DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap4 and S-Lap7

DIOPT Version :9

Sequence 1:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001260959.1	Gene:	S-Lap7 / 36524	FlyBaseID:	FBgn0033868	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	392/526 - (74%)
Similarity:	457/526 - (86%)	Gaps:	8/526 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNKLRNV---LKSVVQRRLPVSHLIQ---IRTACGGESKSSKGLVVGVYQKENDNDPKLTPAGEK 59
            |||||.:   ||:......|  |::.   :|.:||.....:||:|||:||||.|.||||||||.|
  Fly     1 MNKLRQIHCSLKNACVLCKP--HVLSSAGVRFSCGDGKTMAKGVVVGLYQKEGDKDPKLTPAGHK 63

  Fly    60 VNDRLHGKLQEMICQSKITGHLGRGKIFNNIDPEFRSMAVVGVGLEGIGFNELEMLDEGMENVRV 124
            ::.|:.|||.:.||::|:.|.|||||:|:|||.||.::|||||||||||||||||||||||.|||
  Fly    64 IDQRVQGKLMKAICETKLDGRLGRGKVFHNIDTEFAAVAVVGVGLEGIGFNELEMLDEGMEFVRV 128

  Fly   125 AAGIGARSLQEIGVSEVFVDGMDYAEQAAEGAVLAVWRYCDMNSKRKPPHIPKLELYESPDYEGW 189
            |||:||||||:.|::.|.|||||||||||||:.|||||:.|..||:..|.:|.|||:||||:|||
  Fly   129 AAGVGARSLQQQGITNVLVDGMDYAEQAAEGSQLAVWRFPDNLSKKNMPMVPTLELFESPDHEGW 193

  Fly   190 TRGVFKAEAQNLARRMCDTPACCMTPTLFAQATVDALCPCGITVEIRTMEWIEQQRLHSFLMIAK 254
            |||:|||||||||||:.|.||.|||||:||||.||||||||||||:|||:|||.|||::||||||
  Fly   194 TRGIFKAEAQNLARRLSDAPANCMTPTMFAQAAVDALCPCGITVEVRTMDWIEAQRLNAFLMIAK 258

  Fly   255 GSCEPPVLMEITYCGTNPEDKPILFLGKGITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRCV 319
            ||||||||:|::||||.|:||||||:||||||||||:|||.||||:|||..||.||.|||||||:
  Fly   259 GSCEPPVLLELSYCGTAPDDKPILFVGKGITFNSGALNLRPCRGMDEYRGSMSAAACCVAMMRCI 323

  Fly   320 AALALPINVCCIIPLCENMPSGMACKPGDVVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKP 384
            |||:|||||.|||||||||||||:.||||||||:|.||||:|:||||||||::|||||||.||.|
  Fly   324 AALSLPINVTCIIPLCENMPSGMSAKPGDVVTLLNGKSMAIRDLDKAGVVVLSDPLLYGQKTYLP 388

  Fly   385 RLVVDVATLGSGVKKAFGGGATGIFSNSHYIWKQFQSAGALTGDRVWRLPLWNYYRKQITDEMGY 449
            |||||:|||.:|||||||||||||:|||||||||||.||:::||||||||||.|||:|:|||..|
  Fly   389 RLVVDIATLNTGVKKAFGGGATGIWSNSHYIWKQFQRAGSISGDRVWRLPLWQYYRRQVTDERAY 453

  Fly   450 DLSNDGRGLANSCLAAAVLHELVPCVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFL 514
            ||||:|||||:||||||:|||||||||||||||||||||:|||||||||.|.|||||||||.||:
  Fly   454 DLSNNGRGLASSCLAAAILHELVPCVDWAHLDTRGTGLLSKYGLVPYLTKKRMTGRPTRTLVQFV 518

  Fly   515 YQMACP 520
            ||||||
  Fly   519 YQMACP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	373/482 (77%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	373/478 (78%)
S-Lap7	NP_001260959.1	PRK00913	36..518	CDD:234863	373/481 (78%)
S-Lap7	NP_001260959.1	Peptidase_M17	39..518	CDD:238247	373/478 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472683
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	1	1.000	-	-		H114266
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19815at7147
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	13	12.750