DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and nalcn

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_002937125.2 Gene:nalcn / 100492286 XenbaseID:XB-GENE-1012705 Length:1744 Species:Xenopus tropicalis


Alignment Length:2086 Identity:415/2086 - (19%)
Similarity:730/2086 - (34%) Gaps:686/2086 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 RLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVH 152
            |.|.|   .:.:.|:.|..|..|       :|...||        :|:..|:           ||
 Frog    12 RKQSS---RVEAQPVTDFGPDES-------LSDNADI--------LWINKPW-----------VH 47

  Fly   153 PLFSLFIITTILVNCILMIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFILCPF 207
            .|..:..|.:::..|    |.|..|.|          :.:.:...:||.|...|:..||.:....
 Frog    48 SLLRICAIISVISVC----MNTPKTFEHYPPLQYVTFALDTLLMFLYTAEMIAKMHIRGIVKGDT 108

  Fly   208 TYLRDAWNWLDFVVIALAYVTMGIDLGNLA-------------------ALRTFRVLRALKTVAI 253
            :|::|.|...|..::...:|::.:.:..:|                   .:|.||:....:    
 Frog   109 SYVKDRWCVFDGFMVFCLWVSLVLQVFEIAKIVDQMSPWGMLRIPRPLIMIRAFRIYFRFE---- 169

  Fly   254 VPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDEN 318
            :|..: |...:..|.:.:..|.|..:|.|.::.::|:|:: |..|..|:..   |...||||   
 Frog   170 LPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTFHCVTN---DTVHGNLT--- 226

  Fly   319 WDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVC--LQGFG-PNPNYGYTSFDSFGWAFLS 380
              ::|....:.:...||..:          ||...:.|  |:..| .....||:.|:..|.:..:
 Frog   227 --WNNLAIPDTHCSPEGEGY----------QCPRGFRCVDLKELGLSRQELGYSGFNEIGTSIFT 279

  Fly   381 AFRLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEA 444
            .:...:|:.|..|....:.:...|...| ||.:||..::.:.|:.:|::..::.|::.:      
 Frog   280 VYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ------ 338

  Fly   445 AEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEK 509
                                                                             
 Frog   339 ----------------------------------------------------------------- 338

  Fly   510 GNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSH 574
                                                                  |....||||| 
 Frog   339 ------------------------------------------------------FQQMWGSRSS- 348

  Fly   575 KYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRH 639
                                                ..|.|.|.|                    
 Frog   349 ------------------------------------TTSTATTQM-------------------- 357

  Fly   640 SSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHR 704
                         .|.|..||..::.|.....:.:                ...||         
 Frog   358 -------------FHEDAAGGWQLVAVDVNKPQGR----------------APACL--------- 384

  Fly   705 DYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV-MVLNDIIEQAAGRHSRASDRGVSVYYF 768
                                   :.:...::..|..: ||..|:|..|            |.|| 
 Frog   385 -----------------------QKMMRSSIFHMFILSMVAVDVIVAA------------SNYY- 413

  Fly   769 PTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTM 833
                   .|..||.:                                :|.|              
 Frog   414 -------KGENFKRQ--------------------------------YDEF-------------- 425

  Fly   834 FMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELG 898
            ::|                 ...||..|.:||.:|:..:....|.....:.|:.::|..:.|.:.
 Frog   426 YLA-----------------EVAFTMLFDLEALLKIWCLGFTGYISSSLHKFELLLVVGTTLHIY 473

  Fly   899 LEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 962
            .:...  |....|::|||.:|.|..|.| :.:..|.|... .||:|......::.:.:.:.:|:|
 Frog   474 PDLYH--SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGK-KLGSLVVFTASLLIVMSAISLQMF 535

  Fly   963 GKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE----------SMWDCMYVGDVSC 1016
              .:.:..||          ||.|..:||.:|::|..| |::          .||     ..|..
 Frog   536 --CFVEELDR----------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMW-----APVVA 583

  Fly  1017 IPFFLATVVIGNLVVLNLFLALLLSNF-------GSSSLSAPTADNDTN-------KIAEAF-NR 1066
            | :|:...:...|::|:||:|::|.|.       ....|....|:.||.       :|.|.| ||
 Frog   584 I-YFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNR 647

  Fly  1067 IGRFKSWVKRNIADCFKL--IRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELE 1129
            ....|  :.:..:| |.:  ||.....|..|:...:.:..:..:.|.....|     :|..    
 Frog   648 PQMVK--ISKLPSD-FTVPKIRESFMKQFIDRQQQDTSCLLRRLPSASSSSC-----DHSK---- 700

  Fly  1130 LGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGS 1194
                        :.|::|...::..:...: |:|..   .|..:|...:|....|.|......||
 Frog   701 ------------RSGVEENKYIDQKLRKSV-FSIRA---RNLLEKETAVNKILRDCTRQRMLSGS 749

  Fly  1195 HKNRPFKDES------------------------HKG-SAETMEGEEK-----RDASKED--LGL 1227
            .:.:|.|:.|                        .:| |.||:..:..     |:|.:||  :.:
 Frog   750 FEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKM 814

  Fly  1228 DEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCP------DSYYKKF-------------- 1272
            .:|..|:.|.:.         ...:|::.:.:|....|      :..::.|              
 Frog   815 IQEKKEQAEMKR---------KVQEEELRENHPYFDKPLFIVGREHRFRNFCRVIVRARFNASKT 870

  Fly  1273 -PILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQ-DIL 1335
             |:.....::.:.|.:..|.|.|       |.:..:|.:.:.|.:::..|.   |.|.::. ..|
 Frog   871 DPVTGAVKNTKYHQLYDLLGLVT-------YLDWVMIVVTICSCISMMFES---PFRRVMHTPTL 925

  Fly  1336 YYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDF------VIVMVSLI------NFVASLVG 1388
            ...:.:|.:...:|:.:|.:|.|  ::||......||      .|.:||||      |:|.:..|
 Frog   926 QIAEYVFVIFMSIELNLKIMADG--LFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPNYVPAKSG 988

  Fly  1389 AGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1453
            .      :.:..||.|||||....:..||.||..|......||.|.::.|...|:||..||||||
 Frog   989 T------QLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFA 1047

  Fly  1454 GKYFKC--------EDMNGTKLSHEIIPNRNACESENY-----------------TWVNSA-MNF 1492
            ||..||        ||.:|       |...|...|:|.                 .|.|.. .||
 Frog  1048 GKLAKCNDPHILTREDCHG-------IFRINVSVSKNLNLKLKPEEKKPGFWVPRVWANPRNFNF 1105

  Fly  1493 DHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIG 1557
            |:||||.|.||:|.:.|||::: .|.|..|   ..||.  .||:::    |:..|....|.||:|
 Frog  1106 DNVGNAMLALFEVLSLKGWVEV-RDVIIHR---VGPIH--GIYIHV----FVFLGCMIGLTLFVG 1160

  Fly  1558 VIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP---RWRPQAIVFEIVTDK 1619
            |:|.||||.|..|      .:|.||:::.:...::...:||...|||   .:|  |.:::|....
 Frog  1161 VVIANFNENKGTA------LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR--ARMYDITQHP 1217

  Fly  1620 KFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPW-- 1682
            .|...|.:.: |....:...::|..|.....|..::.:|..||..|..:||.|:....|   |  
 Frog  1218 FFKRTIAVLV-LAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKITAMSPAGF---WQS 1278

  Fly  1683 --NLFDVVVVILSILGLVLS-DIIEKY-FVSPTLLRVVRVAKV-GRVLRLVKGAKGIRTLLFALA 1742
              |.:|::|..|.::.::|. .::.:| ::....:.|.|...: |:.:.|       :.||..:.
 Frog  1279 RRNRYDLLVTSLGVIWVILHFALLNEYTYMMGACIIVFRFFSICGKHVTL-------KMLLLTVV 1336

  Fly  1743 MSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGV 1807
            :|:...|.|.:.:||::..:|..|:..|..||....||...||.|.|:::.:||::.|...|:.:
 Frog  1337 VSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSTAGKAITVLFRIVTGEDWNKI 1401

  Fly  1808 L-DAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYS--QATED 1869
            : |.::....| .|||.|.:..:||:....:.:..|:.||...|::|:.:|:|:||:|  .:||:
 Frog  1402 MHDCMVQPPFC-TPDNSKYWETDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1465

  Fly  1870 VQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPN-----KYKIISMDIP 1929
            .|. |:.:|...|..||...|.:....|...::...|.:|...|::....     |:....|:..
 Frog  1466 DQL-LSPNDLRHYQIIWNMVDDKREGVIPAFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERL 1529

  Fly  1930 ICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLI 1994
            ...||:.: .|:|..|     :.:...|.::.::.|:.||      |.:..|:    ||..|:..
 Frog  1530 HSGGDVTF-HDVLSML-----SYRSVDIRKSLQLEELLAR------EQLEYTI----EEEVAKQT 1578

  Fly  1995 QHAWRK 2000
            ...|.|
 Frog  1579 IRMWLK 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 61/303 (20%)
Na_trans_cytopl 515..648 CDD:288761 10/132 (8%)
Ion_trans 835..1028 CDD:278921 43/204 (21%)
Na_trans_assoc 1054..1296 CDD:284034 51/304 (17%)
Ion_trans 1318..1571 CDD:278921 93/291 (32%)
Na_channel_gate 1561..1613 CDD:240441 16/54 (30%)
Ion_trans 1636..1871 CDD:278921 64/244 (26%)
GPHH 1880..1930 CDD:293510 10/54 (19%)
nalcnXP_002937125.2 Ion_trans 44..338 CDD:366146 66/332 (20%)
Ion_trans 390..610 CDD:366146 64/323 (20%)
Ion_trans 894..1168 CDD:366146 93/301 (31%)
Ion_trans 1216..1465 CDD:366146 66/260 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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