DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap4 and S-Lap2

DIOPT Version :9

Sequence 1:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_729394.1	Gene:	S-Lap2 / 326209	FlyBaseID:	FBgn0052351	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	200/501 - (39%)
Similarity:	299/501 - (59%)	Gaps:	23/501 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SKGLVVGVYQKEND-NDPK-LTPAGEKVN-DRLHGKLQEMICQSKITGHLGRGKIFNNIDPE--- 93
            |:|||||||..|.| ||.. |||.|.|.| .:.||:|.|::..|......|..::...::||
  Fly    50 SRGLVVGVYADEEDKNDAGILTPTGWKYNVQKTHGRLLEVLRMSGPMPKRGETRLLFAVEPERVP 114

  Fly    94 -FRSMAVVGVGLEGIGFNELEMLDEGMENVRVAAGIGARSLQEIGVSEVFVDGMDYAEQAAEGAV 157
             :.::||:|:|.|.:|:|..|:|||..|.:|.:.....|.|.|:....:.|:...:||.|||||.
  Fly   115 YYSAVAVIGLGKECLGYNPYEVLDEQKEAIRRSVADACRILAELDTDRIEVENCGHAESAAEGAA 179

  Fly   158 LAVWRYCDMNSKRKPPHIPKLELY----ESPDYEGWTRGVFKAEAQNLARRMCDTPACCMTPTLF 218
            |.:|.|.::...::...:|.::||    |..|.|||..|:.||.||||.|::.:.|:..:|||.|
  Fly   180 LGIWIYQELRDPKRRISVPSIDLYATKDEICDIEGWRIGLQKAAAQNLTRQLQEMPSNLLTPTAF 244

  Fly   219 AQATVDALCPCGITVEIRTMEWIEQQRLHSFLMIAKGSCEPPVLMEITYCGTNPEDKPILFLGKG 283
            ||..|:.||..|:.||::...|.|.|.:|:||.:.|.|||||:.:|::|.||..|::||:.:|:|
  Fly   245 AQNVVEVLCKSGVNVEVKVEGWAESQSMHAFLAVGKASCEPPIFLELSYYGTCAEERPIVLVGQG 309

  Fly   284 ITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRCVAALALPINVCCIIPLCENMPSGMACKPGD 348
            :|:::|.:.|::.:.:...|..|:|||..||..|.||.|.||:|:..:||||||:....:.:|||
  Fly   310 VTYDAGGLCLKEKQELFHMRGDMTGAAVVVATCRAVAGLRLPVNIRGLIPLCENVIGCNSFRPGD 374

  Fly   349 VVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKPRLVVDVATLGSGVKKAFGGGATGIFSNSH 413
            :|..||.|::.|:..|...|:|:||.|||||: :.|:.::|:.|....:::|....|.|:|:||.
  Fly   375 MVKSMNGKTIEVQCTDHEDVLVLADALLYGQN-FCPKCIIDIGTCSGYMRQALDEAACGVFTNSE 438

  Fly   414 YIWKQFQSAGALTGDRVWRLPLWNYYRKQI-----TDEMGYDLSNDGRGLANSCLAAAVLHELVP 473
            .:|:|.:.|...|||||||.||||||.|.:     :|...|.:...||    .|.|||.|.|.||
  Fly   439 ILWQQIKHASMHTGDRVWRFPLWNYYSKAVRAGGRSDVQNYGIGRGGR----PCKAAAFLREFVP 499

  Fly   474 CVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFLYQMAC 519
            |..|.|:|.... ::|:.....|| .:.|.|||||||.:|:.|..|
  Fly   500 CGQWMHIDATNV-MITRGDEFEYL-REGMAGRPTRTLIEFIAQSIC 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	197/494 (40%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	197/494 (40%)
S-Lap2	NP_729394.1	Peptidase_M17	52..538	CDD:238247	196/492 (40%)
S-Lap2	NP_729394.1	PRK00913	53..539	CDD:234863	196/492 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472704
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	12	11.750