Protein Alignment para and cacna1c

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_012814814.1
• Gene: cacna1c / 100488055
• XenbaseID: XB-GENE-991126
• Length: 2196
• Species: Xenopus tropicalis
• Alignment Length: 2213
• Identity: 504/2213 - (22%)
• Similarity: 869/2213 - (39%)
• Gaps: 677/2213 - (30%)

  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIF 185
            :|:..|...|||||..|.|:....|.:.|:.||..||:.:.:          .|...:|..|.:|
 Frog   130 RALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAVYIPFPEDDSNATNSNLERVEYLF 194

  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTM----------GIDLG------ 234
            ..|:|.|:.:||:|.|.:..|..|||:.||.|||:::.:...:.          |..:|
 Frog   195 LIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGGSAIGGKGAGF 259

  Fly   235 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 299
            ::.|||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||:::||.:.:
 Frog   260 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 324

  Fly   300 KCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNP 364
            .|.  :..:|....||:|.                  ..|.....:....|.:..:|..|: ..|
 Frog   325 TCY--YLTNGYPDVLTEEE------------------PSPCALESNNGRHCPNGTLCRSGW-VGP 368

  Fly   365 NYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYLVNLILA 426
            .:|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   |  .::|:.::..|||:::||:|.
 Frog   369 KHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELP--CVYFVSLVIFGSFFVLNLVLG 431

  Fly   427 IVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERAN------AQAQ----AAADAAAA 481
            :::..:.:.::||:..  .:.:.:||.::        |||...      .||:    ...|....
 Frog   432 VLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQAEDIDPENEDEDID 486

  Fly   482 EEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQA 546
            ||...:..|..|.|            |..|.||      :.|.:||.||..|       ..||:.
 Frog   487 EEKPRNMSMPTSET------------ESVNTDN------VGSGDVEEESCGV-------RLAHRI 526

  Fly   547 TKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYAD 611
            :|
 Frog   527 SK--------------------------------------------------------------- 528

  Fly   612 DSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLR 676
                                     |:.|.|....:|.
 Frog   529 -------------------------SKFSRYWRRWNRF--------------------------- 541

  Fly   677 NRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV 741
                                               |.
 Frog   542 -----------------------------------CR---------------------------- 543

  Fly   742 MVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLK 806
                        |..||:.:. :|:|                                    ||
 Frog   544 ------------RKCRAAVKS-NVFY------------------------------------WL- 558

  Fly   807 FQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMA 871
                |..:||             :||:.:|.:|::....:..|..:.|....|.|..|..:|:.:
 Frog   559 ----VIFLVF-------------LNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYS 606

  Fly   872 MSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTLNLLIS 931
            :..:.||...:|.||..||...:||..|...:     |:||||..||||:||:.:.|.:|:.|::
 Frog   607 LGLQAYFVSLFNRFDCFIVCGGILETILVETRIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVA 671

  Fly   932 IMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRV 996
            .:..::.::.:|..:|.:.|.||:::||||||..::     |.:....|..|.:|..:.:.||::
 Frog   672 SLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDEMLTRRSTFDNFPQALLTVFQI 731

  Fly   997 LCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSLSAPT 1052
            |.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:.|.. :.||::..
 Frog   732 LTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQ 795

  Fly  1053 ADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCR 1117
            .:.:..|                                                   |.|.:.|
 Frog   796 KEEEEEK---------------------------------------------------ERKKLAR 809

  Fly  1118 CISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNAT 1182
            ..|.|.......||...:.|   :::. ||:.:|:....||           ..|..:|
 Frog   810 TASPEKKQENESLGKSPVPA---VEEN-KEKIELKAITADG-----------ESPPNTK------ 853

  Fly  1183 DDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKR--DASKEDLGLDEELDEEGECEEGPLDGD 1245
                .|:..:.:::|                 |||.  .:|.|..|  ||.:||.|...||....
 Frog   854 ----ISVEEFSTNEN-----------------EEKTPYPSSNETPG--EEEEEEPEMPVGPRPRP 895

  Fly  1246 II-IHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVIT 1309
            :. :|..::         ..|......|.:...|:         ..|:...:::.|..|...::.
 Frog   896 LSELHIKEK---------AAPMPEASAFFVFRSDN---------RFRVHCHRIVNNNIFTNLILF 942

  Fly  1310 MILMSSLALALEDVHLPQR--PILQDILYYMDRIFTVIFFLEMLIKWLALG---FKVYFT----- 1364
            .||:||::||.||   |.|  .....:|:|.|.:||.||.:|:::|.|...   |...||
 Frog   943 FILLSSISLAAED---PVRHNSFRNQVLFYFDIVFTAIFTVEIVLKILGNADYVFTSIFTLEIIL 1004

  Fly  1365 ----------------NAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRM 1413
                            |.:..||.::|.||||:|.   :.:..|...|.:|.||.||||||::|.
 Frog  1005 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFG---IQSSAINVVKILRVLRVLRPLRAINRA 1066

  Fly  1414 QGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSH-----EIIP 1473
            :|::.||..:..||.:|.|:::|..:...:||.:|||||.||.:.|.|  .:|::.     :.|.
 Frog  1067 KGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYSCTD--SSKITEAECKGKYIT 1129

  Fly  1474 NRNACESE----NYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNI 1534
            .::...|:    :.:|.||..:||:|.:|.:.||.|:||:||.:::..||||...|..||....:
 Frog  1130 YKDGDVSQPMIVDRSWENSKFDFDNVLSAMMALFTVSTFEGWPELLYRAIDSHTEDVGPIYNHRV 1194

  Fly  1535 YMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLK 1599
            .:.::|:.:||..:||.:|:|:|.:|..|.||.::...:.|:...:.|...|          .||
 Frog  1195 EISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY----------ALK 1249

  Fly  1600 AIPRPRWRP----QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVV 1660
            |.|..|:.|    |..|:.:|....|:.::.:.|.||...:.:..|..|.::...::.||.:|..
 Frog  1250 ARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCSFKEAMNILNMLFTG 1314

  Fly  1661 IFSSECLLKIFALR-YHYFIEPWNLFDVVVVILSILGLVLSDIIEKYF----------------- 1707
            :|:.|.:||:.|.: ..||.:|||:||.::||.|::.::||: ...||
 Frog  1315 LFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSVVDVILSE-TNHYFCDAWNTFDALIVVGSIV 1378

  Fly  1708 --------------------------VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLP 1746
                                      :|.|..|:.||.   |:::|:...:||||||:....|..
 Frog  1379 DIAITELNPGEHAQCSSSMNVEENSRISITFFRLFRVM---RLVKLLSRGEGIRTLLWTFIKSFQ 1440

  Fly  1747 ALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLD 1809
            ||..:.||:.::.||:|:.||..|  :.:.:.:.||...||:||.|:::|||:.:|...|..::.
 Frog  1441 ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQEIML 1505

  Fly  1810 AIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1874
            |.:..:.|.|.....  ...|||:.....|:..|::.:||| ||:::|||::|:...|.| ...|
 Frog  1506 ACLPSKPCAPESETS--EEKCGSSFAVFYFISFYMLCAFLI-INLFVAVIMDNFDYLTRD-WSIL 1566

  Fly  1875 TDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRG 1933
            .....|.:..||.::|||....|::..:...|..::|||...|  |::.   ::::|::|: ..|
 Frog  1567 GPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDG 1631

  Fly  1934 DLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQR------------ 1986
            .:|:...:...:......:....:|:..|  |:.|         :...:|::.
 Frog  1632 TVMFNATLFALVRTSLCIKTDGNLEQANE--ELRA---------IIKKIWKRTSMKLLDQVVPPA 1685

  Fly  1987 --------EEYCARLIQHAWRKHKARGEGGGSFEPDTDHG---DGGDPDAGDPAPD--EATDGDA 2038
                    :.|...|||..:||.|.|.|.|...:|...:.   ..|.....|..|:  .|..||.
 Frog  1686 GDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDL 1750

  Fly  2039 PAGGDGSVNGTAEGAAD-ADESNVNSPGEDAAAAAAAAAAAAAAG--------------TT---- 2084
                      |||...| |.:..|::..||.....|........|              ||
 Frog  1751 ----------TAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVGYYQSEVRSAFPQTFTTQRPL 1805

  Fly  2085 ----TAGSPG-AGSAGRQTAVLVES---DGFVTKNGHKVVIHS-------RSPSITSRTADVXAR 2134
                |:|.|| ..|...:.  ||:|   ....:.:|....|::       |.|...|..:.| .:
 Frog  1806 HINKTSGGPGDLDSPSHEK--LVDSTFTPSSYSSSGSNANINNANNTALVRLPCYRSTVSTVEGQ 1868

  Fly  2135 PRP 2137
            .||
 Frog  1869 SRP 1871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	81/312 (26%)
		Na_trans_cytopl	555..740	CDD:463401	5/184 (3%)
		Ion_trans	817..1028	CDD:459842	61/223 (27%)
		Na_trans_assoc	1054..1296	CDD:461936	36/244 (15%)
		Ion_trans	1300..1571	CDD:459842	101/305 (33%)
		Na_channel_gate	1561..1613	CDD:240441	13/55 (24%)
		Ion_trans	1621..1871	CDD:459842	83/295 (28%)
		GPHH	1882..1929	CDD:465306	13/51 (25%)
cacna1c	XP_012814814.1	Ion_trans	151..445	CDD:459842	82/316 (26%)
		Ion_trans	552..793	CDD:459842	78/301 (26%)
		Ion_trans	933..1230	CDD:459842	101/304 (33%)
		Ion_trans	1272..1564	CDD:459842	83/299 (28%)
		GPHH	1573..1626	CDD:465306	13/52 (25%)
		Ca_chan_IQ	1636..1710	CDD:462591	11/84 (13%)
		CAC1F_C	1730..2148	CDD:465298	34/154 (22%)