DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scramb1 and PLSCR1

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_016862117.1	Gene:	PLSCR1 / 5359	HGNCID:	9092	Length:	319	Species:	Homo sapiens

Alignment Length:	350	Identity:	170/350 - (48%)
Similarity:	203/350 - (57%)	Gaps:	59/350 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PPTNYGFMPGPQPAGYAPVPQMPPYGEAPPYGAGQPPYMGGPGGQPPYAGGPGGQPPYVGGPGGQ 117
            |.||.       |.||.  ||.||           ..:.|.||    |:|.||
Human    13 PETNL-------PVGYP--PQYPP-----------TAFQGPPG----YSGYPG------------ 41

  Fly   118 PHYGGGAPPPQAFGGYPPGPAGPGGPPNAFGGYPPGQPQQPIVTQPGMGPGMGPGMAPQGGPAGD 182
                     ||.  .|||.|||..||..|  |:|  .|.||:..||.....:|....|
Human    42 ---------PQV--SYPPPPAGHSGPGPA--GFP--VPNQPVYNQPVYNQPVGAAGVP------- 84

  Fly   183 WMSIPTGIPNCPRGLEYLTTIDQLLVKQKVELLEAFTGFETNNKFTIKNALGQKVYFAAEDNDCC 247
            ||..|....|||.|||||:.|||:|:.|::||||..||||||||:.|||:.||:|||||||.|||
Human    85 WMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCC 149

  Fly   248 TRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSSCLFPCCLQSIEVSAPPGNVIGTIEQEWSICS 312
            |||||||:|||.:|:.||..||||.:.|||.||||..|||||.||:.||||..||.:.|.|..|.
Human   150 TRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCL 214

  Fly   313 PSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVVSLTGE-KIGKISKQWSGLAREIFTDADFFGI 376
            |.|.|.|...:.|::|.||....|.||||:|.:.||..: .:|||||.|:|:.||.|||||.|||
Human   215 PKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGI 279

  Fly   377 NFPLDLDVRMKAVLLGATFLIDAMF 401
            .|||||||:||||::||.|||.::|
Human   280 QFPLDLDVKMKAVMIGACFLIVSLF 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887	15/67 (22%)
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	131/218 (60%)
PLSCR1	XP_016862117.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154996
Domainoid	1	1.000	288	1.000	Domainoid score	I1579
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41418
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2483
Isobase	1	0.950	-	0	Normalized mean entropy	S1940
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		mtm8657
orthoMCL	1	0.900	-	-		OOG6_100156
Panther	1	1.100	-	-	LDO	PTHR23248
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1891
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740