DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S-Lap4 and lap3

DIOPT Version :9

Sequence 1:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001108319.1	Gene:	lap3 / 562854	ZFINID:	ZDB-GENE-060719-1	Length:	517	Species:	Danio rerio

Alignment Length:	494	Identity:	204/494 - (41%)
Similarity:	299/494 - (60%)	Gaps:	14/494 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SKSSKGLVVGVYQKENDND-PKLTPAGEKVNDRLHGKLQEMICQSKITGHLGRGKIFNNIDPEFR 95
            |.:.||||:|||::::|:| ..||.|....:..|.|:|.||:..|......|:.:||..:..:|.
Zfish    28 SSTRKGLVLGVYEQQSDSDGVSLTEAAAAFDRSLSGRLSEMLSLSGPPLKKGKSRIFYGLHQDFP 92

  Fly    96 SMAVVGVGLEGIGFNELEMLDEGMENVRVAAGIGARSLQEIGVSEVFVDGMDYAEQAAEGAVLAV 160
            |:.|||:|....|....|..|...||:|.|...|.|.||::.|:.|.||.....:.|||||||.:
Zfish    93 SVVVVGLGKSDPGVCGKENWDNCKENIRAAVSAGCRQLQDLEVALVEVDPCGDDQSAAEGAVLGL 157

  Fly   161 WRYCDMNSKRKPPHIPKLELYESPDYEGWTRGVFKAEAQNLARRMCDTPACCMTPTLFAQATVD- 224
            :.|.::.:|:| .|: |...:.|.|...|.:||...:.|||||::.:.||..:|||:||. |::
Zfish   158 FEYDELKTKKK-VHV-KTRPHGSVDAAAWQKGVLYGDGQNLARQLMEAPANHVTPTVFAN-TIEQ 219

  Fly   225 --ALCPCGITVEIRTMEWIEQQRLHSFLMIAKGSCEPPVLMEITYCGTNPE-DKPILFLGKGITF 286
              :|....:.|..|...|||.:::.:||.::|||.||||.:|:.|.|::.. ..|::.:||||||
Zfish   220 KLSLFADRVIVHKRPQSWIEGEQMGAFLSVSKGSEEPPVFLELHYKGSSDSAQPPLVLVGKGITF 284

  Fly   287 NSGAMNLRKCRGMEEYRACMSGAASCVAMMRCVAALALPINVCCIIPLCENMPSGMACKPGDVVT 351
            :||.::|:...||:..||.|.|||:..:.:...|||.:|||:..:.|||||||||.|.||||||.
Zfish   285 DSGGISLKPSSGMDAMRADMGGAATVCSAIVTAAALKIPINIIGLAPLCENMPSGKANKPGDVVR 349

  Fly   352 LMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKPRLVVDVATLGSGVKKAFGGGATGIFSNSHYIW 416
            ..|.|::.:.|.|..|.:::||.|.|..| :|||.:::.|||...:..|.|..|||:|:||.::|
Zfish   350 AKNGKTIQIDNTDAEGRLILADALCYAHS-FKPRAIINAATLTGAMDVALGSAATGVFTNSDWLW 413

  Fly   417 KQFQSAGALTGDRVWRLPLWNYYRKQITDEMGYDLSNDGR--GLANSCLAAAVLHELVPCVDWAH 479
            ::...|..:|||||||:||:.:|.||:||....||:|.|:  ....:|.|||.|.|.|....|||
Zfish   414 ERLHKASVVTGDRVWRMPLFQHYTKQVTDSALADLNNVGKYSRSGGACTAAAFLKEFVSANHWAH 478

  Fly   480 LDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFLYQMA 518
            ||.  .|::|....|||| .|.|:|||||||.:|:..:|
Zfish   479 LDI--AGVMTNKDEVPYL-RKGMSGRPTRTLVEFIAGLA 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	202/488 (41%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	201/485 (41%)
lap3	NP_001108319.1	Peptidase_M17	32..510	CDD:238247	201/484 (42%)
lap3	NP_001108319.1	PRK00913	34..511	CDD:234863	200/483 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	O	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.710