DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb1 and plscr3b

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_998031.1	Gene:	plscr3b / 405802	ZFINID:	ZDB-GENE-040426-2517	Length:	314	Species:	Danio rerio

Alignment Length:	322	Identity:	175/322 - (54%)
Similarity:	210/322 - (65%)	Gaps:	22/322 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 MGGPGGQPPYAGGPGGQPPYVGGPGGQPHYGGGAPPPQAFGGYPPGPAGPGGPPNAFG-GYPPGQ 154
            |.|||...|      .||||   |..||  ||.:.||...|||  |..|...||..|. ||.| .
Zfish     1 MSGPGYPSP------NQPPY---PMSQP--GGHSMPPYPMGGY--GDPGQNAPPAGFQVGYQP-V 51

  Fly   155 PQQPIVTQPG-MGPGMGPGMAPQGGPAGDWMSIPTGIP-NCPRGLEYLTTIDQLLVKQKVELLEA 217
            |.|||:.||| :.||..||. |.|.||.  :..|..:| ..|.||||||.|||:|:.||||||||
Zfish    52 PDQPIMYQPGPVSPGPQPGQ-PYGVPAA--VPAPIAVPAGVPPGLEYLTQIDQILIHQKVELLEA 113

  Fly   218 FTGFETNNKFTIKNALGQKVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSSC 282
            |.||||||::.|||:||||:|.|.|.||||||||||..|.|||::.||..:|||.:.||..|.||
Zfish   114 FIGFETNNQYEIKNSLGQKIYSAKEKNDCCTRNCCGALRSFDMKIKDNMDREVIRLIRPYRCVSC 178

  Fly   283 LFPCCLQSIEVSAPPGNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVVS 347
            ..|||||.:|:.||||..||.::|:|..|.|.|.|:....:|||::|||....:.||||.|.:..
Zfish   179 WCPCCLQEMEIQAPPGTPIGYVKQDWHPCYPKFSIMGPNKETVMKLEGPCMACNCCGDVHFELKG 243

  Fly   348 L--TGEKIGKISKQWSGLAREIFTDADFFGINFPLDLDVRMKAVLLGATFLIDAMFFEKAGN 407
            .  ||:.||:|||||:||.:|:|||||.|||.||||:||:|||||:|..||||.|||||.|:
Zfish   244 KDGTGKPIGRISKQWTGLLKEVFTDADNFGIQFPLDMDVKMKAVLMGTCFLIDFMFFEKVGD 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887	16/37 (43%)
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	130/222 (59%)
plscr3b	NP_998031.1	RRM	<4..94	CDD:330708	44/106 (42%)
plscr3b	NP_998031.1	Scramblase	80..302	CDD:252175	130/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41418
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2459
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		otm25733
orthoMCL	1	0.900	-	-		OOG6_100156
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.830