTVTVPI-AVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPE 1159

  Fly  1240 GPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFE 1304
                      |..|:.|:  |..|..:...:||.......:....:.|.|||...::::|:.:||
Mouse  1160 ----------AEPEESLE--PEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFE 1212

  Fly  1305 TAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCW 1369
            |.::.|||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.||::||||||||
Mouse  1213 TFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCW 1277

  Fly  1370 LDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVL 1434
            |||:||.|||::..|:.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.|||
Mouse  1278 LDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1342

  Fly  1435 LVCLIFWLIFAIMGVQLFAGKYFKCED-MNGTKLSHEIIPNRNACES---ENYT--WVNSAMNFD 1493
            ||||||||||:||||.|||||::.|.: ..|......::.|.:.|::   .|.|  |.|..:|||
Mouse  1343 LVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFD 1407

  Fly  1494 HVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGV 1558
            :||..||.|.||||||||:.||..|:|||.|:.||..|.|:|||||||.||||||||||||||||
Mouse  1408 NVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGV 1472

  Fly  1559 IIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDI 1623
            ||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:.|||
Mouse  1473 IIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDI 1536

  Fly  1624 IIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVV 1688
            .||:.|.|||.||.::..|.|.....:|.::|.:|:|:|:.||:||:.:||::||...||:||.|
Mouse  1537 SIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFV 1601

  Fly  1689 VVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICL 1753
            ||||||:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.|
Mouse  1602 VVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1666

  Fly  1754 LLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACD 1818
            ||||||||:||||||.|.:||.:.||:|::||:|||.|||.|||::|||||||:|..|:|.   .
Mouse  1667 LLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS---G 1728

  Fly  1819 PPDND--KGYP-----GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTD 1876
            |||.|  |.:|     |:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|::
Mouse  1729 PPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1793

  Fly  1877 DDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDI 1941
            ||::|:||:|::|||:.||:|.:.:||:|...|:|||.|.||||.::|:||:|:..||.::|:||
Mouse  1794 DDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDI 1858

  Fly  1942 LDALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHA 1997
            |.|.||       ..:.|:||:..:         |:.|....|||:::||.|::||..|.:||.|
Mouse  1859 LFAFTK-------RVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRA 1916

  Fly  1998 WR----KHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADA-- 2056
            :|    |.|.: :....::.|....|.|.|...|...|:..:...|...|.:.:.|:..:.|:
Mouse  1917 YRRYLLKQKVK-KVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTPEKTDVTPSTTSPPSYDSVT 1980

  Fly  2057 ---------DESNVNSPGED 2067
                     |:|.....|:|
Mouse  1981 KPEKEKFEKDKSEKEDKGKD 2000

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.