DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and cacna1hb

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_021331616.1 Gene:cacna1hb / 100007317 ZFINID:ZDB-GENE-090312-128 Length:2102 Species:Danio rerio


Alignment Length:1998 Identity:489/1998 - (24%)
Similarity:841/1998 - (42%) Gaps:528/1998 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 ILVNCIL--MIMP---------TTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNW 216
            ||:||:.  |..|         ....:::.:......:..|..||::|.| :..|..||.|.||.
Zfish     4 ILLNCVTLGMFQPCQDLECHTDRCSILQAFDDFIFAFFAVEMVVKMVALG-VFGPKCYLGDTWNR 67

  Fly   217 LDFVVIALAYVTMGIDLGNL--AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTM 279
            ||..::....:...:|..|:  :|:||.||||.|:.:..||.::.:|..:::::..|.:|::|..
Zfish    68 LDLFIVMAGMLEYSLDGHNVSFSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCF 132

  Fly   280 FSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNS-SNWYSEDEGISFPL--- 340
            |...:|.::|:|::.|:|..:|.    .|.:...|      |:...| |.:|..||....|.   
Zfish   133 FVFFIFGIVGVQLWAGLLRNRCF----FDNNIRML------YNVSGSVSEYYRVDETDDIPFICS 187

  Fly   341 ---------CGN-----ISGAGQCD---DD--------------------YVCLQGFGPNPNYGY 368
                     |.|     ::|| .|:   |:                    |........||:.|.
Zfish   188 TNRENGMLRCSNVPKRRVAGA-DCELTADNVTELVFKEAPHHGCVNWNLYYNTCNASEHNPHNGA 251

  Fly   369 TSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYD 433
            .:||:.|:|:::.|:::|.:.|.|:...|:.|...::.::||.:|.:|||:::||.|.::|..:.
Zfish   252 INFDNIGYAWIAIFQVITLEGWADIMYYVMDAHSFYNFIYFIFLIIVGSFFMINLCLVVIATQFS 316

  Fly   434 ELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSC 498
            |.:::       |.:.::             |:||..::..:..|:.||..:.:.||.|...:.|
Zfish   317 ETKQR-------ENQLMQ-------------EQRARFRSNESTLASLAEPGSCYEEMLKYLAHVC 361

  Fly   499 ISY------------------------ELFVGGEKGNDDNNKEKM-------------------- 519
            ...                        .|.|||..|...:|..||                    
Zfish   362 RKLWRHVVRIYGDLCPKRRKGVANPGTSLSVGGTNGYWSDNGTKMGPTQYCMLHYHHPHQHYISN 426

  Fly   520 --SIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSR-----SSHKYT 577
              .:::::::.:             ||.|.|...:.....:|.|    :|.|..     .|..||
Zfish   427 GIEMKTLQLDRD-------------AHIAKKTPSLPLALQNLKG----LRLGMNYPTILPSKMYT 474

  Fly   578 IRNGRG------RFGIPGSDRKPLVLSTYQDAQ--QHLPYADDSNAVTPMSEENGAIIVPVYYGN 634
            ..:.||      ..||.|  ||..|...|.|..  ||..|....::|          .|....|.
Zfish   475 NSHARGVKAPAFHHGIYG--RKISVCGGYHDTYKLQHGVYPGTCSSV----------CVDSRVGL 527

  Fly   635 LGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNH 699
            :.|:.||..      .....||                                  |..| |:|.
Zfish   528 VSSQSSSCP------ICAQEGD----------------------------------GVNC-DSNG 551

  Fly   700 KLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRG-- 762
            :.|                 .....|.:...|.:|.:|.::                :.|::.  
Zfish   552 ESD-----------------PEKQGPDVGSEQRKTNLDAEE----------------KVSEKRNC 583

  Fly   763 --VSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFIT 825
              :.|:|                 ...:||                      .||...:....|.
Zfish   584 VCMCVHY-----------------ARAVLK----------------------RIVDSKYFNRGIM 609

  Fly   826 LCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIV 890
            :.|::||:.|.:::|:...|:..||:..|..||:.|.:|..:||.|.....|....:||||.|||
Zfish   610 IAILINTLSMGVEYHEQPDELTDVLEISNIVFTSLFVLEMLLKLSACGLFDYISNPYNIFDGIIV 674

  Fly   891 ALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFA 955
            .:|:.|:..:...|.||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:
Zfish   675 IISVCEIVGQADGGFSVLRTFRLLRVLKLVRFLPALRRQLVVLMKTMDNVATFCMLLMLFIFIFS 739

  Fly   956 VMGMQLFGKNYHDHKDRFPDGDL--PRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVGDVSCI 1017
            ::||.|||..:   ..|..:||.  .|.||...:.:.:.||::|..|    .|: .:|.|..|..
Zfish   740 ILGMHLFGCKF---TLRLENGDTVSDRKNFDSLLWAIVTVFQILTQE----DWNVVLYNGMASTS 797

  Fly  1018 P----FFLATVVIGNLVVLNLFLALLLSNF---GSSSLSAPTAD-----NDTNKIAEAFNRIGRF 1070
            |    :|:|.:..||.|:.||.:|:|:..|   |.:|.|....|     .|.:|:.|..|     
Zfish   798 PYAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDASRSDTDDDMSSDYGDEDKLRELLN----- 857

  Fly  1071 KSWVKRNIADCFKLIRNKLTNQISDQP--------SGERTNQISWIWSEGKGVCRCISAEHGDNE 1127
             |..:..:.....:....|..:.|..|        |..|| ::|.|:|:        |..:.:..
Zfish   858 -SGTEMKMQTLMPISNGHLEPRASMPPNNTHVQFNSTPRT-EVSHIYSQ--------SRRNSNTS 912

  Fly  1128 LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSY 1192
            .|| ||:                                         :.|::......:|.||.
Zfish   913 TEL-HDQ-----------------------------------------RSLSSLWGSRRSSWNSL 935

  Fly  1193 GSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEG--------------------EC 1237
            |...|...:.:|  |..|::.....||:..::|..||:....|                    ||
Zfish   936 GHAPNLLRRAQS--GERESLLSGPGRDSIDDNLSEDEKSSLGGVSCLGSFDFPELLQVPRPYLEC 998

  Fly  1238 EEGPLDGDI-----IIH--------AHDED-----------ILDEYPADCCPD----SYYKKFPI 1274
             .|.|||..     |.|        |.|::           :|:.|....|.|    |.|...| 
Zfish   999 -NGRLDGGYNSSPNITHPEPTSTQGAEDDEFEESWCLILKRLLEPYKPQWCRDHEDWSLYLFAP- 1061

  Fly  1275 LAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQD------ 1333
                        ..|.|::..::|.:|.|:..|:..|..:.:.:|||      ||.:|.      
Zfish  1062 ------------QNNFRMRCQKVITHKMFDHIVLFFIFFNCITIALE------RPDIQPDSTERI 1108

  Fly  1334 ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLVGAGG--- 1391
            .|...:.||||||..||.:|.::||...    |..::|..||..:|.||:::.:.||..:||   
Zfish  1109 FLKVSNYIFTVIFVAEMTVKVVSLGLYAGPGSYLKSSWNVLDGFLVFVSIVDILVSLASSGGNRI 1173

  Fly  1392 IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1456
            :...:.:|.||.|||||.:||..|:::||..|:.::..|.|::|:|..|:::|.|:|||||.||:
Zfish  1174 LGILRVLRLLRTLRPLRVISRAPGLKLVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKF 1238

  Fly  1457 FKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDS 1521
            :.||..:...     |.|::.|....|.|:....|||::|.|.:.||.:::..||:.||.|.:|:
Zfish  1239 YHCEGFDTRN-----ITNKSECLQAKYKWIRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA 1298

  Fly  1522 REVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYY 1586
            ..||:||||..|.:|.|||:.|::..|||.||:|:||:::||::.::      :....|.:::..
Zfish  1299 VAVDQQPIRNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQ------DQEEEEARRREE 1357

  Fly  1587 NAMKKMGSKKPLKAIPRPRWR----PQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTY 1647
            ...|:| .||..||:.||.:.    .:..:..:.|....|:.|.:.|.:|:.||:::.|......
Zfish  1358 KRQKRM-EKKRRKALQRPYYADYSPTRLYIHTLCTSHYLDLFITIIIAINVLTMSMEHYRQPKYL 1421

  Fly  1648 NAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLS--DIIEKYFVS 1709
            :..|.|.|..|.::|..|..||:.|..: .:|.|.||..|:.:|:|||:|:.|.  |:.....::
Zfish  1422 DEGLKYCNYFFTLVFVIEAALKLVAFGFRRFFKERWNQLDLAIVLLSIMGITLEEIDLNASLPIN 1486

  Fly  1710 PTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MH 1772
            ||::|::||.::.|||:|:|.|.|:|.||..:..:||.:.|:.||..|:.||:|..|:..|  :.
Zfish  1487 PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLD 1551

  Fly  1773 VKEKS---GINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGS-- 1832
            ..|::   |::....|:.||.:.:.||::||...|:|::...:.|  |   .|||     |.|  
Zfish  1552 CTEENPCEGLSRHATFQNFGMAFLTLFRVSTGDNWNGIMKDTLRE--C---KNDK-----CLSYL 1606

  Fly  1833 ATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDP------ 1891
            ..:...:.:::::::..:::|:.:||::::..::..|.:|     :.:|..|:..:.:.      
Zfish  1607 PLLSPLYFVTFVLMAQFVLVNVVVAVLMKHLEESNIDARE-----EAEMDAELKLELEAGRRQST 1666

  Fly  1892 ---------EGT----QYIRYDQ-----LSEFLDVLEPPL--QIHKPN 1919
                     |||    :.:.:||     ...||.|..|.:  .:..||
Zfish  1667 ASVGGAAGLEGTDAKIETLSHDQGKDPNYGNFLTVGRPSISRMLSLPN 1714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 80/324 (25%)
Na_trans_cytopl 515..648 CDD:288761 33/167 (20%)
Ion_trans 835..1028 CDD:278921 67/199 (34%)
Na_trans_assoc 1054..1296 CDD:284034 54/302 (18%)
Ion_trans 1318..1571 CDD:278921 99/265 (37%)
Na_channel_gate 1561..1613 CDD:240441 11/55 (20%)
Ion_trans 1636..1871 CDD:278921 71/244 (29%)
GPHH 1880..1930 CDD:293510 13/66 (20%)
cacna1hbXP_021331616.1 Ion_trans 1..323 CDD:306908 82/337 (24%)
Ion_trans 601..828 CDD:306908 78/233 (33%)
Ion_trans 1075..1347 CDD:306908 103/288 (36%)
Ion_trans 1392..1597 CDD:306908 66/206 (32%)
Herpes_TAF50 <1739..2026 CDD:308764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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