DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and cacna1h

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_031748783.1 Gene:cacna1h / 100494894 XenbaseID:XB-GENE-6042121 Length:2460 Species:Xenopus tropicalis


Alignment Length:2268 Identity:554/2268 - (24%)
Similarity:959/2268 - (42%) Gaps:527/2268 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTFESAVK 196
            |...:.::.:|.|....:..||:||:.  |..|...|         :|:.:......:..|..:|
 Frog    90 RNWCLRLVCNPWFEHVSMLVILLNCVTLGMFQPCEDTNCMSERCNILEAFDGFIFAFFAVEMVIK 154

  Fly   197 VMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALKTVAIVPGLKT 259
            ::|.| |.....||.|.||||||.::....:...:|..|  |:|:||.||||.|:.:..||.::.
 Frog   155 MVALG-IFGQKCYLGDTWNWLDFFIVMAGMLEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRI 218

  Fly   260 IVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENW--DYH 322
            :|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|            ..|.|:  .|:
 Frog   219 LVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC------------FMDTNFVMSYN 271

  Fly   323 NRNSSNWYSEDEGISFP-LCGN--ISGAGQCDD-------------DY--------------VCL 357
            ......:|..|:....| :|.:  .:|..:|.|             |:              ||.
 Frog   272 FTPLRPYYQVDDAEDNPYICSSNRDNGMLKCQDIPPKMDCSHVYYSDFPSRNSCVNINQYYNVCK 336

  Fly   358 QG-FGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLV 421
            .| |  ||:.|..:||:.|:|:::.|:::|.:.|.|:...|:.|...::.::||::|.:|||:::
 Frog   337 PGEF--NPHKGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMI 399

  Fly   422 NLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAAL 486
            ||.|.::|..:.|.:::       |.:.::             |:||...:..:..|:.:|..:.
 Frog   400 NLCLVVIATQFSETKQR-------ENQLMQ-------------EQRARYLSNDSTIASFSEPGSC 444

  Fly   487 HPEMAKSPTYSCISY--------ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTT- 542
            :.|:.|   |.|..:        .|:      |:..||.:..:               ||...| 
 Frog   445 YEELLK---YICHIFRKVKRRTLRLY------NNWQNKRRKKV---------------QPNSNTN 485

  Fly   543 ---AHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDA- 603
               .|:..|.|..|...|.       ........|.|.|.||..|    |....|.:....... 
 Frog   486 SQGRHRKCKRRITSIHHLI-------HHHHHHHHHHYHISNGSPR----GPRSSPEICDVEMKIM 539

  Fly   604 ----QQHLPYADDS-NAVTPMSEENGAIIVPVYYGN----LGSRHSSYTSHQSRISYTSHGDLLG 659
                |..||.|..| .:::|.||    .:..:|:.:    ...|.||.:|:.|     |:..|..
 Frog   540 KPKNQLRLPPASPSLQSMSPNSE----AVHSIYHADCHLEAPQRKSSKSSNAS-----SNIKLNA 595

  Fly   660 GMAVMGVSTMT-KESKLRNRNTRNQSVGATNGGTTC----------LDTNHKLDHRDYEIGLECT 713
            |:....::..| ..|:....:......|..||....          .|:..|.:|...|.|| |.
 Frog   596 GLNHSNMNYPTIMPSQANKTSPATLPKGKRNGSNAVSLLSSPVSMKADSFGKTNHLVGEHGL-CR 659

  Fly   714 DEAGKIKHHDNP--FIEPVQTQTVVDMKDVMVLNDIIE----QAAGRHSRASDRGVSVYYFPTED 772
             .:.|:.....|  ...|..:..:.::::.....:::|    :.:...|..||.. .||.| |:|
 Frog   660 -SSSKLSGLSVPCSLPSPQPSPLLCEIQNCPYCANLLENPDLELSDSESCESDSN-GVYEF-TQD 721

  Fly   773 ----DDED----GPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIV 829
                |..|    |...|.|..|    ...|:.:|:      :|...:..||...:....|.:.|:
 Frog   722 LRRGDQRDQVQKGRKLKTKPKE----ANKVYLLWE------EFTVRLKRIVDSKYFNRGIMIAIL 776

  Fly   830 VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSL 894
            :||:.|.:::|:..:|:...|:..|..||:.||:|..:||:|.....|.:..:||||.|||.:|:
 Frog   777 INTLSMGIEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAFGIFQYIKNPYNIFDGIIVVISV 841

  Fly   895 LELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGM 959
            .|:..:...||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:::||
 Frog   842 WEIIGQSDGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLVKTMDNVATFCMLLMLFIFIFSILGM 906

  Fly   960 QLFGKNY---HDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-W---------IESMWDCMYV 1011
            .|||..:   .|..:...|    |.||...:.:.:.||::|..| |         ..|.|..:| 
 Frog   907 HLFGCKFTWTADTGETVKD----RKNFDSLLWAIVTVFQILTQEDWNMVLYNGMASTSSWAALY- 966

  Fly  1012 GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKR 1076
                    |:|.:..||.|:.||.:|:|:..|.:.. .|..:|.:.:|.:..|:.          
 Frog   967 --------FVALMTFGNYVLFNLLVAILVEGFQAEG-DATRSDTEEDKASGNFDE---------- 1012

  Fly  1077 NIADCFKLIRNKLTN----QISDQPSGE---RTNQISWIWSEGKGVCR-------------CISA 1121
               |..||...:...    .::..|:|.   |::....|      :.|             |:.:
 Frog  1013 ---DLEKLKELRAAELKMYSLAVTPNGHLDPRSSMPPPI------IMRTAATPMPTPKSSPCMDS 1068

  Fly  1122 EH--GDN--ELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNAT 1182
            .|  ||:  |..:..|..:.|           |..:|.......|..|...|...::|.:     
 Frog  1069 SHPFGDSRRESSVSIDPSIVD-----------QKSLASLRSTPCTPWGTYSNWGSRRSSW----- 1117

  Fly  1183 DDDTASINSYGSHKNRPFKDESHKGSAETM---EGEEKRDASKEDL------------------- 1225
                   ||.|  :....|.:|..|..|::   ||:...|...:|.                   
 Frog  1118 -------NSLG--RAPSIKKKSQSGERESLLSGEGKGSTDDDSDDCKSSPAARVSLHRRAGSLDT 1173

  Fly  1226 --GLD------------------------EELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCC 1264
              .||                        :..|..|:....|.|..:.:..|.||.| ||..| .
 Frog  1174 RGSLDIPDFLQVPTLRHSLSVSPLAMVPSDYQDCNGKMMHVPSDLFVRVEKHREDPL-EYEDD-I 1236

  Fly  1265 PDSY----------YKKFPILAGDDDSPFW----QGW--------GNLRLKTFQLIENKYFETAV 1307
            .|||          ||           |.|    :.|        ...|:...::|.:|.|:..|
 Frog  1237 EDSYCFRIRKMLEPYK-----------PTWCKTHEDWSLYMFSPQNQFRMMCQKVIAHKMFDHVV 1290

  Fly  1308 ITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWC 1368
            :..|.::.:.:|||...:....:.:..|...:.|||.||.|||.||.:||||    ..|..::|.
 Frog  1291 LVFIFLNCITIALERPDIDPNSLERIFLSVSNYIFTAIFVLEMAIKVVALGFVSGENTYLQSSWN 1355

  Fly  1369 WLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1430
            .||.::|.||:|:.|.||..|||   :...:.:|.||.|||||.:||..|:::||..|:.::..|
 Frog  1356 VLDGILVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPI 1420

  Fly  1431 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHV 1495
            .|::|:|..|::||.|:|||||.||::.||.     |....|.||:.|....|.||....|||::
 Frog  1421 GNIVLICCAFFIIFGILGVQLFKGKFYYCEG-----LETRNITNRSECTRARYKWVRRKYNFDNL 1480

  Fly  1496 GNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVII 1560
            |.|.:.||.:::..||:.||.|.:|:...|.||::..|.:|.|||:.|::..|||.||:|:||::
 Frog  1481 GQALMSLFVLSSKDGWVNIMYDGLDAVATDVQPVKNHNPWMLLYFISFLLIVSFFVLNMFVGVVV 1545

  Fly  1561 DNFN--------------EQKK-----KAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1606
            :||:              |:|:     |...|..::|:|.|::.|.|                .:
 Frog  1546 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRSKALYMSEAQRRPYYA----------------EY 1594

  Fly  1607 RPQAI-VFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI 1670
            .|..: :..:.|....|:.|...|.:|:.||:::.|:...:.:..|.|.|.:|.::|..|.|.|:
 Frog  1595 SPARLYIHTMCTSHYLDLFITCIICINVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEALFKL 1659

  Fly  1671 FALRY-HYFIEPWNLFDVVVVILSILGLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAK 1732
            .|..: .:|.:.||..|:.:|:|||:|:.|.:| |.... ::||::|::||.::.|||:|:|.|.
 Frog  1660 VAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEINASLPINPTIIRIMRVLRIARVLKLLKMAT 1724

  Fly  1733 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKS---GINDVYNFKTFGQSM 1792
            |:|.||..:..:||.:.|:.||..|:.||:|..|:..|  :...|::   |::....|:.||.:.
 Frog  1725 GMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNEENPCEGLSRHATFENFGMAF 1789

  Fly  1793 ILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGS--ATVGITFLLSYLVISFLIVINMY 1855
            :.||::||...|:|::...:.|  |:..|.      ||.:  ..:...:.:::::|:..:::|:.
 Frog  1790 LTLFRVSTGDNWNGIMKDTLRE--CNSDDK------NCLTYLPVISPVYFVTFVLIAQFVLVNVV 1846

  Fly  1856 IAVILENYSQATEDVQEGLTDDDYDMYYEIWQQF---------------DPEGTQYIRYDQLSEF 1905
            :||::::..::.::.:|     |.:|..||..:.               |.:||:..:.....|.
 Frog  1847 VAVLMKHLEESNKEAKE-----DAEMDAEIEMEMSRALTPISGGCTPASDGKGTEGGQDPLKGEL 1906

  Fly  1906 LD-----VLEPPLQIHKPNKYK---IISMDIPICR--------GDLMYCVDILDALTKDFFARKG 1954
            |.     |.:..:.:..|...:   :::..:|.|.        ..|..||  |.....||..|.|
 Frog  1907 LKQVGGAVCQENVTLVIPESMEGAALLNDAVPACSIYQQQALPLPLQPCV--LGHEDGDFQRRDG 1969

  Fly  1955 NPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGD 2019
            :.......:.:|:          ||..|....:.|..|.:..|...:                  
 Frog  1970 SGSRNLLAVKKIS----------VSRMLSLPNDSYMFRPVLPAKSSY------------------ 2006

  Fly  2020 GGDPDAGDPAPD-EATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAA--- 2080
                    |..: |.|:.::|.|...|::    .....:.|.:|.|.|....|:.:....:|   
 Frog  2007 --------PLQEVETTEDNSPHGSTASLH----SQPGDNNSLLNIPVECQPQASVSNHQDSADLP 2059

  Fly  2081 ---AGTTTAGSPGAG-SAGRQTAVLVESDGFVTKNGHK--------VVIHSRSPSITS 2126
               ...|::.||... |..||.|:.::|   |.:.|..        ..:|..:||:|:
 Frog  2060 KIPPPHTSSRSPSLNRSLRRQEAIRMDS---VDQGGDSKDLNVESTESLHLGAPSVTT 2114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 83/316 (26%)
Na_trans_cytopl 515..648 CDD:288761 31/146 (21%)
Ion_trans 835..1028 CDD:278921 66/205 (32%)
Na_trans_assoc 1054..1296 CDD:284034 57/335 (17%)
Ion_trans 1318..1571 CDD:278921 106/278 (38%)
Na_channel_gate 1561..1613 CDD:240441 12/71 (17%)
Ion_trans 1636..1871 CDD:278921 69/244 (28%)
GPHH 1880..1930 CDD:293510 10/72 (14%)
cacna1hXP_031748783.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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