DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and scn2a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_031749252.1 Gene:scn2a / 100486750 XenbaseID:XB-GENE-6447552 Length:1970 Species:Xenopus tropicalis


Alignment Length:2050 Identity:927/2050 - (45%)
Similarity:1252/2050 - (61%) Gaps:230/2050 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||:||:.|.|...:.|:|                      |.|:.||:|:..||
 Frog    14 FRYFTRESLKAIEKRISEEKENNAKQEQK----------------------EGEENGPKPNRDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..||.:.|.||||:||||:|..||:|::|||.:|||||:.|:::|.||||:|:.
 Frog    57 AGQSLPF-IYGDIPPRMVSEPLEDLDPYYANQKTFIVLNKGKTLFRFSATSALYILTPFNPVRQA 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.||::.|:.|||.||:.|.:...|. .::.|..||||||.||.:|::||||.|..||:
 Frog   121 AIKILVHSLFNMLIMCTILTNCVFMTLSNPPEWTKNVEYTFTGIYTLESLIKILARGFCLEKFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.|||||..::|||::|||||||||||||::::|||||||||:|:|||.|.||
 Frog   186 LRDPWNWLDFSVIVLAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFP 339
            :|||:|.||||||:|||::||.|..||: .:|.:.|    .|.:. |.:.|.|.:|..:......
 Frog   251 MILTVFCLSVFALIGLQLFMGHLRNKCL-LWPYNSS----VDISL-YEHFNESLFYKLENQKDPL 309

  Fly   340 LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPW 404
            :|||.|..|:|.:.|||::. |.||||||||||:|.|||||.|||||||.||:||||.|||||..
 Frog   310 VCGNSSDTGKCPEGYVCVKA-GRNPNYGYTSFDTFNWAFLSLFRLMTQDCWENLYQLTLRAAGKT 373

  Fly   405 HMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERAN 469
            :|:||:::||||||||||||||:|||:|:      |:.:|..|||::  :||...:..|.:|.|.
 Frog   374 YMIFFVLVIFLGSFYLVNLILAVVAMAYE------EQNQATIEEAVQ--KEAEFQRLKKQQEEAQ 430

  Fly   470 AQAQAAADA-----AAAEEAALHPEMAKSPTYSCISYELFV----------------GGEKGNDD 513
            |.|.|.||.     ..:||..|......|.|.|.:|.:...                |.|||   
 Frog   431 ALAAAVADVFGESQELSEEVGLEDASECSSTVSKLSSKSAKERRNWRKQRKQVAHCDGQEKG--- 492

  Fly   514 NNKEKMSIRSVEVESESVSVIQRQPAPTT--AHQATKVRKVS---TTSLSLPGSPFNIRRGSRSS 573
             :|||.      .:|.|...|:|:....|  ..:..:.||.|   .:.||:.|..|:.||.|::|
 Frog   493 -DKEKC------YKSGSEDSIKRKGLNFTREGRRLEEYRKSSMPHQSLLSIQGPVFSPRRNSKTS 550

  Fly   574 HKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSR 638
                |.:.:.|....||:.               .:|||..:..........:.||..:....:.
 Frog   551 ----IFSFKDRAKDVGSEN---------------DFADDERSTFEEDSRRDPLFVPGRHRARRNS 596

  Fly   639 HSSYTSHQSRI--SYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
            :.|.||..|||  ..:.:|.:...:...||.::...|        :..:|....||| .:|:.|.
 Frog   597 NISQTSRSSRILPLLSMNGKMHSTVDCNGVVSLVGGS--------SAPIGLFPEGTT-TETDRKR 652

  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVY 766
            ....|:|.::..::....:...:  |..:.|.|:.::::               ||.  :..|.:
 Frog   653 RPSSYKISMDLMEDPSLRQRAQS--IASILTNTMEELQE---------------SRR--KCPSCW 698

  Fly   767 YFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVN 831
            |                      |..:.|.:||||..|||.:..|.|||.||||:|.||:.||:|
 Frog   699 Y----------------------KFANCFLIWDCCEAWLKVKRIVKLIVMDPFVDLAITISIVLN 741

  Fly   832 TMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLE 896
            |:|||::|..|......||.:||..||..|..|..:||:|:.|.|||||||||||.:||:|||:|
 Frog   742 TIFMAVEHAHMTPYFISVLTTGNQVFTGIFTAEMVLKLIALDPYYYFQEGWNIFDGLIVSLSLME 806

  Fly   897 LGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 961
            |||....|.||||||||||||||||||||||.||.|:|.::|||||||.||.||:|||||:||||
 Frog   807 LGLSSTGGFSVLRSFRLLRVFKLAKSWPTLNKLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 871

  Fly   962 FGKNYHDHKDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATV 1024
            |||:|.:...:..:. :||||:..||.|||:||||||||||||:|||||.| |...|:..|:..:
 Frog   872 FGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLLVFMLVM 936

  Fly  1025 VIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCF-KLIRNK 1088
            |||||||||||||||||:|.|.:|||...|::.|.|..|..||.|..:..|..:.:.| ||...|
 Frog   937 VIGNLVVLNLFLALLLSSFSSDNLSATDEDSEINNIQIAVGRIQRGVASGKIILREFFEKLFLQK 1001

  Fly  1089 L-----TNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQ 1148
            .     |.|:.:.|....|               |:.   |:..:|:              :||:
 Frog  1002 QKDINETKQLEETPGKNDT---------------CVL---GNAVVEI--------------LKEK 1034

  Fly  1149 TQLEVAIGDGMEFTIHGDMKNNKPKKSKYLN--NATDDDTASINSYGSHKNRPFKDESHKGSAET 1211
            .  :|...|||...|...::.:...:.:|:.  |.|....|...:.|.........|.....::.
 Frog  1035 N--DVRDSDGMTSEIGSSVEKSAENEKEYMTVINKTSLTVAVPIAPGESDFENPNTEEFSSESDP 1097

  Fly  1212 MEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILD-EY-----PADCCPDSYYK 1270
            .|.:||...|....|...::...|.             ...|:.|| ||     |..|..|....
 Frog  1098 EETKEKIKVSSSSEGSTIDIRAPGV-------------ERIEEFLDYEYEETFDPEPCFTDDCVA 1149

  Fly  1271 KFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDIL 1335
            .|.....:.::...:.|.|||...:.::|:.:||:.:|.|||:||.|||.||:::.||..::.||
 Frog  1150 SFTCCQINIENGTGRDWWNLRKTCYTIVEHSWFESFIIFMILLSSGALAFEDIYVEQRRNVKAIL 1214

  Fly  1336 YYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRT 1400
            .|.|::|..||.:|||:||:|.||..|||||||||||:||.:||::.:|:.:|...:.|.|::||
 Frog  1215 EYADKVFAYIFIMEMLLKWVAYGFIKYFTNAWCWLDFIIVDISLVSLIANALGYSELGAIKSLRT 1279

  Fly  1401 LRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC-EDMNG 1464
            |||||||||:||.:|||||||||:.|||||.|||||||||||||:||||.|||||::.| ...:|
 Frog  1280 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCVNTTSG 1344

  Fly  1465 TKLSHEIIPNRNACESENYT-----WVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREV 1524
            .......:.|.:.|.....|     |.|..:|||:||..||.|.||||||||:.||..|:||||:
 Frog  1345 VPFPATDVNNYSDCRMYINTTGAARWKNVKVNFDNVGAGYLALLQVATFKGWMPIMYAAVDSREI 1409

  Fly  1525 DKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1589
            ::||..|.|..||||||.||||||||||||||||||||||:||||.||. ::||||:||||||||
 Frog  1410 NEQPKYENNTTMYLYFVAFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAM 1473

  Fly  1590 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYL 1654
            ||:|||||.|.||||....|.::|:.||.:.||||||:.|.|||.||.::..|.|......|..:
 Frog  1474 KKLGSKKPQKPIPRPANCCQGLIFDFVTKQAFDIIIMILIFLNMVTMMIETDDQSQEMEMYLYRI 1538

  Fly  1655 NAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVA 1719
            ||:|:::|:.|.|||:.:||.:||...||:||:|||||||:|:.|:||||:||.||||.||:|:|
 Frog  1539 NAVFIILFTGEFLLKLISLRQYYFTIGWNIFDLVVVILSIVGMFLADIIERYFFSPTLFRVIRLA 1603

  Fly  1720 KVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYN 1784
            ::||:|||:|.|||||||||||.|||||||||.|||||||||:||||||.|.:||::|||:|::|
 Frog  1604 RIGRILRLIKAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKQSGIDDMFN 1668

  Fly  1785 FKTFGQSMILLFQMSTSAGWDGVLDAIIN--EEACDPPDNDKG--YPGNCGSATVGITFLLSYLV 1845
            |:|||.|||.|||::||||||.:|:.|:|  |..|||.....|  :.|:||:.:|||.|.:||::
 Frog  1669 FETFGNSMICLFQITTSAGWDLLLEPILNSGEPDCDPNAEHPGSLFKGDCGNPSVGIFFFVSYII 1733

  Fly  1846 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLE 1910
            ||||||:||||||||||:|.|||:..|.|.:||::|:||:|::|||..:|:|.|.:||:|.|.|:
 Frog  1734 ISFLIVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDPSASQFIEYSKLSDFADALD 1798

  Fly  1911 PPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG------NPIEETGEIGEIAAR 1969
            |||::.|||..::|:||:|:..||.::|:|||.|.||......|      .|:||.    .:.:.
 Frog  1799 PPLRVPKPNNIQLIAMDLPMVSGDRIHCLDILFAFTKRVLGEGGEMDSLRQPMEER----FMTSN 1859

  Fly  1970 PDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR 2004
            |....|||:::||.|::||..|.:||..:|:.:.:
 Frog  1860 PSKVPYEPITTTLRRKQEEQSAVVIQRCYRRFRLK 1894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 159/271 (59%)
Na_trans_cytopl 515..648 CDD:288761 31/137 (23%)
Ion_trans 835..1028 CDD:278921 119/194 (61%)
Na_trans_assoc 1054..1296 CDD:284034 51/255 (20%)
Ion_trans 1318..1571 CDD:278921 155/258 (60%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 145/238 (61%)
GPHH 1880..1930 CDD:293510 24/49 (49%)
scn2aXP_031749252.1 Ion_trans 127..408 CDD:395416 167/293 (57%)
Na_trans_cytopl 488..678 CDD:403218 51/229 (22%)
Ion_trans 727..940 CDD:395416 131/212 (62%)
Na_trans_assoc 966..1175 CDD:399489 51/255 (20%)
Ion_trans 1179..1454 CDD:395416 162/274 (59%)
Na_channel_gate 1446..1498 CDD:240441 35/52 (67%)
Ion_trans 1503..1758 CDD:395416 156/254 (61%)
GPHH 1770..1817 CDD:407139 23/46 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 345 1.000 Domainoid score I1047
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1626 1.000 Inparanoid score I77
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm48939
Panther 1 1.100 - - O PTHR10037
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
88.160

Return to query results.
Submit another query.