DRSC/TRiP Functional Genomics Resources

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Protein Alignment scramb1 and Plscr4

DIOPT Version :9

Sequence 1:NP_648389.3 Gene:scramb1 / 326186 FlyBaseID:FBgn0052056 Length:416 Species:Drosophila melanogaster
Sequence 2:NP_848826.1 Gene:Plscr4 / 235527 MGIID:2143267 Length:326 Species:Mus musculus


Alignment Length:296 Identity:124/296 - (41%)
Similarity:161/296 - (54%) Gaps:24/296 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 PPQAFGGYPPGPAGPGGPPNA---FGGYPPGQP-----------QQPIVTQPGMGPGMGPGMAPQ 176
            ||.....:.||||||...|:|   .|.|.|.||           ..||..|||..|     :..|
Mouse    30 PPDYNSHFAPGPAGPVASPSAGLPMGYYIPQQPGAIPLYHPTGGTHPIQYQPGKYP-----VTNQ 89

  Fly   177 GGPAGDWMSIPTGIPNCPRGLEYLTTIDQLLVKQKVELLEAFTGFETNNKFTIKNALGQKVYFAA 241
            ..|. .||:.|..:||||.|||||..:|.:.|.|.||.||..|.|||||::.|||.:.|.||...
Mouse    90 PAPI-MWMAGPAPVPNCPPGLEYLAQLDNIHVLQHVEPLELMTRFETNNRYDIKNNIDQMVYIVT 153

  Fly   242 EDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSSCLF--PCCLQSIEVSAPPGNVIGTI 304
            ||.|..|||.....|||.:||.|...:|::.|.||..|:.|.|  ||..|.:||..|||..||.:
Mouse   154 EDTDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCTCCCFCCPCARQELEVQCPPGVTIGFV 218

  Fly   305 EQEWSICSPSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVVSLTG-EKIGKISKQWSGLAREIF 368
            .:.|::|..|:.|.|...:::||:.||..|:....|..|.:.||.| ..||.|.::|:|.. ...
Mouse   219 AEHWNLCRASYSIQNEKKESMMRVRGPCATYGCGSDSVFEINSLDGVSNIGSIIRKWNGFL-STM 282

  Fly   369 TDADFFGINFPLDLDVRMKAVLLGATFLIDAMFFEK 404
            .:||.|.|.|||.|||:|||::.|:.||||.|:||:
Mouse   283 VNADHFEIRFPLALDVKMKAMIFGSCFLIDFMYFER 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scramb1NP_648389.3 Sox_C_TAD <61..>129 CDD:288887 2/2 (100%)
Scramblase 184..404 CDD:252175 99/222 (45%)
Plscr4NP_848826.1 Proline-rich domain (PRD). /evidence=ECO:0000250 1..94 23/69 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 1/1 (100%)
SH3-binding 1. /evidence=ECO:0000255 18..25
DAZAP2 27..>113 CDD:287943 34/88 (39%)
PPxY motif. /evidence=ECO:0000255 30..33 2/2 (100%)
SH3-binding 2. /evidence=ECO:0000255 41..49 4/7 (57%)
SH3-binding 3. /evidence=ECO:0000255 94..102 3/7 (43%)
Scramblase 96..318 CDD:252175 99/222 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0621
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1015148at2759
OrthoFinder 1 1.000 - - FOG0000205
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23248
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X164
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
87.880

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