DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb1 and scramb2

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_647761.1	Gene:	scramb2 / 38362	FlyBaseID:	FBgn0035390	Length:	263	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	143/266 - (53%)
Similarity:	180/266 - (67%)	Gaps:	14/266 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PGGPPNAFGGYPPGQPQQPIVTQPGMGPGMGPGMAPQGGPAGDWMSIPTGIPNCPRGLEYLTTID 204
            |...|....|....|||...|.....||             .:|||||.|:||||:||||||.:|
  Fly    11 PQNAPQDENGAVVLQPQAANVGNNANGP-------------ENWMSIPVGMPNCPQGLEYLTALD 62

  Fly   205 QLLVKQKVELLEAFTGFETNNKFTIKNALGQKVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQE 269
            ||||.||:|.||..|||||.|:|.:||:|||.||||.|::||||||..|.:|||:|::.||||.|
  Fly    63 QLLVSQKIEKLELLTGFETKNRFKVKNSLGQNVYFAYEESDCCTRNMLGRSRPFEMKILDNFQNE 127

  Fly   270 VIHMHRPLACS-SCLFPCCLQSIEVSAPPGNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFC 333
            |:|::||..|. .|.||.|:.::|||||||.|||::||..:...|.|.|.|..||||::||||.|
  Fly   128 VLHLYRPFKCDILCCFPSCMNAVEVSAPPGQVIGSVEQVCTFMRPKFNIKNTCGDTVLQIEGPVC 192

  Fly   334 TFSLCGDVEFNVVSLTGEKIGKISKQWSGLAREIFTDADFFGINFPLDLDVRMKAVLLGATFLID 398
            ......|..|.|:|...|:|||||||||||.||:|||||:|.:.|||:|||||||::..|.||||
  Fly   193 PCKCFSDTNFKVLSANNEEIGKISKQWSGLGRELFTDADYFSVTFPLNLDVRMKALIFAALFLID 257

  Fly   399 AMFFEK 404
            |:::|:
  Fly   258 AVYYEQ 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	132/220 (60%)
scramb2	NP_647761.1	Scramblase	42..263	CDD:252175	132/220 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460699
Domainoid	1	1.000	58	1.000	Domainoid score	I3943
eggNOG	1	0.900	-	-		E1_KOG0621
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I2660
Isobase	1	0.950	-	0	Normalized mean entropy	S1940
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		mtm8892
orthoMCL	1	0.900	-	-		OOG6_100156
Panther	1	1.100	-	-	P	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
	12	11.750