DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S-Lap4 and S-Lap3

DIOPT Version :9

Sequence 1:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001261679.1	Gene:	S-Lap3 / 326187	FlyBaseID:	FBgn0045770	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	360/518 - (69%)
Similarity:	428/518 - (82%)	Gaps:	8/518 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RLPVSHLIQIRT--------ACGGESKSSKGLVVGVYQKENDNDPKLTPAGEKVNDRLHGKLQEM 71
            |..||.:.||.:        |.|...|..||:|:|:|:||:...|:|||||||.:||:.|||.|:
  Fly    18 RCRVSAVPQIGSVRHVTAGCAAGDTVKGGKGIVLGLYEKESGKGPRLTPAGEKFDDRVQGKLSEL 82

  Fly    72 ICQSKITGHLGRGKIFNNIDPEFRSMAVVGVGLEGIGFNELEMLDEGMENVRVAAGIGARSLQEI 136
            :|::|:||.|||||:|||:|.||||:.|||||||||.|||||||||||||||:||||||||||.|
  Fly    83 VCETKLTGRLGRGKVFNNVDSEFRSICVVGVGLEGIAFNELEMLDEGMENVRIAAGIGARSLQSI 147

  Fly   137 GVSEVFVDGMDYAEQAAEGAVLAVWRYCDMNSKRKPPHIPKLELYESPDYEGWTRGVFKAEAQNL 201
            |.|||.||.|||||||||||.||:|||.:..:|:....||||||:.|||.|.||||:||||||||
  Fly   148 GCSEVHVDNMDYAEQAAEGAALAIWRYEENLAKKYRSTIPKLELHGSPDVESWTRGLFKAEAQNL 212

  Fly   202 ARRMCDTPACCMTPTLFAQATVDALCPCGITVEIRTMEWIEQQRLHSFLMIAKGSCEPPVLMEIT 266
            |||:||.||.|||||:.|||.||:|||||||||:|||||||||.|:|||||||||||||||:|:.
  Fly   213 ARRLCDAPANCMTPTIVAQAAVDSLCPCGITVEVRTMEWIEQQHLNSFLMIAKGSCEPPVLLEVA 277

  Fly   267 YCGTNPEDKPILFLGKGITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRCVAALALPINVCCI 331
            ||||.|||||||.:|:|||||||.:|||.|:||:|:|..::|||..:|.||..|||:||||:..:
  Fly   278 YCGTAPEDKPILLVGQGITFNSGGINLRPCKGMDEFRGDLTGAACILAAMRAAAALSLPINITAV 342

  Fly   332 IPLCENMPSGMACKPGDVVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKPRLVVDVATLGSG 396
            ||||||:||||:|||||||||:|.||:||||:.:.||||::||:||||.||||||||||.::..|
  Fly   343 IPLCENLPSGMSCKPGDVVTLLNSKSLAVRNISRTGVVVISDPMLYGQITYKPRLVVDVGSMCKG 407

  Fly   397 VKKAFGGGATGIFSNSHYIWKQFQSAGALTGDRVWRLPLWNYYRKQITDEMGYDLSNDGRGLANS 461
            ||||.|||||||:|||||||||||.||:|||||:||.|||.||:.::.:.:.:||.|||.|.|:|
  Fly   408 VKKAVGGGATGIWSNSHYIWKQFQRAGSLTGDRLWRFPLWRYYKDRVAEHLSFDLLNDGEGYASS 472

  Fly   462 CLAAAVLHELVPCVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFLYQMACPANQK 524
            |||||||||||||.|||||||.|||||:.|||:|||||..|||||||||.|||||:|||...|
  Fly   473 CLAAAVLHELVPCSDWAHLDTYGTGLLSTYGLIPYLTAGRMTGRPTRTLVQFLYQIACPEQPK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	345/482 (72%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	344/478 (72%)
S-Lap3	NP_001261679.1	Peptidase_M17	47..525	CDD:238247	344/477 (72%)
S-Lap3	NP_001261679.1	PRK00913	49..525	CDD:234863	342/475 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472684
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	1	1.000	-	-		H114266
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19815at7147
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	13	12.750