DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap4 and loopin-1

DIOPT Version :9

Sequence 1:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001097338.1	Gene:	loopin-1 / 36847	FlyBaseID:	FBgn0259795	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	290/522 - (55%)
Similarity:	380/522 - (72%)	Gaps:	7/522 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNKLRNVLKSVVQRRLPVSHLIQIR---TACGGESKSSKGLVVGVYQKENDNDPKLTPAGEKVND 62
            |:.:|..|:.|.|.|...|.:...|   |:|    ||.||:|||||.|:.|...|.|.....::|
  Fly     7 MSLVRAGLRMVRQNRSGQSVIPSYRRYATSC----KSPKGVVVGVYTKDGDKPSKTTANAVTLDD 67

  Fly    63 RLHGKLQEMICQSKITGHLGRGKIFNNIDPEFRSMAVVGVGLEGIGFNELEMLDEGMENVRVAAG 127
            .|.|||..:|.:..:.|..|:|.:|:..:.|::::||||||.:|..:||.|.|||||||||||||
  Fly    68 ALGGKLLTLIRERGMDGTPGKGLLFSGFEGEYQAVAVVGVGKQGAAYNENEELDEGMENVRVAAG 132

  Fly   128 IGARSLQEIGVSEVFVDGMDYAEQAAEGAVLAVWRYCDMNSKRKPPHIPKLELYESPDYEGWTRG 192
            .|||:||..|:.||.||.|||.|||||||.||||||.....|:.....|||::|...|.:.|.||
  Fly   133 TGARALQLQGMYEVHVDSMDYPEQAAEGAALAVWRYNANKRKKNRIQTPKLDMYGKGDRDAWVRG 197

  Fly   193 VFKAEAQNLARRMCDTPACCMTPTLFAQATVDALCPCGITVEIRTMEWIEQQRLHSFLMIAKGSC 257
            :||||:||||||:.||||..|||::||||.||||||||::||:|:|:|||...|:||||||||||
  Fly   198 LFKAESQNLARRLSDTPANMMTPSIFAQAAVDALCPCGVSVEVRSMDWIEDMNLNSFLMIAKGSC 262

  Fly   258 EPPVLMEITYCGTNPEDKPILFLGKGITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRCVAAL 322
            |||:|:|.:||||.|||:|:|.||:|:||:||.:.|:...||::||..|:|||.||.::|..|||
  Fly   263 EPPLLLECSYCGTTPEDRPVLLLGQGLTFHSGGLCLKPKTGMDQYRGAMAGAAVCVGVLRAAAAL 327

  Fly   323 ALPINVCCIIPLCENMPSGMACKPGDVVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKPRLV 387
            :||:|:..::||||:||||||.|.||||||:|..:|.::|:|||.||.:||||||.|:||||:||
  Fly   328 SLPLNITAVMPLCEHMPSGMAVKCGDVVTLLNGTTMGIKNVDKAPVVQLADPLLYAQATYKPKLV 392

  Fly   388 VDVATLGSGVKKAFGGGATGIFSNSHYIWKQFQSAGALTGDRVWRLPLWNYYRKQITDEMGYDLS 452
            :|:.|:..||..|.||||:|:::.|..:|:.|:.:|.||||||||.||:.||::.:...:.|||.
  Fly   393 IDIGTVAMGVNYAVGGGASGLWTTSKSVWQNFRKSGGLTGDRVWRFPLFKYYKQIVNKNITYDLC 457

  Fly   453 NDGRGLANSCLAAAVLHELVPCVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFLYQM 517
            |.|||.|:||||||:||.||||.:|||||.||||:.|.....|||....||||||||:.||:|||
  Fly   458 NTGRGPASSCLAAAILHTLVPCAEWAHLDIRGTGMTTTINPRPYLLKDSMTGRPTRTVIQFMYQM 522

  Fly   518 AC 519
            ||
  Fly   523 AC 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	274/482 (57%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	272/478 (57%)
loopin-1	NP_001097338.1	Peptidase_M17	41..518	CDD:238247	271/476 (57%)
loopin-1	NP_001097338.1	PRK00913	43..519	CDD:234863	270/475 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472691
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	1	1.000	-	-		H114266
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19815at7147
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	12	11.800