DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and scn1a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_012826731.2 Gene:scn1a / 100488621 XenbaseID:XB-GENE-978019 Length:2020 Species:Xenopus tropicalis


Alignment Length:2075 Identity:955/2075 - (46%)
Similarity:1293/2075 - (62%) Gaps:236/2075 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.|:||||..||:|||.|..|:.:.|.:                     |:|:|.||:|...||
 Frog    14 FRYFSRESLEAIEKRIAEEKAKKPKQEHR---------------------DDDDDNGPKPSSDLE 57

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..||.:.|.||||:||||.|..||:|:::||.||||||:.|:::|.||||:|:|
 Frog    58 AGKSLPF-IYGDIPPGMVSEPLEDLDPYYMNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRKV 121

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.:|||.|||:.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
 Frog   122 AIKVLVHSLFSMLIMCTILTNCVFMTMSNPPEWTKNVEYTFTGIYTFESLIKILARGFCLEKFTF 186

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..::|||::|||||||||||||::::|||||||||:|:|||.|.||
 Frog   187 LRDPWNWLDFSVIVMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 251

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLD------------------GSWGNLTDE--NW 319
            :|||:|.||||||:|||::||.|..||::..|:|                  ..:||.|:.  :|
 Frog   252 MILTVFCLSVFALIGLQLFMGHLRNKCLQWPPIDYFPLINIPPILNGTMNIHDPFGNTTNSTFDW 316

  Fly   320 DYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRL 384
            :.:..:.:::|..:....|.||||.|.:|||...|:|:: .|.||||||||||:|.|||||.|||
 Frog   317 EEYITDKNHFYKLEGQKDFLLCGNSSDSGQCPKGYICVK-TGKNPNYGYTSFDTFSWAFLSLFRL 380

  Fly   385 MTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEA 449
            ||||:||:||||.|||||..:|:||:::||||||||||||||:|||:|:| |.:|..|||.::||
 Frog   381 MTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKEA 444

  Fly   450 ---------IREAEEAAAAKAAKLEERANAQAQAAADA-------AAAEEAALHPEMAK---SPT 495
                     .::.|||.||..|.|    |...:.:.|.       :::|.:.|..:.||   :..
 Frog   445 EFQQMLEQLKKQQEEAQAAAVAAL----NMSREYSEDGGFGPLSESSSEASKLSSKSAKDRRNRK 505

  Fly   496 YSCISYELFVGGEKGNDDNNKEKMSIRSVE-------VESESVSVIQRQPAPTTAHQATKVRKVS 553
            ......||....|||:|:...:..|..|::       :|...::...:..:|   ||:.      
 Frog   506 KKRKQKELGEEYEKGDDEKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSP---HQSL------ 561

  Fly   554 TTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTP 618
               ||:.||.|:.||.||:| .::.||                  ..:|......:|||.::...
 Frog   562 ---LSIRGSLFSPRRNSRAS-LFSFRN------------------RAKDVGSENDFADDEHSTFE 604

  Fly   619 MSE-ENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRN 682
            .:| ..|::.||   ...|.|.:|..|..|:.|.|             ::.:....|:.:....|
 Frog   605 DNESRRGSLFVP---NRHGERRNSNISQVSKSSKT-------------MTVLPANGKMHSTVDCN 653

  Fly   683 QSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHH---DNPFIEPVQTQTVVDMKD---- 740
            ..|....|.:.                  .|...|.:...   |.|..:...|.|..:::.    
 Frog   654 GVVSLLGGPSV------------------PTSPVGLLLPEVIVDKPASDDNGTTTETEIRKRKSS 700

  Fly   741 -VMVLNDIIEQAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCC 801
             ..|..|::|....|     .|.:||....|   |:.:|.    :.|......|..:.|.:||||
 Frog   701 CYQVPMDLLEDPTAR-----QRALSVASILTNTVEELEES----RQKCPPCWYKFANTFLIWDCC 756

  Fly   802 WVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEAT 866
            ..||..:..|.|||.||||:|.||:|||:||:||||:|:.|.||...||..||..||..|..|..
 Frog   757 ENWLTVKHIVKLIVMDPFVDLAITICIVLNTLFMAMEHYPMTKEFNDVLSIGNLVFTGIFTAEMV 821

  Fly   867 MKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLIS 931
            .||:|:.|.|||||||||||.|||:|||:||||..|:||||||||||||||||||||||||:||.
 Frog   822 FKLIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIK 886

  Fly   932 IMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDG-DLPRWNFTDFMHSFMIVFR 995
            |:|.::|||||||.||.||:|||||:|||||||:|.:...:..:. :||||:..||.|||:||||
 Frog   887 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFR 951

  Fly   996 VLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNK 1059
            ||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...||:.|.
 Frog   952 VLCGEWIETMWDCMEVAGQSMCLLVFMLVMVIGNLVVLNLFLALLLSSFSSDNLTATDDDNEMNN 1016

  Fly  1060 IAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTN-QISWIWSEGK-GVCRCI 1119
            :..|..||.|...:||:.|.:|.:   :.:.|..::|  :|..|..| :.|.:::... .:.:.:
 Frog  1017 LQIAVGRIQRGIDYVKKTIRECIQKAFVKKQKGLDEI--KPLEELHNKRESCLFNHNAVEINKVL 1079

  Fly  1120 SAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKP---KKSKYLNNA 1181
            ....|||....|     ....::|.|.::       .|.|.|..:..:....|   .:|.:.|..
 Frog  1080 DYHKGDNGTTSG-----VGSSVEKYIIDE-------NDYMSFIHNPSLTVTVPIAVGESDFENLN 1132

  Fly  1182 TDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG---PLD 1243
            |:|               |..||     :..|.:||.:.:....|...::...|...||   |:|
 Frog  1133 TED---------------FSSES-----DLEESKEKLNMTSSSEGSTVDIRPPGVVAEGEGEPID 1177

  Fly  1244 GDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVI 1308
                  ...|:.|:  |..|..:...|:|||...:.:....:.|...|...:.::|:.:|||.:|
 Frog  1178 ------IESEEALE--PDACFTEGCVKRFPICYVNIEENKGKLWWTFRKTCYTIVEHNWFETFII 1234

  Fly  1309 TMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFV 1373
            .|||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.||..|||||||||||:
 Frog  1235 FMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFL 1299

  Fly  1374 IVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1438
            ||.|||::.||:.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.|||||||
 Frog  1300 IVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCL 1364

  Fly  1439 IFWLIFAIMGVQLFAGKYFKC-EDMNGTKLSHEIIPNRNAC--ESENYTWVNSAMNFDHVGNAYL 1500
            ||||||:||||.||||||:.| ....|..|....:.||:.|  .:|:..|.|..:|||:||..||
 Frog  1365 IFWLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDCLHLNESARWKNVKVNFDNVGAGYL 1429

  Fly  1501 CLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNE 1565
            .|.||||||||:.||..|:|||:|::||..|.|:|||||||.||||||||||||||||||||||:
 Frog  1430 ALLQVATFKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1494

  Fly  1566 QKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIG 1630
            ||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:.||||||:.|.
 Frog  1495 QKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGLVFDFVTKQAFDIIIMILIC 1558

  Fly  1631 LNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSIL 1695
            |||.||.::..:.|......|.::|.:|:::|:.||:|||.:||::||...||:||.|||||||:
 Frog  1559 LNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILKIISLRHYYFTIGWNIFDFVVVILSIV 1623

  Fly  1696 GLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1760
            |:.|:|:||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.||||||||
 Frog  1624 GMFLADMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1688

  Fly  1761 IFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDND 1823
            |:||||||.|.:||::|||:|::||:|||.|||.|||::|||||||:|..|:|..|  |||....
 Frog  1689 IYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPQMEH 1753

  Fly  1824 KG--YPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIW 1886
            .|  ..|:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|.:||::|:||:|
 Frog  1754 PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVW 1818

  Fly  1887 QQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFA 1951
            ::|||:.||:|.|.:||.|.|.|:|||:|.|||:.::|:||:|:..||.::|:|||.|.||....
 Frog  1819 EKFDPDATQFIEYSKLSNFADALDPPLRIAKPNRVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1883

  Fly  1952 RKGN-------PIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR 2004
             :|:       |:||.    .:|:.|....|||::|||.|::||....:||..:||:..|
 Frog  1884 -EGDEMDALRLPMEER----FMASNPSKASYEPITSTLRRKQEELSVVIIQRCFRKYLLR 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 163/291 (56%)
Na_trans_cytopl 515..648 CDD:288761 30/140 (21%)
Ion_trans 835..1028 CDD:278921 125/194 (64%)
Na_trans_assoc 1054..1296 CDD:284034 53/252 (21%)
Ion_trans 1318..1571 CDD:278921 162/255 (64%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 146/238 (61%)
GPHH 1880..1930 CDD:293510 26/49 (53%)
scn1aXP_012826731.2 Ion_trans 128..435 CDD:395416 172/308 (56%)
Na_trans_cytopl 515..723 CDD:403218 54/277 (19%)
Ion_trans 772..985 CDD:395416 138/212 (65%)
Na_trans_assoc 1011..1222 CDD:399489 53/252 (21%)
Ion_trans 1226..1498 CDD:395416 170/271 (63%)
Na_channel_gate 1490..1542 CDD:240441 36/52 (69%)
Ion_trans 1547..1802 CDD:395416 157/254 (62%)
GPHH 1814..1861 CDD:407139 25/46 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 345 1.000 Domainoid score I1047
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1626 1.000 Inparanoid score I77
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm48939
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.080

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