DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and scn5a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_031760488.1 Gene:scn5a / 100485924 XenbaseID:XB-GENE-6037407 Length:1989 Species:Xenopus tropicalis


Alignment Length:2095 Identity:957/2095 - (45%)
Similarity:1258/2095 - (60%) Gaps:326/2095 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||.|||..||:|||.|.                  .|..|| |.|.::.:|...|:|.|.||
 Frog    13 FRRFTPESLAAIEKRIAEEQ------------------ARSAKQ-ENRAEENNEGGKPRPHPDLE 58

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:| |:.|.||..|...|||||||:|.|..||:|::|||.||||||:.|::::.||:||||.
 Frog    59 AGKQLP-RIYGDFPKHLIGQPLEDIDPFYRNKKTFIVLNKGKTIFRFSATPALYIISPFHPIRRA 122

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIM-PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            :|.||||.|||:||:.|||.||:.|.| .::..::..|..|||||||||.:|::||||.|.|||:
 Frog   123 SIKILVHSLFSMFIMCTILTNCVFMAMSDSSAWLKYVEYTFTGIYTFESMIKILARGFCLKPFTF 187

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||.|..:||||::|||||||||||||::::|||||||||:|:||:.|.||
 Frog   188 LRDPWNWLDFSVIVMAYATEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVRKLADV 252

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHN---------RNSSNWY 330
            :|||:|.||||||.|||::||.|.|||::              :.||.|         .|.|.|.
 Frog   253 MILTVFCLSVFALTGLQLFMGHLKQKCVR--------------DLDYFNATRMGMLDWSNESMWS 303

  Fly   331 SEDEGISFP-------------LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAF 382
            |.:..||.|             ||||.|.||:|.|.::|:: .|.||||||||||:|||||||.|
 Frog   304 SYEAFISDPANIYHKDGAKDALLCGNSSDAGKCPDGFICMK-TGRNPNYGYTSFDTFGWAFLSLF 367

  Fly   383 RLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEE 447
            ||||||:||:|||..|||||..:|:||:.:||||||||||||||:|||:|:|..:....|..|:|
 Frog   368 RLMTQDYWENLYQQTLRAAGKTYMIFFVFVIFLGSFYLVNLILAVVAMAYEEQNQATIAEAEAKE 432

  Fly   448 EAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGND 512
            ...::|.|       :|::...|.|....|||:.....:.|..:||.                  
 Frog   433 REFQQAME-------QLKKEQEALASKGPDAASHSSCEMSPFSSKSA------------------ 472

  Fly   513 DNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSL-PGSPFNIRRGSRSSHKY 576
               ||:.:.|..:..||:....:....|........:||:|...:.. |||      |.|...:.
 Frog   473 ---KERRNRRKKKKSSETEEYGEDMKPPRGEMDEESLRKMSILGIGFGPGS------GKRRISQG 528

  Fly   577 TIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADD--SNAVTPMSEENGAIIVPVYYGNLGSRH 639
            :|.|.|.|               .:|......:|||  |||   .....|:::||     ...|.
 Frog   529 SIFNFRFR---------------NRDLCSETEFADDEVSNA---SDGHRGSLLVP-----RAGRR 570

  Fly   640 SSYTSHQSRIS------YTSHG------DLLGGMAVMG----VSTMTKESKLRNRNTRNQSVGA- 687
            .|..|..|.:|      ||.:|      |..|.::::|    .|..|....|.......:..|| 
 Frog   571 QSTQSQTSPLSFANTPGYTQNGKRNSSVDCNGVVSLVGGAGTYSNPTSPGGLLLPAVIVEKSGAE 635

  Fly   688 TNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA 752
            .|...|.|:.:.......:.:.:|..|             :|.|.|..|  ..|.||.:.:|:. 
 Frog   636 ENASPTDLELSRMQLLMPHALSVEYVD-------------QPFQRQRAV--STVSVLTNALEEL- 684

  Fly   753 GRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFD 817
                             .|...:..|.:...|        ..:.:||||.:||..::.|..:|.|
 Frog   685 -----------------EESRQKCPPCWNHFA--------QSYLIWDCCSLWLDIKDGVKFVVMD 724

  Fly   818 PFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGW 882
            ||::|.||:|||:||:|||::|:.|..|.|.:|..|||.||..|..|...|::|:.|.||||:||
 Frog   725 PFIDLTITICIVLNTLFMALEHYKMTPEFEYMLSVGNYVFTGIFTAEMVFKIIALDPYYYFQQGW 789

  Fly   883 NIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVL 947
            ||||.|||.|||:||.|..:..|||||||||||||||||||||||.||.|:|.::|||||||.||
 Frog   790 NIFDSIIVCLSLMELCLASMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 854

  Fly   948 CIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV 1011
            .||:|||||:|:||||:||.:...:. .:..||||:..||.|||:||||||||||||:|||||.|
 Frog   855 AIIVFIFAVVGVQLFGRNYFECVCKISAECKLPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEV 919

  Fly  1012 -GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVK 1075
             |...||..|:..:|||||||||||||||||:|.:.:||||..|.:.|.:..|..||.|...:||
 Frog   920 AGQPLCILVFMLVMVIGNLVVLNLFLALLLSSFSADNLSAPDEDGEMNNLQIAIARIQRGIRFVK 984

  Fly  1076 RNIADCF----------------------KLIRN-KLTNQIS-------DQPSGERTN-QIS--- 1106
            :.|.|.|                      :.|.| .|.|.|:       |...|..|| .||   
 Frog   985 KAIVDFFCNLFTRPDKPAQAFKSNLSTKNQNINNINLNNHINMSNTCKEDFREGNSTNGGISKNG 1049

  Fly  1107 --WIWSEGKG------VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTI 1163
              ::.||...      :..|:....|::::|. |:|           .||             :|
 Frog  1050 EKYVVSESDDYMTSPRLSVCVPIALGESDVEY-HEE-----------DEQ-------------SI 1089

  Fly  1164 HGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEE--KRDASKEDLG 1226
            ..|::.:|.|:        ||..:..::....|:|...::..:.|.|..:.||  ..||::.|  
 Frog  1090 FTDVEISKEKQ--------DDSISECSTVDLRKSRELIEQLPESSEEFADPEECFTEDANRPD-- 1144

  Fly  1227 LDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLR 1291
                       ..|.|               .| ..||      :..|..|..     :.|..||
 Frog  1145 -----------GTGCL---------------RY-CSCC------RIDITTGAG-----KIWWKLR 1171

  Fly  1292 LKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLA 1356
            ...|:::|:.:|||.:|.|||:||.|||.||:::.|:.:::.||.|.|::||.:|.||||:||:|
 Frog  1172 KTCFKIVEHNWFETFIIFMILLSSGALAFEDIYIDQKKVVKTILEYADKVFTYVFVLEMLLKWVA 1236

  Fly  1357 LGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVN 1421
            .|||.|||||||||||.||.:|:...:.:....|.:.:.|::|||||||||||:||.:|||||||
 Frog  1237 YGFKKYFTNAWCWLDFFIVDISVACLMVTTFSKGNVGSVKSLRTLRALRPLRALSRFEGMRVVVN 1301

  Fly  1422 ALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGT---KLSHEIIPNRNAC----E 1479
            ||:.|||||.|||||||||||||:||||.|||||:.||  :|.|   :||:..:.|::.|    .
 Frog  1302 ALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGKC--VNATTKEELSYLTVDNKSMCNDFIN 1364

  Fly  1480 SENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFI 1544
            :|.| |..:.:|||:||..||.|.||||||||:.||..|:||||:::|||.|.|.|||||||.||
 Frog  1365 TEAY-WTKTKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSREIEQQPIYEINKYMYLYFVIFI 1428

  Fly  1545 IFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQ 1609
            ||||||||||||||||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|
 Frog  1429 IFGSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQ 1492

  Fly  1610 AIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR 1674
            ..||:|||.:.||||||:.|.|||.||.::..|.|.....:|..:|..|||:||.||:|||.|||
 Frog  1493 GFVFDIVTKQAFDIIIMILICLNMVTMMVETDDQSKEIENLLYKINLAFVVLFSGECILKILALR 1557

  Fly  1675 YHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLF 1739
            |::|...||:||.|||||||:|:|||||||||||||||.||:|:|::||||||::||||||||||
 Frog  1558 YYFFTIGWNIFDFVVVILSIVGIVLSDIIEKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLF 1622

  Fly  1740 ALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGW 1804
            ||.|||||||||.|||||||||:||||||.|.:||.:|||:|::||:|||.|||.|||::|||||
 Frog  1623 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKMESGIDDMFNFQTFGNSMICLFQITTSAGW 1687

  Fly  1805 DGVLDAIINE--EACDPPDNDKGYP--GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQ 1865
            ||:|:.|:|.  ..|||...:.|.|  ||||:.:|||.|.:||::||||||:|||||:||||:|.
 Frog  1688 DGLLNPILNSGPPDCDPDIANPGSPTLGNCGNPSVGICFFVSYIIISFLIVVNMYIAIILENFSV 1752

  Fly  1866 ATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPI 1930
            |||:..|.|::||::|:||:|::||||.||:|.|..||.|.|.|..||:|.||||.|:|:||:|:
 Frog  1753 ATEESTEPLSEDDFEMFYEVWEKFDPEATQFISYSVLSNFADTLSEPLRIAKPNKIKLIAMDLPM 1817

  Fly  1931 CRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQR 1986
            ..||.::|:|||.|.||       ..:.|:||:..:         ||.|....|||:::||.|::
 Frog  1818 VSGDRIHCLDILFAFTK-------RVLGESGEMDALKVQMEEKFMAANPSKISYEPITTTLKRKQ 1875

  Fly  1987 EEYCARLIQHAWRKH 2001
            ||..|.:||.|:|:|
 Frog  1876 EEVSACVIQRAYRRH 1890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 165/293 (56%)
Na_trans_cytopl 515..648 CDD:288761 31/135 (23%)
Ion_trans 835..1028 CDD:278921 119/194 (61%)
Na_trans_assoc 1054..1296 CDD:284034 56/285 (20%)
Ion_trans 1318..1571 CDD:278921 159/259 (61%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 155/238 (65%)
GPHH 1880..1930 CDD:293510 28/49 (57%)
scn5aXP_031760488.1 Ion_trans 129..424 CDD:395416 174/309 (56%)
Na_trans_cytopl 485..675 CDD:403218 50/233 (21%)
Ion_trans 724..937 CDD:395416 131/212 (62%)
Na_trans_assoc 963..1176 CDD:399489 56/285 (20%)
Ion_trans 1180..1453 CDD:395416 167/275 (61%)
Na_channel_gate 1445..1497 CDD:240441 36/52 (69%)
Ion_trans 1502..1757 CDD:395416 166/254 (65%)
GPHH 1769..1816 CDD:407139 27/46 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 340 1.000 Domainoid score I1089
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1626 1.000 Inparanoid score I77
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm48939
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
77.060

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