Protein Alignment para and scn3a

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_012826714.1
• Gene: scn3a / 100125099
• XenbaseID: XB-GENE-5812330
• Length: 2019
• Species: Xenopus tropicalis
• Alignment Length: 2125
• Identity: 964/2125 - (45%)
• Similarity: 1300/2125 - (61%)
• Gaps: 221/2125 - (10%)

  Fly    17 RPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQ 81
            |..|||||..:|:|.|.|.                  .||..||:.|  |:|::.||:|:..||.
 Frog    15 RLLTRESLAVLEKRFAEEK------------------ARKASQKDRR--DDDDENGPKPNSDLEA 59

  Fly    82 GVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVA 146
            |..:|. :.|..|..:.:.|:||:||||||..||:|:::||.||||||:.|:::|.||||:||::
 Frog    60 GKNLPF-IYGDIPQGMVAVPMEDLDPYYSNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRRIS 123

  Fly   147 IYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTYL 210
            |.||||.|||:.|:.|||.||..|.|...|. .::.|..|||||||||.||::||||.|..||:|
 Frog   124 IKILVHSLFSMLIMCTILTNCFFMTMSNPPEWTKNVEYTFTGIYTFESLVKILARGFCLESFTFL 188

  Fly   211 RDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275
            ||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||:
 Frog   189 RDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVM 253

  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW-----GNLTDENWDYHNR----------- 324
            |||:|.||||||:|||::||.|..||::       |     .|:|    .|.|.
 Frog   254 ILTVFCLSVFALIGLQLFMGHLRNKCVR-------WPPEYEPNIT----SYFNETAGLYINVTLN 307

  Fly   325 --NSSNWYSEDEGISF-P------LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLS 380
              |...:..|:....| |      ||||.|.||||...||||: .|.||||||||||:|.|||||
 Frog   308 PFNREEYILEETNFYFLPGTRDALLCGNSSDAGQCPKGYVCLK-TGRNPNYGYTSFDTFSWAFLS 371

  Fly   381 AFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAA 445
            .||||||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.
 Frog   372 LFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAE 435

  Fly   446 EEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKG 510
            ::||..:         ..:|:....|.:..|.|.|||......|.:....|..:| |......|.
 Frog   436 QKEAEFQ---------LMMEQLKKHQEEIQAAALAAETMDGSREFSGGTGYGGLS-ESSSEASKP 490

  Fly   511 NDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSH- 574
            :..:.||:.:.|....:.|       |.....|......:..|.||:...|..|:| .|:|.::
 Frog   491 SSKSAKERRNRRKKRKQKE-------QGEDEKADDEKFHKSASETSIKRKGFRFSI-EGNRLTYE 547

  Fly   575 -KYTIRNG-----RGRFGIPGSDRKPLVLS---TYQDAQQHLPYADDSNAVTPMSE-ENGAIIVP 629
             ||:..:.     ||....|..|.:..:.|   ..:|......:|||.::....:| ..|::.||
 Frog   548 KKYSSPHQSRLSFRGSLFFPRRDSRASLCSFRGRGKDVGSENDFADDEHSTFEDNESRRGSLFVP 612

  Fly   630 VYYGNLGSRHSSYTSHQSR------ISYTSHG--DLLGGMAVM-GVSTMTKESKLRNRNTRNQSV 685
            ..:|...:.:.|.||..||      ::...|.  |..|.:::: |.|..|..:.|..........
 Frog   613 HRHGERRNSNISQTSKASRTLPVLPVNGKMHSTVDCNGVVSLLGGPSGPTSPAGLLLPEVIIDKP 677

  Fly   686 GATNGGTTCLDTNHKLDHR---DYEIGLECTDEAGKIKHHDNPFIE-PVQTQTVVDMKDVMVLND 746
            .:.:.||   :|.::|..|   .|.:.::              |:| |:..|..:.:  ...|.:
 Frog   678 ASDDNGT---NTENELRKRRLSSYHVSMD--------------FLEDPILRQRALSI--ASNLTN 723

  Fly   747 IIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWV 811
            .:|:                   .|:..|..|...:|.       .:.:.:|||...|||.:..|
 Frog   724 TMEE-------------------LEESREKCPPCWNKF-------ANTYLIWDCSDSWLKIKHVV 762

  Fly   812 SLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKY 876
            :|||.||||:|.||:|||:||:||||:|:.:..|....|..||..||..|..|...||:|:.|.|
 Frog   763 NLIVMDPFVDLAITICIVLNTLFMAMEHYPITDEFAGALNVGNLVFTGIFTAEMVFKLIALDPYY 827

  Fly   877 YFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALG 941
            |||.||||||.:||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::||||
 Frog   828 YFQVGWNIFDGVIVSLSLMELGLSDVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 892

  Fly   942 NLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 1004
            |||.||.||:|||||:|||||||:|.:...:. ||. :||||:..||.|||:||||||||||||:
 Frog   893 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAPDDCELPRWHMNDFFHSFLIVFRVLCGEWIET 957

  Fly  1005 MWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIG 1068
            |||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...||:.|.:..|..|:.
 Frog   958 MWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATEDDNEMNNLQIAVARMH 1022

  Fly  1069 RFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHD 1133
            ...::|||.:.:   .|:|..   :..|.:.|.|..:..:.::...   ||| .|...|:...:|
 Frog  1023 EGIAYVKRKMRE---FIQNAF---VKKQKALEETKPLEDMQNQKDS---CIS-NHTTVEISKEYD 1077

  Fly  1134 EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNR 1198
             .|.||.:       |.....||..:|..|     .::.....:::|.:...|..| :.|.....
 Frog  1078 -YLKDGNV-------TTATSGIGSSVEKYI-----IDESDYMSFIHNPSLTVTVPI-AVGESDFE 1128

  Fly  1199 PFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADC 1263
            ....|.....::..|.:||.::|....|...::...||.|..|   .:.:....|      |..|
 Frog  1129 NLNTEEFSSESDLEESKEKLNSSSSSEGSTVDIRPAGEGEPVP---QVEVEEFQE------PDAC 1184

  Fly  1264 CPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR 1328
            ..|...::||....|.....|:.|.|||...|.::|:.:|||.:|.||||||.|||.||:::.||
 Frog  1185 FTDGCIRRFPCCVVDVSHGKWKQWWNLRKTCFLIVEHNWFETFIIFMILMSSGALAFEDIYIEQR 1249

  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQ 1393
            ..::.||.|.|::||.||.||||:||:|.||:.|||||||||||:||.|||::.:|:.:|...:.
 Frog  1250 KTIKIILEYADKVFTYIFILEMLLKWVAYGFQKYFTNAWCWLDFLIVDVSLVSLIANALGYSELG 1314

  Fly  1394 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1458
            |.|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:||||.:|:|||..
 Frog  1315 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFSGKYGY 1379

  Fly  1459 CEDMNGTK---LSHEIIPNRNACE---SENYT--WVNSAMNFDHVGNAYLCLFQVATFKGWIQIM 1515
            |  :|.|.   ..:.|:.||:.|.   |||.|  |.|..:|||:||..||.|.||||||||::||
 Frog  1380 C--VNYTDDVVFDYTIVNNRSQCMDLISENKTARWKNVKVNFDNVGFGYLALLQVATFKGWMEIM 1442

  Fly  1516 NDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1580
            ..|:|||:.::||..|.|:|||||||.||||||||||||||||||||||:||||.||. ::||||
 Frog  1443 YAAVDSRKQEEQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTE 1506

  Fly  1581 DQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASD 1645
            :||||||||||:|||||.|.:|||..:.|..||:.|:.:.|||.||:.|.|||.||.::..|.|.
 Frog  1507 EQKKYYNAMKKLGSKKPQKPVPRPDNKFQGAVFDFVSKQPFDIAIMILICLNMVTMMIETDDQSI 1571

  Fly  1646 TYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSP 1710
            .....|.::||:|:|:|:.||:||:.:||::||...||:||.|||||||:|:.|:|:||||||||
 Frog  1572 ETENNLYWINAVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLADLIEKYFVSP 1636

  Fly  1711 TLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKE 1775
            ||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:||||||.|.:||:
 Frog  1637 TLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKK 1701

  Fly  1776 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDNDKG--YPGNCGSATVG 1836
            ::||:|::||:|||.|||.|||::|||||||:|..|:|..|  |||.....|  ..|:||:.:||
 Frog  1702 EAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPKAEHSGSSVKGDCGNPSVG 1766

  Fly  1837 ITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQ 1901
            |.|.:||::||||:|:||||||||||:|.|||:..|.|.:||::|:||:|::||...||:|:|.:
 Frog  1767 IFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDSNATQFIQYVK 1831

  Fly  1902 LSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTK------DFFARKGNPIEET 1960
            |::|.|.|:|||::.|||..::|:||:|:..||.::|:|:|.|.||      |.......|:||.
 Frog  1832 LTDFADALDPPLRMPKPNNAQLIAMDLPMVSGDRIHCLDVLFAFTKRVLGEGDEMDNLRQPMEER 1896

  Fly  1961 GEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR-GEGGGSFEPDTDHG-DGGDP 2023
                .:|:.|....|||::|||.|::||..|.:||..:|.:..| |....||..:.:.| |||..
 Frog  1897 ----FMASNPSKASYEPITSTLRRKQEELAAIVIQRCYRCYALRKGIKHASFMYNQEKGKDGGSL 1957

  Fly  2024 DAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDA 2068
            ........:..:|          |.|.| .||...|..:.|..|:
 Frog  1958 LTRKDMLSDRLNG----------NSTTE-KADITPSTTSPPSYDS 1991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	177/309 (57%)
		Na_trans_cytopl	555..740	CDD:463401	45/208 (22%)
		Ion_trans	817..1028	CDD:459842	135/213 (63%)
		Na_trans_assoc	1054..1296	CDD:461936	53/241 (22%)
		Ion_trans	1300..1571	CDD:459842	175/278 (63%)
		Na_channel_gate	1561..1613	CDD:240441	34/51 (67%)
		Ion_trans	1621..1871	CDD:459842	157/253 (62%)
		GPHH	1882..1929	CDD:465306	22/46 (48%)
scn3a	XP_012826714.1	Ion_trans	129..430	CDD:459842	178/313 (57%)
		Na_trans_cytopl	556..719	CDD:463401	36/181 (20%)
		Ion_trans	768..982	CDD:459842	135/213 (63%)
		Na_trans_assoc	1008..1216	CDD:461936	53/240 (22%)
		Ion_trans	1221..1496	CDD:459842	173/276 (63%)
		Na_channel_gate	1488..1540	CDD:240441	35/52 (67%)
		Ion_trans	1545..1800	CDD:459842	157/254 (62%)
		IQCD	1915..1952	CDD:467745	11/36 (31%)