Protein Alignment para and cacna1h

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_031748783.1
• Gene: cacna1h / 100494894
• XenbaseID: XB-GENE-6042121
• Length: 2460
• Species: Xenopus tropicalis
• Alignment Length: 2268
• Identity: 554/2268 - (24%)
• Similarity: 959/2268 - (42%)
• Gaps: 527/2268 - (23%)

  Fly   143 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTFESAVK 196
            |...:.::.:|.|....:..||:||:.  |..|...|         :|:.:......:..|..:|
 Frog    90 RNWCLRLVCNPWFEHVSMLVILLNCVTLGMFQPCEDTNCMSERCNILEAFDGFIFAFFAVEMVIK 154

  Fly   197 VMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALKTVAIVPGLKT 259
            ::|.| |.....||.|.||||||.::....:...:|..|  |:|:||.||||.|:.:..||.::.
 Frog   155 MVALG-IFGQKCYLGDTWNWLDFFIVMAGMLEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRI 218

  Fly   260 IVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENW--DYH 322
            :|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|            ..|.|:  .|:
 Frog   219 LVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC------------FMDTNFVMSYN 271

  Fly   323 NRNSSNWYSEDEGISFP-LCGN--ISGAGQCDD-------------DY--------------VCL 357
            ......:|..|:....| :|.:  .:|..:|.|             |:              ||.
 Frog   272 FTPLRPYYQVDDAEDNPYICSSNRDNGMLKCQDIPPKMDCSHVYYSDFPSRNSCVNINQYYNVCK 336

  Fly   358 QG-FGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLV 421
            .| |  ||:.|..:||:.|:|:::.|:::|.:.|.|:...|:.|...::.::||::|.:|||:::
 Frog   337 PGEF--NPHKGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMI 399

  Fly   422 NLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAAL 486
            ||.|.::|..:.|.:::       |.:.::             |:||...:..:..|:.:|..:.
 Frog   400 NLCLVVIATQFSETKQR-------ENQLMQ-------------EQRARYLSNDSTIASFSEPGSC 444

  Fly   487 HPEMAKSPTYSCISY--------ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTT- 542
            :.|:.|   |.|..:        .|:      |:..||.:..:               ||...|
 Frog   445 YEELLK---YICHIFRKVKRRTLRLY------NNWQNKRRKKV---------------QPNSNTN 485

  Fly   543 ---AHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDA- 603
               .|:..|.|..|...|.       ........|.|.|.||..|    |....|.:.......
 Frog   486 SQGRHRKCKRRITSIHHLI-------HHHHHHHHHHYHISNGSPR----GPRSSPEICDVEMKIM 539

  Fly   604 ----QQHLPYADDS-NAVTPMSEENGAIIVPVYYGN----LGSRHSSYTSHQSRISYTSHGDLLG 659
                |..||.|..| .:::|.||    .:..:|:.:    ...|.||.:|:.|     |:..|..
 Frog   540 KPKNQLRLPPASPSLQSMSPNSE----AVHSIYHADCHLEAPQRKSSKSSNAS-----SNIKLNA 595

  Fly   660 GMAVMGVSTMT-KESKLRNRNTRNQSVGATNGGTTC----------LDTNHKLDHRDYEIGLECT 713
            |:....::..| ..|:....:......|..||....          .|:..|.:|...|.|| |.
 Frog   596 GLNHSNMNYPTIMPSQANKTSPATLPKGKRNGSNAVSLLSSPVSMKADSFGKTNHLVGEHGL-CR 659

  Fly   714 DEAGKIKHHDNP--FIEPVQTQTVVDMKDVMVLNDIIE----QAAGRHSRASDRGVSVYYFPTED 772
             .:.|:.....|  ...|..:..:.::::.....:::|    :.:...|..||.. .||.| |:|
 Frog   660 -SSSKLSGLSVPCSLPSPQPSPLLCEIQNCPYCANLLENPDLELSDSESCESDSN-GVYEF-TQD 721

  Fly   773 ----DDED----GPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIV 829
                |..|    |...|.|..|    ...|:.:|:      :|...:..||...:....|.:.|:
 Frog   722 LRRGDQRDQVQKGRKLKTKPKE----ANKVYLLWE------EFTVRLKRIVDSKYFNRGIMIAIL 776

  Fly   830 VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSL 894
            :||:.|.:::|:..:|:...|:..|..||:.||:|..:||:|.....|.:..:||||.|||.:|:
 Frog   777 INTLSMGIEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAFGIFQYIKNPYNIFDGIIVVISV 841

  Fly   895 LELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGM 959
            .|:..:...||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:::||
 Frog   842 WEIIGQSDGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLVKTMDNVATFCMLLMLFIFIFSILGM 906

  Fly   960 QLFGKNY---HDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-W---------IESMWDCMYV 1011
            .|||..:   .|..:...|    |.||...:.:.:.||::|..| |         ..|.|..:|
 Frog   907 HLFGCKFTWTADTGETVKD----RKNFDSLLWAIVTVFQILTQEDWNMVLYNGMASTSSWAALY- 966

  Fly  1012 GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKR 1076
                    |:|.:..||.|:.||.:|:|:..|.:.. .|..:|.:.:|.:..|:.
 Frog   967 --------FVALMTFGNYVLFNLLVAILVEGFQAEG-DATRSDTEEDKASGNFDE---------- 1012

  Fly  1077 NIADCFKLIRNKLTN----QISDQPSGE---RTNQISWIWSEGKGVCR-------------CISA 1121
               |..||...:...    .::..|:|.   |::....|      :.|             |:.:
 Frog  1013 ---DLEKLKELRAAELKMYSLAVTPNGHLDPRSSMPPPI------IMRTAATPMPTPKSSPCMDS 1068

  Fly  1122 EH--GDN--ELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNAT 1182
            .|  ||:  |..:..|..:.|           |..:|.......|..|...|...::|.:
 Frog  1069 SHPFGDSRRESSVSIDPSIVD-----------QKSLASLRSTPCTPWGTYSNWGSRRSSW----- 1117

  Fly  1183 DDDTASINSYGSHKNRPFKDESHKGSAETM---EGEEKRDASKEDL------------------- 1225
                   ||.|  :....|.:|..|..|::   ||:...|...:|.
 Frog  1118 -------NSLG--RAPSIKKKSQSGERESLLSGEGKGSTDDDSDDCKSSPAARVSLHRRAGSLDT 1173

  Fly  1226 --GLD------------------------EELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCC 1264
              .||                        :..|..|:....|.|..:.:..|.||.| ||..| .
 Frog  1174 RGSLDIPDFLQVPTLRHSLSVSPLAMVPSDYQDCNGKMMHVPSDLFVRVEKHREDPL-EYEDD-I 1236

  Fly  1265 PDSY----------YKKFPILAGDDDSPFW----QGW--------GNLRLKTFQLIENKYFETAV 1307
            .|||          ||           |.|    :.|        ...|:...::|.:|.|:..|
 Frog  1237 EDSYCFRIRKMLEPYK-----------PTWCKTHEDWSLYMFSPQNQFRMMCQKVIAHKMFDHVV 1290

  Fly  1308 ITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWC 1368
            :..|.::.:.:|||...:....:.:..|...:.|||.||.|||.||.:||||    ..|..::|.
 Frog  1291 LVFIFLNCITIALERPDIDPNSLERIFLSVSNYIFTAIFVLEMAIKVVALGFVSGENTYLQSSWN 1355

  Fly  1369 WLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1430
            .||.::|.||:|:.|.||..|||   :...:.:|.||.|||||.:||..|:::||..|:.::..|
 Frog  1356 VLDGILVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPI 1420

  Fly  1431 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHV 1495
            .|::|:|..|::||.|:|||||.||::.||.     |....|.||:.|....|.||....|||::
 Frog  1421 GNIVLICCAFFIIFGILGVQLFKGKFYYCEG-----LETRNITNRSECTRARYKWVRRKYNFDNL 1480

  Fly  1496 GNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVII 1560
            |.|.:.||.:::..||:.||.|.:|:...|.||::..|.:|.|||:.|::..|||.||:|:||::
 Frog  1481 GQALMSLFVLSSKDGWVNIMYDGLDAVATDVQPVKNHNPWMLLYFISFLLIVSFFVLNMFVGVVV 1545

  Fly  1561 DNFN--------------EQKK-----KAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1606
            :||:              |:|:     |...|..::|:|.|::.|.|                .:
 Frog  1546 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRSKALYMSEAQRRPYYA----------------EY 1594

  Fly  1607 RPQAI-VFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI 1670
            .|..: :..:.|....|:.|...|.:|:.||:::.|:...:.:..|.|.|.:|.::|..|.|.|:
 Frog  1595 SPARLYIHTMCTSHYLDLFITCIICINVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEALFKL 1659

  Fly  1671 FALRY-HYFIEPWNLFDVVVVILSILGLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAK 1732
            .|..: .:|.:.||..|:.:|:|||:|:.|.:| |.... ::||::|::||.::.|||:|:|.|.
 Frog  1660 VAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEINASLPINPTIIRIMRVLRIARVLKLLKMAT 1724

  Fly  1733 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKS---GINDVYNFKTFGQSM 1792
            |:|.||..:..:||.:.|:.||..|:.||:|..|:..|  :...|::   |::....|:.||.:.
 Frog  1725 GMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNEENPCEGLSRHATFENFGMAF 1789

  Fly  1793 ILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGS--ATVGITFLLSYLVISFLIVINMY 1855
            :.||::||...|:|::...:.|  |:..|.      ||.:  ..:...:.:::::|:..:::|:.
 Frog  1790 LTLFRVSTGDNWNGIMKDTLRE--CNSDDK------NCLTYLPVISPVYFVTFVLIAQFVLVNVV 1846

  Fly  1856 IAVILENYSQATEDVQEGLTDDDYDMYYEIWQQF---------------DPEGTQYIRYDQLSEF 1905
            :||::::..::.::.:|     |.:|..||..:.               |.:||:..:.....|.
 Frog  1847 VAVLMKHLEESNKEAKE-----DAEMDAEIEMEMSRALTPISGGCTPASDGKGTEGGQDPLKGEL 1906

  Fly  1906 LD-----VLEPPLQIHKPNKYK---IISMDIPICR--------GDLMYCVDILDALTKDFFARKG 1954
            |.     |.:..:.:..|...:   :::..:|.|.        ..|..||  |.....||..|.|
 Frog  1907 LKQVGGAVCQENVTLVIPESMEGAALLNDAVPACSIYQQQALPLPLQPCV--LGHEDGDFQRRDG 1969

  Fly  1955 NPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGD 2019
            :.......:.:|:          ||..|....:.|..|.:..|...:
 Frog  1970 SGSRNLLAVKKIS----------VSRMLSLPNDSYMFRPVLPAKSSY------------------ 2006

  Fly  2020 GGDPDAGDPAPD-EATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAA--- 2080
                    |..: |.|:.::|.|...|::    .....:.|.:|.|.|....|:.:....:|
 Frog  2007 --------PLQEVETTEDNSPHGSTASLH----SQPGDNNSLLNIPVECQPQASVSNHQDSADLP 2059

  Fly  2081 ---AGTTTAGSPGAG-SAGRQTAVLVESDGFVTKNGHK--------VVIHSRSPSITS 2126
               ...|::.||... |..||.|:.::|   |.:.|..        ..:|..:||:|:
 Frog  2060 KIPPPHTSSRSPSLNRSLRRQEAIRMDS---VDQGGDSKDLNVESTESLHLGAPSVTT 2114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	87/329 (26%)
		Na_trans_cytopl	555..740	CDD:463401	41/207 (20%)
		Ion_trans	817..1028	CDD:459842	70/223 (31%)
		Na_trans_assoc	1054..1296	CDD:461936	57/335 (17%)
		Ion_trans	1300..1571	CDD:459842	110/296 (37%)
		Na_channel_gate	1561..1613	CDD:240441	12/71 (17%)
		Ion_trans	1621..1871	CDD:459842	74/259 (29%)
		GPHH	1882..1929	CDD:465306	9/69 (13%)
cacna1h	XP_031748783.1	Ion_trans	99..418	CDD:459842	87/340 (26%)
		Ion_trans	764..998	CDD:459842	79/247 (32%)
		Ion_trans	1283..1555	CDD:459842	107/276 (39%)
		Ion_trans	1607..1838	CDD:459842	70/238 (29%)