DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb1 and Plscr1

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_006243598.1	Gene:	Plscr1 / 117540	RGDID:	620521	Length:	352	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	196/377 - (51%)
Similarity:	228/377 - (60%)	Gaps:	39/377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPAPGHPQPPPPTNYGFMPGPQPAGYAPVPQMPPYGEAPPYGAGQPPYMGGPGGQPPYAGGPGGQ 107
            ||.||   |..|...|   .|:.|.| |:||....|...||...|.||   ||.|.||||..|
  Rat    10 PPYPG---PYLPAIQG---PPEHAAY-PIPQADYQGSQGPYPGPQGPY---PGPQGPYAGPQG-- 62

  Fly   108 PPYVGGPGGQPHYGGGAPPPQAFGGYP-PGPAGPGGPPNAFGGYPPGQP--QQPIVTQPGMGPGM 169
             ||   ||.|..|.|    ||  |.|| |.|..|..|.:..||.|.|.|  .||....||
  Rat    63 -PY---PGPQGPYAG----PQ--GPYPGPQPGYPVPPGSYAGGDPSGFPVQHQPAYNHPG----- 112

  Fly   170 GPGMAPQGGPAGDWMSIPTGIPNCPRGLEYLTTIDQLLVKQKVELLEAFTGFETNNKFTIKNALG 234
            |||..|       ||..|....:||.||||||.|||:||.|::||||..||||||||:.|||:||
  Rat   113 GPGGTP-------WMQAPPPPLDCPPGLEYLTQIDQILVHQQIELLEVLTGFETNNKYEIKNSLG 170

  Fly   235 QKVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSSCLFPCCLQSIEVSAPPGN 299
            |:||||.||.|||||||||.:|||.:|:.||..:||:.:.|||.||||.||||||.||:.||||.
  Rat   171 QRVYFAVEDTDCCTRNCCGASRPFTLRILDNMGREVMTLERPLRCSSCCFPCCLQEIEIQAPPGV 235

  Fly   300 VIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVVSLTGEK-IGKISKQWSGL 363
            .:|.:.|.|..|.|.|.:.|.....|:::.||....|.|.|::|.:.||..|. :|||||||||.
  Rat   236 PVGYVIQTWHPCLPKFTLQNEKRQDVLKVVGPCVVCSCCSDIDFELKSLDEESVVGKISKQWSGF 300

  Fly   364 AREIFTDADFFGINFPLDLDVRMKAVLLGATFLIDAMFFEKAGNQETDRPGM 415
            .||.|||||.|||.|||||||:||||:|||.||||.||||:.||:| .|.|:
  Rat   301 VREAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFERTGNEE-QRSGV 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887	28/67 (42%)
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	133/220 (60%)
Plscr1	XP_006243598.1	Scramblase	132..341	CDD:252175	129/208 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1544
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41418
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2271
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		mtm9137
orthoMCL	1	0.900	-	-		OOG6_100156
Panther	1	1.100	-	-	LDO	PTHR23248
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830