DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb1 and PLSCR5

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_016861862.1	Gene:	PLSCR5 / 389158	HGNCID:	19952	Length:	300	Species:	Homo sapiens

Alignment Length:	254	Identity:	113/254 - (44%)
Similarity:	158/254 - (62%)	Gaps:	19/254 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 PGMGPGMAP---QGGPAGD------W-MSIP---TGIP--NCPRGLEYLTTIDQLLVKQKVELLE 216
            ||..|| ||   |..||..      | :|:|   :.:|  :.|.|||||:.:|.:::.|:||||.
Human    14 PGFLPG-APDPDQSLPASSNPGNQAWQLSLPLPSSFLPTVSLPPGLEYLSQLDLIIIHQQVELLG 77

  Fly   217 AFTGFETNNKFTIKNALGQKVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSS 281
            ...|.||:||:.|||:|||::|||.|::.|..|..|...|...:|:.||..:|||.::|||.|:|
Human    78 MILGTETSNKYEIKNSLGQRIYFAVEESICFNRTFCSTLRSCTLRITDNSGREVITVNRPLRCNS 142

  Fly   282 CLFPCCLQSIEVSAPPGNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVV 346
            |..||.||.:|:.||||.::|.:.|:|....|.|.|.|...:.:::|.||..|....|||:|.|.
Human   143 CWCPCYLQELEIQAPPGTIVGYVTQKWDPFLPKFTIQNANKEDILKIVGPCVTCGCFGDVDFEVK 207

  Fly   347 SLTGEK--IGKISKQWSGLAREIFTDADFFGINFPLDLDVRMKAVLLGATFLIDAMFFE 403
            :: .||  ||||||.|||...::||:||.|||:.|.||||.:||.::||.||..:|.||
Human   208 TI-NEKLTIGKISKYWSGFVNDVFTNADNFGIHVPADLDVTVKAAMIGACFLFVSMGFE 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	103/227 (45%)
PLSCR5	XP_016861862.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1579
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		mtm8657
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.920