DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and scn3a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_012826714.1 Gene:scn3a / 100125099 XenbaseID:XB-GENE-5812330 Length:2019 Species:Xenopus tropicalis


Alignment Length:2125 Identity:964/2125 - (45%)
Similarity:1300/2125 - (61%) Gaps:221/2125 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 RPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQ 81
            |..|||||..:|:|.|.|.                  .||..||:.|  |:|::.||:|:..||.
 Frog    15 RLLTRESLAVLEKRFAEEK------------------ARKASQKDRR--DDDDENGPKPNSDLEA 59

  Fly    82 GVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVA 146
            |..:|. :.|..|..:.:.|:||:||||||..||:|:::||.||||||:.|:::|.||||:||::
 Frog    60 GKNLPF-IYGDIPQGMVAVPMEDLDPYYSNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRRIS 123

  Fly   147 IYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTYL 210
            |.||||.|||:.|:.|||.||..|.|...|. .::.|..|||||||||.||::||||.|..||:|
 Frog   124 IKILVHSLFSMLIMCTILTNCFFMTMSNPPEWTKNVEYTFTGIYTFESLVKILARGFCLESFTFL 188

  Fly   211 RDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275
            ||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||:
 Frog   189 RDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVM 253

  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW-----GNLTDENWDYHNR----------- 324
            |||:|.||||||:|||::||.|..||::       |     .|:|    .|.|.           
 Frog   254 ILTVFCLSVFALIGLQLFMGHLRNKCVR-------WPPEYEPNIT----SYFNETAGLYINVTLN 307

  Fly   325 --NSSNWYSEDEGISF-P------LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLS 380
              |...:..|:....| |      ||||.|.||||...||||: .|.||||||||||:|.|||||
 Frog   308 PFNREEYILEETNFYFLPGTRDALLCGNSSDAGQCPKGYVCLK-TGRNPNYGYTSFDTFSWAFLS 371

  Fly   381 AFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAA 445
            .||||||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.
 Frog   372 LFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAE 435

  Fly   446 EEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKG 510
            ::||..:         ..:|:....|.:..|.|.|||......|.:....|..:| |......|.
 Frog   436 QKEAEFQ---------LMMEQLKKHQEEIQAAALAAETMDGSREFSGGTGYGGLS-ESSSEASKP 490

  Fly   511 NDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSH- 574
            :..:.||:.:.|....:.|       |.....|......:..|.||:...|..|:| .|:|.:: 
 Frog   491 SSKSAKERRNRRKKRKQKE-------QGEDEKADDEKFHKSASETSIKRKGFRFSI-EGNRLTYE 547

  Fly   575 -KYTIRNG-----RGRFGIPGSDRKPLVLS---TYQDAQQHLPYADDSNAVTPMSE-ENGAIIVP 629
             ||:..:.     ||....|..|.:..:.|   ..:|......:|||.::....:| ..|::.||
 Frog   548 KKYSSPHQSRLSFRGSLFFPRRDSRASLCSFRGRGKDVGSENDFADDEHSTFEDNESRRGSLFVP 612

  Fly   630 VYYGNLGSRHSSYTSHQSR------ISYTSHG--DLLGGMAVM-GVSTMTKESKLRNRNTRNQSV 685
            ..:|...:.:.|.||..||      ::...|.  |..|.:::: |.|..|..:.|..........
 Frog   613 HRHGERRNSNISQTSKASRTLPVLPVNGKMHSTVDCNGVVSLLGGPSGPTSPAGLLLPEVIIDKP 677

  Fly   686 GATNGGTTCLDTNHKLDHR---DYEIGLECTDEAGKIKHHDNPFIE-PVQTQTVVDMKDVMVLND 746
            .:.:.||   :|.::|..|   .|.:.::              |:| |:..|..:.:  ...|.:
 Frog   678 ASDDNGT---NTENELRKRRLSSYHVSMD--------------FLEDPILRQRALSI--ASNLTN 723

  Fly   747 IIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWV 811
            .:|:                   .|:..|..|...:|.       .:.:.:|||...|||.:..|
 Frog   724 TMEE-------------------LEESREKCPPCWNKF-------ANTYLIWDCSDSWLKIKHVV 762

  Fly   812 SLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKY 876
            :|||.||||:|.||:|||:||:||||:|:.:..|....|..||..||..|..|...||:|:.|.|
 Frog   763 NLIVMDPFVDLAITICIVLNTLFMAMEHYPITDEFAGALNVGNLVFTGIFTAEMVFKLIALDPYY 827

  Fly   877 YFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALG 941
            |||.||||||.:||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::||||
 Frog   828 YFQVGWNIFDGVIVSLSLMELGLSDVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 892

  Fly   942 NLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 1004
            |||.||.||:|||||:|||||||:|.:...:. ||. :||||:..||.|||:||||||||||||:
 Frog   893 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAPDDCELPRWHMNDFFHSFLIVFRVLCGEWIET 957

  Fly  1005 MWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIG 1068
            |||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...||:.|.:..|..|:.
 Frog   958 MWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATEDDNEMNNLQIAVARMH 1022

  Fly  1069 RFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHD 1133
            ...::|||.:.:   .|:|..   :..|.:.|.|..:..:.::...   ||| .|...|:...:|
 Frog  1023 EGIAYVKRKMRE---FIQNAF---VKKQKALEETKPLEDMQNQKDS---CIS-NHTTVEISKEYD 1077

  Fly  1134 EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNR 1198
             .|.||.:       |.....||..:|..|     .::.....:::|.:...|..| :.|.....
 Frog  1078 -YLKDGNV-------TTATSGIGSSVEKYI-----IDESDYMSFIHNPSLTVTVPI-AVGESDFE 1128

  Fly  1199 PFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADC 1263
            ....|.....::..|.:||.::|....|...::...||.|..|   .:.:....|      |..|
 Frog  1129 NLNTEEFSSESDLEESKEKLNSSSSSEGSTVDIRPAGEGEPVP---QVEVEEFQE------PDAC 1184

  Fly  1264 CPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR 1328
            ..|...::||....|.....|:.|.|||...|.::|:.:|||.:|.||||||.|||.||:::.||
 Frog  1185 FTDGCIRRFPCCVVDVSHGKWKQWWNLRKTCFLIVEHNWFETFIIFMILMSSGALAFEDIYIEQR 1249

  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQ 1393
            ..::.||.|.|::||.||.||||:||:|.||:.|||||||||||:||.|||::.:|:.:|...:.
 Frog  1250 KTIKIILEYADKVFTYIFILEMLLKWVAYGFQKYFTNAWCWLDFLIVDVSLVSLIANALGYSELG 1314

  Fly  1394 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1458
            |.|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:||||.:|:|||..
 Frog  1315 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFSGKYGY 1379

  Fly  1459 CEDMNGTK---LSHEIIPNRNACE---SENYT--WVNSAMNFDHVGNAYLCLFQVATFKGWIQIM 1515
            |  :|.|.   ..:.|:.||:.|.   |||.|  |.|..:|||:||..||.|.||||||||::||
 Frog  1380 C--VNYTDDVVFDYTIVNNRSQCMDLISENKTARWKNVKVNFDNVGFGYLALLQVATFKGWMEIM 1442

  Fly  1516 NDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1580
            ..|:|||:.::||..|.|:|||||||.||||||||||||||||||||||:||||.||. ::||||
 Frog  1443 YAAVDSRKQEEQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTE 1506

  Fly  1581 DQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASD 1645
            :||||||||||:|||||.|.:|||..:.|..||:.|:.:.|||.||:.|.|||.||.::..|.|.
 Frog  1507 EQKKYYNAMKKLGSKKPQKPVPRPDNKFQGAVFDFVSKQPFDIAIMILICLNMVTMMIETDDQSI 1571

  Fly  1646 TYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSP 1710
            .....|.::||:|:|:|:.||:||:.:||::||...||:||.|||||||:|:.|:|:||||||||
 Frog  1572 ETENNLYWINAVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLADLIEKYFVSP 1636

  Fly  1711 TLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKE 1775
            ||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:||||||.|.:||:
 Frog  1637 TLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKK 1701

  Fly  1776 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDNDKG--YPGNCGSATVG 1836
            ::||:|::||:|||.|||.|||::|||||||:|..|:|..|  |||.....|  ..|:||:.:||
 Frog  1702 EAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPKAEHSGSSVKGDCGNPSVG 1766

  Fly  1837 ITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQ 1901
            |.|.:||::||||:|:||||||||||:|.|||:..|.|.:||::|:||:|::||...||:|:|.:
 Frog  1767 IFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDSNATQFIQYVK 1831

  Fly  1902 LSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTK------DFFARKGNPIEET 1960
            |::|.|.|:|||::.|||..::|:||:|:..||.::|:|:|.|.||      |.......|:||.
 Frog  1832 LTDFADALDPPLRMPKPNNAQLIAMDLPMVSGDRIHCLDVLFAFTKRVLGEGDEMDNLRQPMEER 1896

  Fly  1961 GEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR-GEGGGSFEPDTDHG-DGGDP 2023
                .:|:.|....|||::|||.|::||..|.:||..:|.:..| |....||..:.:.| |||..
 Frog  1897 ----FMASNPSKASYEPITSTLRRKQEELAAIVIQRCYRCYALRKGIKHASFMYNQEKGKDGGSL 1957

  Fly  2024 DAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDA 2068
            ........:..:|          |.|.| .||...|..:.|..|:
 Frog  1958 LTRKDMLSDRLNG----------NSTTE-KADITPSTTSPPSYDS 1991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 169/296 (57%)
Na_trans_cytopl 515..648 CDD:288761 33/143 (23%)
Ion_trans 835..1028 CDD:278921 122/195 (63%)
Na_trans_assoc 1054..1296 CDD:284034 53/241 (22%)
Ion_trans 1318..1571 CDD:278921 164/260 (63%)
Na_channel_gate 1561..1613 CDD:240441 34/51 (67%)
Ion_trans 1636..1871 CDD:278921 147/238 (62%)
GPHH 1880..1930 CDD:293510 23/49 (47%)
scn3aXP_012826714.1 Ion_trans 151..430 CDD:278921 166/291 (57%)
Na_trans_cytopl 512..627 CDD:288761 26/115 (23%)
Ion_trans 786..982 CDD:278921 122/195 (63%)
Na_trans_assoc 1008..1216 CDD:284034 53/240 (22%)
Ion_trans 1239..1496 CDD:278921 162/258 (63%)
Na_channel_gate 1488..1540 CDD:240441 35/52 (67%)
Ion_trans 1562..1800 CDD:278921 147/237 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 345 1.000 Domainoid score I1047
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H75001
Inparanoid 1 1.050 1626 1.000 Inparanoid score I77
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm48939
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.080

Return to query results.
Submit another query.