DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb1 and PLSCR4

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001121776.1	Gene:	PLSCR4 / 57088	HGNCID:	16497	Length:	329	Species:	Homo sapiens

Alignment Length:	399	Identity:	148/399 - (37%)
Similarity:	181/399 - (45%)	Gaps:	77/399 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGFQPNAPPAEGFGYPPPTGG-HNAPYPPAPGHPQPPPPTNYGFMPGPQPAGYAPVPQMPPYGEA 80
            ||..|.||       ..|.|. .|...||.| .|..||..|..|:|||.
Human     2 SGVVPTAP-------EQPAGEMENQTKPPDP-RPDAPPEYNSHFLPGPP---------------- 42

  Fly    81 PPYGAGQPPYMGGPGGQPPYAGGPGGQPPYVGGPGGQPHYGGGAPPPQAFGGYPPGPAGPGGPPN 145
               |...||..|.|||.|                               .|.|.|      ..|:
Human    43 ---GTAVPPPTGYPGGLP-------------------------------MGYYSP------QQPS 67

  Fly   146 AFGGYPPGQPQQPIVTQPGMGPGMGPGMAPQGGPAGDWMSIPTGIPNCPRGLEYLTTIDQLLVKQ 210
            .|..|.|.....|:..|||..|     |..|..|. .||..||.:.|||.|||||..:|.:.|.|
Human    68 TFPLYQPVGGIHPVRYQPGKYP-----MPNQSVPI-TWMPGPTPMANCPPGLEYLVQLDNIHVLQ 126

  Fly   211 KVELLEAFTGFETNNKFTIKNALGQKVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHR 275
            ..|.||..|.|||||::.|||...|.||...||.|..|||.....|||.:||.|...:|::.|.|
Human   127 HFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDCMGREIMTMQR 191

  Fly   276 PLACSSCLFPCC---LQSIEVSAPPGNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFCTFSL 337
            |..|:.|.| ||   .|.:||..|||..||.:.:.|::|...:.|.|...:.|||:.||..|:..
Human   192 PFRCTCCCF-CCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGC 255

  Fly   338 CGDVEFNVVSLTG-EKIGKISKQWSGLAREIFTDADFFGINFPLDLDVRMKAVLLGATFLIDAMF 401
            ..|..|.|.||.| ..||.|.::|:||. ....|||.|.|:|||||||:|||::.||.||||.|:
Human   256 GSDSVFEVKSLDGISNIGSIIRKWNGLL-SAMADADHFDIHFPLDLDVKMKAMIFGACFLIDFMY 319

  Fly   402 FEKAGNQET 410
            ||::..|.:
Human   320 FERSPPQRS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887	11/67 (16%)
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	103/223 (46%)
PLSCR4	NP_001121776.1	Proline-rich domain (PRD). /evidence=ECO:0000250	1..98		42/165 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		22/75 (29%)
		SH3-binding 1. /evidence=ECO:0000255	18..25		3/6 (50%)
		PPxY motif. /evidence=ECO:0000255	30..33		2/2 (100%)
		Atrophin-1	<36..100	CDD:331285	27/125 (22%)
		SH3-binding 2. /evidence=ECO:0000255	41..49		3/26 (12%)
		SH3-binding 3. /evidence=ECO:0000255	98..106		4/7 (57%)
		Scramblase	100..322	CDD:252175	103/223 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880